Strain Name:

B6.129S6-Stat5a/Stat5btm2Mam/Mmjax

Availability:

Cryopreserved - Ready for recovery     Available at the JAX MMRRC

Please refer to the Mutant Mouse Regional Resource Center (MMRRC) for information about B6.129S6-Stat5a/Stat5btm2Mam/Mmjax MMRRC Stock Number 032053.
These mutant mice possess loxP sites flanking the signal transducer and activator of transcription 5A and B (Stat5a/Stat5b) loci and may be useful for studying cell proliferation, differentiation and survival in in any given cell type.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Generation?+F1pN1
Generation Definitions
 
Donating InvestigatorDr. Lothar Hennighausen,   National Institutes of Health

Description
Homozygote: Mice homozygous for the targeted mutation are viable and fertile and exhibit no overt phenotypic abnormalities. When used in conjunction with a Cre recombinase-expressing strain, this strain is useful in generating tissue-specific conditional mutants of the floxed gene. This mutant mouse strain may be useful in generating conditional mutations to study cell proliferation, differentiation and survival in in any given cell type.

Heterozygote: Not evaluated

Development
A targeting vector was designed to place Stat5a and Stat5b in a head to toe orientation with no genes between them. A loxP flanked neomycin resistance gene was inserted downstream of Stat5b and a loxP flanked hygromycin resistance gene was inserted downstream of Stat5a. The construct was electroporated into 129S6/SvEvTac derived TC-1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into blastocysts. The resulting chimeric animals were crossed to C57BL/6J mice for more than 10 generations. Correctly genotyped pups from each generation were selected using marker assisted genome scan analysis (speed congenic). Upon arrival, mice were bred to C57BL/6J for at least 1 generation to establish the colony.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Stat5a
002833   B6;129S6-Stat5atm1Mam/J
007806   C.129S(B6)-Stat5atm1Mam/J
003502   FVB.129S6-Stat5atm1Mam/J
View Strains carrying other alleles of Stat5a     (3 strains)

Strains carrying other alleles of Stat5b
024351   B6N(Cg)-Stat5btm1.1(KOMP)Vlcg/J
007810   C.129-Stat5btm1Hwd/J
View Strains carrying other alleles of Stat5b     (2 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Growth Hormone Insensitivity with Immunodeficiency   (STAT5B)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Stat5a/Stat5btm2Mam/Stat5a/Stat5btm2Mam

        involves: 129S6/SvEvTac * Black Swiss
  • normal phenotype
  • no abnormal phenotype detected
    • homozygotes are indistinguishable from wild-type littermates   (MGI Ref ID J:92770)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cre-lox System
      loxP-flanked Sequences
Diabetes and Obesity Research
      loxP
Hematological Research
Immunology, Inflammation and Autoimmunity Research
Reproductive Biology Research
      Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Stat5a/Stat5btm2Mam
Allele Name targeted mutation 2, Lothar Hennighausen
Allele Type Targeted (Conditional ready (e.g. floxed), No functional change)
Common Name(s) Stat5fl; Stat5a/bfl;
Strain of Origin129S6/SvEvTac
Gene Symbol and Name Stat5a, signal transducer and activator of transcription 5A
Chromosome 11
Gene Common Name(s) AA959963; MGF; STAT5; expressed sequence AA959963;
Molecular Note Targeting vectors were designed to insert a floxed hygro downstream of Stat5a and a floxed neo downstream of Stat5b, thereby surrounding the Stat5a and Stat5b loci with loxP sites. [MGI Ref ID J:92770]
 
Gene Symbol and Name Stat5b, signal transducer and activator of transcription 5B
Chromosome 11
Gene Common Name(s) STAT5;

Genotyping

Genotyping Information

Genotyping Protocols

Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre Melt Curve Analysis, Simple Probe
Stat5a/Stat5btm2Mam, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Cui Y; Riedlinger G; Miyoshi K; Tang W; Li C; Deng CX; Robinson GW; Hennighausen L. 2004. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol 24(18):8037-47. [PubMed: 15340066]  [MGI Ref ID J:92770]

Additional References

Stat5a/Stat5btm2Mam related

Bell BD; Kitajima M; Larson RP; Stoklasek TA; Dang K; Sakamoto K; Wagner KU; Reizis B; Hennighausen L; Ziegler SF. 2013. The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses. Nat Immunol 14(4):364-71. [PubMed: 23435120]  [MGI Ref ID J:194747]

Berger A; Hoelbl-Kovacic A; Bourgeais J; Hoefling L; Warsch W; Grundschober E; Uras IZ; Menzl I; Putz EM; Hoermann G; Schuster C; Fajmann S; Leitner E; Kubicek S; Moriggl R; Gouilleux F; Sexl V. 2014. PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. Leukemia 28(3):629-41. [PubMed: 24263804]  [MGI Ref ID J:206976]

Burchill MA; Yang J; Vogtenhuber C; Blazar BR; Farrar MA. 2007. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol 178(1):280-90. [PubMed: 17182565]  [MGI Ref ID J:141932]

Chen Q; Kim YC; Laurence A; Punkosdy GA; Shevach EM. 2011. IL-2 Controls the Stability of Foxp3 Expression in TGF-{beta}-Induced Foxp3+ T Cells In Vivo. J Immunol 186(11):6329-37. [PubMed: 21525380]  [MGI Ref ID J:173188]

Cooney LA; Towery K; Endres J; Fox DA. 2011. Sensitivity and resistance to regulation by IL-4 during Th17 maturation. J Immunol 187(9):4440-50. [PubMed: 21949021]  [MGI Ref ID J:179441]

Dai X; Chen Y; Di L; Podd A; Li G; Bunting KD; Hennighausen L; Wen R; Wang D. 2007. Stat5 is essential for early B cell development but not for B cell maturation and function. J Immunol 179(2):1068-79. [PubMed: 17617599]  [MGI Ref ID J:143004]

Duy C; Hurtz C; Shojaee S; Cerchietti L; Geng H; Swaminathan S; Klemm L; Kweon SM; Nahar R; Braig M; Park E; Kim YM; Hofmann WK; Herzog S; Jumaa H; Koeffler HP; Yu JJ; Heisterkamp N; Graeber TG; Wu H; Ye BH; Melnick A; Muschen M. 2011. BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature 473(7347):384-8. [PubMed: 21593872]  [MGI Ref ID J:172636]

Eckelhart E; Warsch W; Zebedin E; Simma O; Stoiber D; Kolbe T; Rulicke T; Mueller M; Casanova E; Sexl V. 2011. A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development. Blood 117(5):1565-73. [PubMed: 21127177]  [MGI Ref ID J:169574]

Elias KM; Laurence A; Davidson TS; Stephens G; Kanno Y; Shevach EM; O'Shea JJ. 2008. Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood 111(3):1013-20. [PubMed: 17951529]  [MGI Ref ID J:130685]

Engblom D; Kornfeld JW; Schwake L; Tronche F; Reimann A; Beug H; Hennighausen L; Moriggl R; Schutz G. 2007. Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression. Genes Dev 21(10):1157-62. [PubMed: 17504935]  [MGI Ref ID J:121556]

Hirose J; Masuda H; Tokuyama N; Omata Y; Matsumoto T; Yasui T; Kadono Y; Hennighausen L; Tanaka S. 2014. Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5-Dusp axis in the osteoclast. J Exp Med 211(1):153-63. [PubMed: 24367002]  [MGI Ref ID J:208357]

Hoelbl A; Kovacic B; Kerenyi MA; Simma O; Warsch W; Cui Y; Beug H; Hennighausen L; Moriggl R; Sexl V. 2006. Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation. Blood 107(12):4898-906. [PubMed: 16493008]  [MGI Ref ID J:122463]

Holloway MG; Cui Y; Laz EV; Hosui A; Hennighausen L; Waxman DJ. 2007. Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus. Endocrinology 148(5):1977-86. [PubMed: 17317776]  [MGI Ref ID J:122326]

Hurtz C; Hatzi K; Cerchietti L; Braig M; Park E; Kim YM; Herzog S; Ramezani-Rad P; Jumaa H; Muller MC; Hofmann WK; Hochhaus A; Ye BH; Agarwal A; Druker BJ; Shah NP; Melnick AM; Muschen M. 2011. BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J Exp Med 208(11):2163-74. [PubMed: 21911423]  [MGI Ref ID J:178790]

Johnston RJ; Choi YS; Diamond JA; Yang JA; Crotty S. 2012. STAT5 is a potent negative regulator of TFH cell differentiation. J Exp Med 209(2):243-50. [PubMed: 22271576]  [MGI Ref ID J:181874]

Kimura A; Rieger MA; Simone JM; Chen W; Wickre MC; Zhu BM; Hoppe PS; O'Shea JJ; Schroeder T; Hennighausen L. 2009. The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis. Blood 114(21):4721-8. [PubMed: 19779039]  [MGI Ref ID J:155489]

Klover P; Hennighausen L. 2007. Postnatal Body Growth Is Dependent on the Transcription Factors Signal Transducers and Activators of Transcription 5a/b in Muscle: A Role for Autocrine/Paracrine Insulin-Like Growth Factor I. Endocrinology 148(4):1489-97. [PubMed: 17158201]  [MGI Ref ID J:119237]

Kovanen PE; Young L; Al-Shami A; Rovella V; Pise-Masison CA; Radonovich MF; Powell J; Fu J; Brady JN; Munson PJ; Leonard WJ. 2005. Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes. Int Immunol 17(8):1009-21. [PubMed: 15980098]  [MGI Ref ID J:104228]

Laurence A; Tato CM; Davidson TS; Kanno Y; Chen Z; Yao Z; Blank RB; Meylan F; Siegel R; Hennighausen L; Shevach EM; O'shea JJ. 2007. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26(3):371-81. [PubMed: 17363300]  [MGI Ref ID J:120176]

Lee JY; Gavrilova O; Davani B; Na R; Robinson GW; Hennighausen L. 2007. The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging. Biochim Biophys Acta 1773(9):1455-61. [PubMed: 17599554]  [MGI Ref ID J:127051]

Lee JY; Muenzberg H; Gavrilova O; Reed JA; Berryman D; Villanueva EC; Louis GW; Leinninger GM; Bertuzzi S; Seeley RJ; Robinson GW; Myers MG; Hennighausen L. 2008. Loss of Cytokine-STAT5 Signaling in the CNS and Pituitary Gland Alters Energy Balance and Leads to Obesity. PLoS ONE 3(2):e1639. [PubMed: 18286195]  [MGI Ref ID J:132806]

Li HS; Yang CY; Nallaparaju KC; Zhang H; Liu YJ; Goldrath AW; Watowich SS. 2012. The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development. Blood 120(22):4363-73. [PubMed: 23033267]  [MGI Ref ID J:190939]

Liao W; Schones DE; Oh J; Cui Y; Cui K; Roh TY; Zhao K; Leonard WJ. 2008. Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression. Nat Immunol 9(11):1288-96. [PubMed: 18820682]  [MGI Ref ID J:143336]

Malin S; McManus S; Cobaleda C; Novatchkova M; Delogu A; Bouillet P; Strasser A; Busslinger M. 2010. Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat Immunol 11(2):171-9. [PubMed: 19946273]  [MGI Ref ID J:158463]

Meyer RD; Laz EV; Su T; Waxman DJ. 2009. Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5. Mol Endocrinol 23(11):1914-26. [PubMed: 19797429]  [MGI Ref ID J:153887]

Mitchell DM; Williams MA. 2013. Disparate Roles for STAT5 in Primary and Secondary CTL Responses. J Immunol 190(7):3390-8. [PubMed: 23440411]  [MGI Ref ID J:194739]

Nordstrom SM; Holliday BA; Sos BC; Smyth JW; Levy RE; Dukes JW; Lord ST; Weiss EJ. 2010. Increased thrombosis susceptibility and altered fibrin formation in STAT5-deficient mice. Blood 116(25):5724-33. [PubMed: 20823455]  [MGI Ref ID J:167417]

Park JH; Adoro S; Guinter T; Erman B; Alag AS; Catalfamo M; Kimura MY; Cui Y; Lucas PJ; Gress RE; Kubo M; Hennighausen L; Feigenbaum L; Singer A. 2010. Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Nat Immunol 11(3):257-64. [PubMed: 20118929]  [MGI Ref ID J:158504]

Qi X; Hong J; Chaves L; Zhuang Y; Chen Y; Wang D; Chabon J; Graham B; Ohmori K; Li Y; Huang H. 2013. Antagonistic regulation by the transcription factors C/EBPalpha and MITF specifies basophil and mast cell fates. Immunity 39(1):97-110. [PubMed: 23871207]  [MGI Ref ID J:208242]

Rochman Y; Kashyap M; Robinson GW; Sakamoto K; Gomez-Rodriguez J; Wagner KU; Leonard WJ. 2010. Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. Proc Natl Acad Sci U S A 107(45):19455-60. [PubMed: 20974963]  [MGI Ref ID J:167374]

Seki Y; Yang J; Okamoto M; Tanaka S; Goitsuka R; Farrar MA; Kubo M. 2007. IL-7/STAT5 cytokine signaling pathway is essential but insufficient for maintenance of naive CD4 T cell survival in peripheral lymphoid organs. J Immunol 178(1):262-70. [PubMed: 17182563]  [MGI Ref ID J:141934]

Shi M; Lin TH; Appell KC; Berg LJ. 2008. Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation. Immunity 28(6):763-73. [PubMed: 18549798]  [MGI Ref ID J:137735]

Singireddy AV; Inglis MA; Zuure WA; Kim JS; Anderson GM. 2013. Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin's effects on fertility in mice. Endocrinology 154(7):2434-45. [PubMed: 23696567]  [MGI Ref ID J:201185]

Swaminathan S; Huang C; Geng H; Chen Z; Harvey R; Kang H; Ng C; Titz B; Hurtz C; Sadiyah MF; Nowak D; Thoennissen GB; Rand V; Graeber TG; Koeffler HP; Carroll WL; Willman CL; Hall AG; Igarashi K; Melnick A; Muschen M. 2013. BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint. Nat Med 19(8):1014-22. [PubMed: 23852341]  [MGI Ref ID J:200089]

Tripathi P; Kurtulus S; Wojciechowski S; Sholl A; Hoebe K; Morris SC; Finkelman FD; Grimes HL; Hildeman DA. 2010. STAT5 is critical to maintain effector CD8+ T cell responses. J Immunol 185(4):2116-24. [PubMed: 20644163]  [MGI Ref ID J:162623]

Villarino AV; Tato CM; Stumhofer JS; Yao Z; Cui YK; Hennighausen L; O'Shea JJ; Hunter CA. 2007. Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals. J Exp Med 204(1):65-71. [PubMed: 17227909]  [MGI Ref ID J:125293]

Walz C; Ahmed W; Lazarides K; Betancur M; Patel N; Hennighausen L; Zaleskas VM; Van Etten RA. 2012. Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice. Blood 119(15):3550-60. [PubMed: 22234689]  [MGI Ref ID J:183819]

Wang Z; Li G; Tse W; Bunting KD. 2009. Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement. Blood 113(20):4856-65. [PubMed: 19258595]  [MGI Ref ID J:148957]

Xiao W; Hong H; Kawakami Y; Kato Y; Wu D; Yasudo H; Kimura A; Kubagawa H; Bertoli LF; Davis RS; Chau LA; Madrenas J; Hsia CC; Xenocostas A; Kipps TJ; Hennighausen L; Iwama A; Nakauchi H; Kawakami T. 2009. Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. Cancer Cell 16(2):161-71. [PubMed: 19647226]  [MGI Ref ID J:151972]

Yamaji D; Kang K; Robinson GW; Hennighausen L. 2013. Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration. Nucleic Acids Res 41(3):1622-36. [PubMed: 23275557]  [MGI Ref ID J:200216]

Yamaji D; Na R; Feuermann Y; Pechhold S; Chen W; Robinson GW; Hennighausen L. 2009. Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A. Genes Dev 23(20):2382-7. [PubMed: 19833766]  [MGI Ref ID J:153755]

Yan D; Hutchison RE; Mohi G. 2012. Critical requirement for Stat5 in a mouse model of polycythemia vera. Blood 119(15):3539-49. [PubMed: 22144185]  [MGI Ref ID J:183821]

Yang XO; Zhang H; Kim BS; Niu X; Peng J; Chen Y; Kerketta R; Lee YH; Chang SH; Corry DB; Wang D; Watowich SS; Dong C. 2013. The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nat Immunol 14(7):732-40. [PubMed: 23727894]  [MGI Ref ID J:204829]

Yang XP; Ghoreschi K; Steward-Tharp SM; Rodriguez-Canales J; Zhu J; Grainger JR; Hirahara K; Sun HW; Wei L; Vahedi G; Kanno Y; O'Shea JJ; Laurence A. 2011. Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat Immunol 12(3):247-54. [PubMed: 21278738]  [MGI Ref ID J:169304]

Yao Z; Cui Y; Watford WT; Bream JH; Yamaoka K; Hissong BD; Li D; Durum SK; Jiang Q; Bhandoola A; Hennighausen L; O'Shea JJ. 2006. Stat5a/b are essential for normal lymphoid development and differentiation. Proc Natl Acad Sci U S A 103(4):1000-5. [PubMed: 16418296]  [MGI Ref ID J:105655]

Yao Z; Kanno Y; Kerenyi M; Stephens G; Durant L; Watford WT; Laurence A; Robinson GW; Shevach EM; Moriggl R; Hennighausen L; Wu C; O'Shea JJ. 2007. Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 109(10):4368-75. [PubMed: 17227828]  [MGI Ref ID J:143022]

Zhu BM; McLaughlin SK; Na R; Liu J; Cui Y; Martin C; Kimura A; Robinson GW; Andrews NC; Hennighausen L. 2008. Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. Blood 112(5):2071-80. [PubMed: 18552213]  [MGI Ref ID J:138904]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhile maintaining a live colony, these mice are bred as homozygotes.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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