Strain Name:

B6.129S7-Sox9tm2Crm/J

Stock Number:

013106

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Availability:

Repository- Live

These floxed mutant mice possess loxP sites flanking the Sox9 gene, This strain may be useful for generating conditional mutations in applications related to endochondral bone formation, limb development and patterning, joint formation, and hair and stem cell differentiation.

Description

Strain Information

Former Names B6.129S7-Sox9tm1Crm/J    (Changed: 22-MAR-11 )
B6J;129S7-Sox9tm1Crm/J    (Changed: 20-JUL-10 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   17-FEB-12
Specieslaboratory mouse
GenerationN9+F7 (11-DEC-13)
Generation Definitions
 
Donating Investigator Benoit de Crombrugghe,   UT MD Anderson Cancer Center

Description
These Sox9flox mutant mice possess a loxP site upstream of exon 2, a neomycin resistance (neo) cassette followed by another loxP site downstream of exon 3 of the SRY-box containing gene 9 gene, Sox9. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are bred to mice that express Cre recombinase, the resulting offspring will have exons 2-3 deleted in the cre-expressing tissue, resulting in inactivation of Sox9 gene function. Breeding these Sox9flox mice to strains that express Cre recombinase ubiquitously results in severe bone defects and perilethality. This strain may be useful for studying cell fate determination including endochondral bone formation, limb development and patterning, joint formation, and hair and stem cell differentiation

Development
A targeting vector was designed to insert a loxP site upstream of exon 2, and a neomycin resistance (neo) cassette followed by another loxP site downstream of exon 3 of the SRY-box containing gene 9 gene, Sox9. The construct was electroporated into 129SvEv embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts and the donating investigator reported that resulting mice were bred to C57BL/6J (see SNP note below) for at least 8 generations to establish a colony of Sox9flox mice. Upon arrival at The Jackson Laboratory, mice were bred to C57BL/6J inbred mice (Stock No. 000664) for at least one generation to establish the colony.

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, at least 2 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.

Control Information

  Control
   000664 C57BL/6J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Sox9
018829   STOCK Tg(Sox9-cre/ERT2)1Msan/J
View Strains carrying other alleles of Sox9     (1 strain)

Additional Web Information

Introduction to Cre-lox technology

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Campomelic Dysplasia
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype relates to a compound genotype created using this strain.
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Sox9tm1Crm/Sox9+

        involves: 129S7/SvEvBrd * C57BL/6 * CD-1
  • mortality/aging
  • complete neonatal lethality
    • lethal by 20 hours after birth   (MGI Ref ID J:69875)
    • delayed or defective precartilagenous condensations observed at E18, result in lethal defects at birth, especially cleft palate   (MGI Ref ID J:69875)
  • craniofacial phenotype
  • abnormal Meckel's cartilage morphology
    • Meckel's cartilage is interrupted and bent toward the body midline at E14.5   (MGI Ref ID J:69875)
  • abnormal hyoid bone morphology
    • hyoid bone is thinner and bent in the center with the central part of the bone missing in severely affected mutants   (MGI Ref ID J:69875)
  • bifurcated tongue
    • bifurcated tongue   (MGI Ref ID J:69875)
  • cleft secondary palate
    • bilateral cleft of the secondary palate at birth   (MGI Ref ID J:69875)
  • micrognathia   (MGI Ref ID J:69875)
  • short mandible   (MGI Ref ID J:69875)
  • skeleton phenotype
  • abnormal Meckel's cartilage morphology
    • Meckel's cartilage is interrupted and bent toward the body midline at E14.5   (MGI Ref ID J:69875)
  • abnormal bone mineralization
    • premature mineralization occurs in many bones, especially the vertebrae and craniofacial bones   (MGI Ref ID J:69875)
  • abnormal hyoid bone morphology
    • hyoid bone is thinner and bent in the center with the central part of the bone missing in severely affected mutants   (MGI Ref ID J:69875)
  • abnormal ilium morphology
    • ilium is thinner   (MGI Ref ID J:69875)
    • ilium is angulated in severely affected mutants   (MGI Ref ID J:69875)
  • abnormal ischium morphology
    • ischium is thin   (MGI Ref ID J:69875)
  • abnormal laryngeal cartilage morphology
    • thinner laryngeal cartilage   (MGI Ref ID J:69875)
  • abnormal long bone morphology
    • variable degrees of bilateral and anterior bending of long bones   (MGI Ref ID J:69875)
    • absent deltoid tuberosity   (MGI Ref ID J:69875)
    • bowed radius
      • prominent by E14.5 and occurs in the middle of the bone shaft   (MGI Ref ID J:69875)
    • bowed tibia
      • prominent by E14.5   (MGI Ref ID J:69875)
    • bowed ulna
      • prominent by E14.5; bending is most severe in the ulnae   (MGI Ref ID J:69875)
      • angulation of the ulnae is more anterior in the bone shaft than in the radii   (MGI Ref ID J:69875)
  • abnormal pubis morphology
    • bending of the pubic bone in severely affected mutants   (MGI Ref ID J:69875)
    • small pubis
      • smaller and thinner   (MGI Ref ID J:69875)
  • abnormal scapula morphology
    • the blades of scapulae consist of two parts that are not completely connected at E14.5   (MGI Ref ID J:69875)
    • abnormal scapular spine morphology
      • only the two ends of the spines are present, with the major central part missing at E14.5   (MGI Ref ID J:69875)
    • small scapula
  • abnormal skeleton development
    • all endochondral skeletal elements of E14.5 mutants are smaller and thinner   (MGI Ref ID J:69875)
    • abnormal cartilage development
      • cartilage hypoplasia; involves nearly all skeletal elements derived from endochondral ossifications   (MGI Ref ID J:69875)
      • development of cartilage primordia is delayed and smaller in size at E12.5   (MGI Ref ID J:69875)
      • abnormal bending of cartilage elements observed at E14.5   (MGI Ref ID J:69875)
      • increased width of hypertrophic chondrocyte zone
        • hypertrophic zone is larger   (MGI Ref ID J:69875)
  • abnormal sternum morphology
    • manubrium sternum is missing or exhibits anterior bending   (MGI Ref ID J:69875)
    • abnormal sternebra morphology
      • sternebrae are thinner and not as regular as in wildtype in neonates   (MGI Ref ID J:69875)
    • abnormal xiphoid process morphology
      • xyphoid process is abnormal with a much smaller xiphoid cartilage   (MGI Ref ID J:69875)
    • short sternum   (MGI Ref ID J:69875)
  • abnormal tracheal cartilage morphology
    • tracheal rings are thinner   (MGI Ref ID J:69875)
  • micrognathia   (MGI Ref ID J:69875)
  • short mandible   (MGI Ref ID J:69875)
  • small thoracic cage   (MGI Ref ID J:69875)
  • digestive/alimentary phenotype
  • bifurcated tongue
    • bifurcated tongue   (MGI Ref ID J:69875)
  • cleft secondary palate
    • bilateral cleft of the secondary palate at birth   (MGI Ref ID J:69875)
  • meteorism
    • heterozygous mutants accumulate air in their stomachs and intestines   (MGI Ref ID J:69875)
  • limbs/digits/tail phenotype
  • abnormal tail morphology
    • frequently exhibit a crooked tail   (MGI Ref ID J:69875)
  • absent deltoid tuberosity   (MGI Ref ID J:69875)
  • bowed radius
    • prominent by E14.5 and occurs in the middle of the bone shaft   (MGI Ref ID J:69875)
  • bowed tibia
    • prominent by E14.5   (MGI Ref ID J:69875)
  • bowed ulna
    • prominent by E14.5; bending is most severe in the ulnae   (MGI Ref ID J:69875)
    • angulation of the ulnae is more anterior in the bone shaft than in the radii   (MGI Ref ID J:69875)
  • respiratory system phenotype
  • abnormal laryngeal cartilage morphology
    • thinner laryngeal cartilage   (MGI Ref ID J:69875)
  • abnormal tracheal cartilage morphology
    • tracheal rings are thinner   (MGI Ref ID J:69875)
  • respiratory distress
    • heterozygous mutants display gasping respiration and accumulate air in their stomachs and intestines   (MGI Ref ID J:69875)
  • growth/size/body phenotype
  • bifurcated tongue
    • bifurcated tongue   (MGI Ref ID J:69875)
  • cleft secondary palate
    • bilateral cleft of the secondary palate at birth   (MGI Ref ID J:69875)
  • meteorism
    • heterozygous mutants accumulate air in their stomachs and intestines   (MGI Ref ID J:69875)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Limb Patterning Defects
Perinatal Lethality

Internal/Organ Research
Skeleton
      Bone

Research Tools
Cre-lox System
      loxP-flanked Sequences

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Sox9tm2Crm
Allele Name targeted mutation 2, Benoit de Crombrugghe
Allele Type Targeted (Conditional ready (e.g. floxed), No functional change)
Common Name(s) Sox9flox; Sox9loxP;
Strain of Origin129S/SvEv
Gene Symbol and Name Sox9, SRY (sex determining region Y)-box 9
Chromosome 11
Gene Common Name(s) 2010306G03Rik; AV220920; CMD1; CMPD1; RIKEN cDNA 2010306G03 gene; SRA1; expressed sequence AV220920;
Molecular Note A neomycin resistance gene was inserted downstream of exon 3 and loxP sites flanking exon 2 and neo were introduced. [MGI Ref ID J:79879]

Genotyping

Genotyping Information

Genotyping Protocols

Sox9tm1Crm, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Sox9tm2Crm related

Akiyama H; Chaboissier MC; Behringer RR; Rowitch DH; Schedl A; Epstein JA; de Crombrugghe B. 2004. Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A 101(17):6502-7. [PubMed: 15096597]  [MGI Ref ID J:89752]

Akiyama H; Chaboissier MC; Martin JF; Schedl A; De Crombrugghe B. 2002. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev 16(21):2813-28. [PubMed: 12414734]  [MGI Ref ID J:79879]

Blitz E; Sharir A; Akiyama H; Zelzer E. 2013. Tendon-bone attachment unit is formed modularly by a distinct pool of Scx- and Sox9-positive progenitors. Development 140(13):2680-90. [PubMed: 23720048]  [MGI Ref ID J:198653]

Chaboissier MC; Kobayashi A; Vidal VI; Lutzkendorf S; van de Kant HJ; Wegner M; de Rooij DG; Behringer RR; Schedl A. 2004. Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development 131(9):1891-901. [PubMed: 15056615]  [MGI Ref ID J:89368]

Chang H; Gao F; Guillou F; Taketo MM; Huff V; Behringer RR. 2008. Wt1 negatively regulates {beta}-catenin signaling during testis development. Development 135(10):1875-85. [PubMed: 18403409]  [MGI Ref ID J:134687]

Chen Z; Huang J; Liu Y; Dattilo LK; Huh SH; Ornitz D; Beebe DC. 2014. FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands. Development 141(13):2691-701. [PubMed: 24924191]  [MGI Ref ID J:213873]

Cheung M; Chaboissier MC; Mynett A; Hirst E; Schedl A; Briscoe J. 2005. The transcriptional control of trunk neural crest induction, survival, and delamination. Dev Cell 8(2):179-92. [PubMed: 15691760]  [MGI Ref ID J:105025]

Eshkar-Oren I; Viukov SV; Salameh S; Krief S; Oh CD; Akiyama H; Gerber HP; Ferrara N; Zelzer E. 2009. The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf. Development 136(8):1263-72. [PubMed: 19261698]  [MGI Ref ID J:147285]

Finzsch M; Stolt CC; Lommes P; Wegner M. 2008. Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor {alpha} expression. Development 135(4):637-46. [PubMed: 18184726]  [MGI Ref ID J:130977]

Hines EA; Jones MK; Verheyden JM; Harvey JF; Sun X. 2013. Establishment of smooth muscle and cartilage juxtaposition in the developing mouse upper airways. Proc Natl Acad Sci U S A 110(48):19444-9. [PubMed: 24218621]  [MGI Ref ID J:203056]

Ikegami D; Akiyama H; Suzuki A; Nakamura T; Nakano T; Yoshikawa H; Tsumaki N. 2011. Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development 138(8):1507-19. [PubMed: 21367821]  [MGI Ref ID J:171508]

Kadaja M; Keyes BE; Lin M; Pasolli HA; Genander M; Polak L; Stokes N; Zheng D; Fuchs E. 2014. SOX9: a stem cell transcriptional regulator of secreted niche signaling factors. Genes Dev 28(4):328-41. [PubMed: 24532713]  [MGI Ref ID J:209139]

Kang P; Lee HK; Glasgow SM; Finley M; Donti T; Gaber ZB; Graham BH; Foster AE; Novitch BG; Gronostajski RM; Deneen B. 2012. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron 74(1):79-94. [PubMed: 22500632]  [MGI Ref ID J:188394]

Kim Y; Kobayashi A; Sekido R; DiNapoli L; Brennan J; Chaboissier MC; Poulat F; Behringer RR; Lovell-Badge R; Capel B. 2006. Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol 4(6):e187. [PubMed: 16700629]  [MGI Ref ID J:110252]

Lavery R; Chassot AA; Pauper E; Gregoire EP; Klopfenstein M; de Rooij DG; Mark M; Schedl A; Ghyselinck NB; Chaboissier MC. 2012. Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals. PLoS Genet 8(12):e1003170. [PubMed: 23300469]  [MGI Ref ID J:194924]

Lavery R; Lardenois A; Ranc-Jianmotamedi F; Pauper E; Gregoire EP; Vigier C; Moreilhon C; Primig M; Chaboissier MC. 2011. XY Sox9 embryonic loss-of-function mouse mutants show complete sex reversal and produce partially fertile XY oocytes. Dev Biol 354(1):111-22. [PubMed: 21466799]  [MGI Ref ID J:173657]

Matheu A; Collado M; Wise C; Manterola L; Cekaite L; Tye AJ; Canamero M; Bujanda L; Schedl A; Cheah KS; Skotheim RI; Lothe RA; Lopez de Munain A; Briscoe J; Serrano M; Lovell-Badge R. 2012. Oncogenicity of the Developmental Transcription Factor Sox9. Cancer Res 72(5):1301-1315. [PubMed: 22246670]  [MGI Ref ID J:181492]

McKillop WM; Dragan M; Schedl A; Brown A. 2013. Conditional Sox9 ablation reduces chondroitin sulfate proteoglycan levels and improves motor function following spinal cord injury. Glia 61(2):164-77. [PubMed: 23027386]  [MGI Ref ID J:191141]

Mori-Akiyama Y; Akiyama H; Rowitch DH; de Crombrugghe B. 2003. Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci U S A 100(16):9360-5. [PubMed: 12878728]  [MGI Ref ID J:84790]

Mori-Akiyama Y; van den Born M; van Es JH; Hamilton SR; Adams HP; Zhang J; Clevers H; de Crombrugghe B. 2007. SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology 133(2):539-46. [PubMed: 17681175]  [MGI Ref ID J:128277]

Nakamura Y; Yamamoto K; He X; Otsuki B; Kim Y; Murao H; Soeda T; Tsumaki N; Deng JM; Zhang Z; Behringer RR; Crombrugghe Bd; Postlethwait JH; Warman ML; Nakamura T; Akiyama H. 2011. Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nat Commun 2:251. [PubMed: 21427722]  [MGI Ref ID J:205660]

Nowak JA; Polak L; Pasolli HA; Fuchs E. 2008. Hair follicle stem cells are specified and function in early skin morphogenesis. Cell Stem Cell 3(1):33-43. [PubMed: 18593557]  [MGI Ref ID J:207286]

Park SW; Kim M; Kim JY; Ham A; Brown KM; Mori-Akiyama Y; Ouellette AJ; D'Agati VD; Lee HT. 2012. Paneth cell-mediated multiorgan dysfunction after acute kidney injury. J Immunol 189(11):5421-33. [PubMed: 23109723]  [MGI Ref ID J:190668]

Reginensi A; Clarkson M; Neirijnck Y; Lu B; Ohyama T; Groves AK; Sock E; Wegner M; Costantini F; Chaboissier MC; Schedl A. 2011. SOX9 controls epithelial branching by activating RET effector genes during kidney development. Hum Mol Genet 20(6):1143-53. [PubMed: 21212101]  [MGI Ref ID J:168845]

Sahar DE; Longaker MT; Quarto N. 2005. Sox9 neural crest determinant gene controls patterning and closure of the posterior frontal cranial suture. Dev Biol 280(2):344-61. [PubMed: 15882577]  [MGI Ref ID J:98269]

Sato T; van Es JH; Snippert HJ; Stange DE; Vries RG; van den Born M; Barker N; Shroyer NF; van de Wetering M; Clevers H. 2011. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469(7330):415-8. [PubMed: 21113151]  [MGI Ref ID J:168728]

Scott CE; Wynn SL; Sesay A; Cruz C; Cheung M; Gomez Gaviro MV; Booth S; Gao B; Cheah KS; Lovell-Badge R; Briscoe J. 2010. SOX9 induces and maintains neural stem cells. Nat Neurosci 13(10):1181-9. [PubMed: 20871603]  [MGI Ref ID J:165253]

Shi Z; Chiang CI; Mistretta TA; Major A; Mori-Akiyama Y. 2013. SOX9 directly regulates IGFBP-4 in the intestinal epithelium. Am J Physiol Gastrointest Liver Physiol 305(1):G74-83. [PubMed: 23660500]  [MGI Ref ID J:202780]

Stolt CC; Lommes P; Sock E; Chaboissier MC; Schedl A; Wegner M. 2003. The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Genes Dev 17(13):1677-89. [PubMed: 12842915]  [MGI Ref ID J:84301]

Stolt CC; Schlierf A; Lommes P; Hillgartner S; Werner T; Kosian T; Sock E; Kessaris N; Richardson WD; Lefebvre V; Wegner M. 2006. SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev Cell 11(5):697-709. [PubMed: 17084361]  [MGI Ref ID J:116148]

Stolt CC; Schmitt S; Lommes P; Sock E; Wegner M. 2005. Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord. Dev Biol 281(2):309-17. [PubMed: 15893981]  [MGI Ref ID J:98585]

Sutton E; Hughes J; White S; Sekido R; Tan J; Arboleda V; Rogers N; Knower K; Rowley L; Eyre H; Rizzoti K; McAninch D; Goncalves J; Slee J; Turbitt E; Bruno D; Bengtsson H; Harley V; Vilain E; Sinclair A; Lovell-Badge R; Thomas P. 2011. Identification of SOX3 as an XX male sex reversal gene in mice and humans. J Clin Invest 121(1):328-41. [PubMed: 21183788]  [MGI Ref ID J:171839]

Thomsen MK; Ambroisine L; Wynn S; Cheah KS; Foster CS; Fisher G; Berney DM; Moller H; Reuter VE; Scardino P; Cuzick J; Ragavan N; Singh PB; Martin FL; Butler CM; Cooper CS; Swain A. 2010. SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation. Cancer Res 70(3):979-87. [PubMed: 20103652]  [MGI Ref ID J:156856]

Thomsen MK; Butler CM; Shen MM; Swain A. 2008. Sox9 is required for prostate development. Dev Biol 316(2):302-11. [PubMed: 18325490]  [MGI Ref ID J:135788]

Topol L; Chen W; Song H; Day TF; Yang Y. 2009. Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus. J Biol Chem 284(5):3323-33. [PubMed: 19047045]  [MGI Ref ID J:147223]

Vidal VP; Chaboissier MC; Lutzkendorf S; Cotsarelis G; Mill P; Hui CC; Ortonne N; Ortonne JP; Schedl A. 2005. Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol 15(15):1340-51. [PubMed: 16085486]  [MGI Ref ID J:100131]

Wang Y; Liu C; Rohr J; Liu H; He F; Yu J; Sun C; Li L; Gu S; Chen Y. 2011. Tissue interaction is required for glenoid fossa development during temporomandibular joint formation. Dev Dyn 240(11):2466-73. [PubMed: 21953591]  [MGI Ref ID J:177115]

Yamashita S; Miyaki S; Kato Y; Yokoyama S; Sato T; Barrionuevo F; Akiyama H; Scherer G; Takada S; Asahara H. 2012. L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity. J Biol Chem 287(26):22206-15. [PubMed: 22547066]  [MGI Ref ID J:187536]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, homozygous mice may be bred together.
Mating SystemHomozygote x Homozygote         (Female x Male)   17-FEB-12
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $232.00Female or MaleHomozygous for Sox9tm2Crm  
Price per Pair (US dollars $)Pair Genotype
$464.00Homozygous for Sox9tm2Crm x Homozygous for Sox9tm2Crm  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $301.60Female or MaleHomozygous for Sox9tm2Crm  
Price per Pair (US dollars $)Pair Genotype
$603.20Homozygous for Sox9tm2Crm x Homozygous for Sox9tm2Crm  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000664 C57BL/6J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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