Strain Name:

NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ

Stock Number:

013062

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Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
Common Names: NSG-SGM3;     NSGS;    
This multi-allelic mouse line combines an immunodeficient environment with the presence of several transgenic human cyotokines supportive of human myeloid cell expansion. They represent an especially useful model for the hosting of xenografts.

Description

Strain Information

Type Congenic; Mutant Strain; Spontaneous Mutation; Targeted Mutation; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemSee Colony Maintenance under the Health & Care tab         (Female x Male)   13-JAN-14
Specieslaboratory mouse
GenerationN12+N1F4pF3 (13-JAN-14)
Generation Definitions
 
Donating Investigator James C Mulloy,   Cincinnati Children's Hospital Medical Center

Description
These mice contain three coinjected transgenes, human interleukin-3 (IL-3), human granulocyte/macrophage-stimulating factor (GM-CSF), and human Steel factor (SF) gene, each driven by a human cytomegalovirus promoter/enhancer sequence. These mice are maintained on the NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice (Stock No. 005557) background. These mice constitutively produce 2-4 ng/ml serum levels of human IL-3, GM-CSF, and SF. The Il2rg-/- specific NOD.SCID background supports human and murine hematopoietic cell engraftment, and suppresses human erythropoiesis, enhances human myelopoiesis, and reduces human B-lymphopoiesis in mice after transplant of human bone marrow or fetal liver cells.

Development
Three separate transgenes were designed each carrying either the human interleukin-3 (IL-3) gene, the human granulocyte/macrophage-stimulating factor (GM-CSF) gene, or human Steel factor (SF) gene. Expression of each gene is driven by a human cytomegalovirus promoter/enhancer sequence, and is followed by a human growth hormone cassette and a polyadenylation (polyA) sequence. The transgenes were microinjected into fertilized C57BL/6xC3H/HeN oocytes. The resulting founders, carrying all three transgenes (3GS) were backcrossed to BALB/c-scid/scid mice for several generations and subsequently backcrossed to NOD.CB17-Prkdcscid mice for at least 11 generations. These mice were bred to NOD.Cg-Prkdcscid Il2rgtm1Wjl mice, and were then interbred until all offspring were homozygous for 3GS and the IL2rg targeted mutation. Upon arrival at The Jackson Laboratory, transgenic mice were bred to NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice (Stock No. 005557) for one generation to establish the colony. Thereafter, females homozygous for Prkdcscid, homozygous for Il2rgtm1Wjl and homozygous for the 3GS transgenes were bred with males homozygous for Prkdcscid, hemizygous for the X-linked Il2rgtm1Wjl and homozygous for the 3GS transgenes.

Control Information

  Control
   001303 NOD.CB17-Prkdcscid/J
   005557 NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Il2rgtm1Wjl     (19 strains)

Strains carrying   Prkdcscid allele
018018   B10ScSn.Cg-Prkdcscid Dmdmdx/J
001913   B6.CB17-Prkdcscid/SzJ
017917   B6.Cg-Dysfprmd Prkdcscid/J
021146   B6.Cg-Fcgrttm1Dcr Prkdcscid Tg(CAG-FCGRT)276Dcr/DcrJ
018441   B6.Cg-Fcgrttm1Dcr Prkdcscid Tg(FCGRT)32Dcr/DcrJ
018541   B6.Cg-Fcgrttm1Dcr Prkdcscid/DcrJ
010816   B6;C-Ghrhrlit Prkdcscid/BmJ
001131   C3SnSmn.CB17-Prkdcscid/J
001803   CBySmn.CB17-Prkdcscid/J
004083   NOD.129(B6)-Prkdcscid Iduatm1Clk/J
001303   NOD.CB17-Prkdcscid/J
002571   NOD.Cg Prkdcscid-B2mb/Dvs
004644   NOD.Cg Prkdcscid-Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy/YgyJ
010636   NOD.Cg-B2mtm1Unc Prkdcscid Il2rgtm1Wjl/SzJ
005345   NOD.Cg-Cd38tm1Lnd Prkdcscid/LtJ
014553   NOD.Cg-Hgftm1.1(HGF)Aveo Prkdcscid Il2rgtm1Wjl/J
004262   NOD.Cg-Prkdcscid Tg(HLA-A2.1)1Enge/Dvs
012478   NOD.Cg-Prkdcscid Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/GckJ
004346   NOD.Cg-Prkdcscid Tg(Ins2-CD80)3B7Flv/DvsJ
004230   NOD.Cg-Prkdcscid Tg(Ins2-E3)1Dvs/DvsJ
003843   NOD.Cg-Prkdcscid Tg(Ins2-GAD2)1Lt/LtJ
003844   NOD.Cg-Prkdcscid Tg(Ins2-GAD2)2Lt/LtJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/DvsJ
016148   NOD.Cg-Prkdcscid Alox15tm1Fun/NadlJ
002570   NOD.Cg-Prkdcscid B2mtm1Unc/J
006605   NOD.Cg-Prkdcscid Emv30b Tg(HLA-A/H2-D/B2M)1Dvs/DvsJ
002313   NOD.Cg-Prkdcscid Emv30b/Dvs
005053   NOD.Cg-Prkdcscid Gusbmps/SndsJ
004606   NOD.Cg-Prkdcscid H2-Ab1tm1Doi Tg(HLA-DQA1,HLA-DQB1)1Dv/SzJ
005589   NOD.Cg-Prkdcscid H2-Ab1tm1Doi/SzJ
021885   NOD.Cg-Prkdcscid H2-Ab1tm1Gru Il2rgtm1Wjl/SzJ
023848   NOD.Cg-Prkdcscid H2-K1tm1Bpe H2-D1tm1Bpe Il2rgtm1Wjl/SzJ
014570   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(HLA-A/H2-D/B2M)1Dvs/SzJ
012479   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/GckRolyJ
017637   NOD.Cg-Prkdcscid Il2rgtm1Wjl H2-Ab1tm1Gru Tg(HLA-DRB1)31Dmz/SzJ
012480   NOD.Cg-Prkdcscid Il2rgtm1Wjl Hprtb-m3/EshJ
021937   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CAG-EGFP)1Osb/SzJ
009617   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(HLA-A2.1)1Enge/SzJ
017830   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(PGK1-KITLG*220)441Daw/SzJ
005557   NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
011066   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy/YgyJGckRolyJ
017620   NOD.Cg-Prkdcscid Tg(CAG-DsRed*MST)1Nagy/KupwJ
017619   NOD.Cg-Prkdcscid Tg(CAG-EGFP)1Osb/KupwJ
006609   NOD.Cg-Prkdcscid Tg(HLA-A2.1)1Enge/DvsJ
007840   NOD.Cg-Prkdcscid Tg(Ins2-CD86)12B70Flv/FswJ
002380   NOD.Cg-Tg(Ins2-TAg)1Lt Prkdcscid/DvsJ
022396   NOR.CB17(NOD)-Prkdcscid/JsdJ
014543   STOCK Hgftm1.1(HGF)Aveo Prkdcscid/J
010605   STOCK Prkdcscid Gnrh1hpg/BmJ
View Strains carrying   Prkdcscid     (49 strains)

Strains carrying   Tg(CMV-IL3,CSF2,KITLG)1Eav allele
024099   NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/J
View Strains carrying   Tg(CMV-IL3,CSF2,KITLG)1Eav     (1 strain)

View Strains carrying other alleles of CSF2     (3 strains)

View Strains carrying other alleles of IL3     (3 strains)

View Strains carrying other alleles of Il2rg     (9 strains)

View Strains carrying other alleles of KITLG     (3 strains)

Strains carrying other alleles of CMV
017456   B6(C)-Tg(CAG-mCherry,-GAL4)769Gsn/J
017457   B6(C)-Tg(CAG-mCherry,-GAL4)774Gsn/J
021469   B6(D2)-Tg(CAG-GFP,-Uprt)985Cdoe/J
018439   B6.129S6-Tg(CAG-Bgeo,-SMN2)E9Dscd/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
016197   B6.Cg-Tg(CAG-OTC/CAT)4033Prab/J
018021   B6.Cg-Tg(CAG-Tfb1m)AGsha/J
016882   B6.Cg-Tg(CMV-CASP3)14Edge/J
016908   B6.Cg-Tg(CMV-CASP3)17Edge/J
008300   B6.Cg-Tg(CMV-Klc1)73Gsn/J
008301   B6.Cg-Tg(CMV-Klc1)90Gsn/J
007237   B6.Cg-Tg(CMV-Serpine1)1Dgi/J
025854   B6.FVB-Ptprca Tg(CAG-luc,-GFP)L2G85Chco Thy1a/J
018056   B6.FVB-Tg(CAG-boNT/B,-EGFP)U75-56Fwp/J
017524   B6;129-Tg(CMV-Bgeo,-WGA,-ALPP)1Mgmj/J
014605   B6;129S-Tg(CMV-BBS1)6Vcs/J
017954   B6;C-Tg(CAG-Epha4/Efna5,-mCherry)1Slp/J
016532   B6N.FVB(Cg)-Tg(CAG-rtTA3)4288Slowe/J
003465   BALB/c-Tg(CMV-cre)1Cgn/J
010545   C.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
014564   C57BL/6-Tg(CMV-Tsc2*)1Arbi/KlanJ
006362   C57BL/6J-Tg(CMV-Cox8a/EYFP)17J/J
010548   D1.FVB(Cg)-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
018543   FVB-Tg(CAG-cat,-Twist1)1Dbsp/J
008450   FVB-Tg(CAG-luc,-GFP)L2G85Chco/J
006439   FVB-Tg(tetO/CMV-KRAS*G12C)9.1Msmi/J
018393   FVB/N-Tg(CAG-EGFP,TGFB1*)C8Kul/J
004375   FVB/N-Tg(tetO-Kras2)12Hev/J
004644   NOD.Cg Prkdcscid-Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy/YgyJ
011066   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy/YgyJGckRolyJ
010542   NOD.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
014092   STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J
013753   STOCK Tg(CAG-KikGR)33Hadj/J
013754   STOCK Tg(CAG-KikGR)75Hadj/J
019082   STOCK Tg(CMV-GFP,-BBS4)4T25Vcs/J
002471   STOCK Tg(hCMV-cre)140Sau/J
014093   STOCK Tg(tetO-CHRM3*)1Blr/J
View Strains carrying other alleles of CMV     (37 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Combined Immunodeficiency, X-Linked; CIDX   (IL2RG)
Severe Combined Immunodeficiency, X-Linked; SCIDX1   (IL2RG)
- Potential model based on transgenic expression of an ortholog of a human gene that is associated with this disease. Phenotypic similarity to the human disease has not been tested.
Hyperpigmentation, Familial Progressive, 2; FPH2   (KITLG)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Il2rgtm1Wjl related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Prkdcscid related
Immunodeficiency
      B and T cell deficiency

Internal/Organ Research
Lymphoid Tissue Defects
      B and T cell deficiency

Research Tools
Cancer Research
      B and T cell deficiency, xenograft/transplant host
Toxicology Research
      xenograft/transplant host

Virology Research
B and T Cell Deficiency
      AIDS research tool

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Il2rgtm1Wjl
Allele Name targeted mutation 1, Warren J Leonard
Allele Type Targeted (Null/Knockout)
Common Name(s) CD132-; IL2Rgammanull; Il2rgtm1Wjll; [KO]gammac; gammac-; gc-;
Mutation Made ByDr. Warren Leonard,   NHLBI, NIH
Strain of Origin129S4/SvJae
ES Cell Line NameJ1
ES Cell Line Strain129S4/SvJae
Gene Symbol and Name Il2rg, interleukin 2 receptor, gamma chain
Chromosome X
Gene Common Name(s) Ab2-183; CD132; CIDX; IL-2RG; IMD4; P64; SCIDX; SCIDX1; [g]c; common cytokine receptor gamma chain; common gamma chain; gamma C receptor; gamma(c); gc;
Molecular Note A neomycin resistance cassette replaced part of exon 3 and all of exons 4 - 8 of the gene, resulting in the loss of most of the extracellular domain and all of the transmembrane and cytoplasmic domains of the protein. [MGI Ref ID J:24117]
 
Allele Symbol Prkdcscid
Allele Name severe combined immunodeficiency
Allele Type Spontaneous
Common Name(s) SCID;
Strain of OriginC.B-17
Gene Symbol and Name Prkdc, protein kinase, DNA activated, catalytic polypeptide
Chromosome 16
Gene Common Name(s) AI326420; AU019811; DNA-PK; DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH; HYRC; HYRC1; XRCC7; doxorubicin nephropathy; dxnph; expressed sequence AI326420; expressed sequence AU019811; p350; scid; severe combined immunodeficiency; slip;
Molecular Note A T-to-A transversion point mutation at a position corresponding to codon 4095 created a premature stop codon. [MGI Ref ID J:35393] [MGI Ref ID J:39329]
 
Allele Symbol Tg(CMV-IL3,CSF2,KITLG)1Eav
Allele Name transgene insertion 1, CJ Eaves
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) 3/GM/SF;
Strain of Origin(C57BL/6 x C3H/HeN)F1
Expressed Gene KITLG, KIT ligand, human
Expressed Gene CSF2, colony stimulating factor 2 (granulocyte-macrophage), human
Expressed Gene IL3, interleukin 3, human
Promoter CMV, cytomegalovirus, human
Molecular Note cDNAs encoding human interleukin 3, colony stimulating factor 2 (granulocyte-macrophage) and kit ligand were independently ligated into expression cassettes in which the cDNA resides downstream of the cytomegalovirus (CMV) promoter/enhancer sequence and is followed by human growth factor intronic and polyadenylation sequences. A transgenic mouse that was shown by ELISA to have serum levels of all three growth factors at ng/ml levels was used to establish a line with the same phenotype. [MGI Ref ID J:87755]
 
 
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Il2rgtm1Wjl-PROBE,

Probe


Prkdcscid End Point, End Point Analysis
Tg(CMV-IL3,CSF2,KITLG), Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Wei J; Wunderlich M; Fox C; Alvarez S; Cigudosa JC; Wilhelm JS; Zheng Y; Cancelas JA; Gu Y; Jansen M; Dimartino JF; Mulloy JC. 2008. Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer Cell 13(6):483-95. [PubMed: 18538732]  [MGI Ref ID J:166360]

Wunderlich M; Chou FS; Link KA; Mizukawa B; Perry RL; Carroll M; Mulloy JC. 2010. AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3. Leukemia 24(10):1785-8. [PubMed: 20686503]  [MGI Ref ID J:166359]

Additional References

Il2rgtm1Wjl related

Agliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer 123(9):2222-7. [PubMed: 18688847]  [MGI Ref ID J:142410]

Akkina R; Berges BK; Palmer BE; Remling L; Neff CP; Kuruvilla J; Connick E; Folkvord J; Gagliardi K; Kassu A; Akkina SR. 2011. Humanized Rag1gammac Mice Support Multilineage Hematopoiesis and Are Susceptible to HIV-1 Infection via Systemic and Vaginal Routes. PLoS One 6(6):e20169. [PubMed: 21695116]  [MGI Ref ID J:174292]

Al-Shami A; Spolski R; Kelly J; Fry T; Schwartzberg PL; Pandey A; Mackall CL; Leonard WJ. 2004. A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med 200(2):159-68. [PubMed: 15263024]  [MGI Ref ID J:108209]

Ali N; Flutter B; Sanchez Rodriguez R; Sharif-Paghaleh E; Barber LD; Lombardi G; Nestle FO. 2012. Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rgammanull mice display a T-effector memory phenotype. PLoS One 7(8):e44219. [PubMed: 22937164]  [MGI Ref ID J:191672]

Andre MC; Erbacher A; Gille C; Schmauke V; Goecke B; Hohberger A; Mang P; Wilhelm A; Mueller I; Herr W; Lang P; Handgretinger R; Hartwig UF. 2010. Long-term human CD34(+) stem cell-engrafted nonobese diabetic/SCID/IL-2Rgamma(null) mice show impaired CD8(+) T cell maintenance and a functional arrest of immature NK cells. J Immunol 185(5):2710-20. [PubMed: 20668220]  [MGI Ref ID J:163262]

Arpke RW; Darabi R; Mader TL; Zhang Y; Toyama A; Lonetree CL; Nash N; Lowe DA; Perlingeiro RC; Kyba M. 2013. A New Immuno- Dystrophin-Deficient Model, the NSG-Mdx Mouse, Provides Evidence for Functional Improvement Following Allogeneic Satellite Cell Transplantation. Stem Cells :. [PubMed: 23606600]  [MGI Ref ID J:199729]

Ashkar AA; Black GP; Wei Q; He H; Liang L; Head JR; Croy BA. 2003. Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy. J Immunol 171(6):2937-44. [PubMed: 12960317]  [MGI Ref ID J:85375]

Baerenwaldt A; Lux A; Danzer H; Spriewald BM; Ullrich E; Heidkamp G; Dudziak D; Nimmerjahn F. 2011. Fcgamma receptor IIB (FcgammaRIIB) maintains humoral tolerance in the human immune system in vivo. Proc Natl Acad Sci U S A 108(46):18772-7. [PubMed: 22065769]  [MGI Ref ID J:180174]

Baird JR; Byrne KT; Lizotte PH; Toraya-Brown S; Scarlett UK; Alexander MP; Sheen MR; Fox BA; Bzik DJ; Bosenberg M; Mullins DW; Turk MJ; Fiering S. 2013. Immune-Mediated Regression of Established B16F10 Melanoma by Intratumoral Injection of Attenuated Toxoplasma gondii Protects against Rechallenge. J Immunol 190(1):469-78. [PubMed: 23225891]  [MGI Ref ID J:190812]

Ballas ZK; Buchta CM; Rosean TR; Heusel JW; Shey MR. 2013. Role of NK cell subsets in organ-specific murine melanoma metastasis. PLoS One 8(6):e65599. [PubMed: 23776508]  [MGI Ref ID J:204234]

Barroso-delJesus A; Lucena-Aguilar G; Sanchez L; Ligero G; Gutierrez-Aranda I; Menendez P. 2011. The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells. FASEB J 25(5):1497-508. [PubMed: 21266536]  [MGI Ref ID J:172780]

Bayer AL; Lee JY; de la Barrera A; Surh CD; Malek TR. 2008. A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells. J Immunol 181(1):225-34. [PubMed: 18566388]  [MGI Ref ID J:137409]

Berger A; Hoelbl-Kovacic A; Bourgeais J; Hoefling L; Warsch W; Grundschober E; Uras IZ; Menzl I; Putz EM; Hoermann G; Schuster C; Fajmann S; Leitner E; Kubicek S; Moriggl R; Gouilleux F; Sexl V. 2014. PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. Leukemia 28(3):629-41. [PubMed: 24263804]  [MGI Ref ID J:206976]

Bertilaccio MT; Simonetti G; Dagklis A; Rocchi M; Rodriguez TV; Apollonio B; Mantovani A; Ponzoni M; Ghia P; Garlanda C; Caligaris-Cappio F; Muzio M. 2011. Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models. Blood 118(3):660-9. [PubMed: 21652674]  [MGI Ref ID J:174861]

Bezman NA; Chakraborty T; Bender T; Lanier LL. 2011. miR-150 regulates the development of NK and iNKT cells. J Exp Med 208(13):2717-31. [PubMed: 22124110]  [MGI Ref ID J:179053]

Billerbeck E; Barry WT; Mu K; Dorner M; Rice CM; Ploss A. 2011. Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2R{gamma}null humanized mice. Blood 117(11):3076-86. [PubMed: 21252091]  [MGI Ref ID J:170510]

Billerbeck E; Horwitz JA; Labitt RN; Donovan BM; Vega K; Budell WC; Koo GC; Rice CM; Ploss A. 2013. Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice. J Immunol 191(4):1753-64. [PubMed: 23833235]  [MGI Ref ID J:205706]

Bobbala D; Chen XL; Leblanc C; Mayhue M; Stankova J; Tanaka T; Chen YG; Ilangumaran S; Ramanathan S. 2012. Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse. Diabetologia 55(11):3010-20. [PubMed: 22890824]  [MGI Ref ID J:191833]

Boitano AE; Wang J; Romeo R; Bouchez LC; Parker AE; Sutton SE; Walker JR; Flaveny CA; Perdew GH; Denison MS; Schultz PG; Cooke MP. 2010. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329(5997):1345-8. [PubMed: 20688981]  [MGI Ref ID J:167433]

Braumuller H; Wieder T; Brenner E; Assmann S; Hahn M; Alkhaled M; Schilbach K; Essmann F; Kneilling M; Griessinger C; Ranta F; Ullrich S; Mocikat R; Braungart K; Mehra T; Fehrenbacher B; Berdel J; Niessner H; Meier F; van den Broek M; Haring HU; Handgretinger R; Quintanilla-Martinez L; Fend F; Pesic M; Bauer J; Zender L; Schaller M; Schulze-Osthoff K; Rocken M. 2013. T-helper-1-cell cytokines drive cancer into senescence. Nature 494(7437):361-5. [PubMed: 23376950]  [MGI Ref ID J:194546]

Brehm MA; Racki WJ; Leif J; Burzenski L; Hosur V; Wetmore A; Gott B; Herlihy M; Ignotz R; Dunn R; Shultz LD; Greiner DL. 2012. Engraftment of human HSC in non-irradiated newborn NOD-scid IL2rgammanull mice is enhanced by transgenic expression of membrane-bound human SCF. Blood :. [PubMed: 22246028]  [MGI Ref ID J:180273]

Brickshawana A; Shapiro VS; Kita H; Pease LR. 2011. Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow. J Immunol 187(11):5795-804. [PubMed: 22048767]  [MGI Ref ID J:179700]

Bucher C; Koch L; Vogtenhuber C; Goren E; Munger M; Panoskaltsis-Mortari A; Sivakumar P; Blazar BR. 2009. IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation. Blood 114(26):5375-84. [PubMed: 19843883]  [MGI Ref ID J:155701]

Bueno C; Lopes LF; Greaves M; Menendez P. 2007. Toward development of a novel NOD/SCID-based in vivo strategy to model multiple myeloma pathogenesis. Exp Hematol 35(10):1477-8. [PubMed: 17681665]  [MGI Ref ID J:126691]

Bugl S; Wirths S; Radsak MP; Schild H; Stein P; Andre MC; Muller MR; Malenke E; Wiesner T; Marklin M; Frick JS; Handgretinger R; Rammensee HG; Kanz L; Kopp HG. 2013. Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling. Blood 121(5):723-33. [PubMed: 23223360]  [MGI Ref ID J:194620]

Burchill MA; Yang J; Vogtenhuber C; Blazar BR; Farrar MA. 2007. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol 178(1):280-90. [PubMed: 17182565]  [MGI Ref ID J:141932]

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Tg(CMV-IL3,CSF2,KITLG)1Eav related

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX18

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, females homozygous for Prkdcscid, homozygous for Il2rgtm1Wjl and homozygous for the 3GS transgenes may be bred with males homozygous for Prkdcscid, hemizygous for the X-linked Il2rgtm1Wjl and homozygous for the 3GS transgenes.
Mating SystemSee Colony Maintenance under the Health & Care tab         (Female x Male)   13-JAN-14
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $130.00MaleHomozygous for Prkdcscid, Hemizygous for Il2rgtm1Wjl, Homozygous for Tg(CMV-IL3,CSF2,KITLG)1Eav  
$130.00FemaleHomozygous for Prkdcscid, Homozygous for Il2rgtm1Wjl, Homozygous for Tg(CMV-IL3,CSF2,KITLG)1Eav  
Price per Pair (US dollars $)Pair Genotype
$260.00Homozygous for Prkdcscid, Homozygous for Il2rgtm1Wjl, Homozygous for Tg(CMV-IL3,CSF2,KITLG)1Eav x Homozygous for Prkdcscid, Hemizygous for Il2rgtm1Wjl, Homozygous for Tg(CMV-IL3,CSF2,KITLG)1Eav  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $169.00MaleHomozygous for Prkdcscid, Hemizygous for Il2rgtm1Wjl, Homozygous for Tg(CMV-IL3,CSF2,KITLG)1Eav  
$169.00FemaleHomozygous for Prkdcscid, Homozygous for Il2rgtm1Wjl, Homozygous for Tg(CMV-IL3,CSF2,KITLG)1Eav  
Price per Pair (US dollars $)Pair Genotype
$338.00Homozygous for Prkdcscid, Homozygous for Il2rgtm1Wjl, Homozygous for Tg(CMV-IL3,CSF2,KITLG)1Eav x Homozygous for Prkdcscid, Hemizygous for Il2rgtm1Wjl, Homozygous for Tg(CMV-IL3,CSF2,KITLG)1Eav  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   001303 NOD.CB17-Prkdcscid/J
   005557 NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Research institutions require an MTA, companies require a license prior to shipping.

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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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