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| These Sox2Cre transgenic mice express Cre recombinase under the control of the mouse Sox2 promoter, and may be useful for generating epiblast-derived specific conditional mutations. | ||||||||||||||||||||||
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Description
Strain Information
Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Noncarrier x Hemizygote (Female x Male) 01-AUG-12 Mating System Hemizygote x Noncarrier (Female x Male) 01-AUG-12 Species laboratory mouse Generation N4+N1
Generation DefinitionsDonating Investigator IMR Colony, The Jackson Laboratory Description
These transgenic mice express Cre recombinase under the control of the mouse SRY-box containing gene 2 promoter. Mice hemizygous for the Sox2Cre transgene are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these transgenic mice are bred with mice containing loxP-flanked sequences, Cre-mediated recombination will result in deletion of the floxed sequences in Cre-expressing tissues in the offspring. Specifically, Cre recombinase activity is detected in the epiblast cells at embryonic day 6.5, with little or no activity in other cells at gastrulation. Some activity is also detected in extra embryonic derivatives of the epiblast, the yolk sac mesoderm and amnion. No Cre recombinase activity is detected in primitive endoderm derived tissues, visceral endoderm. The phenotype of homozygous mice has not been characterized to date (April 2011). These Sox2Cre transgenic may be useful for generating epiblast-derived specific conditional mutations. Transgene expression is active in the female germline. Offspring arising from a hemizygous transgenic female will exhibit Cre recombinase activity, regardless of phenotype. This maternal inheritance effect, due to female germline expression of the transgene, can provide a rapid and efficient breeding mechanism for generating null animals.In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
The Sox2Cre transgene was designed with 12.5 kb of upstream regulatory sequence from the mouse Sox2 locus (SRY-box containing gene 2), a chicken β-actin intron, a Cre recombinase gene, and a rabbit β-globin poly(A) sequence. This transgene was introduced into B6CBAF1 donor eggs. The resulting founder animals were initially crossed to C57BL/6 mice, and then crossed to outbred Swiss Webster mice. The donating investigator reporetd that the mice were backcrossed to C57BL/6 for 11 generations before being sent to The Jackson Laboratory Repository (as Stock No. 008454). There, some mice were subsequently backcrossed to C57BL/6NJ inbred mice (Stock No. 005304) for several generations using a marker-assisted, speed congenic approach to generate this congenic strain (see SNP note below).A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 2 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 005304 C57BL/6NJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(Sox2-cre)1Amc allele
008454 B6.Cg-Tg(Sox2-cre)1Amc/J 004783 STOCK Tg(Sox2-cre)1Amc/J View Strains carrying Tg(Sox2-cre)1Amc (2 strains)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Cre Recombinase Expression: Germline/Embryonic Expression
Developmental Biology Research
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Sox2-cre)1Amc | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Andrew P McMahon | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Sox2-cre; Sox2::Cre; Sox2Cre; | ||
| Mutation Made By | Andrew McMahon, University of Southern California | ||
| Strain of Origin | (C57BL/6 x CBA)F1 | ||
| Site of Expression | epiblast cells at embryonic day 6.5, with little or no activity in other cells at gastrulation; some activity is also detected in extra embryonic derivatives of the epi-blast, the yolk sac mesoderm and amnion; no activity is detected in primitive endoderm derived tissues, visceral endoderm | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Sox2, SRY-box containing gene 2, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Sox2-cre)1Amc, transgene insertion 1, Andrew P McMahon | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Sox2-cre; Sox2Cre; | ||
| Driver Note | Sox2 | ||
| General Note | Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of a mouse Sox2 promoter. Expression of this transgene is sex-dependent, with increased efficiency when passed through the female germline. When the transgene is passed through the male germline,cre activity is observed in epiblast cells as early as E6.5 of only those embryos that inherit the transgene and no expression is detected in extraembryonic tissue. When the transgene is passed through the female germline, cre activity is observed throughout the embryo (including the yolk sac) in all early embryos regardless of whether or not they inherit the transgene. [MGI Ref ID J:124941] [MGI Ref ID J:134483] [MGI Ref ID J:178271] [MGI Ref ID J:83040] [MGI Ref ID J:86588] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Hayashi S; Lewis P; Pevny L; McMahon AP. 2002. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev 119 Suppl 1:S97-S101. [PubMed: 14516668] [MGI Ref ID J:83040]
Additional References
Tg(Sox2-cre)1Amc relatedArnold SJ; Hofmann UK; Bikoff EK; Robertson EJ. 2008. Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development 135(3):501-11. [PubMed: 18171685] [MGI Ref ID J:131055]
Arnold SJ; Sugnaseelan J; Groszer M; Srinivas S; Robertson EJ. 2009. Generation and analysis of a mouse line harboring GFP in the Eomes/Tbr2 locus. Genesis 47(11):775-81. [PubMed: 19830823] [MGI Ref ID J:154785]
Artner I; Blanchi B; Raum JC; Guo M; Kaneko T; Cordes S; Sieweke M; Stein R. 2007. MafB is required for islet beta cell maturation. Proc Natl Acad Sci U S A 104(10):3853-8. [PubMed: 17360442] [MGI Ref ID J:120055]
Artus J; Piliszek A; Hadjantonakis AK. 2011. The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev Biol 350(2):393-404. [PubMed: 21146513] [MGI Ref ID J:170416]
Badea TC; Williams J; Smallwood P; Shi M; Motajo O; Nathans J. 2012. Combinatorial expression of brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis. J Neurosci 32(3):995-1007. [PubMed: 22262898] [MGI Ref ID J:179888]
Barrott JJ; Cash GM; Smith AP; Barrow JR; Murtaugh LC. 2011. Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome. Proc Natl Acad Sci U S A :. [PubMed: 21768372] [MGI Ref ID J:173672]
Barrow JR; Howell WD; Rule M; Hayashi S; Thomas KR; Capecchi MR; McMahon AP. 2007. Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev Biol 312(1):312-20. [PubMed: 18028899] [MGI Ref ID J:130205]
Bernardo GM; Lozada KL; Miedler JD; Harburg G; Hewitt SC; Mosley JD; Godwin AK; Korach KS; Visvader JE; Kaestner KH; Abdul-Karim FW; Montano MM; Keri RA. 2010. FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis. Development 137(12):2045-54. [PubMed: 20501593] [MGI Ref ID J:161401]
Biondi CA; Das D; Howell M; Islam A; Bikoff EK; Hill CS; Robertson EJ. 2007. Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling. Biochem J 404(2):235-45. [PubMed: 17300215] [MGI Ref ID J:141589]
Bissonauth V; Roy S; Gravel M; Guillemette S; Charron J. 2006. Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis. Development 133(17):3429-40. [PubMed: 16887817] [MGI Ref ID J:112223]
Bloomekatz J; Grego-Bessa J; Migeotte I; Anderson KV. 2012. Pten regulates collective cell migration during specification of the anterior-posterior axis of the mouse embryo. Dev Biol 364(2):192-201. [PubMed: 22342906] [MGI Ref ID J:183946]
Carroll TJ; Park JS; Hayashi S; Majumdar A; McMahon AP. 2005. Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell 9(2):283-92. [PubMed: 16054034] [MGI Ref ID J:100575]
Chambliss KL; Wu Q; Oltmann S; Konaniah ES; Umetani M; Korach KS; Thomas GD; Mineo C; Yuhanna IS; Kim SH; Madak-Erdogan Z; Maggi A; Dineen SP; Roland CL; Hui DY; Brekken RA; Katzenellenbogen JA; Katzenellenbogen BS; Shaul PW. 2010. Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice. J Clin Invest 120(7):2319-30. [PubMed: 20577047] [MGI Ref ID J:163783]
Chang MJ; Wu H; Achille NJ; Reisenauer MR; Chou CW; Zeleznik-Le NJ; Hemenway CS; Zhang W. 2010. Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes. Cancer Res 70(24):10234-42. [PubMed: 21159644] [MGI Ref ID J:194304]
Cheloufi S; Dos Santos CO; Chong MM; Hannon GJ. 2010. A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature 465(7298):584-9. [PubMed: 20424607] [MGI Ref ID J:161968]
Chen CY; Tsai MS; Lin CY; Yu IS; Chen YT; Lin SR; Juan LW; Chen YT; Hsu HM; Lee LJ; Lin SW. 2012. Rescue of the genetically engineered Cul4b mutant mouse as a potential model for human X-linked mental retardation. Hum Mol Genet 21(19):4270-85. [PubMed: 22763239] [MGI Ref ID J:187403]
Chen J; Nathans J. 2007. Estrogen-Related Receptor beta/NR3B2 Controls Epithelial Cell Fate and Endolymph Production by the Stria Vascularis. Dev Cell 13(3):325-37. [PubMed: 17765677] [MGI Ref ID J:124941]
Chen S; Law CS; Grigsby CL; Olsen K; Hong TT; Zhang Y; Yeghiazarians Y; Gardner DG. 2011. Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Circulation 124(17):1838-47. [PubMed: 21947295] [MGI Ref ID J:189471]
Chen YT; Tsai MS; Yang TL; Ku AT; Huang KH; Huang CY; Chou FJ; Fan HH; Hong JB; Yen ST; Wang WL; Lin CC; Hsu YC; Su KY; Su IC; Jang CW; Behringer RR; Favaro R; Nicolis SK; Chien CL; Lin SW; Yu IS. 2012. R26R-GR: a Cre-activable dual fluorescent protein reporter mouse. PLoS One 7(9):e46171. [PubMed: 23049968] [MGI Ref ID J:191943]
Chu GC; Dunn NR; Anderson DC; Oxburgh L; Robertson EJ. 2004. Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo. Development 131(15):3501-12. [PubMed: 15215210] [MGI Ref ID J:92066]
Costello I; Pimeisl IM; Drager S; Bikoff EK; Robertson EJ; Arnold SJ. 2011. The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation. Nat Cell Biol 13(9):1084-91. [PubMed: 21822279] [MGI Ref ID J:176969]
Di-Gregorio A; Sancho M; Stuckey DW; Crompton LA; Godwin J; Mishina Y; Rodriguez TA. 2007. BMP signalling inhibits premature neural differentiation in the mouse embryo. Development 134(18):3359-69. [PubMed: 17699604] [MGI Ref ID J:124681]
Dieguez-Hurtado R; Martin J; Martinez-Corral I; Martinez MD; Megias D; Olmeda D; Ortega S. 2011. A Cre-reporter transgenic mouse expressing the far-red fluorescent protein Katushka. Genesis 49(1):36-45. [PubMed: 21254335] [MGI Ref ID J:167974]
Dubielecka PM; Ladwein KI; Xiong X; Migeotte I; Chorzalska A; Anderson KV; Sawicki JA; Rottner K; Stradal TE; Kotula L. 2011. Essential role for Abi1 in embryonic survival and WAVE2 complex integrity. Proc Natl Acad Sci U S A 108(17):7022-7. [PubMed: 21482783] [MGI Ref ID J:171342]
Dubois NC; Adolphe C; Ehninger A; Wang RA; Robertson EJ; Trumpp A. 2008. Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function. Development 135(14):2455-65. [PubMed: 18550708] [MGI Ref ID J:137630]
Edwards MM; Mammadova-Bach E; Alpy F; Klein A; Hicks WL; Roux M; Simon-Assmann P; Smith RS; Orend G; Wu J; Peachey NS; Naggert JK; Lefebvre O; Nishina PM. 2010. Mutations in Lama1 disrupt retinal vascular development and inner limiting membrane formation. J Biol Chem 285(10):7697-711. [PubMed: 20048158] [MGI Ref ID J:160722]
Elling U; Klasen C; Eisenberger T; Anlag K; Treier M. 2006. Murine inner cell mass-derived lineages depend on Sall4 function. Proc Natl Acad Sci U S A 103(44):16319-24. [PubMed: 17060609] [MGI Ref ID J:115635]
Feng JQ; Scott G; Guo D; Jiang B; Harris M; Ward T; Ray M; Bonewald LF; Harris SE; Mishina Y. 2008. Generation of a conditional null allele for Dmp1 in mouse. Genesis 46(2):87-91. [PubMed: 18257058] [MGI Ref ID J:135314]
Festing MH; Speer MY; Yang HY; Giachelli CM. 2009. Generation of mouse conditional and null alleles of the type III sodium-dependent phosphate cotransporter PiT-1. Genesis 47(12):858-63. [PubMed: 19882669] [MGI Ref ID J:156027]
Fotopoulou S; Oikonomou N; Grigorieva E; Nikitopoulou I; Paparountas T; Thanassopoulou A; Zhao Z; Xu Y; Kontoyiannis DL; Remboutsika E; Aidinis V. 2010. ATX expression and LPA signalling are vital for the development of the nervous system. Dev Biol 339(2):451-64. [PubMed: 20079728] [MGI Ref ID J:159118]
French CA; Groszer M; Preece C; Coupe AM; Rajewsky K; Fisher SE. 2007. Generation of mice with a conditional Foxp2 null allele. Genesis 45(7):440-6. [PubMed: 17619227] [MGI Ref ID J:125023]
Gambardella L; Hemberger M; Hughes B; Zudaire E; Andrews S; Vermeren S. 2010. PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis. Sci Signal 3(145):ra76. [PubMed: 20978237] [MGI Ref ID J:185401]
Garci-Higuera I; Manchado E; Dubus P; Canamero M; Mendez J; Moreno S; Malumbres M. 2008. Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat Cell Biol 10(7):802-11. [PubMed: 18552834] [MGI Ref ID J:137456]
Guttormsen J; Koster MI; Stevens JR; Roop DR; Williams T; Winger QA. 2008. Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice. Dev Biol 317(1):187-95. [PubMed: 18353300] [MGI Ref ID J:136080]
Hayashi S; Tenzen T; McMahon AP. 2003. Maternal inheritance of Cre activity in a Sox2Cre deleter strain. Genesis 37(2):51-3. [PubMed: 14595839] [MGI Ref ID J:86588]
He C; Hu H; Braren R; Fong SY; Trumpp A; Carlson TR; Wang RA. 2008. c-myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo. Development 135(14):2467-77. [PubMed: 18550710] [MGI Ref ID J:137645]
He F; Popkie AP; Xiong W; Li L; Wang Y; Phiel CJ; Chen Y. 2010. Gsk3beta is required in the epithelium for palatal elevation in mice. Dev Dyn 239(12):3235-46. [PubMed: 20981831] [MGI Ref ID J:166721]
Hewitt SC; Kissling GE; Fieselman KE; Jayes FL; Gerrish KE; Korach KS. 2010. Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene. FASEB J 24(12):4660-7. [PubMed: 20667977] [MGI Ref ID J:191182]
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Huang X; Litingtung Y; Chiang C. 2007. Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly. Hum Mol Genet 16(12):1454-68. [PubMed: 17468181] [MGI Ref ID J:125109]
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Ichikawa-Tomikawa N; Ogawa J; Douet V; Xu Z; Kamikubo Y; Sakurai T; Kohsaka S; Chiba H; Hattori N; Yamada Y; Arikawa-Hirasawa E. 2012. Laminin alpha1 is essential for mouse cerebellar development. Matrix Biol 31(1):17-28. [PubMed: 21983115] [MGI Ref ID J:184432]
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Jager R; Schafer S; Hau-Liersch M; Schorle H. 2010. Loss of transcription factor AP-2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland. Dev Dyn 239(3):1027-1033. [PubMed: 20131354] [MGI Ref ID J:156927]
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Jiang R; Wang S; Takahashi K; Fujita H; Fruci CR; Breyer MD; Harris RC; Takahashi T. 2012. Generation of a conditional allele for the mouse endothelial nitric oxide synthase gene. Genesis 50(9):685-92. [PubMed: 22467476] [MGI Ref ID J:187860]
Jiang Z; Zhu L; Hu L; Slesnick TC; Pautler RG; Justice MJ; Belmont JW. 2013. Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left-right patterning and heart development. Hum Mol Genet 22(5):879-89. [PubMed: 23184148] [MGI Ref ID J:192577]
Jin J; Desai BN; Navarro B; Donovan A; Andrews NC; Clapham DE. 2008. Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science 322(5902):756-60. [PubMed: 18974357] [MGI Ref ID J:140630]
Jun AS; Meng H; Ramanan N; Matthaei M; Chakravarti S; Bonshek R; Black GC; Grebe R; Kimos M. 2012. An alpha 2 collagen VIII transgenic knock-in mouse model of Fuchs endothelial corneal dystrophy shows early endothelial cell unfolded protein response and apoptosis. Hum Mol Genet 21(2):384-93. [PubMed: 22002996] [MGI Ref ID J:179022]
Katsanou V; Milatos S; Yiakouvaki A; Sgantzis N; Kotsoni A; Alexiou M; Harokopos V; Aidinis V; Hemberger M; Kontoyiannis DL. 2009. The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Mol Cell Biol 29(10):2762-76. [PubMed: 19307312] [MGI Ref ID J:149149]
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Lee D; Yu M; Lee E; Kim H; Yang Y; Kim K; Pannicia C; Kurie JM; Threadgill DW. 2009. Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium. J Clin Invest 119(9):2702-13. [PubMed: 19690388] [MGI Ref ID J:152703]
Li Y; Zhang H; Litingtung Y; Chiang C. 2006. Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc Natl Acad Sci U S A 103(17):6548-53. [PubMed: 16611729] [MGI Ref ID J:109101]
Liu C; Nathans J. 2008. An essential role for frizzled 5 in mammalian ocular development. Development 135(21):3567-76. [PubMed: 18832390] [MGI Ref ID J:143446]
Liu C; Wang Y; Smallwood PM; Nathans J. 2008. An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus. J Neurosci 28(22):5641-53. [PubMed: 18509025] [MGI Ref ID J:136390]
Lobov IB; Rao S; Carroll TJ; Vallance JE; Ito M; Ondr JK; Kurup S; Glass DA; Patel MS; Shu W; Morrisey EE; McMahon AP; Karsenty G; Lang RA. 2005. WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 437(7057):417-21. [PubMed: 16163358] [MGI Ref ID J:101493]
Lu CC; Robertson EJ. 2004. Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning. Dev Biol 273(1):149-59. [PubMed: 15302604] [MGI Ref ID J:93140]
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MacDonald ST; Bamforth SD; Chen CM; Farthing CR; Franklyn A; Broadbent C; Schneider JE; Saga Y; Lewandoski M; Bhattacharya S. 2008. Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency. Cardiovasc Res 79(3):448-57. [PubMed: 18440989] [MGI Ref ID J:137951]
Macfarlan TS; Gifford WD; Agarwal S; Driscoll S; Lettieri K; Wang J; Andrews SE; Franco L; Rosenfeld MG; Ren B; Pfaff SL. 2011. Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev 25(6):594-607. [PubMed: 21357675] [MGI Ref ID J:169674]
Mao J; McKean DM; Warrier S; Corbin JG; Niswander L; Zohn IE. 2010. The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Development 137(18):3079-88. [PubMed: 20702562] [MGI Ref ID J:164587]
Mao Y; Mulvaney J; Zakaria S; Yu T; Morgan KM; Allen S; Basson MA; Francis-West P; Irvine KD. 2011. Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development 138(5):947-57. [PubMed: 21303848] [MGI Ref ID J:169135]
McDonel P; Demmers J; Tan DW; Watt F; Hendrich BD. 2012. Sin3a is essential for the genome integrity and viability of pluripotent cells. Dev Biol 363(1):62-73. [PubMed: 22206758] [MGI Ref ID J:182713]
Migeotte I; Grego-Bessa J; Anderson KV. 2011. Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo. Development 138(14):3011-20. [PubMed: 21693517] [MGI Ref ID J:173526]
Migeotte I; Omelchenko T; Hall A; Anderson KV. 2010. Rac1-dependent collective cell migration is required for specification of the anterior-posterior body axis of the mouse. PLoS Biol 8(8):e1000442. [PubMed: 20689803] [MGI Ref ID J:166095]
Migliorini D; Bogaerts S; Defever D; Vyas R; Denecker G; Radaelli E; Zwolinska A; Depaepe V; Hochepied T; Skarnes WC; Marine JC. 2011. Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice. J Clin Invest 121(4):1329-43. [PubMed: 21403399] [MGI Ref ID J:178271]
Miura S; Singh AP; Mishina Y. 2010. Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo. Dev Biol 341(1):246-54. [PubMed: 20211162] [MGI Ref ID J:159998]
Morsut L; Yan KP; Enzo E; Aragona M; Soligo SM; Wendling O; Mark M; Khetchoumian K; Bressan G; Chambon P; Dupont S; Losson R; Piccolo S. 2010. Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo. Development 137(15):2571-8. [PubMed: 20573697] [MGI Ref ID J:163858]
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Rajagopal J; Carroll TJ; Guseh JS; Bores SA; Blank LJ; Anderson WJ; Yu J; Zhou Q; McMahon AP; Melton DA. 2008. Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development 135(9):1625-34. [PubMed: 18367557] [MGI Ref ID J:134483]
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Rudloff S; Kemler R. 2012. Differential requirements for beta-catenin during mouse development. Development 139(20):3711-21. [PubMed: 22991437] [MGI Ref ID J:187739]
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Sgantzis N; Yiakouvaki A; Remboutsika E; Kontoyiannis DL. 2011. HuR controls lung branching morphogenesis and mesenchymal FGF networks. Dev Biol 354(2):267-79. [PubMed: 21515253] [MGI Ref ID J:173650]
Shibata M; Blauvelt KE; Liem KF Jr; Garcia-Garcia MJ. 2011. TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues. Development 138(24):5333-43. [PubMed: 22110054] [MGI Ref ID J:178936]
Shibata M; Garcia-Garcia MJ. 2011. The mouse KRAB zinc-finger protein CHATO is required in embryonic-derived tissues to control yolk sac and placenta morphogenesis. Dev Biol 349(2):331-41. [PubMed: 21094155] [MGI Ref ID J:168015]
Shun MC; Raghavendra NK; Vandegraaff N; Daigle JE; Hughes S; Kellam P; Cherepanov P; Engelman A. 2007. LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration. Genes Dev 21(14):1767-78. [PubMed: 17639082] [MGI Ref ID J:177408]
Song H; Hu J; Chen W; Elliott G; Andre P; Gao B; Yang Y. 2010. Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning. Nature 466(7304):378-82. [PubMed: 20562861] [MGI Ref ID J:162640]
Song H; Mak KK; Topol L; Yun K; Hu J; Garrett L; Chen Y; Park O; Chang J; Simpson RM; Wang CY; Gao B; Jiang J; Yang Y. 2010. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A :. [PubMed: 20080598] [MGI Ref ID J:156541]
Spruce T; Pernaute B; Di-Gregorio A; Cobb BS; Merkenschlager M; Manzanares M; Rodriguez TA. 2010. An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo. Dev Cell 19(2):207-19. [PubMed: 20708584] [MGI Ref ID J:163670]
Stenman JM; Rajagopal J; Carroll TJ; Ishibashi M; McMahon J; McMahon AP. 2008. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science 322(5905):1247-50. [PubMed: 19023080] [MGI Ref ID J:142352]
Stringer EJ; Duluc I; Saandi T; Davidson I; Bialecka M; Sato T; Barker N; Clevers H; Pritchard CA; Winton DJ; Wright NA; Freund JN; Deschamps J; Beck F. 2012. Cdx2 determines the fate of postnatal intestinal endoderm. Development 139(3):465-74. [PubMed: 22190642] [MGI Ref ID J:179732]
Stuckey DW; Di Gregorio A; Clements M; Rodriguez TA. 2011. Correct patterning of the primitive streak requires the anterior visceral endoderm. PLoS One 6(3):e17620. [PubMed: 21445260] [MGI Ref ID J:171680]
Sugimoto M; Kondo M; Hirose M; Suzuki M; Mekada K; Abe T; Kiyonari H; Ogura A; Takagi N; Artzt K; Abe K. 2012. Molecular identification of t(w5): Vps52 promotes pluripotential cell differentiation through cell-cell interactions. Cell Rep 2(5):1363-74. [PubMed: 23142660] [MGI Ref ID J:190873]
Sutherland MJ; Wang S; Quinn ME; Haaning A; Ware SM. 2013. Zic3 is required in the migrating primitive streak for node morphogenesis and left-right patterning. Hum Mol Genet 22(10):1913-23. [PubMed: 23303524] [MGI Ref ID J:194989]
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Tachibana-Konwalski K; Godwin J; van der Weyden L; Champion L; Kudo NR; Adams DJ; Nasmyth K. 2010. Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes. Genes Dev 24(22):2505-16. [PubMed: 20971813] [MGI Ref ID J:166151]
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Tian H; Jeong J; Harfe BD; Tabin CJ; McMahon AP. 2005. Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. Development 132(1):133-42. [PubMed: 15576405] [MGI Ref ID J:94270]
Tian Y; Lei L; Cammarano M; Nekrasova T; Minden A. 2009. Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation. Mech Dev 126(8-9):710-20. [PubMed: 19464366] [MGI Ref ID J:152821]
Tortelote GG; Hernandez-Hernandez JM; Quaresma AJ; Nickerson JA; Imbalzano AN; Rivera-Perez JA. 2013. Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice. Dev Biol 374(1):164-73. [PubMed: 23085236] [MGI Ref ID J:192194]
Tsiairis CD; McMahon AP. 2008. Disp1 regulates growth of mammalian long bones through the control of Ihh distribution. Dev Biol 317(2):480-5. [PubMed: 18395198] [MGI Ref ID J:136115]
Tyberghein K; Goossens S; Haigh JJ; van Roy F; van Hengel J. 2012. Tissue-wide overexpression of alpha-T-catenin results in aberrant trophoblast invasion but does not cause embryonic mortality in mice. Placenta 33(7):554-60. [PubMed: 22534068] [MGI Ref ID J:187209]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX18
Colony Maintenance
Breeding & Husbandry Transgenic mice were bred to C57BL/6NJ inbred mice (Stock No. 005304) for many generations to establish this congenic strain. When maintaining the live congenic colony, hemizygous mice may be bred with wildtype (noncarrier) siblings or to C57BL/6NJ inbred mice (Stock No. 005304). The phenotype of homozygous mice has not been characterized to date (April 2011). Of note, transgene expression is active in the female germline. Offspring arising from a hemizygous transgenic female will exhibit Cre recombinase activity, regardless of phenotype. Mating System Noncarrier x Hemizygote (Female x Male) 01-AUG-12 Hemizygote x Noncarrier (Female x Male) 01-AUG-12 Diet Information LabDiet® 5K20
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for Tg(Sox2-cre)1Amc
Price per Pair (US dollars $) Pair Genotype $296.00 Hemizygous for Tg(Sox2-cre)1Amc x Noncarrier $296.00 Noncarrier x Hemizygous for Tg(Sox2-cre)1Amc Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for Tg(Sox2-cre)1Amc
Price per Pair (US dollars $) Pair Genotype $384.80 Hemizygous for Tg(Sox2-cre)1Amc x Noncarrier $384.80 Noncarrier x Hemizygous for Tg(Sox2-cre)1Amc Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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|
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Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 005304 C57BL/6NJ | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.