Strain Name:

STOCK Sagtm1Jnc/J

Stock Number:

013197

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Availability:

Cryopreserved - Ready for recovery

This visual arrestin knock out mouse strain may be useful in studies of photoreceptor adaptation, phototransduction, and retinopathy.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6.129-Sagtm1Jnc/J    (Changed: 04-MAY-11 )
Type Congenic; Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
GenerationN5pN1
Generation Definitions
 
Donating Investigator Jeannie Chen,   University of Southern California

Important Note

Breeding colonies at The Jackson Laboratory are maintained in normal light conditions. We will attempt to maintain this colony in shelf positions that allow the least amount of light possible (i.e., lower shelves), but can not guarantee the extent of retinal damage (if any) in the mice we provide. For experimental use, we strongly suggest investigators use the mice we provide for breeding purposes rather than experiments. This allows each investigator to generate their own experimental offspring in light conditions ideal for their own respective experiments.

Description
Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These mutant mice are photosensitive and if not maintained under low light conditions will develop progressive retinal degeneration. No gene product (protein) is detected by Northern blot analysis of retinas from homozygous mice maintained in cyclic (12 hour light: 12 hour dark) conditions. Photoreceptor loss in homozygotes maintained in cyclic light conditions begins at approximately 100 days of age, progressing to loss of more than half of the photoreceptors by 1 year of age. After 1 week of constant light exposure, homozygotes lose 30% of photoreceptors; after 3 weeks of constant light exposure, more than 60% of photoreceptors are lost. Homozygotes maintained under cyclic light conditions exhibit disorganized and 25% shorter retinal rod outer segment layer, as well as reduced levels of retinal rhodopsin. Recovery phase response to light flash stimulation of the retina is significantly longer in homozygotes, although light adaptation function is normal.

IMPORTANT NOTE: Breeding colonies at The Jackson Laboratory are maintained in normal light conditions. We will attempt to maintain this colony in shelf positions that allow the least amount of light possible (i.e., lower shelves), but can not guarantee the extent of retinal damage (if any) in the mice we provide. For experimental use, we strongly suggest investigators use the mice we provide for breeding purposes rather than experiments. This allows each investigator to generate their own experimental offspring in light conditions ideal for their own respective experiments.

Development
A targeting vector containing MC1neopA cassette was used to disrupt part of the 5' promoter and exons 1 and 2. The construct was electroporated into 129/SvEv derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The donating investigator reports these mice were then backcrossed to C57BL/6 for five generations (see SNP results below). Upon arrival at The Jackson Laboratory, the mice were crossed to C57BL/6J (Stock No. 000664) at least once to establish the colony.

In March 2011, a 32 SNP (single nucleotide polymorphism) panel analysis with markers covering all 19 chromosomes and the X chromosome was performed on the first generation of rederived mice at The Jackson Laboratory Repository. This revealed markers that were not C57BL/6 allele-type at nine loci (representing seven different chromosomes: 1, 3, 6, 8, 12, 13, and 17). The marker on chromosome 17 (~34 Mbp) is neither C57BL/6 nor 129S allele-type. The other eight markers may be 129S (or other) allele-type. These data suggest the mice sent to The Jackson Laboratory Repository were not fully backcrossed onto the C57BL/6 genetic background, and are on a more mixed genetic background of C57BL/6 and 129S with contributions from either A, C3H/He, SJL, SWR, and/or other unknown lines. Furthermore, this data might suggest the mice are on a mixed C57BL/6;129S genetic background with some other contamination on chromosome 17 (that may or may not affect the MHC genes).

Control Information

  Control
   000664 C57BL/6J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Sagtm1Jnc allele
017752   B6.129S-Sagtm1Jnc Tg(Rho-Sag*)240Seva/Mmjax
017753   B6.129S-Sagtm1Jnc Tg(Rho-Sag*)50Seva/Mmjax
View Strains carrying   Sagtm1Jnc     (2 strains)

Strains carrying other alleles of Sag
017752   B6.129S-Sagtm1Jnc Tg(Rho-Sag*)240Seva/Mmjax
017753   B6.129S-Sagtm1Jnc Tg(Rho-Sag*)50Seva/Mmjax
View Strains carrying other alleles of Sag     (2 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Oguchi Disease 1   (SAG)
Retinitis Pigmentosa 47; RP47   (SAG)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Sagtm1Jnc/Sagtm1Jnc

        involves: 129S/SvEv
  • vision/eye phenotype
  • *normal* vision/eye phenotype
    • mice exhibit normal cone electrophysiology   (MGI Ref ID J:139694)
    • abnormal retinal rod cell outer segment morphology
      • the rod outer segment is disorganized and 25% shorter than in wild-type mice   (MGI Ref ID J:43294)
      • however, raising mice in darkness reduces the effect   (MGI Ref ID J:43294)
    • abnormal rod electrophysiology
      • slow phase of the dim-flash response is 10-fold longer than in the Arrb1tm1Jnc Rhotm1Shda double homozygotes   (MGI Ref ID J:120882)
      • prolonged decay of slow-phase response is associated with increased meta-II decay   (MGI Ref ID J:120882)
      • rods exhibit an abnormal falling phase of the flash response compared to in wild-type mice   (MGI Ref ID J:43294)
      • recovery from flash response is prolonged in the final phase unlike wild type mice   (MGI Ref ID J:43294)
      • however, response to light adaptation is normal   (MGI Ref ID J:43294)
  • nervous system phenotype
  • abnormal retinal rod cell outer segment morphology
    • the rod outer segment is disorganized and 25% shorter than in wild-type mice   (MGI Ref ID J:43294)
    • however, raising mice in darkness reduces the effect   (MGI Ref ID J:43294)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Sensorineural Research
      retinal degeneration

Sensorineural Research
Eye Defects
Retinal Degeneration

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Sagtm1Jnc
Allele Name targeted mutation 1, Jeannie Chen
Allele Type Targeted (Null/Knockout)
Common Name(s) Arrb1tm1Jnc; arr1-; arrestin-;
Mutation Made By Jeannie Chen,   University of Southern California
Strain of Origin129S/SvEv
Gene Symbol and Name Sag, S-antigen, retina and pineal gland (arrestin)
Chromosome 1
Gene Common Name(s) A930001K18Rik; Arr1; RIKEN cDNA A930001K18 gene; RP47; S-AG; SAGMR; SANTI; arrestin; arrestin 1; rod arrestin; visual arrestin 1;
Molecular Note Part of the 5' promoter and exons 1 and 2 were replaced with a neomycin resistance cassette via homologous recombination. Gene expression was undetectable in rod cells of homozygous mutant animals as shown by Western blot analysis. [MGI Ref ID J:43294]

Genotyping

Genotyping Information

Genotyping Protocols

Sagtm1Jnc, Separated PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Sagtm1Jnc related

Brill E; Malanson KM; Radu RA; Boukharov NV; Wang Z; Chung HY; Lloyd MB; Bok D; Travis GH; Obin M; Lem J. 2007. A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducin. Invest Ophthalmol Vis Sci 48(12):5445-53. [PubMed: 18055791]  [MGI Ref ID J:132555]

Brown BM; Ramirez T; Rife L; Craft CM. 2010. Visual Arrestin 1 contributes to cone photoreceptor survival and light adaptation. Invest Ophthalmol Vis Sci 51(5):2372-80. [PubMed: 20019357]  [MGI Ref ID J:164108]

Burns ME; Mendez A; Chen CK; Almuete A; Quillinan N; Simon MI; Baylor DA; Chen J. 2006. Deactivation of phosphorylated and nonphosphorylated rhodopsin by arrestin splice variants. J Neurosci 26(3):1036-44. [PubMed: 16421323]  [MGI Ref ID J:104814]

Chan S; Rubin WW; Mendez A; Liu X; Song X; Hanson SM; Craft CM; Gurevich VV; Burns ME; Chen J. 2007. Functional comparisons of visual arrestins in rod photoreceptors of transgenic mice. Invest Ophthalmol Vis Sci 48(5):1968-75. [PubMed: 17460248]  [MGI Ref ID J:123310]

Chen J; Shi G; Concepcion FA; Xie G; Oprian D; Chen J. 2006. Stable rhodopsin/arrestin complex leads to retinal degeneration in a transgenic mouse model of autosomal dominant retinitis pigmentosa. J Neurosci 26(46):11929-37. [PubMed: 17108167]  [MGI Ref ID J:115576]

Chen J; Simon MI; Matthes MT; Yasumura D; LaVail MM. 1999. Increased susceptibility to light damage in an arrestin knockout mouse model of Oguchi disease (stationary night blindness) [see comments] Invest Ophthalmol Vis Sci 40(12):2978-82. [PubMed: 10549660]  [MGI Ref ID J:58211]

Choi S; Hao W; Chen CK; Simon MI. 2001. Gene expression profiles of light-induced apoptosis in arrestin/rhodopsin kinase-deficient mouse retinas. Proc Natl Acad Sci U S A 98(23):13096-101. [PubMed: 11687607]  [MGI Ref ID J:85250]

Cleghorn WM; Tsakem EL; Song X; Vishnivetskiy SA; Seo J; Chen J; Gurevich EV; Gurevich VV. 2011. Progressive reduction of its expression in rods reveals two pools of arrestin-1 in the outer segment with different roles in photoresponse recovery. PLoS One 6(7):e22797. [PubMed: 21818392]  [MGI Ref ID J:175851]

Doan T; Azevedo AW; Hurley JB; Rieke F. 2009. Arrestin competition influences the kinetics and variability of the single-photon responses of mammalian rod photoreceptors. J Neurosci 29(38):11867-79. [PubMed: 19776273]  [MGI Ref ID J:153044]

Fu Y; Kefalov V; Luo DG; Xue T; Yau KW. 2008. Quantal noise from human red cone pigment. Nat Neurosci 11(5):565-71. [PubMed: 18425122]  [MGI Ref ID J:136254]

Gross OP; Burns ME. 2010. Control of rhodopsin's active lifetime by arrestin-1 expression in mammalian rods. J Neurosci 30(9):3450-7. [PubMed: 20203204]  [MGI Ref ID J:159020]

Hamer RD; Nicholas SC; Tranchina D; Liebman PA; Lamb TD. 2003. Multiple steps of phosphorylation of activated rhodopsin can account for the reproducibility of vertebrate rod single-photon responses. J Gen Physiol 122(4):419-44. [PubMed: 12975449]  [MGI Ref ID J:105946]

Imai H; Kefalov V; Sakurai K; Chisaka O; Ueda Y; Onishi A; Morizumi T; Fu Y; Ichikawa K; Nakatani K; Honda Y; Chen J; Yau KW; Shichida Y. 2007. Molecular properties of rhodopsin and rod function. J Biol Chem 282(9):6677-84. [PubMed: 17194706]  [MGI Ref ID J:120882]

Lopes VS; Jimeno D; Khanobdee K; Song X; Chen B; Nusinowitz S; Williams DS. 2010. Dysfunction of heterotrimeric kinesin-2 in rod photoreceptor cells and the role of opsin mislocalization in rapid cell death. Mol Biol Cell 21(23):4076-88. [PubMed: 20926680]  [MGI Ref ID J:182935]

Lyubarsky AL; Chen C; Simon MI; Pugh EN Jr. 2000. Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses. J Neurosci 20(6):2209-17. [PubMed: 10704496]  [MGI Ref ID J:60964]

Lyubarsky AL; Lem J; Chen J; Falsini B; Iannaccone A; Pugh EN Jr. 2002. Functionally rodless mice: transgenic models for the investigation of cone function in retinal disease and therapy. Vision Res 42(4):401-15. [PubMed: 11853756]  [MGI Ref ID J:130998]

Mendez A; Lem J; Simon M; Chen J. 2003. Light-dependent translocation of arrestin in the absence of rhodopsin phosphorylation and transducin signaling. J Neurosci 23(8):3124-9. [PubMed: 12716919]  [MGI Ref ID J:123823]

Moaven H; Koike Y; Jao CC; Gurevich VV; Langen R; Chen J. 2013. Visual arrestin interaction with clathrin adaptor AP-2 regulates photoreceptor survival in the vertebrate retina. Proc Natl Acad Sci U S A 110(23):9463-8. [PubMed: 23690606]  [MGI Ref ID J:197413]

Nair KS; Hanson SM; Mendez A; Gurevich EV; Kennedy MJ; Shestopalov VI; Vishnivetskiy SA; Chen J; Hurley JB; Gurevich VV; Slepak VZ. 2005. Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions. Neuron 46(4):555-67. [PubMed: 15944125]  [MGI Ref ID J:99855]

Nikonov SS; Brown BM; Davis JA; Zuniga FI; Bragin A; Pugh EN Jr; Craft CM. 2008. Mouse cones require an arrestin for normal inactivation of phototransduction. Neuron 59(3):462-74. [PubMed: 18701071]  [MGI Ref ID J:139694]

Palczewski K; Van Hooser JP; Garwin GG; Chen J; Liou GI; Saari JC. 1999. Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin. Biochemistry 38(37):12012-9. [PubMed: 10508404]  [MGI Ref ID J:57704]

Roca A; Shin KJ; Liu X; Simon MI; Chen J. 2004. Comparative analysis of transcriptional profiles between two apoptotic pathways of light-induced retinal degeneration. Neuroscience 129(3):779-90. [PubMed: 15541899]  [MGI Ref ID J:124312]

Shi G; Yau KW; Chen J; Kefalov VJ. 2007. Signaling properties of a short-wave cone visual pigment and its role in phototransduction. J Neurosci 27(38):10084-93. [PubMed: 17881515]  [MGI Ref ID J:145225]

Shi GW; Chen J; Concepcion F; Motamedchaboki K; Marjoram P; Langen R; Chen J. 2005. Light causes phosphorylation of nonactivated visual pigments in intact mouse rod photoreceptor cells. J Biol Chem 280(50):41184-91. [PubMed: 16219764]  [MGI Ref ID J:105603]

Song X; Vishnivetskiy SA; Gross OP; Emelianoff K; Mendez A; Chen J; Gurevich EV; Burns ME; Gurevich VV. 2009. Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation. Curr Biol 19(8):700-5. [PubMed: 19361994]  [MGI Ref ID J:148930]

Song X; Vishnivetskiy SA; Seo J; Chen J; Gurevich EV; Gurevich VV. 2011. Arrestin-1 expression level in rods: balancing functional performance and photoreceptor health. Neuroscience 174:37-49. [PubMed: 21075174]  [MGI Ref ID J:170273]

Strissel KJ; Sokolov M; Trieu LH; Arshavsky VY. 2006. Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin. J Neurosci 26(4):1146-53. [PubMed: 16436601]  [MGI Ref ID J:104993]

Xu J; Dodd RL; Makino CL; Simon MI; Baylor DA; Chen J. 1997. Prolonged photoresponses in transgenic mouse rods lacking arrestin. Nature 389(6650):505-9. [PubMed: 9333241]  [MGI Ref ID J:43294]

Zuniga FI; Craft CM. 2010. Deciphering the structure and function of als2cr4 in the mouse retina. Invest Ophthalmol Vis Sci 51(9):4407-15. [PubMed: 20375344]  [MGI Ref ID J:164092]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice can be bred as homozygotes.

IMPORTANT NOTE: Breeding colonies at The Jackson Laboratory are maintained in normal light conditions. We will attempt to maintain this colony in shelf positions that allow the least amount of light possible (i.e., lower shelves), but can not guarantee the extent of retinal damage (if any) in the mice we provide. For experimental use, we strongly suggest investigators use the mice we provide for breeding purposes rather than experiments. This allows each investigator to generate their own experimental offspring in light conditions ideal for their own respective experiments.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   000664 C57BL/6J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

Breeding colonies at The Jackson Laboratory are maintained in normal light conditions. We will attempt to maintain this colony in shelf positions that allow the least amount of light possible (i.e., lower shelves), but can not guarantee the extent of retinal damage (if any) in the mice we provide. For experimental use, we strongly suggest investigators use the mice we provide for breeding purposes rather than experiments. This allows each investigator to generate their own experimental offspring in light conditions ideal for their own respective experiments.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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