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| This strain is one of a set of 3 NOD.B6 congenic Idd10 and Idd18 strains (Stock No. 013185, 013186). Stocks 13185, 13186 and 13187 resulted from crossing segments of C57BL/6J derived chromosome 3 into the NOD/MrkTac background. Mice of this strain contain C57BL/6J derived Idd10, Idd18.2 and Idd18.3 regions. These strains may be useful to better understand the variation of diabetic resistance conferred by Idd loci and may be useful for identifying diabetes susceptible candidate genes within the Idd18 subloci. | |||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names NOD.B6-Idd10C57BL/6J Idd18.2C57BL/6J Idd18.3C57BL/6J/2412MrkTacJ (Changed: 05-NOV-10 ) Type Qtl; Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain NOD/MrkTacfBR Donor Strain C57BL/6J H2 Haplotype g7 Generation N14F?+F2pN1
Generation DefinitionsDonating Investigator Linda Wicker, University of Cambridge, UK Description
This NOD/MrkTac congenic strain, commonly referred to as NOD.B6-Idd10/18R53, line 2412 is viable and fertile. . Mice of this strain contain a genomic segment from the diabetes resistant strain C57BL/6J (Stock No. 000664) introgressed into the NOD chromosome 3. The C57BL/6 genomic segment includes Idd10, Idd18.2 and Idd18.3; while the Idd3, Idd17 and Idd18.1 regions are of NOD origin. The Idd10 region contains major candidate gene Cd101 (100Mb); and the recently identified 966Kb (108.3Mb-109.3Mb) Idd18.3 region contains 22 genes and 1 pseudogene. Thymocytes of 3-week old male congenic mice express 1.46 fold more full length VAV3 mRNA than thymocytes of line 7754 (Stock No. 013186); which carries a C57BL/6J derived Idd18.1 (Vav3), Idd18.2 and Idd18.3. Diabetes incidence overlaps with line 7754 and is reported to be about 54%.
This strain is useful for conducting mapping experiments to further define the Idd18.3 region.Development
This strain was produced by mating mice from NOD/MrkTac (NOD) to C57BL/6J followed by 13 additional crosses to NOD with selection for chromosome 3, Idd10, Idd18.2 and Idd18.3 markers. Siblings carrying the C57BL/6J derived segments were intercrossed to make homozygous. 5kSNP Chip Data, based on NCBI, build 36, identifies no C57BL/6J genetic contamination of other chromosomes. In 2010, the Type 1 Diabetes Resource received this strain at generation N14F?.
Control Information
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Idd10C57BL/6 allele
View Strains carrying Idd10C57BL/6 (6 strains)
003067 B6.NOD-(D3Mit132-Tshb) (D17Mit21-D17Mit10)/J 003059 B6.NOD-(D3Mit132-Tshb)/J 010971 NOD.B-(D3Mit93-D3Mit124)(D4Mit114-D4Mit142)/1112MrkJ
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains
Recombinant Congenic Strains
Immunology, Inflammation and Autoimmunity Research
Autoimmunity
Type 1 Diabetes
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Idd10C57BL/6 | ||
|---|---|---|---|
| Allele Name | C57BL/6 | ||
| Allele Type | QTL | ||
| Strain of Origin | B6.PL-Thy1a/CyJ | ||
| Gene Symbol and Name | Idd10, insulin dependent diabetes susceptibility 10 | ||
| Chromosome | 3 | ||
| Gene Common Name(s) | Idd-10; | ||
| General Note |
Idd10 and Idd18 interact to promote disease resistance. Homozygosity for C57BL/6-derived alleles at both Idd10 and Idd18 confers significantly increased resistance to type 1 diabetes. Idd10 and Idd17 interact to promote disease resistance. Homozygosity for C57BL/6-derived alleles at both Idd10 and Idd17 confers significantly increased resistance to type 1 diabetes. Idd10 and Idd3 interact to promote disease resistance. Homozygosity for C57BL/6-derived alleles at both Idd10 and Idd3 confers significantly increased resistance to type 1 diabetes. | ||
| Molecular Note | This allele confers resistance to insulin dependent diabetes compared to NOD. [MGI Ref ID J:42103] | ||
| Allele Symbol | Idd18.2C57BL/6J | ||
| Allele Name | C57BL/6J | ||
| Allele Type | QTL | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | Idd18.2, insulin dependent diabetes susceptibility 18.2 | ||
| Chromosome | 3 | ||
| General Note | Located between Idd10 and Idd18.3 on Chromosome 3. | ||
| Molecular Note | No published characterization of this QTL has yet appeared. [MGI Ref ID J:160442] | ||
| Allele Symbol | Idd18.3C57BL/6J | ||
| Allele Name | C57BL/6J | ||
| Allele Type | QTL | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | Idd18.3, insulin dependent diabetes susceptibility 18.3 | ||
| Chromosome | 3 | ||
| General Note | Located in a 996 Kb interval in the region between but not including AC093365_1 and AL845310_10. Twenty-two genes and one pseudogene are located in this region. | ||
| Molecular Note | Twenty-two genes are located in this QTL region. [MGI Ref ID J:160442] | ||
References
References provided by MGI
Selected Reference(s)
Fraser HI; Dendrou CA; Healy B; Rainbow DB; Howlett S; Smink LJ; Gregory S; Steward CA; Todd JA; Peterson LB; Wicker LS. 2010. Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene. J Immunol 184(9):5075-84. [PubMed: 20363978] [MGI Ref ID J:160442]
Additional References
Idd10C57BL/6 relatedMatsuki N; Stanic AK; Embers ME; Van Kaer L; Morel L; Joyce S. 2003. Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice. J Immunol 170(11):5429-37. [PubMed: 12759418] [MGI Ref ID J:85823]
Moritoki Y; Tsuda M; Tsuneyama K; Zhang W; Yoshida K; Lian ZX; Yang GX; Ridgway WM; Wicker LS; Ansari AA; Gershwin ME. 2011. B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis. Cell Immunol 268(1):16-23. [PubMed: 21349500] [MGI Ref ID J:170707]
Podolin PL; Denny P; Armitage N; Lord CJ; Hill NJ; Levy ER; Peterson LB ; Todd JA ; Wicker LS ; Lyons PA. 1998. Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse chromosome 3. Mamm Genome 9(4):283-6. [PubMed: 9530623] [MGI Ref ID J:46659]
Podolin PL; Denny P; Lord CJ; Hill NJ; Todd JA; Peterson LB; Wicker LS; Lyons PA. 1997. Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two gene mediating the Idd10 effect and eliminates the candidate Fcgr1. J Immunol 159(4):1835-1843. [PubMed: 9257847] [MGI Ref ID J:42103]
Yang GX; Wu Y; Tsukamoto H; Leung PS; Lian ZX; Rainbow DB; Hunter KM; Morris GA; Lyons PA; Peterson LB; Wicker LS; Gershwin ME; Ridgway WM. 2011. CD8 T cells mediate direct biliary ductule damage in nonobese diabetic autoimmune biliary disease. J Immunol 186(2):1259-67. [PubMed: 21169553] [MGI Ref ID J:168755]
Health & husbandry
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.Colony Maintenance
Breeding & Husbandry While maintaining a live colony, this strain is mated homozygote x homozygote.
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2250.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2925.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- This strain is included in the Type 1 Diabetes Repository collection.
Control Information
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | (approximate) | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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