Strain Name:

B6;SJL-Tg(Thy1-TARDBP)4Singh/J

Stock Number:

012836

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Availability:

Cryopreserved - Ready for recovery

Mice hemizygous for this TDP43 transgene contain the mouse Thy1 promoter driving expression of the human TAR DNA binding protein (TARDBP or TDP-43) gene in neurons throughout the central nervous system. These mice may be useful in studying the accumulation of TDP-43 in neurodegenerative diseases such as ALS and FTLD.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Stock; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
GenerationN?pN1
Generation Definitions
 
Donating Investigator Samir Kumar-Singh,   University of Antwerp

Description
Mice hemizygous for this TDP43 transgene are viable, fertile, and express human TAR DNA binding protein (TARDBP or TDP-43) gene. Expression is directed in neurons throughout the central nervous system by the mouse Thy1 promoter. These TDP-43 transgenic mice exhibit a dose-dependent degeneration of cortical and spinal motor neurons and develop a spastic quadriplegia reminiscent of Amyotrophic Lateral Sclerosis (ALS). They also show degeneration of nonmotor cortical and subcortical neurons characteristic of frontotemporal lobar degeneration (FTLD). Neurons in the affected spinal cord and brain regions showed accumulation of TDP-43 nuclear and cytoplasmic aggregates that were both ubiquitinated and phosphorylated as observed in human ALS/FTLD disease. These mice show abnormal limb reflex by 14 months and 40% reduced motor performance by 15 months of age. The Donating Investigator maintains these mice as hemizygotes and mates carriers to produce homozygotes, which exhibit an accelerated phenotype. Homozygotes develop an abnormal hindlimb clasping reflex by 14 days, and a 2-fold decrease in the stride of hindlimbs and forelimbs. Their footprints were characterized by separated forelimb and hindlimb prints, markedly wide-based stance, small stride, and frequent off-line stumbling. In addition, TDP-43 was present in the nucleus and cytoplasm of 10% of spinal neurons in homozygotes and less than 1% in hemizygotes. These mice may be useful in studying the accumulation of TDP-43 in neurodegenerative diseases such as ALS and FTLD.

Development
The TDP-43 transgene was designed with the human TAR DNA binding protein (TARDBP or TDP-43) gene driven by a mouse Thy1 promoter and SV40 polyadenylation site. The transgene was microinjected into fertilized C57BL/6/SJL oocytes. The Donating Investigator states that the transgene had integrated at locus 6qB3 of the mouse genome (nucleotide 56,524,796) and did not interrupt any known gene. Mice from founder line 4 were bred to C57BL/6 mice to establish a colony. Upon arrival at The Jackson Laboratory, transgenic mice were bred to B6SJLF1/J mice (Stock No. 100012) to establish the colony.

Control Information

  Control
   Noncarrier
   100012 B6SJLF1/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying other alleles of TARDBP     (13 strains)

Strains carrying other alleles of Thy1
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
001317   B6.Cg-Gpi1a Thy1a Igha/J
017798   B6.Cg-Mapttm1Hnd Tg(Thy1-MAPT*)3610Gds/Mmjax
009126   B6.Cg-Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
025855   B6.Cg-Ptprca Lag3tm1Doi Tg(CAG-luc,-GFP)L2G85Chco Thy1a/J
022073   B6.Cg-Rag1tm1Mom Thy1a Tg(Tcra2C,Tcrb2C)1Dlo/J
014550   B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
008730   B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
007901   B6.Cg-Tg(Thy1-Brainbow1.0)HLich/J
007911   B6.Cg-Tg(Thy1-Brainbow1.1)MLich/J
007921   B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J
003710   B6.Cg-Tg(Thy1-CFP)23Jrs/J
014131   B6.Cg-Tg(Thy1-CFP)IJrs/GfngJ
007940   B6.Cg-Tg(Thy1-CFP/COX8A)C1Lich/J
007967   B6.Cg-Tg(Thy1-CFP/COX8A)S2Lich/J
012597   B6.Cg-Tg(Thy1-COL25A1)861Yfu/J
007612   B6.Cg-Tg(Thy1-COP4/EYFP)18Gfng/J
007615   B6.Cg-Tg(Thy1-COP4/EYFP)9Gfng/J
013161   B6.Cg-Tg(Thy1-Clomeleon)1Gjau/J
007919   B6.Cg-Tg(Thy1-EGFP)OJrs/GfngJ
005630   B6.Cg-Tg(Thy1-EYFP)15Jrs/J
009611   B6.Cg-Tg(Thy1-Nlgn1)6Hnes/J
009612   B6.Cg-Tg(Thy1-Nlgn2)6Hnes/J
021069   B6.Cg-Tg(Thy1-PA-GFP)5Rmpl/J
021070   B6.Cg-Tg(Thy1-PA-GFP)6Rmpl/J
003709   B6.Cg-Tg(Thy1-YFP)16Jrs/J
003782   B6.Cg-Tg(Thy1-YFP)HJrs/J
005627   B6.Cg-Tg(Thy1-YFP/Syp)10Jrs/J
007606   B6.Cg-Tg(Thy1-cre/ERT2,-EYFP)AGfng/J
025854   B6.FVB-Ptprca Tg(CAG-luc,-GFP)L2G85Chco Thy1a/J
000406   B6.PL-Thy1a/CyJ
000983   B6.PL/(84NS)CyJ
004807   B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax
007910   B6;CBA-Tg(Thy1-Brainbow1.0)LLich/J
011070   B6;CBA-Tg(Thy1-EGFP)SJrs/NdivJ
017892   B6;CBA-Tg(Thy1-GCaMP2.2c)8Gfng/J
017893   B6;CBA-Tg(Thy1-GCaMP3)6Gfng/J
014130   B6;CBA-Tg(Thy1-YFP)GJrs/GfngJ
014651   B6;CBA-Tg(Thy1-spH)21Vnmu/J
015814   B6;CBA-Tg(Thy1-spH)64Vnmu/FrkJ
012341   B6;SJL-Tg(Thy1-COP3/EYFP)1Gfng/J
012344   B6;SJL-Tg(Thy1-COP3/EYFP)4Gfng/J
012348   B6;SJL-Tg(Thy1-COP3/EYFP)8Gfng/J
012350   B6;SJL-Tg(Thy1-COP4*H134R/EYFP)20Gfng/J
008004   B6;SJL-Tg(Thy1-ECFP/VAMP2)1Sud/J
007610   B6;SJL-Tg(Thy1-cre/ERT2,-EYFP)VGfng/J
012332   B6;SJL-Tg(Thy1-hop/EYFP)2Gfng/J
012334   B6;SJL-Tg(Thy1-hop/EYFP)4Gfng/J
006554   B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
025401   B6SJL-Tg(Thy1-COX8A/Dendra)57Gmnf/J
017590   B6SJL-Tg(Thy1-DCTN1*G59S)M2Pcw/J
007880   B6SJL-Tg(Thy1-Stx1a/EYFP)1Sud/J
007856   B6SJL-Tg(Thy1-Syt1/ECFP)1Sud/J
017589   B6SJL-Tg(Thy1-TARDBP*G298S)S97Pcw/J
017351   BKa.Cg-Ptprcb Bmi1tm1Ilw Thy1a/J
007687   BKa.Cg-Sox17tm1Sjm Ptprcb Thy1a/J
007686   BKa.Cg-Sox17tm2Sjm Ptprcb Thy1a/J
024703   C3A.Cg-Pde6b+Tg(Thy1-CFP)23Jrs/SjJ
007027   C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
010800   C57BL/6-Tg(Thy1-PTGS2)300Kand/J
010703   C57BL/6-Tg(Thy1-PTGS2)303Kand/J
012769   C57BL/6-Tg(Thy1-Sncg)HvP36Putt/J
024339   C57BL/6J-Tg(Thy1-GCaMP6f)GP5.11Dkim/J
025393   C57BL/6J-Tg(Thy1-GCaMP6f)GP5.17Dkim/J
024276   C57BL/6J-Tg(Thy1-GCaMP6f)GP5.5Dkim/J
025776   C57BL/6J-Tg(Thy1-GCaMP6s)GP4.12Dkim/J
024275   C57BL/6J-Tg(Thy1-GCaMP6s)GP4.3Dkim/J
025533   C57BL/6N-Sncatm1Mjff Tg(Thy1-SNCA)15Mjff/J
016936   C57BL/6N-Tg(Thy1-SNCA)12Mjff/J
017682   C57BL/6N-Tg(Thy1-SNCA)15Mjff/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
005443   CBy.PL(B6)-Thy1a/ScrJ
024704   D2.Cg-Gpnmb+Tg(Thy1-CFP)23Jrs/SjJ
025018   D2.Cg-Gpnmb+Tg(Thy1-YFP)HJrs/SjJ
018671   D2.Cg-Tg(Thy1-CFP)23Jrs/SjJ
024705   D2.Cg-Tg(Thy1-YFP)HJrs/SjJ
025019   D2.Cg-Tg(Thy1-YFP/Syp)10Jrs/SjJ
008230   FVB(Cg)-Tg(Thy1-SOD1*G93A)T3Hgrd/J
006143   FVB/N-Tg(Thy1-cre)1Vln/J
024476   NOD.Cg-Stat4tm1Gru Thy1a Ifngr1tm1Agt Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/LmbrJ
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004483   NOD.NON-Thy1a/1LtJ
002721   NOD.NON-Thy1a/J
005651   SJL.AK-Thy1a/TseJ
003961   SJL.Cg Thy1a-Noxo1hslt/J
021226   STOCK Tg(Thy1-Brainbow3.1)18Jrs/J
021225   STOCK Tg(Thy1-Brainbow3.1)3Jrs/J
021227   STOCK Tg(Thy1-Brainbow3.2)7Jrs/J
013162   STOCK Tg(Thy1-Clomeleon)12Gjau/J
013163   STOCK Tg(Thy1-Clomeleon)13Gjau/J
007788   STOCK Tg(Thy1-EGFP)MJrs/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
View Strains carrying other alleles of Thy1     (94 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Characteristics of this human disease are associated with transgenes and other mutation types in the mouse.
Amyotrophic Lateral Sclerosis 1; ALS1
Frontotemporal Dementia; FTD
- Potential model based on transgenic expression of an ortholog of a human gene that is associated with this disease. Phenotypic similarity to the human disease has not been tested.
Amyotrophic Lateral Sclerosis 10, with or without Frontotemporal Dementia;   (TARDBP)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tg(Thy1-TARDBP)4Singh/0

        involves: C57BL/6J * SJL/J
  • behavior/neurological phenotype
  • impaired coordination
    • 40% reduced motor performance at about 15 months of age   (MGI Ref ID J:157550)
  • limb grasping
    • abnormal limb reflex at about 14 months of age   (MGI Ref ID J:157550)
  • nervous system phenotype
  • Purkinje cell degeneration   (MGI Ref ID J:157550)
  • abnormal hippocampus morphology
    • large neuronal cytoplasmic and intranuclear inclusions are present to some extent in hippocampal/subicular neurons   (MGI Ref ID J:157550)
    • abnormal subiculum morphology
      • large neuronal cytoplasmic and intranuclear inclusions are present to some extent in hippocampal/subicular neurons   (MGI Ref ID J:157550)
  • abnormal neocortex morphology
    • large neuronal cytoplasmic and intranuclear inclusions are present in cortical layer V of the anterior cortex including the primary motor cortex   (MGI Ref ID J:157550)
  • abnormal somatosensory cortex morphology
    • large neuronal cytoplasmic and intranuclear inclusions are present in somatosensory areas of the hind- and forelimbs   (MGI Ref ID J:157550)
  • abnormal spinal cord ventral horn morphology
    • atrophy and increased number of pyknotic neurons in the ventral horn region of the lumbosacral and cervical spinal cord occurs in a transgene dose dependent manner   (MGI Ref ID J:157550)
  • astrocytosis
    • highly transgene dose dependent   (MGI Ref ID J:157550)
  • microgliosis
    • highly transgene dose dependent   (MGI Ref ID J:157550)
  • neuronal intranuclear inclusions
    • present in cortical layer V of the anterior cortex including the primary motor cortex and somatosensory areas of the hind- and forelimbs and to some extent in the hippocampal/subicular neurons   (MGI Ref ID J:157550)
  • hematopoietic system phenotype
  • microgliosis
    • highly transgene dose dependent   (MGI Ref ID J:157550)
  • immune system phenotype
  • microgliosis
    • highly transgene dose dependent   (MGI Ref ID J:157550)

Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh

        involves: C57BL/6J * SJL/J
  • mortality/aging
  • premature death
    • average survival time is 24 days   (MGI Ref ID J:157550)
  • behavior/neurological phenotype
  • abnormal gait
    • wide based stance, small stride, and frequent off line stumbling   (MGI Ref ID J:157550)
    • short stride length
      • footprint analysis shows a significant about 2 fold decrease in the stride of hindlimbs and of forelimbs   (MGI Ref ID J:157550)
  • abnormal limb posture
    • wide based stance   (MGI Ref ID J:157550)
  • impaired coordination
    • show a statistically significant about 2.5 fold reduced performance on rotarod   (MGI Ref ID J:157550)
  • limb grasping
    • at about 14 days of age mice develop hindlimb grasping   (MGI Ref ID J:157550)
  • paralysis
    • after about 22 days of age, an extremely rapid disease progression begins with mice becoming completely paralyzed and dying within 3-4 days   (MGI Ref ID J:157550)
  • muscle phenotype
  • muscle spasm
    • at about 22 days of age, fasciculations and spasms of facial muscles are observed   (MGI Ref ID J:157550)
  • nervous system phenotype
  • Purkinje cell degeneration   (MGI Ref ID J:157550)
  • abnormal hippocampus morphology
    • large neuronal cytoplasmic and intranuclear inclusions are present to some extent in hippocampal/subicular neurons   (MGI Ref ID J:157550)
    • neuronal loss is seen in all affected brain regions   (MGI Ref ID J:157550)
    • abnormal hippocampus CA3 region morphology
      • loss of CA3 hippocampal neurons and degeneration of Purkinje cells   (MGI Ref ID J:157550)
    • abnormal subiculum morphology
      • large neuronal cytoplasmic and intranuclear inclusions are present to some extent in hippocampal/subicular neurons   (MGI Ref ID J:157550)
      • neuronal loss is seen in all affected brain regions   (MGI Ref ID J:157550)
  • abnormal neocortex morphology
    • large neuronal cytoplasmic and intranuclear inclusions are present in cortical layer V of the anterior cortex including the primary motor cortex   (MGI Ref ID J:157550)
    • neuronal loss is seen in all affected brain regions including both the superficial and deep cortical layers of the anterior cortex   (MGI Ref ID J:157550)
  • abnormal somatosensory cortex morphology
    • large neuronal cytoplasmic and intranuclear inclusions are present in somatosensory areas of the hind- and forelimbs   (MGI Ref ID J:157550)
    • neuronal loss is seen in all affected brain regions   (MGI Ref ID J:157550)
  • abnormal spinal cord morphology
    • number of neurons in the lumbosacral region is significantly lower   (MGI Ref ID J:157550)
    • abnormal spinal cord ventral horn morphology
      • atrophy and increased number of pyknotic neurons in the ventral horn region of the lumbosacral and cervical spinal cord occurs in a transgene dose dependent manner   (MGI Ref ID J:157550)
    • decreased motor neuron number
      • quantitative neuronal loss is shown in motor cortex at 24 days   (MGI Ref ID J:157550)
      • number of neurons in the lumbosacral region of the spinal cord is significantly lower   (MGI Ref ID J:157550)
    • motor neuron degeneration
      • vacuolar degeneration of several cranial motor nuclei is observed   (MGI Ref ID J:157550)
  • astrocytosis
    • highly transgene dose dependent   (MGI Ref ID J:157550)
  • decreased neuron number
    • neuronal loss is seen in all affected brain regions including both the superficial and deep cortical layers of the anterior cortex   (MGI Ref ID J:157550)
    • large neuronal cytoplasmic and intranuclear inclusions are present in somatosensory areas of the hind- and forelimbs   (MGI Ref ID J:157550)
    • decreased motor neuron number
      • quantitative neuronal loss is shown in motor cortex at 24 days   (MGI Ref ID J:157550)
      • number of neurons in the lumbosacral region of the spinal cord is significantly lower   (MGI Ref ID J:157550)
  • microgliosis
    • highly transgene dose dependent   (MGI Ref ID J:157550)
  • neuronal intranuclear inclusions
    • present in cortical layer V of the anterior cortex including the primary motor cortex and somatosensory areas of the hind- and forelimbs and to some extent in the hippocampal/subicular neurons   (MGI Ref ID J:157550)
  • hematopoietic system phenotype
  • microgliosis
    • highly transgene dose dependent   (MGI Ref ID J:157550)
  • immune system phenotype
  • microgliosis
    • highly transgene dose dependent   (MGI Ref ID J:157550)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Amyotrophic Lateral Sclerosis (ALS)
Ataxia (Movement) Defects
Neurodegeneration

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(Thy1-TARDBP)4Singh
Allele Name transgene insertion 4, Samir Kumar-Singh
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) TAR4;
Mutation Made By Samir Kumar-Singh,   University of Antwerp
Strain of Origin(C57BL/6J x SJL/J)F2
Expressed Gene TARDBP, TAR DNA binding protein, human
Promoter Thy1, thymus cell antigen 1, theta, mouse, laboratory
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Tg(Thy1-TARDBP)4Singh, Standard PCR
Tg(Thy1-TARDBP)4Singh,

Separated MCA



Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Wils H; Kleinberger G; Janssens J; Pereson S; Joris G; Cuijt I; Smits V; Ceuterick-de Groote C; Van Broeckhoven C; Kumar-Singh S. 2010. TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration. Proc Natl Acad Sci U S A 107(8):3858-63. [PubMed: 20133711]  [MGI Ref ID J:157550]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, hemizygous mice may be bred to wildtype mice from the colony or B6SJLF1/J mice (Stock No. 100012). The Donating Investigator maintained these mice as hemizygotes and mates carriers to produce homozygotes, which exhibit an accelerated phenotype by 14 days of age.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Noncarrier
   100012 B6SJLF1/J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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