Strain Name:

B6.129S(Cg)-Stat1tm1Dlv/J

Stock Number:

012606

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Availability:

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Use Restrictions Apply, see Terms of Use
In this strain, a neo cassette replaces exons 3-5 and part of exon 2 of the endogenous mouse signal transducer and activator of transcription 1 (Stat1) gene, abolishing gene function. These mice may be useful for studying the mechanisms of IFN-induced and STAT1-dependant resistance to infection.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemWild-type x Heterozygote         (Female x Male)   30-AUG-13
Mating SystemHeterozygote x Wild-type         (Female x Male)   30-AUG-13
Specieslaboratory mouse
GenerationN8+pN1 (17-OCT-13)
Generation Definitions
 
Donating Investigator David E. Levy,   New York University
Donating Investigator Tiffany A. Reese,   Washington University School of Medicine

Description
In this strain, a neo cassette replaces exons 3-5 and part of exon 2 of the endogenous mouse signal transducer and activator of transcription 1 (Stat1) gene, abolishing gene function. Mice homozygous for the Stat1 allele are viable and fertile when maintained under SPF conditions. Homozygotes tend to be runted and die within 48 hours of weaning due to hepatic necrosis due to viral infection in conventional facilities. Homozygous Stat1-/- mice fail to mount transcriptional responses to IFNα or IFNγ, as shown by lack of induction of normal IFN inducible genes ISG54, IRF-1, or ISGF3γp48. STAT1 response results in abnormal innate immunity, but may be redundant in pathways other than IFN due to various compensatory mechanisms. These mice may be useful for studying the mechanisms of INF-induced and STAT1-dependant resistance to infection.

Development
A targeting vector was designed by Dr. David E. Levy (New York University School of Medicine) to replace exons 3-5 and part of exon 2 encoding the signal transducer and activator of transcription 1 (Stat1) gene with a neomycin resistance (neo) cassette in reverse orientation to the gene. The construct was electroporated into 129S/SvEv-derived CCE embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts and the resulting chimeric males were bred to C57BL/6 females and subsequently to CD1 mice to generate a colony of Stat1-/- mice. These mice were backcrossed 8 generations to C57BL/6 background and following micro satellite marker analysis 100% C57BL/6 animals were selected for subsequent interbreeding. Upon arrival at The Jackson Laboratory, mice were bred to C57BL/6J (Stock No. 000664) for at least one generation to establish the colony.

Control Information

  Control
   Wild-type from the colony
   000664 C57BL/6J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Stat1
012901   B6;129S-Stat1tm1Mam/Mmjax
View Strains carrying other alleles of Stat1     (1 strain)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Candidiasis, Familial, 7; CANDF7   (STAT1)
Immunodeficiency 31a; IMD31A   (STAT1)
Immunodeficiency 31b; IMD31B   (STAT1)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Stat1tm1Dlv/Stat1tm1Dlv

        B6.129-Stat1tm1Dlv
  • immune system phenotype
  • increased susceptibility to viral infection
    • slighty more susceptible to MCMV and Sindbis viral infection than wild-type   (MGI Ref ID J:81243)

Stat1tm1Dlv/Stat1tm1Dlv

        B6.129S-Stat1tm1Dlv
  • immune system phenotype
  • abnormal NK cell physiology
    • proportions of spleen NK cells expressing intracellular IFN-gamma from MCMV infected mice are increased   (MGI Ref ID J:79552)
    • there is 75% less actively proliferating NK cells in the spleen after MCMV infection compared to controls   (MGI Ref ID J:79552)
    • NK cells have less proliferation in response to IFN-alpha treatment compared to controls and thus do not have the 2- to 6-fold gains in liver NK cell numbers that wild-type controls do   (MGI Ref ID J:79552)
    • impaired natural killer cell mediated cytotoxicity
      • NK cells from MCMV-infected mice have about 3-fold less cytotoxicity than wild-type NK cells   (MGI Ref ID J:79552)
      • NK cells fail to increase their cytolytic activity when treated with recombinant IFN-alpha   (MGI Ref ID J:79552)
  • increased circulating interferon-gamma level
    • serum IFN-gamma levels are 6-fold higher than controls in mice infected with MCMV   (MGI Ref ID J:79552)
  • increased circulating interleukin-12b level
    • mice infected with LCMV have 5-fold higher levels of IL-12 p40 than in controls   (MGI Ref ID J:79552)
  • homeostasis/metabolism phenotype
  • increased circulating interferon-gamma level
    • serum IFN-gamma levels are 6-fold higher than controls in mice infected with MCMV   (MGI Ref ID J:79552)
  • increased circulating interleukin-12b level
    • mice infected with LCMV have 5-fold higher levels of IL-12 p40 than in controls   (MGI Ref ID J:79552)
  • hematopoietic system phenotype
  • abnormal NK cell physiology
    • proportions of spleen NK cells expressing intracellular IFN-gamma from MCMV infected mice are increased   (MGI Ref ID J:79552)
    • there is 75% less actively proliferating NK cells in the spleen after MCMV infection compared to controls   (MGI Ref ID J:79552)
    • NK cells have less proliferation in response to IFN-alpha treatment compared to controls and thus do not have the 2- to 6-fold gains in liver NK cell numbers that wild-type controls do   (MGI Ref ID J:79552)
    • impaired natural killer cell mediated cytotoxicity
      • NK cells from MCMV-infected mice have about 3-fold less cytotoxicity than wild-type NK cells   (MGI Ref ID J:79552)
      • NK cells fail to increase their cytolytic activity when treated with recombinant IFN-alpha   (MGI Ref ID J:79552)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Stat1tm1Dlv/Stat1tm1Dlv

        either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)
  • mortality/aging
  • complete lethality at weaning
    • mice fail to thrive, with death occurring withing 48 hours of weaning   (MGI Ref ID J:31325)
  • digestive/alimentary phenotype
  • abnormal intestine morphology
    • intestinal lesions of necrotic foci with syncytial giant cells at necroscopy, incomplete penetrance   (MGI Ref ID J:31325)
  • growth/size/body phenotype
  • decreased body size   (MGI Ref ID J:31325)
  • immune system phenotype
  • abnormal leukocyte physiology
    • splenocytes and macrophages failed to respond transcriptionally after exposure to IFN-gamma   (MGI Ref ID J:31325)
  • increased susceptibility to viral infection
    • observed in conventional facility, where mouse hepatitis virus was common   (MGI Ref ID J:31325)
    • observed when exposed to vesicular stomatitis virus (VSV) under specific pathogen-free conditions   (MGI Ref ID J:31325)
  • liver/biliary system phenotype
  • multifocal hepatic necrosis
    • with syncytial cell formation at necroscopy   (MGI Ref ID J:31325)
  • hematopoietic system phenotype
  • abnormal leukocyte physiology
    • splenocytes and macrophages failed to respond transcriptionally after exposure to IFN-gamma   (MGI Ref ID J:31325)

Stat1tm1Dlv/Stat1tm1Dlv

        involves: 129S/SvEv
  • immune system phenotype
  • abnormal MHC II cell surface expression on macrophages
    • unstimulated bone marrow derived macrophages have much lower expression of class II on cell surface   (MGI Ref ID J:130622)
  • decreased level of surface class I molecules
    • unstimulated bone marrow derived macrophages have lower expression of class I on the cell surface   (MGI Ref ID J:130622)
  • decreased susceptibility to endotoxin shock
    • no mice die of LPS at a dose of 37 mg/kg body weight compared to 80% of Stat1tm1Tdec homozygotes dying at this dose   (MGI Ref ID J:130622)
  • increased circulating interferon-gamma level
    • LPS administration leads to about 10-fold higher levels of IFN-gamma in the sera of mice compared to wild-type mice treated with LPS   (MGI Ref ID J:130622)
  • increased susceptibility to bacterial infection
    • mice all die when infected with 104 or higher Listeria monocytogenes bacteria while all wild-type mice survive   (MGI Ref ID J:130622)
  • increased susceptibility to viral infection
    • primary fibroblasts pre-treated with IFN-gamma and then exposed to vesicular stomatitis virus are all dead 24 hours later regardless of the amount of IFN-gamma used   (MGI Ref ID J:130622)
  • homeostasis/metabolism phenotype
  • increased circulating interferon-gamma level
    • LPS administration leads to about 10-fold higher levels of IFN-gamma in the sera of mice compared to wild-type mice treated with LPS   (MGI Ref ID J:130622)
  • vision/eye phenotype
  • *normal* vision/eye phenotype
    • lens development is normal   (MGI Ref ID J:88422)
  • hematopoietic system phenotype
  • abnormal MHC II cell surface expression on macrophages
    • unstimulated bone marrow derived macrophages have much lower expression of class II on cell surface   (MGI Ref ID J:130622)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cell Biology Research
Transcriptional Regulation

Hematological Research
Immunological Defects

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      Macrophage defects

Research Tools
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: transcriptional activation

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Stat1tm1Dlv
Allele Name targeted mutation 1, David E Levy
Allele Type Targeted (Null/Knockout)
Common Name(s) STAT1-; STAT-; Stat1 KO;
Mutation Made By David Levy,   New York University
Strain of Origin129S/SvEv-Gpi1
Gene Symbol and Name Stat1, signal transducer and activator of transcription 1
Chromosome 1
Gene Common Name(s) 2010005J02Rik; AA408197; CANDF7; DD6G4-4; IMD31A; IMD31B; IMD31C; ISGF-3; RIKEN cDNA 2010005J02 gene; STAT91; expressed sequence AA408197;
Molecular Note A neomycin resistance cassette replaced 5.7 kb of sequence, including 3 exons and a portion of a fourth encoding amino acids 221-365. This allele produces a partial nonfunctional protein product. [MGI Ref ID J:31325]

Genotyping

Genotyping Information

Genotyping Protocols

Stat1tm1Dlv,

SEPARATED MELT



Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Durbin JE; Hackenmiller R; Simon MC; Levy DE. 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84(3):443-50. [PubMed: 8608598]  [MGI Ref ID J:31325]

Additional References

Stat1tm1Dlv related

Anfossi N; Robbins SH; Ugolini S; Georgel P; Hoebe K; Bouneaud C; Ronet C; Kaser A; DiCioccio CB; Tomasello E; Blumberg RS; Beutler B; Reiner SL; Alexopoulou L; Lantz O; Raulet DH; Brossay L; Vivier E. 2004. Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules. J Immunol 173(6):3773-82. [PubMed: 15356124]  [MGI Ref ID J:92767]

Bancerek J; Poss ZC; Steinparzer I; Sedlyarov V; Pfaffenwimmer T; Mikulic I; Dolken L; Strobl B; Muller M; Taatjes DJ; Kovarik P. 2013. CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response. Immunity 38(2):250-62. [PubMed: 23352233]  [MGI Ref ID J:193482]

Barbi J; Snider HM; Bhardwaj N; Lezama-Davila CM; Durbin JE; Satoskar AR. 2009. Signal transducer and activator of transcription 1 in T cells plays an indispensable role in immunity to Leishmania major by mediating Th1 cell homing to the site of infection. FASEB J 23(11):3990-9. [PubMed: 19641143]  [MGI Ref ID J:154485]

Chen LS; Wei PC; Liu T; Kao CH; Pai LM; Lee CK. 2009. STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response. J Biomed Sci 16:22. [PubMed: 19272190]  [MGI Ref ID J:164049]

Chen ST; Lin YL; Huang MT; Wu MF; Cheng SC; Lei HY; Lee CK; Chiou TW; Wong CH; Hsieh SL. 2008. CLEC5A is critical for dengue-virus-induced lethal disease. Nature 453(7195):672-6. [PubMed: 18496526]  [MGI Ref ID J:172968]

Chen ST; Liu RS; Wu MF; Lin YL; Chen SY; Tan DT; Chou TY; Tsai IS; Li L; Hsieh SL. 2012. CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality. PLoS Pathog 8(4):e1002655. [PubMed: 22536153]  [MGI Ref ID J:195391]

Chen Y; Langrish CL; McKenzie B; Joyce-Shaikh B; Stumhofer JS; McClanahan T; Blumenschein W; Churakovsa T; Low J; Presta L; Hunter CA; Kastelein RA; Cua DJ. 2006. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest 116(5):1317-26. [PubMed: 16670771]  [MGI Ref ID J:108945]

Collison LW; Delgoffe GM; Guy CS; Vignali KM; Chaturvedi V; Fairweather D; Satoskar AR; Garcia KC; Hunter CA; Drake CG; Murray PJ; Vignali DA. 2012. The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol 13(3):290-9. [PubMed: 22306691]  [MGI Ref ID J:181328]

Crozat K; Georgel P; Rutschmann S; Mann N; Du X; Hoebe K; Beutler B. 2006. Analysis of the MCMV resistome by ENU mutagenesis. Mamm Genome 17(5):398-406. [PubMed: 16688530]  [MGI Ref ID J:105543]

Datta S; Parajuli N; Tymoszuk P; Ottina E; Parson W; Sgonc R; Villunger A; Doppler W. 2014. Replenishment of the B cell compartment after doxorubicin-induced hematopoietic toxicity is facilitated by STAT1. J Leukoc Biol 95(6):853-66. [PubMed: 24295829]  [MGI Ref ID J:211880]

Deppong CM; Xu J; Brody SL; Green JM. 2012. Airway epithelial cells suppress T cell proliferation by an IFNgamma/STAT1/TGFbeta-dependent mechanism. Am J Physiol Lung Cell Mol Physiol 302(1):L167-73. [PubMed: 22003092]  [MGI Ref ID J:183329]

Dorner M; Horwitz JA; Donovan BM; Labitt RN; Budell WC; Friling T; Vogt A; Catanese MT; Satoh T; Kawai T; Akira S; Law M; Rice CM; Ploss A. 2013. Completion of the entire hepatitis C virus life cycle in genetically humanized mice. Nature 501(7466):237-41. [PubMed: 23903655]  [MGI Ref ID J:205017]

Duek A; Lundberg P; Shimizu T; Grisouard J; Karow A; Kubovcakova L; Hao-Shen H; Dirnhofer S; Skoda RC. 2014. Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F-driven mouse model of MPNs. Blood 123(25):3943-50. [PubMed: 24820309]  [MGI Ref ID J:211277]

Durbin JE; Fernandez-Sesma A; Lee CK; Rao TD; Frey AB; Moran TM; Vukmanovic S; Garcia-Sastre A; Levy DE. 2000. Type I IFN modulates innate and specific antiviral immunity. J Immunol 164(8):4220-8. [PubMed: 10754318]  [MGI Ref ID J:123432]

Durbin JE; Johnson TR; Durbin RK; Mertz SE; Morotti RA; Peebles RS; Graham BS. 2002. The role of IFN in respiratory syncytial virus pathogenesis. J Immunol 168(6):2944-52. [PubMed: 11884466]  [MGI Ref ID J:126678]

Ebong S; Chepelinsky AB; Robinson ML; Zhao H; Yu CR; Egwuagu CE. 2004. Characterization of the roles of STAT1 and STAT3 signal transduction pathways in mammalian lens development. Mol Vis 10:122-31. [PubMed: 14978477]  [MGI Ref ID J:88422]

Ellis SL; Gysbers V; Manders PM; Li W; Hofer MJ; Muller M; Campbell IL. 2010. The cell-specific induction of CXC chemokine ligand 9 mediated by IFN-gamma in microglia of the central nervous system is determined by the myeloid transcription factor PU.1. J Immunol 185(3):1864-77. [PubMed: 20585034]  [MGI Ref ID J:162468]

Fallarino F; Gajewski TF. 1999. Cutting edge: differentiation of antitumor CTL in vivo requires host expression of Stat1. J Immunol 163(8):4109-13. [PubMed: 10510345]  [MGI Ref ID J:111636]

Farlik M; Reutterer B; Schindler C; Greten F; Vogl C; Muller M; Decker T. 2010. Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. Immunity 33(1):25-34. [PubMed: 20637660]  [MGI Ref ID J:162548]

Fielhaber JA; Carroll SF; Dydensborg AB; Shourian M; Triantafillopoulos A; Harel S; Hussain SN; Bouchard M; Qureshi ST; Kristof AS. 2012. Inhibition of mammalian target of rapamycin augments lipopolysaccharide-induced lung injury and apoptosis. J Immunol 188(9):4535-42. [PubMed: 22450807]  [MGI Ref ID J:188464]

Gerbitz A; Sukumar M; Helm F; Wilke A; Friese C; Fahrenwaldt C; Lehmann FM; Loddenkemper C; Kammertoens T; Mautner J; Schmitt CA; Blankenstein T; Bornkamm GW. 2012. Stromal interferon-gamma signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice. PLoS One 7(3):e34552. [PubMed: 22479645]  [MGI Ref ID J:187120]

Gil MP; Bohn E; O'Guin AK; Ramana CV; Levine B; Stark GR; Virgin HW; Schreiber RD. 2001. Biologic consequences of Stat1-independent IFN signaling. Proc Natl Acad Sci U S A 98(12):6680-5. [PubMed: 11390995]  [MGI Ref ID J:81243]

Gil MP; Ploquin MJ; Watford WT; Lee SH; Kim K; Wang X; Kanno Y; O'Shea JJ; Biron CA. 2012. Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function. Blood 120(18):3718-28. [PubMed: 22968462]  [MGI Ref ID J:191417]

Gimeno R; Lee CK; Schindler C; Levy DE. 2005. Stat1 and stat2 but not stat3 arbitrate contradictory growth signals elicited by alpha/beta interferon in T lymphocytes. Mol Cell Biol 25(13):5456-65. [PubMed: 15964802]  [MGI Ref ID J:99124]

Guarda G; Braun M; Staehli F; Tardivel A; Mattmann C; Forster I; Farlik M; Decker T; Du Pasquier RA; Romero P; Tschopp J. 2011. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34(2):213-23. [PubMed: 21349431]  [MGI Ref ID J:168972]

Halupa A; Bailey ML; Huang K; Iscove NN; Levy DE; Barber DL. 2005. A novel role for STAT1 in regulating murine erythropoiesis: deletion of STAT1 results in overall reduction of erythroid progenitors and alters their distribution. Blood 105(2):552-61. [PubMed: 15213094]  [MGI Ref ID J:96513]

Hannesdottir L; Daschil N; Philipp S; Tymoszuk P; Muller-Holzner E; Klima G; Verdorfer I; Doppler W. 2012. MMTV-neu mice deficient in STAT1 are susceptible to develop ovarian teratomas. Int J Dev Biol 56(4):279-83. [PubMed: 22562203]  [MGI Ref ID J:184519]

Hannesdottir L; Tymoszuk P; Parajuli N; Wasmer MH; Philipp S; Daschil N; Datta S; Koller JB; Tripp CH; Stoitzner P; Muller-Holzner E; Wiegers GJ; Sexl V; Villunger A; Doppler W. 2013. Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response. Eur J Immunol 43(10):2718-29. [PubMed: 23843024]  [MGI Ref ID J:201671]

Hirahara K; Ghoreschi K; Yang XP; Takahashi H; Laurence A; Vahedi G; Sciume G; Hall AO; Dupont CD; Francisco LM; Chen Q; Tanaka M; Kanno Y; Sun HW; Sharpe AH; Hunter CA; O'Shea JJ. 2012. Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1. Immunity 36(6):1017-30. [PubMed: 22726954]  [MGI Ref ID J:187415]

Hofer MJ; Li W; Lim SL; Campbell IL. 2010. The type I interferon-alpha mediates a more severe neurological disease in the absence of the canonical signaling molecule interferon regulatory factor 9. J Neurosci 30(3):1149-57. [PubMed: 20089923]  [MGI Ref ID J:157694]

Huang B; Pan PY; Li Q; Sato AI; Levy DE; Bromberg J; Divino CM; Chen SH. 2006. Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res 66(2):1123-31. [PubMed: 16424049]  [MGI Ref ID J:106544]

Huber M; Steinwald V; Guralnik A; Brustle A; Kleemann P; Rosenplanter C; Decker T; Lohoff M. 2008. IL-27 inhibits the development of regulatory T cells via STAT3. Int Immunol 20(2):223-34. [PubMed: 18156621]  [MGI Ref ID J:130922]

Iyer SS; Ghaffari AA; Cheng G. 2010. Lipopolysaccharide-Mediated IL-10 Transcriptional Regulation Requires Sequential Induction of Type I IFNs and IL-27 in Macrophages. J Immunol 185(11):6599-607. [PubMed: 21041726]  [MGI Ref ID J:166135]

Jiang LJ; Zhang NN; Ding F; Li XY; Chen L; Zhang HX; Zhang W; Chen SJ; Wang ZG; Li JM; Chen Z; Zhu J. 2011. RA-inducible gene-I induction augments STAT1 activation to inhibit leukemia cell proliferation. Proc Natl Acad Sci U S A 108(5):1897-902. [PubMed: 21224412]  [MGI Ref ID J:169128]

Johnson LM; Scott P. 2007. STAT1 expression in dendritic cells, but not T cells, is required for immunity to Leishmania major. J Immunol 178(11):7259-66. [PubMed: 17513775]  [MGI Ref ID J:147831]

Johnson TR; Mertz SE; Gitiban N; Hammond S; Legallo R; Durbin RK; Durbin JE. 2005. Role for innate IFNs in determining respiratory syncytial virus immunopathology. J Immunol 174(11):7234-41. [PubMed: 15905569]  [MGI Ref ID J:99027]

Kacha AK; Fallarino F; Markiewicz MA; Gajewski TF. 2000. Spontaneous rejection of poorly immunogenic P1.HTR tumors by Stat6-deficient mice J Immunol 165(11):6024-8. [PubMed: 11086033]  [MGI Ref ID J:65893]

Karaghiosoff M; Steinborn R; Kovarik P; Kriegshauser G; Baccarini M; Donabauer B; Reichart U; Kolbe T; Bogdan C; Leanderson T; Levy D; Decker T; Muller M. 2003. Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock. Nat Immunol 4(5):471-7. [PubMed: 12679810]  [MGI Ref ID J:83115]

Kelchtermans H; Struyf S; De Klerck B; Mitera T; Alen M; Geboes L; Van Balen M; Dillen C; Put W; Gysemans C; Billiau A; Van Damme J; Matthys P. 2007. Protective role of IFN-gamma in collagen-induced arthritis conferred by inhibition of mycobacteria-induced granulocyte chemotactic protein-2 production. J Leukoc Biol 81(4):1044-53. [PubMed: 17200147]  [MGI Ref ID J:121452]

Kim G; Shinnakasu R; Saris CJ; Cheroutre H; Kronenberg M. 2013. A Novel Role for IL-27 in Mediating the Survival of Activated Mouse CD4 T Lymphocytes. J Immunol 190(4):1510-8. [PubMed: 23335749]  [MGI Ref ID J:193497]

Kimura HJ; Chen CY; Tzou SC; Rocchi R; Landek-Salgado MA; Suzuki K; Kimura M; Rose NR; Caturegli P. 2009. Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism: studies in humans and mice. PLoS One 4(11):e7857. [PubMed: 19924240]  [MGI Ref ID J:155418]

King KY; Baldridge MT; Weksberg DC; Chambers SM; Lukov GL; Wu S; Boles NC; Jung SY; Qin J; Liu D; Songyang Z; Eissa NT; Taylor GA; Goodell MA. 2011. Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood 118(6):1525-33. [PubMed: 21633090]  [MGI Ref ID J:176943]

Kohlmeier JE; Cookenham T; Roberts AD; Miller SC; Woodland DL. 2010. Type I interferons regulate cytolytic activity of memory CD8(+) T cells in the lung airways during respiratory virus challenge. Immunity 33(1):96-105. [PubMed: 20637658]  [MGI Ref ID J:162550]

Kovacic B; Stoiber D; Moriggl R; Weisz E; Ott RG; Kreibich R; Levy DE; Beug H; Freissmuth M; Sexl V. 2006. STAT1 acts as a tumor promoter for leukemia development. Cancer Cell 10(1):77-87. [PubMed: 16843267]  [MGI Ref ID J:110949]

Kusmartsev S; Gabrilovich DI. 2005. STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion. J Immunol 174(8):4880-91. [PubMed: 15814715]  [MGI Ref ID J:109996]

Lassnig C; Kolb A; Strobl B; Enjuanes L; Muller M. 2005. Studying human pathogens in animal models: fine tuning the humanized mouse. Transgenic Res 14(6):803-6. [PubMed: 16315087]  [MGI Ref ID J:103578]

Lassnig C; Sanchez CM; Egerbacher M; Walter I; Majer S; Kolbe T; Pallares P; Enjuanes L; Muller M. 2005. Development of a transgenic mouse model susceptible to human coronavirus 229E. Proc Natl Acad Sci U S A 102(23):8275-80. [PubMed: 15919828]  [MGI Ref ID J:99728]

Lee CK; Gimeno R; Levy DE. 1999. Differential regulation of constitutive major histocompatibility complex class I expression in T and B lymphocytes. J Exp Med 190(10):1451-64. [PubMed: 10562320]  [MGI Ref ID J:58494]

Lee CK; Rao DT; Gertner R; Gimeno R; Frey AB; Levy DE. 2000. Distinct requirements for IFNs and STAT1 in NK cell function. J Immunol 165(7):3571-7. [PubMed: 11034357]  [MGI Ref ID J:119588]

Lee YS; Amadi-Obi A; Yu CR; Egwuagu CE. 2011. Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10. Immunology 132(4):492-502. [PubMed: 21294722]  [MGI Ref ID J:172099]

Lenschow DJ; Lai C; Frias-Staheli N; Giannakopoulos NV; Lutz A; Wolff T; Osiak A; Levine B; Schmidt RE; Garcia-Sastre A; Leib DA; Pekosz A; Knobeloch KP; Horak I; Virgin HW 4th. 2007. IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses. Proc Natl Acad Sci U S A 104(4):1371-6. [PubMed: 17227866]  [MGI Ref ID J:119518]

Lesinski GB; Anghelina M; Zimmerer J; Bakalakos T; Badgwell B; Parihar R; Hu Y; Becknell B; Abood G; Chaudhury AR; Magro C; Durbin J; Carson WE 3rd. 2003. The antitumor effects of IFN-alpha are abrogated in a STAT1-deficient mouse. J Clin Invest 112(2):170-80. [PubMed: 12865406]  [MGI Ref ID J:84618]

Levy DE; Gilliland DG. 2000. Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice. Oncogene 19(21):2505-10. [PubMed: 10851049]  [MGI Ref ID J:62690]

Li J. 2013. JAK-STAT and bone metabolism. JAKSTAT 2(3):e23930. [PubMed: 24069548]  [MGI Ref ID J:202463]

Li J; Bessho K; Shivakumar P; Mourya R; Mohanty SK; Dos Santos JL; Miura IK; Porta G; Bezerra JA. 2011. Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype. J Clin Invest 121(11):4244-56. [PubMed: 22005305]  [MGI Ref ID J:178721]

Liddle FJ; Frank DA. 2008. STAT1 expression is not required for polyp formation in Min mice. Mol Carcinog 47(2):75-9. [PubMed: 17683066]  [MGI Ref ID J:129797]

Lim WS; Timmins JM; Seimon TA; Sadler A; Kolodgie FD; Virmani R; Tabas I. 2008. Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo. Circulation 117(7):940-51. [PubMed: 18227389]  [MGI Ref ID J:145081]

Longhi MP; Trumpfheller C; Idoyaga J; Caskey M; Matos I; Kluger C; Salazar AM; Colonna M; Steinman RM. 2009. Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant. J Exp Med 206(7):1589-602. [PubMed: 19564349]  [MGI Ref ID J:150266]

Merritt C; Enslen H; Diehl N; Conze D; Davis RJ; Rincon M. 2000. Activation of p38 mitogen-activated protein kinase in vivo selectively induces apoptosis of CD8(+) but not CD4(+) T cells. Mol Cell Biol 20(3):936-46. [PubMed: 10629051]  [MGI Ref ID J:59995]

Mikhak Z; Farsidjani A; Luster AD. 2009. Endotoxin augmented antigen-induced Th1 cell trafficking amplifies airway neutrophilic inflammation. J Immunol 182(12):7946-56. [PubMed: 19494319]  [MGI Ref ID J:149283]

Mikhak Z; Fleming CM; Medoff BD; Thomas SY; Tager AM; Campanella GS; Luster AD. 2006. STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells. J Immunol 176(8):4959-67. [PubMed: 16585592]  [MGI Ref ID J:131153]

Miyagi T; Gil MP; Wang X; Louten J; Chu WM; Biron CA. 2007. High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells. J Exp Med 204(10):2383-96. [PubMed: 17846149]  [MGI Ref ID J:126055]

Moore ML; Newcomb DC; Parekh VV; Van Kaer L; Collins RD; Zhou W; Goleniewska K; Chi MH; Mitchell D; Boyce JA; Durbin JE; Sturkie C; Peebles RS Jr. 2009. STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J Immunol 183(3):2016-26. [PubMed: 19587017]  [MGI Ref ID J:151702]

Nakayamada S; Poholek AC; Lu KT; Takahashi H; Kato M; Iwata S; Hirahara K; Cannons JL; Schwartzberg PL; Vahedi G; Sun HW; Kanno Y; O'Shea JJ. 2014. Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program. J Immunol 192(5):2156-66. [PubMed: 24489092]  [MGI Ref ID J:209939]

Newcomb DC; Boswell MG; Huckabee MM; Goleniewska K; Dulek DE; Reiss S; Lukacs NW; Kolls JK; Peebles RS Jr. 2012. IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner. J Immunol 188(3):1027-35. [PubMed: 22210911]  [MGI Ref ID J:180747]

Newcomb DC; Boswell MG; Sherrill TP; Polosukhin VV; Boyd KL; Goleniewska K; Brody SL; Kolls JK; Adler KB; Peebles RS Jr. 2013. IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia. Am J Respir Cell Mol Biol 48(6):711-6. [PubMed: 23392574]  [MGI Ref ID J:211754]

Nguyen KB; Salazar-Mather TP; Dalod MY; Van Deusen JB; Wei XQ; Liew FY; Caligiuri MA; Durbin JE; Biron CA. 2002. Coordinated and distinct roles for IFN-alphabeta, IL-12, and IL-15 regulation of NK cell responses to viral infection. J Immunol 169(8):4279-87. [PubMed: 12370359]  [MGI Ref ID J:79552]

Nishibori T; Tanabe Y; Su L; David M. 2004. Impaired Development of CD4+ CD25+ Regulatory T Cells in the Absence of STAT1: Increased Susceptibility to Autoimmune Disease. J Exp Med 199(1):25-34. [PubMed: 14699080]  [MGI Ref ID J:87436]

Pasieka TJ; Collins L; O'Connor MA; Chen Y; Parker ZM; Berwin BL; Piwnica-Worms DR; Leib DA. 2011. Bioluminescent imaging reveals divergent viral pathogenesis in two strains of Stat1-deficient mice, and in alphassgamma interferon receptor-deficient mice. PLoS One 6(9):e24018. [PubMed: 21915277]  [MGI Ref ID J:177699]

Pasieka TJ; Lu B; Leib DA. 2008. Enhanced pathogenesis of an attenuated herpes simplex virus for mice lacking Stat1. J Virol 82(12):6052-5. [PubMed: 18400863]  [MGI Ref ID J:136268]

Perry ST; Buck MD; Lada SM; Schindler C; Shresta S. 2011. STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor. PLoS Pathog 7(2):e1001297. [PubMed: 21379341]  [MGI Ref ID J:172471]

Pilz A; Kratky W; Stockinger S; Simma O; Kalinke U; Lingnau K; von Gabain A; Stoiber D; Sexl V; Kolbe T; Rulicke T; Muller M; Decker T. 2009. Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL. J Immunol 183(4):2286-93. [PubMed: 19620292]  [MGI Ref ID J:151558]

Putz EM; Gotthardt D; Hoermann G; Csiszar A; Wirth S; Berger A; Straka E; Rigler D; Wallner B; Jamieson AM; Pickl WF; Zebedin-Brandl EM; Muller M; Decker T; Sexl V. 2013. CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance. Cell Rep 4(3):437-44. [PubMed: 23933255]  [MGI Ref ID J:201893]

Radwan M; Stiefvater R; Grunert T; Sharif O; Miller I; Marchetti-Deschmann M; Allmaier G; Gemeiner M; Knapp S; Kovarik P; Muller M; Strobl B. 2010. Tyrosine kinase 2 controls IL-1beta production at the translational level. J Immunol 185(6):3544-53. [PubMed: 20713887]  [MGI Ref ID J:163818]

Robbins SH; Tessmer MS; Van Kaer L; Brossay L. 2005. Direct effects of T-bet and MHC class I expression, but not STAT1, on peripheral NK cell maturation. Eur J Immunol 35(3):757-65. [PubMed: 15719366]  [MGI Ref ID J:96620]

Rosas LE; Keiser T; Pyles R; Durbin J; Satoskar AR. 2003. Development of protective immunity against cutaneous leishmaniasis is dependent on STAT1-mediated IFN signaling pathway. Eur J Immunol 33(7):1799-805. [PubMed: 12811839]  [MGI Ref ID J:84419]

Rosas LE; Snider HM; Barbi J; Satoskar AA; Lugo-Villarino G; Keiser T; Papenfuss T; Durbin JE; Radzioch D; Glimcher LH; Satoskar AR. 2006. Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani. J Immunol 177(1):22-5. [PubMed: 16785492]  [MGI Ref ID J:134384]

Roth KM; Gunn JS; Lafuse W; Satoskar AR. 2009. Francisella inhibits STAT1-mediated signaling in macrophages and prevents activation of antigen-specific T cells. Int Immunol 21(1):19-28. [PubMed: 19001470]  [MGI Ref ID J:143760]

Rothfuchs AG; Trumstedt C; Mattei F; Schiavoni G; Hidmark A; Wigzell H; Rottenberg ME. 2006. STAT1 regulates IFN-alpha beta- and IFN-gamma-dependent control of infection with Chlamydia pneumoniae by nonhemopoietic cells. J Immunol 176(11):6982-90. [PubMed: 16709859]  [MGI Ref ID J:131788]

Sahni M; Ambrosetti DC; Mansukhani A; Gertner R; Levy D; Basilico C. 1999. FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. Genes Dev 13(11):1361-6. [PubMed: 10364154]  [MGI Ref ID J:115220]

Sahni M; Raz R; Coffin JD; Levy D; Basilico C. 2001. STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2. Development 128(11):2119-29. [PubMed: 11493533]  [MGI Ref ID J:69956]

Sanz E; Hofer MJ; Unzeta M; Campbell IL. 2008. Minimal role for STAT1 in interleukin-6 signaling and actions in the murine brain. Glia 56(2):190-9. [PubMed: 18023015]  [MGI Ref ID J:156290]

Sauer I; Schaljo B; Vogl C; Gattermeier I; Kolbe T; Muller M; Blackshear PJ; Kovarik P. 2006. Interferons limit inflammatory responses by induction of tristetraprolin. Blood 107(12):4790-7. [PubMed: 16514065]  [MGI Ref ID J:132823]

Sen A; Rothenberg ME; Mukherjee G; Feng N; Kalisky T; Nair N; Johnstone IM; Clarke MF; Greenberg HB. 2012. Innate immune response to homologous rotavirus infection in the small intestinal villous epithelium at single-cell resolution. Proc Natl Acad Sci U S A 109(50):20667-72. [PubMed: 23188796]  [MGI Ref ID J:193120]

Shi S; Blumenthal A; Hickey CM; Gandotra S; Levy D; Ehrt S. 2005. Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1. J Immunol 175(5):3318-28. [PubMed: 16116224]  [MGI Ref ID J:113220]

Shornick LP; Wells AG; Zhang Y; Patel AC; Huang G; Takami K; Sosa M; Shukla NA; Agapov E; Holtzman MJ. 2008. Airway Epithelial versus Immune Cell Stat1 Function for Innate Defense against Respiratory Viral Infection. J Immunol 180(5):3319-28. [PubMed: 18292557]  [MGI Ref ID J:131724]

Shresta S; Sharar KL; Prigozhin DM; Snider HM; Beatty PR; Harris E. 2005. Critical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in mice. J Immunol 175(6):3946-54. [PubMed: 16148142]  [MGI Ref ID J:116690]

Srinivasan P; Maric M. 2011. Signal transducer and activator of transcription 1 negatively regulates constitutive gamma interferon-inducible lysosomal thiol reductase expression. Immunology 132(2):209-16. [PubMed: 21039465]  [MGI Ref ID J:168634]

Staehli F; Ludigs K; Heinz LX; Seguin-Estevez Q; Ferrero I; Braun M; Schroder K; Rebsamen M; Tardivel A; Mattmann C; MacDonald HR; Romero P; Reith W; Guarda G; Tschopp J. 2012. NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells. J Immunol 188(8):3820-8. [PubMed: 22412192]  [MGI Ref ID J:184076]

Stewart CA; Metheny H; Iida N; Smith L; Hanson M; Steinhagen F; Leighty RM; Roers A; Karp CL; Muller W; Trinchieri G. 2013. Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation. J Clin Invest :. [PubMed: 24216477]  [MGI Ref ID J:204181]

Stockinger S; Materna T; Stoiber D; Bayr L; Steinborn R; Kolbe T; Unger H; Chakraborty T; Levy DE; Muller M; Decker T. 2002. Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes. J Immunol 169(11):6522-9. [PubMed: 12444163]  [MGI Ref ID J:119320]

Strobl B; Bubic I; Bruns U; Steinborn R; Lajko R; Kolbe T; Karaghiosoff M; Kalinke U; Jonjic S; Muller M. 2005. Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus. J Immunol 175(6):4000-8. [PubMed: 16148148]  [MGI Ref ID J:116703]

Thibault DL; Chu AD; Graham KL; Balboni I; Lee LY; Kohlmoos C; Landrigan A; Higgins JP; Tibshirani R; Utz PJ. 2008. IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice. J Clin Invest 118(4):1417-26. [PubMed: 18340381]  [MGI Ref ID J:135976]

Thompson CL; Hofer MJ; Campbell IL; Holmes AJ. 2010. Community dynamics in the mouse gut microbiota: a possible role for IRF9-regulated genes in community homeostasis. PLoS One 5(4):e10335. [PubMed: 20428250]  [MGI Ref ID J:160133]

Timmins JM; Ozcan L; Seimon TA; Li G; Malagelada C; Backs J; Backs T; Bassel-Duby R; Olson EN; Anderson ME; Tabas I. 2009. Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest 119(10):2925-41. [PubMed: 19741297]  [MGI Ref ID J:154647]

Todoric J; Strobl B; Jais A; Boucheron N; Bayer M; Amann S; Lindroos J; Teperino R; Prager G; Bilban M; Ellmeier W; Krempler F; Muller M; Wagner O; Patsch W; Pospisilik JA; Esterbauer H. 2011. Cross-talk between interferon-gamma and hedgehog signaling regulates adipogenesis. Diabetes 60(6):1668-76. [PubMed: 21536945]  [MGI Ref ID J:177949]

VanDeusen JB; Shah MH; Becknell B; Blaser BW; Ferketich AK; Nuovo GJ; Ahmer BM; Durbin J; Caligiuri MA. 2006. STAT-1-mediated repression of monocyte interleukin-10 gene expression in vivo. Eur J Immunol 36(3):623-30. [PubMed: 16482512]  [MGI Ref ID J:114830]

Varinou L; Ramsauer K; Karaghiosoff M; Kolbe T; Pfeffer K; Muller M; Decker T. 2003. Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity. Immunity 19(6):793-802. [PubMed: 14670297]  [MGI Ref ID J:130622]

Verdeguer F; Blattler SM; Cunningham JT; Hall JA; Chim H; Puigserver P. 2014. Decreased genetic dosage of hepatic Yin Yang 1 causes diabetic-like symptoms. Mol Endocrinol 28(3):308-16. [PubMed: 24467246]  [MGI Ref ID J:213006]

Villarino AV; Stumhofer JS; Saris CJ; Kastelein RA; de Sauvage FJ; Hunter CA. 2006. IL-27 limits IL-2 production during Th1 differentiation. J Immunol 176(1):237-47. [PubMed: 16365415]  [MGI Ref ID J:126267]

Wallner B; Leitner NR; Vielnascher RM; Kernbauer E; Kolbe T; Karaghiosoff M; Rulicke T; Decker T; Muller M. 2012. Generation of mice with a conditional Stat1 null allele. Transgenic Res 21(1):217-24. [PubMed: 21553074]  [MGI Ref ID J:183580]

Wang S; Raven JF; Koromilas AE. 2010. STAT1 represses Skp2 gene transcription to promote p27Kip1 stabilization in Ras-transformed cells. Mol Cancer Res 8(5):798-805. [PubMed: 20407011]  [MGI Ref ID J:205236]

Welstead GG; Iorio C; Draker R; Bayani J; Squire J; Vongpunsawad S; Cattaneo R; Richardson CD. 2005. Measles virus replication in lymphatic cells and organs of CD150 (SLAM) transgenic mice. Proc Natl Acad Sci U S A 102(45):16415-20. [PubMed: 16260741]  [MGI Ref ID J:103429]

Wesley JD; Robbins SH; Sidobre S; Kronenberg M; Terrizzi S; Brossay L. 2005. Cutting edge: IFN-gamma signaling to macrophages is required for optimal Valpha14i NK T/NK cell cross-talk. J Immunol 174(7):3864-8. [PubMed: 15778340]  [MGI Ref ID J:97977]

Wesley JD; Tessmer MS; Paget C; Trottein F; Brossay L. 2007. A Y chromosome-linked factor impairs NK T development. J Immunol 179(6):3480-7. [PubMed: 17785781]  [MGI Ref ID J:152056]

Wu C; Pot C; Apetoh L; Thalhamer T; Zhu B; Murugaiyan G; Xiao S; Lee Y; Rangachari M; Yosef N; Kuchroo VK. 2013. Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation. Proc Natl Acad Sci U S A 110(19):7802-7. [PubMed: 23630250]  [MGI Ref ID J:197331]

Yang T; Stark P; Janik K; Wigzell H; Rottenberg ME. 2008. SOCS-1 Protects against Chlamydia pneumoniae-Induced Lethal Inflammation but Hampers Effective Bacterial Clearance. J Immunol 180(6):4040-9. [PubMed: 18322213]  [MGI Ref ID J:132932]

Yokoyama CC; Loh J; Zhao G; Stappenbeck TS; Wang D; Huang HV; Virgin HW; Thackray LB. 2012. Adaptive immunity restricts replication of novel murine astroviruses. J Virol 86(22):12262-70. [PubMed: 22951832]  [MGI Ref ID J:189022]

Yu CR; Mahdi RM; Liu X; Zhang A; Naka T; Kishimoto T; Egwuagu CE. 2008. SOCS1 regulates CCR7 expression and migration of CD4+ T cells into peripheral tissues. J Immunol 181(2):1190-8. [PubMed: 18606672]  [MGI Ref ID J:137465]

Yu CR; Mahdi RR; Oh HM; Amadi-Obi A; Levy-Clarke G; Burton J; Eseonu A; Lee Y; Chan CC; Egwuagu CE. 2011. Suppressor of cytokine signaling-1 (SOCS1) inhibits lymphocyte recruitment into the retina and protects SOCS1 transgenic rats and mice from ocular inflammation. Invest Ophthalmol Vis Sci 52(9):6978-86. [PubMed: 21778271]  [MGI Ref ID J:181394]

Zwaferink H; Stockinger S; Hazemi P; Lemmens-Gruber R; Decker T. 2008. IFN-{beta} Increases Listeriolysin O-Induced Membrane Permeabilization and Death of Macrophages. J Immunol 180(6):4116-23. [PubMed: 18322222]  [MGI Ref ID J:132928]

Zwaferink H; Stockinger S; Reipert S; Decker T. 2008. Stimulation of inducible nitric oxide synthase expression by beta interferon increases necrotic death of macrophages upon Listeria monocytogenes infection. Infect Immun 76(4):1649-56. [PubMed: 18268032]  [MGI Ref ID J:133523]

de Hooge AS; van de Loo FA; Koenders MI; Bennink MB; Arntz OJ; Kolbe T; van den Berg WB. 2004. Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice. Arthritis Rheum 50(6):2014-23. [PubMed: 15188379]  [MGI Ref ID J:106196]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX18

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, heterozygous mice may be bred to wildtype mice from the colony, or to C57BL/6J inbred mice (Stock No. 000664). Homozygous mice in a conventional facility may die within 48 hours of weaning. Homozygotes only survive and breed normally after embryo transfer to a specific pathogen-free (SPF) recipient in an SPF facility.
Mating SystemWild-type x Heterozygote         (Female x Male)   30-AUG-13
Heterozygote x Wild-type         (Female x Male)   30-AUG-13

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90Female or MaleHeterozygous for Stat1tm1Dlv  
Price per Pair (US dollars $)Pair Genotype
$271.90Heterozygous for Stat1tm1Dlv x Wild-type for Stat1tm1Dlv  
$271.90Wild-type for Stat1tm1Dlv x Heterozygous for Stat1tm1Dlv  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90Female or MaleHeterozygous for Stat1tm1Dlv  
Price per Pair (US dollars $)Pair Genotype
$353.50Heterozygous for Stat1tm1Dlv x Wild-type for Stat1tm1Dlv  
$353.50Wild-type for Stat1tm1Dlv x Heterozygous for Stat1tm1Dlv  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   Wild-type from the colony
   000664 C57BL/6J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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