Strain Name:

STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J

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Common Names: BLG-Cre; Brca1F22-24; p53 KO;     BLG-Cre; Brca1F22-24/F22-24; p53+/-;    
These mice carry the beta-lactoglobulin Cre (BLG-Cre) transgene, are homozygous for floxed exons 22-24 of the breast cancer 1 (Brca1) allele, and are heterozygous for p53 tumor-suppressor gene (Trp53) deficiency. This strain may be useful for studying human basal-like cancer and breast cancer, as well as providing a useful tool for testing new therapeutics.


Strain Information

Type Targeted Mutation; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Mating SystemSee Breeding & Husbandry under the Health & Care tab         (Female x Male)   03-NOV-10
Specieslaboratory mouse
GenerationF?+F12 (29-APR-15)
Generation Definitions
Donating Investigator Afshan McCarthy,   The Breakthrough Toby Robins Breast Canc

Important Note
To induce the tumor development in these mice, the donating investigator reports that BLG-Cre; Brca1tm1Aash; Trp53+/- mice should be allowed to go through two rounds of pregnancy and then set aside to allow Cre activation and the loss of Brca1 function.

BLG-Cre; Brca1tm1Aash; Trp53+/- mice that carry the beta-lactoglobulin Cre (BLG-Cre) transgene are homozygous for floxed exons 22-24 of the breast cancer 1 (Brca1) allele, and are heterozygous for p53 tumor-suppressor gene (Trp53) deficiency. Mice of this genotype are viable, fertile, normal in size and do not display any behavioral abnormalities. BLG-Cre; Brca1tm1Aash; Trp53+/- females have expression of the BLG-Cre transgene during lactation; which leads to loss of Brca1 function in the mammary gland. This results in formation of mammary tumors exhibiting high grade central necrosis and metaplastic elements in the form of spindle cell and squamous cell differentiation; as seen in human basal-like breast cancers and BRCA1 mutation carriers. Heterozygosity for the mutant p53 allele accelerates the formation of mammary tumors. This strain may be useful for studying human basal-like cancer and breast cancer, as well as providing a useful tool for testing new therapeutics.

This mouse colony harbors three mutations: a p53- mutation, the Brca1F22-24 mutation, and a BLG-Cre transgene. The description of each is below.

To generate the p53 mutant allele, a targeting vector was designed to replace part of exon 5 of the mouse p53 tumor-suppressor gene, p53, with a PolII-neomycin (neo) resistance cassette (Harvey et al, Nat Gen, 1993; 5; 225-29). This construct was electroporated into 129S7/SvEvBrd-Hprt1+-derived AB1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts and the resulting chimeric males were bred to C57BL/6 females. These mice were intercrossed to establish a colony of p53 transgenic mice.

To generate the Brca1F22-24 mutant allele, a targeting vector was designed by Dr. Alan Ashworth (Breakthrough Breast Cancer Research Centre, London) to replace exons 22-24 of the mouse breast cancer 1 gene (Brca1) with a loxP site, a cDNA sequence encoded by exons 22-24, a 3' myc epitope, bovine growth hormone polyA signal, a second loxP site, a splice acceptor sequence, and a PGK-neo cassette. This construct was electroporated into (129X1/SvJ x 129S1/Sv)F1-Kitl+-derived R1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts and the resulting chimeric mice were bred to C57BL/6 mice. These mice were intercrossed to establish a colony of Brca1F22-24/F22-24 mice on a mixed background.

The BLG-Cre transgene was designed by Dr. Alan R. Clarke (while at University Medical School, Edinburgh, United Kingdom) to have Cre recombinase under the control of the sheep mammary gland specific promoter of the ovine beta-lactoglobulin (BLG) gene. The construct included exon 1 of sheep BLG, and a Cre recombinase with a modified initiation codon and a polyadenylation signal (polyA). The construct was microinjected into the pronuclei of (CBA x C57BL/6) fertilized oocytes, and mice from founder line 74 were identified and bred to C57BL/6 mice. These mice were intercrossed to establish a colony of BLG-cre mice on a mixed background.

Mutant mice were bred together to generate the triple mutant colony. Mice heterozygous for the p53 allele, homozygous for the floxed Brca1 allele (Brca1F22-24/F22-24), and hemizygous for the BLG-cre transgene (also called BLG-Cre; Brca1F22-24/F22-24; p53+/- mice) were maintained on a mixed genetic background prior to sending to The Jackson Laboratory Repository. Upon arrival, mice were bred to C57BL/6J inbred mice (Stock No. 000664) for at least one generation to establish the colony.

Control Information

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  Considerations for Choosing Controls

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View Strains carrying   Tg(LGB-cre)74Acl     (1 strain)

View Strains carrying other alleles of Trp53     (26 strains)

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023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
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008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
027205   C57BL/6-Tg(Nms-icre)20Ywa/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
022883   C57BL/6J-Tg(Six6-cre)3Grsr/GrsrJ
022887   C57BL/6J-Tg(Six6-cre)7Grsr/GrsrJ
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
026861   D2.129P2(B6)-Lyz2tm1(cre)Ifo/SjJ
026858   D2.129S4(B6)-Meox2tm1(cre)Sor/SjJ
026266   D2.B6-Tg(Zp3-cre)93Knw/SjJ
026852   D2.Cg-Tg(Gfap-cre)73.12Mvs/SjJ
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
026859   D2.Cg-Tg(Sox2-cre)1Amc/SjJ
026857   D2.FVB-Tg(GFAP-cre)25Mes/SjJ
026860   D2.FVB-Tg(Tek-cre)2352Rwng/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
017595   FVB.Cg-Tg(CAG-cre/Esr1*)5Amc/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
025062   FVB/N-Tg(Figla-EGFP,-icre)ZP3Dean/Mmjax
017928   FVB/N-Tg(Mpz-cre)26Mes/J
025066   FVB/N-Tg(Mylpf-cre)3Kraj/Mmjax
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
023806   NOD.129P2(Cg)-Cd19tm1(cre)Cgn/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
026229   STOCK Akap12tm1Ihg Rb1tm2Brn Tg(Pbsn-cre)4Prb/J
012706   STOCK Ccktm1.1(cre)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
010802   STOCK Gad2tm2(cre)Zjh/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
023407   STOCK HhatTg(TFAP2A-cre)1Will/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
010530   STOCK Pax7tm1(cre)Mrc/J
019378   STOCK Ptf1atm2(cre/ESR1)Cvw/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
012719   STOCK Tgfb3tm1(cre)Vk/J
008813   STOCK Trpa1tm2Kykw Tg(CAG-cre/Esr1*)5Amc/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
008783   STOCK Tg(CAG-cre/Esr1*)5Amc Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
004453   STOCK Tg(CAG-cre/Esr1*)5Amc/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008861   STOCK Tg(Ela1-Cre/ERT2)1Stof/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
022763   STOCK Tg(Eno2-cre/ERT2)1Pohlk/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
023426   STOCK Tg(Kiss1-cre)J2-4Cfe/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
019755   STOCK Tg(Six3-cre)69Frty/GcoJ
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-icre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (412 strains)

Additional Web Information

Introduction to Cre-lox technology


Phenotype Information

View Related Disease (OMIM) Terms

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Brca1tm1Aash/Brca1tm1Aash Trp53tm1Brd/Trp53+ Tg(LGB-cre)74Acl/0

        involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * CBA   (conditional)
  • tumorigenesis
  • increased mammary gland tumor incidence
    • mice develop mammary gland tumors with higher frequency (64%; 25/39 animals) and shorter latency of 6-46 weeks (all but one tumor had developed by 31 weeks) relative to control mice; 6/39 mice had multiple tumors in the same and in adjacent glands   (MGI Ref ID J:119996)
    • tumors develop in the inguinal and thoracic glands with equal frequency, and on both sides of the body   (MGI Ref ID J:119996)
    • majority of tumors (30/33) show marked nuclear pleomorphism; central necrosis is seen in about 67% of tumors (23/32)   (MGI Ref ID J:119996)
    • most (29/33) neoplasms show mixed pushing and infiltrative borders, while only 4/33 showed a prominent inflammatory infiltrate   (MGI Ref ID J:119996)
    • most (29/33) tumors show homologous metaplastic elements in form of squamous or spindly differentiation   (MGI Ref ID J:119996)
    • increased mammary gland ductal carcinoma incidence
      • high grade ductal carcinoma in situ (DCIS) is observed admixed with, or adjacent to, the invasive tumor in some cases, and occasionally columnar cell lesions with cytological atypia are seen with those tumors; columnar cell changes are found in adjacent tissue in a few tumors   (MGI Ref ID J:119996)
  • increased salivary adenocarcinoma incidence
    • some (2/59) develop salivary gland malignant myoepithelial tumors   (MGI Ref ID J:119996)
  • endocrine/exocrine gland phenotype
  • abnormal mammary gland development
    • only 2/33 tumors show beta-catenin upregulation that was restricted to areas of squamous differentiation and basaloid cells   (MGI Ref ID J:119996)
  • integument phenotype
  • abnormal mammary gland development
    • only 2/33 tumors show beta-catenin upregulation that was restricted to areas of squamous differentiation and basaloid cells   (MGI Ref ID J:119996)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence
      Mammary Gland Tumors
      Mammary Gland Tumors: females only
      tumor metastasis

Endocrine Deficiency Research
Mammary Gland Defects

Neurobiology Research
Cre-lox System
      loxP-flanked Sequences

Research Tools
Cre-lox System
      Cre Recombinase Expression
Developmental Biology Research
      Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System
Reproductive Biology Research
      Cre-lox System

cre related

Research Tools
Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Brca1tm1Aash
Allele Name targeted mutation 1, Alan Ashworth
Allele Type Targeted (Conditional ready (e.g. floxed), No functional change)
Common Name(s) Brca1F22-24;
Mutation Made By Alan Ashworth,   The Breakthrough Toby Robins Breast canc
Strain of Origin(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Site of Expressionmammary epithelial cells
Gene Symbol and Name Brca1, breast cancer 1
Chromosome 11
Gene Common Name(s) BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53;
Molecular Note Exons 22-24 were replaced with a floxed sequence containing cDNA for exons 22-24 with an in frame myc epitope and a bovine growth hormone poly A sequence. This vector allows conditional excision of the second, terminal BRCT domain. Downstream of the floxed sequence, a splice acceptor and PGK-neo were inserted. [MGI Ref ID J:119996]
Allele Symbol Tg(LGB-cre)74Acl
Allele Name transgene insertion 74, Alan R Clarke
Allele Type Transgenic (cre- or Flp-expressing)
Common Name(s) BLG-Cre; Blg-CreTg;
Mutation Made By Alan Clarke,   University Medical School, Edinburgh, Un
Strain of Origin(CBA x C57BL/6)
Site of ExpressionCre recombinase is active in the mammary gland.
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Promoter LGB, beta-lactoglobulin, sheep
Driver Note BLG
Molecular Note This transgene expresses Cre recombinase under the control of a sheep beta-lactoglobulin promoter (LGB), active in the mammary gland. [MGI Ref ID J:70554]
Allele Symbol Trp53tm1Brd
Allele Name targeted mutation 1, Allan Bradley
Allele Type Targeted (Null/Knockout)
Common Name(s) P-; TSG-p53; Trp53N; Trp53delta; p53-; p53N;
Strain of Origin129S7/SvEvBrd-Hprt<+>
Gene Symbol and Name Trp53, transformation related protein 53
Chromosome 11
Gene Common Name(s) BCC7; LFS1; P53; p44;
Molecular Note A PolII-neomycin resistance cassette which lacked a polyadenylation signal was inserted into exon 5 of the gene. The insertion was accompanied by a small deletion of a 450 bp fragment containing 106 nucleotides of exon 5 and 350 nucleotides of intron 4. [MGI Ref ID J:1999] [MGI Ref ID J:96886]


Genotyping Information

Genotyping Protocols

Brca1tm1Aash, Melt Curve Analysis
Generic Cre Melt Curve Analysis, MELT
Generic Cre Melt Curve Analysis, Probe
Trp53tm1Brd, High Resolution Melting
Brca1tm1Aash, Standard PCR
Generic Cre, Standard PCR
Trp53tm1Brd, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

McCarthy A; Savage K; Gabriel A; Naceur C; Reis-Filho JS; Ashworth A. 2007. A mouse model of basal-like breast carcinoma with metaplastic elements. J Pathol 211(4):389-98. [PubMed: 17212342]  [MGI Ref ID J:119996]

Additional References

Brca1tm1Aash related

Molyneux G; Geyer FC; Magnay FA; McCarthy A; Kendrick H; Natrajan R; Mackay A; Grigoriadis A; Tutt A; Ashworth A; Reis-Filho JS; Smalley MJ. 2010. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 7(3):403-17. [PubMed: 20804975]  [MGI Ref ID J:164435]

Trp53tm1Brd related

Adam J; Deans B; Thacker J. 2007. A role for Xrcc2 in the early stages of mouse development. DNA Repair (Amst) 6(2):224-34. [PubMed: 17116431]  [MGI Ref ID J:120961]

Akhtar RS; Geng Y; Klocke BJ; Latham CB; Villunger A; Michalak EM; Strasser A; Carroll SL; Roth KA. 2006. BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death. J Neurosci 26(27):7257-64. [PubMed: 16822983]  [MGI Ref ID J:110228]

Akhtar RS; Geng Y; Klocke BJ; Roth KA. 2006. Neural precursor cells possess multiple p53-dependent apoptotic pathways. Cell Death Differ 13(10):1727-39. [PubMed: 16514420]  [MGI Ref ID J:126291]

Akli S; Van Pelt CS; Bui T; Meijer L; Keyomarsi K. 2011. Cdk2 is Required for Breast Cancer Mediated by the Low-Molecular-Weight Isoform of Cyclin E. Cancer Res 71(9):3377-86. [PubMed: 21385896]  [MGI Ref ID J:171726]

Akli S; Van Pelt CS; Bui T; Multani AS; Chang S; Johnson D; Tucker S; Keyomarsi K. 2007. Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway. Cancer Res 67(15):7212-22. [PubMed: 17671189]  [MGI Ref ID J:123914]

Alexander BM; Van Kirk EA; Naughton LM; Murdoch WJ. 2007. Ovarian morphometrics in TP53-deficient mice. Anat Rec (Hoboken) 290(1):59-64. [PubMed: 17441198]  [MGI Ref ID J:174177]

Allen SM; Florell SR; Hanks AN; Alexander A; Diedrich MJ; Altieri DC; Grossman D. 2003. Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression. Cancer Res 63(3):567-72. [PubMed: 12566297]  [MGI Ref ID J:81530]

Amleh A; Nair SJ; Sun J; Sutherland A; Hasty P; Li R. 2009. Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis. PLoS ONE 4(4):e5034. [PubMed: 19340312]  [MGI Ref ID J:148508]

Amson R; Lassalle JM; Halley H; Prieur S; Lethrosne F; Roperch JP; Israeli D; Gendron MC; Duyckaerts C; Checler F; Dausset J; Cohen D; Oren M; Telerman A. 2000. Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice. Proc Natl Acad Sci U S A 97(10):5346-50. [PubMed: 10805794]  [MGI Ref ID J:111370]

An JY; Kim EA; Jiang Y; Zakrzewska A; Kim DE; Lee MJ; Mook-Jung I; Zhang Y; Kwon YT. 2010. UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination. Proc Natl Acad Sci U S A 107(5):1912-7. [PubMed: 20080676]  [MGI Ref ID J:157596]

Antonini D; Russo MT; De Rosa L; Gorrese M; Del Vecchio L; Missero C. 2010. Transcriptional repression of miR-34 family contributes to p63-mediated cell cycle progression in epidermal cells. J Invest Dermatol 130(5):1249-57. [PubMed: 20090763]  [MGI Ref ID J:159929]

Armata HL; Garlick DS; Sluss HK. 2007. The ataxia telangiectasia-mutated target site Ser18 is required for p53-mediated tumor suppression. Cancer Res 67(24):11696-703. [PubMed: 18089799]  [MGI Ref ID J:130855]

Armata HL; Golebiowski D; Jung DY; Ko HJ; Kim JK; Sluss HK. 2010. Requirement of the ATM/p53 tumor suppressor pathway for glucose homeostasis. Mol Cell Biol 30(24):5787-94. [PubMed: 20956556]  [MGI Ref ID J:191181]

Armata HL; Shroff P; Garlick DE; Penta K; Tapper AR; Sluss HK. 2011. Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis. PLoS One 6(9):e24813. [PubMed: 21980358]  [MGI Ref ID J:191179]

Aubrecht J; Secretan MB; Bishop AJ; Schiestl RH. 1999. Involvement of p53 in X-ray induced intrachromosomal recombination in mice. Carcinogenesis 20(12):2229-36. [PubMed: 10590213]  [MGI Ref ID J:59211]

Babbe H; Chester N; Leder P; Reizis B. 2007. The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage. Mol Cell Biol 27(5):1947-59. [PubMed: 17210642]  [MGI Ref ID J:118992]

Babbe H; McMenamin J; Hobeika E; Wang J; Rodig SJ; Reth M; Leder P. 2009. Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage. J Immunol 182(1):347-60. [PubMed: 19109166]  [MGI Ref ID J:142894]

Bachelier R; Xu X; Li C; Qiao W; Furth PA; Lubet RA; Deng CX. 2005. Effect of bilateral oophorectomy on mammary tumor formation in BRCA1 mutant mice. Oncol Rep 14(5):1117-20. [PubMed: 16211273]  [MGI Ref ID J:103868]

Bachelier R; Xu X; Wang X; Li W; Naramura M; Gu H; Deng CX. 2003. Normal lymphocyte development and thymic lymphoma formation in Brca1 exon-11-deficient mice. Oncogene 22(4):528-37. [PubMed: 12555066]  [MGI Ref ID J:81541]

Bae BI; Xu H; Igarashi S; Fujimuro M; Agrawal N; Taya Y; Hayward SD; Moran TH; Montell C; Ross CA; Snyder SH; Sawa A. 2005. p53 Mediates Cellular Dysfunction and Behavioral Abnormalities in Huntington's Disease. Neuron 47(1):29-41. [PubMed: 15996546]  [MGI Ref ID J:99630]

Bagchi A; Papazoglu C; Wu Y; Capurso D; Brodt M; Francis D; Bredel M; Vogel H; Mills AA. 2007. CHD5 is a tumor suppressor at human 1p36. Cell 128(3):459-75. [PubMed: 17289567]  [MGI Ref ID J:121726]

Bagchi D; Balmoori J; Bagchi M; Ye X; Williams CB; Stohs SJ. 2000. Role of p53 tumor suppressor gene in the toxicity of TCDD, endrin, naphthalene, and chromium (vi) in liver and brain tissues of mice Free Radic Biol Med 28(6):895-903. [PubMed: 10802220]  [MGI Ref ID J:62442]

Bailey SL; Gurley KE; Hoon-Kim K; Kelly-Spratt KS; Kemp CJ. 2008. Tumor suppression by p53 in the absence of Atm. Mol Cancer Res 6(7):1185-92. [PubMed: 18583527]  [MGI Ref ID J:139874]

Bajenaru ML; Donahoe J; Corral T; Reilly KM; Brophy S; Pellicer A; Gutmann DH. 2001. Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes. Glia 33(4):314-23. [PubMed: 11246230]  [MGI Ref ID J:80411]

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Xu X; Qiao W; Linke SP; Cao L; Li WM; Furth PA; Harris CC; Deng CX. 2001. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet 28(3):266-71. [PubMed: 11431698]  [MGI Ref ID J:70271]

Xu X; Wagner KU; Larson D; Weaver Z; Li C; Ried T; Hennighausen L ; Wynshaw-Boris A ; Deng CX. 1999. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation [see comments] Nat Genet 22(1):37-43. [PubMed: 10319859]  [MGI Ref ID J:54533]

Yamamoto M; Tsukamoto T; Sakai H; Shirai N; Ohgaki H; Furihata C; Donehower LA; Yoshida K; Tatematsu M. 2000. p53 knockout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis Carcinogenesis 21(10):1891-7. [PubMed: 11023548]  [MGI Ref ID J:65239]

Yamanaka Y; Heike T; Kumada T; Shibata M; Takaoka Y; Kitano A; Shiraishi K; Kato T; Nagato M; Okawa K; Furushima K; Nakao K; Nakamura Y; Taketo MM; Aizawa S; Nakahata T. 2008. Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality. Mech Dev 125(5-6):441-50. [PubMed: 18337066]  [MGI Ref ID J:135988]

Yan CT; Kaushal D; Murphy M; Zhang Y; Datta A; Chen C; Monroe B; Mostoslavsky G; Coakley K; Gao Y; Mills KD; Fazeli AP; Tepsuporn S; Hall G; Mulligan R; Fox E; Bronson R; De Girolami U; Lee C; Alt FW. 2006. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci U S A 103(19):7378-83. [PubMed: 16670198]  [MGI Ref ID J:109585]

Yin L; Ghebranious N; Chakraborty S; Sheehan CE; Ilic Z; Sell S. 1998. Control of mouse hepatocyte proliferation and ploidy by p53 and p53ser246 mutation in vivo. Hepatology 27(1):73-80. [PubMed: 9425920]  [MGI Ref ID J:90869]

Yokoyama A; Ficara F; Murphy MJ; Meisel C; Naresh A; Kitabayashi I; Cleary ML. 2011. Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways. J Cell Sci 124(Pt 13):2208-19. [PubMed: 21670200]  [MGI Ref ID J:183048]

Yoshikai Y; Sato T; Morita S; Kohara Y; Takagi R; Mishima Y; Kominami R. 2008. Effect of Bcl11b genotypes and gamma-radiation on the development of mouse thymic lymphomas. Biochem Biophys Res Commun 373(2):282-5. [PubMed: 18558082]  [MGI Ref ID J:137956]

Yoshizuka N; Lai M; Liao R; Cook R; Xiao C; Han J; Sun P. 2012. PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway. Mol Cancer Res 10(6):810-20. [PubMed: 22665523]  [MGI Ref ID J:205386]

Youssef AF; Borellini F; Jacobson-Kram D; Fort FL. 2001. Analysis for loss of heterozygosity (LOH) of p53 allele in tumors derived from p53+/- and CD-1 mice following repeated subcutaneous injections of solutions containing antioxidants. Environ Mol Mutagen 37(1):27-30. [PubMed: 11170239]  [MGI Ref ID J:67508]

Yue HH; Diehl GE; Winoto A. 2005. Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice. Cell Death Differ 12(1):94-7. [PubMed: 15514675]  [MGI Ref ID J:94118]

Zaidi AU; D'Sa-Eipper C; Brenner J; Kuida K; Zheng TS; Flavell RA; Rakic P; Roth KA. 2001. Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways. J Neurosci 21(1):169-75. [PubMed: 11150333]  [MGI Ref ID J:66953]

Zerafa N; Westwood JA; Cretney E; Mitchell S; Waring P; Iezzi M; Smyth MJ. 2005. Cutting edge: TRAIL deficiency accelerates hematological malignancies. J Immunol 175(9):5586-90. [PubMed: 16237043]  [MGI Ref ID J:103779]

Zhang H; Cicchetti G; Onda H; Koon HB; Asrican K; Bajraszewski N; Vazquez F; Carpenter CL; Kwiatkowski DJ. 2003. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. J Clin Invest 112(8):1223-33. [PubMed: 14561707]  [MGI Ref ID J:162300]

Zhang QS; Eaton L; Snyder ER; Houghtaling S; Mitchell JB; Finegold M; Van Waes C; Grompe M. 2008. Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice. Cancer Res 68(5):1601-8. [PubMed: 18316625]  [MGI Ref ID J:132758]

Zhang Z; Liu Q; Lantry LE; Wang Y; Kelloff GJ; Anderson MW; Wiseman RW; Lubet RA; You M. 2000. A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin. Cancer Res 60(4):901-7. [PubMed: 10706103]  [MGI Ref ID J:61217]

Zheng SJ; Lamhamedi-Cherradi SE; Wang P; Xu L; Chen YH. 2005. Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function. Diabetes 54(5):1423-8. [PubMed: 15855329]  [MGI Ref ID J:105195]

Zhou XZ; Huang P; Shi R; Lee TH; Lu G; Zhang Z; Bronson R; Lu KP. 2011. The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. J Clin Invest 121(4):1266-82. [PubMed: 21436583]  [MGI Ref ID J:171997]

Zhu C; Mills KD; Ferguson DO; Lee C; Manis J; Fleming J; Gao Y; Morton CC; Alt FW. 2002. Unrepaired DNA Breaks in p53-Deficient Cells Lead to Oncogenic Gene Amplification Subsequent to Translocations. Cell 109(7):811-21. [PubMed: 12110179]  [MGI Ref ID J:77972]

Zhu J; Nguyen MT; Nakamura E; Yang J; Mackem S. 2012. Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway. Genesis 50(2):102-11. [PubMed: 21913308]  [MGI Ref ID J:187873]

di Masi A; Antoccia A; Dimauro I; Argentino-Storino A; Mosiello A; Mango R; Novelli G; Tanzarella C. 2006. Gene expression and apoptosis induction in p53-heterozygous irradiated mice. Mutat Res 594(1-2):49-62. [PubMed: 16169021]  [MGI Ref ID J:106402]

van Meyel DJ; Sanchez-Sweatman OH; Kerkvliet N; Stitt L; Ramsay DA; Khokha R; Chambers AF; Cairncross JG. 1998. Genetic background influences timing, morphology and dissemination of lymphomas in p53-deficient mice. Int J Oncol 13(5):917-22. [PubMed: 9772279]  [MGI Ref ID J:51144]

van Vlijmen BJ; Gerritsen G; Franken AL; Boesten LS; Kockx MM; Gijbels MJ; Vierboom MP; van Eck M; van De Water B; van Berkel TJ; Havekes LM. 2001. Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE*3-Leiden transgenic mice. Circ Res 88(8):780-6. [PubMed: 11325869]  [MGI Ref ID J:133095]

van de Vrugt HJ; Eaton L; Hanlon Newell A; Al-Dhalimy M; Liskay RM; Olson SB; Grompe M. 2009. Embryonic lethality after combined inactivation of Fancd2 and Mlh1 in mice. Cancer Res 69(24):9431-8. [PubMed: 19934329]  [MGI Ref ID J:155534]

van der Weyden L; Adams DJ. 2013. Cancer of mice and men: old twists and new tails. J Pathol 230(1):4-16. [PubMed: 23436574]  [MGI Ref ID J:196071]

Tg(LGB-cre)74Acl related

Akhtar N; Marlow R; Lambert E; Schatzmann F; Lowe ET; Cheung J; Katz E; Li W; Wu C; Dedhar S; Naylor MJ; Streuli CH. 2009. Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation. Development 136(6):1019-27. [PubMed: 19211680]  [MGI Ref ID J:146635]

Akhtar N; Streuli CH. 2013. An integrin-ILK-microtubule network orients cell polarity and lumen formation in glandular epithelium. Nat Cell Biol 15(1):17-27. [PubMed: 23263281]  [MGI Ref ID J:195230]

Baxter FO; Came PJ; Abell K; Kedjouar B; Huth M; Rajewsky K; Pasparakis M; Watson CJ. 2006. IKK{beta}/2 induces TWEAK and apoptosis in mammary epithelial cells. Development 133(17):3485-94. [PubMed: 16887827]  [MGI Ref ID J:112268]

Chapman RS; Lourenco PC; Tonner E; Flint DJ; Selbert S; Takeda K; Akira S; Clarke AR; Watson CJ. 1999. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev 13(19):2604-16. [PubMed: 10521404]  [MGI Ref ID J:58106]

Chester N; Babbe H; Pinkas J; Manning C; Leder P. 2006. Mutation of the murine Bloom's syndrome gene produces global genome destabilization. Mol Cell Biol 26(17):6713-26. [PubMed: 16914751]  [MGI Ref ID J:112115]

Farrell AS; Pelz C; Wang X; Daniel CJ; Wang Z; Su Y; Janghorban M; Zhang X; Morgan C; Impey S; Sears RC. 2013. Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis. Mol Cell Biol 33(15):2930-49. [PubMed: 23716601]  [MGI Ref ID J:204572]

Forys JT; Kuzmicki CE; Saporita AJ; Winkeler CL; Maggi LB Jr; Weber JD. 2014. ARF and p53 coordinate tumor suppression of an oncogenic IFN-beta-STAT1-ISG15 signaling axis. Cell Rep 7(2):514-26. [PubMed: 24726362]  [MGI Ref ID J:211814]

Gallagher RC; Hay T; Meniel V; Naughton C; Anderson TJ; Shibata H; Ito M; Clevers H; Noda T; Sansom OJ; Mason JO; Clarke AR. 2002. Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. Oncogene 21(42):6446-57. [PubMed: 12226748]  [MGI Ref ID J:79068]

Hay T; Matthews JR; Pietzka L; Lau A; Cranston A; Nygren AO; Douglas-Jones A; Smith GC; Martin NM; O'Connor M; Clarke AR. 2009. Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin. Cancer Res 69(9):3850-5. [PubMed: 19383921]  [MGI Ref ID J:148266]

Hughes K; Wickenden JA; Allen JE; Watson CJ. 2012. Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression. J Pathol 227(1):106-17. [PubMed: 22081431]  [MGI Ref ID J:183317]

Karim SA; Creedon H; Patel H; Carragher NO; Morton JP; Muller WJ; Evans TR; Gusterson B; Sansom OJ; Brunton VG. 2013. Dasatinib inhibits mammary tumour development in a genetically engineered mouse model. J Pathol 230(4):430-40. [PubMed: 23616343]  [MGI Ref ID J:198826]

Kritikou EA; Sharkey A; Abell K; Came PJ; Anderson E; Clarkson RW; Watson CJ. 2003. A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland. Development 130(15):3459-68. [PubMed: 12810593]  [MGI Ref ID J:83804]

Li W; Ferguson BJ; Khaled WT; Tevendale M; Stingl J; Poli V; Rich T; Salomoni P; Watson CJ. 2009. PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool. Proc Natl Acad Sci U S A 106(12):4725-30. [PubMed: 19261859]  [MGI Ref ID J:147092]

Mamillapalli R; VanHouten J; Dann P; Bikle D; Chang W; Brown E; Wysolmerski J. 2013. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology 154(9):3031-42. [PubMed: 23782944]  [MGI Ref ID J:202283]

Matthews JR; Clarke AR. 2005. p53 mediates a default programme of mammary gland involution in the absence of STAT3. Oncogene 24(19):3083-90. [PubMed: 15735683]  [MGI Ref ID J:98296]

McCarthy A; Lord CJ; Savage K; Grigoriadis A; Smith DP; Weigelt B; Reis-Filho JS; Ashworth A. 2009. Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation. J Pathol 219(3):306-16. [PubMed: 19681070]  [MGI Ref ID J:153735]

Melchor L; Molyneux G; Mackay A; Magnay FA; Atienza M; Kendrick H; Nava-Rodrigues D; Lopez-Garcia MA; Milanezi F; Greenow K; Robertson D; Palacios J; Reis-Filho JS; Smalley MJ. 2014. Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models. J Pathol 233(2):124-37. [PubMed: 24615332]  [MGI Ref ID J:210989]

Meniel V; Hay T; Douglas-Jones A; Sansom OJ; Clarke AR. 2005. Mutations in Apc and p53 synergize to promote mammary neoplasia. Cancer Res 65(2):410-6. [PubMed: 15695381]  [MGI Ref ID J:96023]

Molyneux G; Geyer FC; Magnay FA; McCarthy A; Kendrick H; Natrajan R; Mackay A; Grigoriadis A; Tutt A; Ashworth A; Reis-Filho JS; Smalley MJ. 2010. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 7(3):403-17. [PubMed: 20804975]  [MGI Ref ID J:164435]

Naylor MJ; Li N; Cheung J; Lowe ET; Lambert E; Marlow R; Wang P; Schatzmann F; Wintermantel T; Schuetz G; Clarke AR; Mueller U; Hynes NE; Streuli CH. 2005. Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation. J Cell Biol 171(4):717-28. [PubMed: 16301336]  [MGI Ref ID J:104534]

Neville MC; Webb P; Ramanathan P; Mannino MP; Pecorini C; Monks J; Anderson SM; MacLean P. 2013. The insulin receptor plays an important role in secretory differentiation in the mammary gland. Am J Physiol Endocrinol Metab 305(9):E1103-14. [PubMed: 23982156]  [MGI Ref ID J:203934]

Oliver CH; Khaled WT; Frend H; Nichols J; Watson CJ. 2012. The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Genes Dev 26(10):1086-97. [PubMed: 22588720]  [MGI Ref ID J:184505]

Rudolph MC; Monks J; Burns V; Phistry M; Marians R; Foote MR; Bauman DE; Anderson SM; Neville MC. 2010. Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium. Am J Physiol Endocrinol Metab 299(6):E918-27. [PubMed: 20739508]  [MGI Ref ID J:170224]

Sargeant TJ; Lloyd-Lewis B; Resemann HK; Ramos-Montoya A; Skepper J; Watson CJ. 2014. Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization. Nat Cell Biol 16(11):1057-68. [PubMed: 25283994]  [MGI Ref ID J:217705]

Selbert S; Bentley DJ; Melton DW; Rannie D; Lourenco P; Watson CJ; Clarke AR. 1998. Efficient BLG-Cre mediated gene deletion in the mammary gland. Transgenic Res 7(5):387-96. [PubMed: 9859227]  [MGI Ref ID J:70554]

Stewart MK; Plante I; Bechberger JF; Naus CC; Laird DW. 2014. Mammary gland specific knockdown of the physiological surge in Cx26 during lactation retains normal mammary gland development and function. PLoS One 9(7):e101546. [PubMed: 24988191]  [MGI Ref ID J:218935]

VanHouten JN; Dann P; Stewart AF; Watson CJ; Pollak M; Karaplis AC; Wysolmerski JJ. 2003. Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation. (Correction J Clin Invest 2004:113(3):492)n J Clin Invest 112(9):1429-36. [PubMed: 14597768]  [MGI Ref ID J:86536]

Wakefield A; Soukupova J; Montagne A; Ranger J; French R; Muller WJ; Clarkson RW. 2013. Bcl3 selectively promotes metastasis of ERBB2-driven mammary tumors. Cancer Res 73(2):745-55. [PubMed: 23149915]  [MGI Ref ID J:194106]

Yazinski SA; Westcott PM; Ong K; Pinkas J; Peters RM; Weiss RS. 2009. Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration. Proc Natl Acad Sci U S A 106(50):21282-7. [PubMed: 19918068]  [MGI Ref ID J:155573]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, females heterozygous for the p53 allele, homozygous for the floxed Brca1 allele and not carrying the BLG-cre transgene may be bred with males homozygous for the p53 allele, homozygous for the floxed Brca1 allele and hemizygous the BLG-cre transgene.

To induce the tumor development in these mice, the donating investigator reports that BLG-Cre; Brca1F22-24/F22-24; p53+/- mice should be allowed to go through two rounds of pregnancy and then set aside to allow Cre activation and the loss of Brca1 function.

Mating SystemSee Breeding & Husbandry under the Health & Care tab         (Female x Male)   03-NOV-10
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $246.90Female or MaleHeterozygous for Trp53tm1Brd, Homozygous for Brca1tm1Aash, Hemizygous for Tg(LGB-cre)74Acl  
$246.90Female or MaleHeterozygous for Trp53tm1Brd, Homozygous for Brca1tm1Aash, Noncarrier  
Individual Mouse $246.90Female or MaleHomozygous for Trp53tm1Brd, Homozygous for Brca1tm1Aash, Hemizygous for Tg(LGB-cre)74Acl  
$246.90Female or MaleHomozygous for Trp53tm1Brd, Homozygous for Brca1tm1Aash, Noncarrier  
Price per Pair (US dollars $)Pair Genotype
$493.80Heterozygous for Trp53tm1Brd, Homozygous for Brca1tm1Aash, Noncarrier x Heterozygous for Trp53tm1Brd, Homozygous for Brca1tm1Aash, Hemizygous for Tg(LGB-cre)74Acl  
$493.80Heterozygous for Trp53tm1Brd, Homozygous for Brca1tm1Aash, Noncarrier x Homozygous for Trp53tm1Brd, Homozygous for Brca1tm1Aash, Hemizygous for Tg(LGB-cre)74Acl  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $321.00Female or MaleHeterozygous for Trp53tm1Brd, Homozygous for Brca1tm1Aash, Hemizygous for Tg(LGB-cre)74Acl  
$321.00Female or MaleHeterozygous for Trp53tm1Brd, Homozygous for Brca1tm1Aash, Noncarrier  
Individual Mouse $321.00Female or MaleHomozygous for Trp53tm1Brd, Homozygous for Brca1tm1Aash, Hemizygous for Tg(LGB-cre)74Acl  
$321.00Female or MaleHomozygous for Trp53tm1Brd, Homozygous for Brca1tm1Aash, Noncarrier  
Price per Pair (US dollars $)Pair Genotype
$642.00Heterozygous for Trp53tm1Brd, Homozygous for Brca1tm1Aash, Noncarrier x Heterozygous for Trp53tm1Brd, Homozygous for Brca1tm1Aash, Hemizygous for Tg(LGB-cre)74Acl  
$642.00Heterozygous for Trp53tm1Brd, Homozygous for Brca1tm1Aash, Noncarrier x Homozygous for Trp53tm1Brd, Homozygous for Brca1tm1Aash, Hemizygous for Tg(LGB-cre)74Acl  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   None Available
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Important Note

To induce the tumor development in these mice, the donating investigator reports that BLG-Cre; Brca1tm1Aash; Trp53+/- mice should be allowed to go through two rounds of pregnancy and then set aside to allow Cre activation and the loss of Brca1 function.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.