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| FcRn-/- hFcRn (line 32) Tg mice are useful in evaluating the pharmacokinetics and pharmacodynamics of human immunoglobulin G (hIgG), such as therapeutic IgG. These mice carry a null mutation for the mouse gene and a transgene expressing the human FcRn α-chain transgene under the control of its natural human promoter. | ||||||||||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
Strain Information
Type Congenic; Mutant Strain; Targeted Mutation; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System See Colony Maintenance under the Health & husbandry tab (Female x Male) 22-JUN-11 Species laboratory mouse Generation N11F13+F8 (22-JUN-11)
Generation DefinitionsDonating Investigator Dr. Derry Roopenian, The Jackson Laboratory Description
FcRn-/- hFcRn (32) Tg mice harbor a knockout allele of the FcRn α-chain (Fcgrttm1Dcr) and express a human FcRn α-chain (FCGRT) transgene under control of the human FcRn promoter. In this line, serum albumin levels are slightly above those seen in C57BL/6J mice, while mouse IgG levels are low due to the species-specific activity of human FcRn. Line 32 is more efficient in prolonging the serum half-life of hIgG compared with line 276 (see Stock no. 004919). In Petkova et. al. 2006, the antibody half-life of Hu4D5-IgG1 antibodies in hemizygous hFcRn (32) Tg/0 mice of this strain is shown to be similar to that observed in FcRn-/- hFcRn (276) Tg/Tg homozygous mice (see Stock no. 004919). (Hu4D5-IgG1 human antibodies are directed against human EGFR2.) Mice hemizygous or homozygous for the hFcRn (32) Tg in this model may be useful for studying human FcRn biology and the behavior of IgG antibodies and Fc-domain proteins, including Fc-engineered molecules.Development
These knockout/transgenic mice were generated in the laboratory of Dr. Derry Roopenian (The Jackson Laboratory) by crossing Fcgrttm1Dcr mutant mice with Tg(FCGRT)32Dcr transgenic mice (coisogenic on a C57BL/6J genetic background). These double mutant mice were backcrossed for 11 generations to C57BL/6J prior to transfer to The Jackson Laboratory Repository.To generate the FcRn α-chain knockout mice (Fcgrttm1Dcr; see also Stock No. 003982), a targeting vector was designed to replace 1588 nucleotide fragments (encoding promoter sequence 5' of the transcriptional start site, exon1, intron 2, and most of exon2) with a PGK-Neor cassette. The vector was electroporated into 129/SvJ-derived ESV/J-1182 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric animals were crossed to C57BL/6J mice.
To generate the hFcRn line 32 transgenic mice, a 33-Kb cosmid clone including the complete FCGRT gene (approximately 11kb as well as 10kb of 5' and 3' flanking sequences) was microinjected into fertilized C57BL/6J mouse eggs.
Control Information
| Control | ||
|---|---|---|
| See control note: | (approximate) Stock No. 003982 is an appropriate experimental control as well. | |
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Fcgrttm1Dcr allele
View Strains carrying Fcgrttm1Dcr (11 strains)
018441 B6.Cg-Fcgrttm1Dcr Prkdcscid Tg(FCGRT)32Dcr/DcrJ
021146 B6.Cg-Fcgrttm1Dcr Prkdcscid Tg(CAG-FCGRT)276Dcr/DcrJ 004919 B6.Cg-Fcgrttm1Dcr Tg(CAG-FCGRT)276Dcr/DcrJ 016919 B6.Cg-Rag1tm1Mom Fcgrttm1Dcr Tg(CAG-FCGRT)276Dcr/DcrJ
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Fcgrttm1Dcr relatedImmunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
genes regulating susceptibility to infectious disease and endotoxin
Immunodeficiency
MHC class I deficiency
defects in humoral immune responses
Research Tools
Immunology and Inflammation Research
MHC class I deficiency
genes regulating susceptibility to infectious disease and endotoxin
Virology Research
Reduced MHC Class I Responses to Specific Viruses
Immunology, Inflammation and Autoimmunity Research
Autoimmunity
CD Antigens, Antigen Receptors, and Histocompatibility Markers
genes regulating susceptibility to infectious disease and endotoxin
Immunodeficiency
defects in humoral immune responses
Research Tools
Immunology and Inflammation Research
genes regulating susceptibility to infectious disease and endotoxin
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Fcgrttm1Dcr | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Derry C Roopenian | ||
| Allele Type | Targeted (knock-out) | ||
| Common Name(s) | FcRn-; | ||
| Strain of Origin | 129X1/SvJ | ||
| ES Cell Line Name | RW-4 | ||
| ES Cell Line Strain | 129X1/SvJ | ||
| Gene Symbol and Name | Fcgrt, Fc receptor, IgG, alpha chain transporter | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | FCRN; alpha-chain; neonatal Fc receptor; | ||
| Molecular Note | Sequence from exon 1 and part of exon2 was replaced with a PGK-neo cassette. Quantitative PCR of liver cDNA indicated the absence of mRNA. Western blot analysis of neonatal intestinal extracts failed to reveal protein product. [MGI Ref ID J:94189] | ||
| Allele Symbol | Tg(FCGRT)32Dcr | ||
| Allele Name | transgene insertion 32, Derry C Roopenian | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | Tg32; hFcRn(32) vhFcRn (32) Tg hFcRn (32) Tg; | ||
| Strain of Origin | C57BL/6J | ||
| Expressed Gene | FCGRT, Fc fragment of IgG, receptor, transporter, alpha, human | ||
| Promoter | FCGRT, Fc fragment of IgG, receptor, transporter, alpha, human | ||
| Molecular Note | A 34Kb fragment of a BAC containing the entire human FCGRT , Fc fragment of IgG, receptor, transporter, alpha, gene (approximately 11kb) and approximately 10kb of flanking sequence was sublconed into a SuperCos vector. The resulting cosmid was microinjected into fertilized C57BL/6J mouse eggs. Founder line 32 was established. [MGI Ref ID J:133048] [MGI Ref ID J:94189] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Fcgrttm1Dcr, Standard PCR
Tg(FCGRT), QPCR
Tg(FCGRT), Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Petkova SB; Akilesh S; Sproule TJ; Christianson GJ; Al Khabbaz H; Brown AC; Presta LG; Meng YG; Roopenian DC. 2006. Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol 18(12):1759-69. [PubMed: 17077181] [MGI Ref ID J:133048]
Roopenian DC; Christianson GJ; Sproule TJ. 2010. Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies. Methods Mol Biol 602:93-104. [PubMed: 20012394] [MGI Ref ID J:170668]
Additional References
Fcgrttm1Dcr relatedTg(FCGRT)32Dcr relatedAkilesh S; Christianson GJ; Roopenian DC; Shaw AS. 2007. Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism. J Immunol 179(7):4580-8. [PubMed: 17878355] [MGI Ref ID J:152349]
Akilesh S; Huber TB; Wu H; Wang G; Hartleben B; Kopp JB; Miner JH; Roopenian DC; Unanue ER; Shaw AS. 2008. Podocytes use FcRn to clear IgG from the glomerular basement membrane. Proc Natl Acad Sci U S A 105(3):967-72. [PubMed: 18198272] [MGI Ref ID J:131366]
Akilesh S; Petkova S; Sproule TJ; Shaffer DJ; Christianson GJ; Roopenian D. 2004. The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease. J Clin Invest 113(9):1328-33. [PubMed: 15124024] [MGI Ref ID J:95104]
Andersen JT; Foss S; Kenanova VE; Olafsen T; Leikfoss IS; Roopenian DC; Wu AM; Sandlie I. 2012. Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life. J Biol Chem 287(27):22927-37. [PubMed: 22570488] [MGI Ref ID J:188378]
Bai Y; Ye L; Tesar DB; Song H; Zhao D; Bjorkman PJ; Roopenian DC; Zhu X. 2011. Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport. Proc Natl Acad Sci U S A 108(45):18406-11. [PubMed: 22042859] [MGI Ref ID J:180229]
Baker K; Qiao SW; Kuo TT; Aveson VG; Platzer B; Andersen JT; Sandlie I; Chen Z; de Haar C; Lencer WI; Fiebiger E; Blumberg RS. 2011. Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells. Proc Natl Acad Sci U S A 108(24):9927-32. [PubMed: 21628593] [MGI Ref ID J:173310]
Binstadt BA; Patel PR; Alencar H; Nigrovic PA; Lee DM; Mahmood U; Weissleder R; Mathis D; Benoist C. 2006. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7(3):284-92. [PubMed: 16444258] [MGI Ref ID J:112604]
Chaudhury C; Kim J; Mehnaz S; Wani MA; Oberyszyn TM; Bronson CL; Mohanty S; Hayton WL; Robinson JM; Anderson CL. 2006. Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation. J Nutr 136(12):2993-8. [PubMed: 17116709] [MGI Ref ID J:117735]
Chaudhury C; Mehnaz S; Robinson JM; Hayton WL; Pearl DK; Roopenian DC; Anderson CL. 2003. The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med 197(3):315-22. [PubMed: 12566415] [MGI Ref ID J:110885]
Chen P; Li C; Lang S; Zhu G; Reheman A; Spring CM; Freedman J; Ni H. 2010. Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy. Blood 116(18):3660-8. [PubMed: 20647570] [MGI Ref ID J:166478]
Crow AR; Suppa SJ; Chen X; Mott PJ; Lazarus AH. 2011. The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody-mediated amelioration of murine immune thrombocytopenia. Blood 118(24):6403-6. [PubMed: 22001393] [MGI Ref ID J:179078]
Crowley H; Alroy J; Sproule TJ; Roopenian D; Huber BT. 2006. The MHC class I-related FcRn ameliorates murine Lyme arthritis. Int Immunol 18(3):409-14. [PubMed: 16415101] [MGI Ref ID J:106617]
Deane R; Sagare A; Hamm K; Parisi M; LaRue B; Guo H; Wu Z; Holtzman DM; Zlokovic BV. 2005. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci 25(50):11495-503. [PubMed: 16354907] [MGI Ref ID J:103998]
Dumont JA; Liu T; Low SC; Zhang X; Kamphaus G; Sakorafas P; Fraley C; Drager D; Reidy T; McCue J; Franck HW; Merricks EP; Nichols TC; Bitonti AJ; Pierce GF; Jiang H. 2012. Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs. Blood 119(13):3024-30. [PubMed: 22246033] [MGI Ref ID J:182551]
Kim J; Bronson CL; Hayton WL; Radmacher MD; Roopenian DC; Robinson JM; Anderson CL. 2006. Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces. Am J Physiol Gastrointest Liver Physiol 290(2):G352-60. [PubMed: 16210471] [MGI Ref ID J:106048]
Kim J; Mohanty S; Ganesan LP; Hua K; Jarjoura D; Hayton WL; Robinson JM; Anderson CL. 2009. FcRn in the yolk sac endoderm of mouse is required for IgG transport to fetus. J Immunol 182(5):2583-9. [PubMed: 19234152] [MGI Ref ID J:146267]
Koltun M; Nikolovski J; Strong K; Nikolic-Paterson D; Comper WD. 2005. Mechanism of hypoalbuminemia in rodents. Am J Physiol Heart Circ Physiol 288(4):H1604-10. [PubMed: 15539420] [MGI Ref ID J:97362]
Letourneau S; van Leeuwen EM; Krieg C; Martin C; Pantaleo G; Sprent J; Surh CD; Boyman O. 2010. IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25. Proc Natl Acad Sci U S A 107(5):2171-6. [PubMed: 20133862] [MGI Ref ID J:157531]
Li N; Zhao M; Hilario-Vargas J; Prisayanh P; Warren S; Diaz LA; Roopenian DC; Liu Z. 2005. Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases. J Clin Invest 115(12):3440-50. [PubMed: 16284651] [MGI Ref ID J:104709]
Mezo AR; McDonnell KA; Hehir CA; Low SC; Palombella VJ; Stattel JM; Kamphaus GD; Fraley C; Zhang Y; Dumont JA; Bitonti AJ. 2008. Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn. Proc Natl Acad Sci U S A 105(7):2337-42. [PubMed: 18272495] [MGI Ref ID J:132181]
Nakata K; Kobayashi K; Ishikawa Y; Yamamoto M; Funada Y; Kotani Y; Blumberg RS; Karasuyama H; Yoshida M; Nishimura Y. 2010. The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner. Biochem Biophys Res Commun 395(2):238-43. [PubMed: 20362552] [MGI Ref ID J:160346]
Patel DA; Puig-Canto A; Challa DK; Perez Montoyo H; Ober RJ; Ward ES. 2011. Neonatal Fc receptor blockade by Fc engineering ameliorates arthritis in a murine model. J Immunol 187(2):1015-22. [PubMed: 21690327] [MGI Ref ID J:178025]
Roopenian DC; Christianson GJ; Sproule TJ; Brown AC; Akilesh S; Jung N; Petkova S; Avanessian L; Choi EY; Shaffer DJ; Eden PA; Anderson CL. 2003. The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs. J Immunol 170(7):3528-33. [PubMed: 12646614] [MGI Ref ID J:94189]
Sarav M; Wang Y; Hack BK; Chang A; Jensen M; Bao L; Quigg RJ. 2009. Renal FcRn reclaims albumin but facilitates elimination of IgG. J Am Soc Nephrol 20(9):1941-52. [PubMed: 19661163] [MGI Ref ID J:166328]
Stein C; Kling L; Proetzel G; Roopenian DC; de Angelis MH; Wolf E; Rathkolb B. 2011. Clinical chemistry of human FcRn transgenic mice. Mamm Genome :. [PubMed: 22193411] [MGI Ref ID J:179989]
Stoklasek TA; Colpitts SL; Smilowitz HM; Lefrancois L. 2010. MHC Class I and TCR Avidity Control the CD8 T Cell Response to IL-15/IL-15R{alpha} Complex. J Immunol 185(11):6857-65. [PubMed: 21041729] [MGI Ref ID J:166134]
Vidarsson G; Stemerding AM; Stapleton NM; Spliethoff SE; Janssen H; Rebers FE; de Haas M; van de Winkel JG. 2006. FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis. Blood 108(10):3573-9. [PubMed: 16849638] [MGI Ref ID J:140454]
Wang W; Vlasak J; Li Y; Pristatsky P; Fang Y; Pittman T; Roman J; Wang Y; Prueksaritanont T; Ionescu R. 2011. Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies. Mol Immunol 48(6-7):860-6. [PubMed: 21256596] [MGI Ref ID J:170957]
Yoshida M; Kobayashi K; Kuo TT; Bry L; Glickman JN; Claypool SM; Kaser A; Nagaishi T; Higgins DE; Mizoguchi E; Wakatsuki Y; Roopenian DC; Mizoguchi A; Lencer WI; Blumberg RS. 2006. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Invest 116(8):2142-2151. [PubMed: 16841095] [MGI Ref ID J:113122]
Zalevsky J; Chamberlain AK; Horton HM; Karki S; Leung IW; Sproule TJ; Lazar GA; Roopenian DC; Desjarlais JR. 2010. Enhanced antibody half-life improves in vivo activity. Nat Biotechnol 28(2):157-9. [PubMed: 20081867] [MGI Ref ID J:161273]
Kliwinski C; Cooper PR; Perkinson R; Mabus JR; Tam SH; Wilkinson TM; Giles-Komar J; Scallon B; Powers GD; Hornby PJ. 2013. Contribution of FcRn binding to intestinal uptake of IgG in suckling rat pups and human FcRn-transgenic mice. Am J Physiol Gastrointest Liver Physiol 304(3):G262-70. [PubMed: 23220220] [MGI Ref ID J:194859]
Roopenian DC; Christianson GJ; Sproule TJ; Brown AC; Akilesh S; Jung N; Petkova S; Avanessian L; Choi EY; Shaffer DJ; Eden PA; Anderson CL. 2003. The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs. J Immunol 170(7):3528-33. [PubMed: 12646614] [MGI Ref ID J:94189]
Stein C; Kling L; Proetzel G; Roopenian DC; de Angelis MH; Wolf E; Rathkolb B. 2011. Clinical chemistry of human FcRn transgenic mice. Mamm Genome :. [PubMed: 22193411] [MGI Ref ID J:179989]
Wang W; Vlasak J; Li Y; Pristatsky P; Fang Y; Pittman T; Roman J; Wang Y; Prueksaritanont T; Ionescu R. 2011. Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies. Mol Immunol 48(6-7):860-6. [PubMed: 21256596] [MGI Ref ID J:170957]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, mice homozygous for the Fcgrttm1Dcr allele and hemizygous for the Tg(FCGRT)32Dcr transgene can be bred to mice homozygous for the Fcgrttm1Dcr allele and wildtype (noncarrier) for the transgene. Mating System See Colony Maintenance under the Health & husbandry tab (Female x Male) 22-JUN-11
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Homozygous for Fcgrttm1Dcr, Hemizygous for Tg(FCGRT)32Dcr $232.00 Female or Male Homozygous for Fcgrttm1Dcr, Homozygous for Tg(FCGRT)32Dcr
Price per Pair (US dollars $) Pair Genotype $464.00 Homozygous for Fcgrttm1Dcr, Homozygous for Tg(FCGRT)32Dcr x Homozygous for Fcgrttm1Dcr, Homozygous for Tg(FCGRT)32Dcr Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Homozygous for Fcgrttm1Dcr, Hemizygous for Tg(FCGRT)32Dcr $301.60 Female or Male Homozygous for Fcgrttm1Dcr, Homozygous for Tg(FCGRT)32Dcr
Price per Pair (US dollars $) Pair Genotype $603.20 Homozygous for Fcgrttm1Dcr, Homozygous for Tg(FCGRT)32Dcr x Homozygous for Fcgrttm1Dcr, Homozygous for Tg(FCGRT)32Dcr Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
|
|
|
Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
Control Information
| Control | ||
|---|---|---|
| See control note: | (approximate) Stock No. 003982 is an appropriate experimental control as well. | |
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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