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| These Pdx-Cre transgenic mice express Cre recombinase under the control of the mouse Pdx1 promoter and may be useful for generating pancreas-specific conditional mutations. | |||||||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
Strain Information
Former Names B6;CBA-Tg(Pdx1-cre)6Cvw/J (Changed: 01-OCT-12 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Noncarrier x Hemizygote (Female x Male) 18-OCT-11 Mating System Hemizygote x Noncarrier (Female x Male) 18-OCT-11 Species laboratory mouse Generation F?+F1 (22-FEB-12)
Generation DefinitionsDonating Investigator Andrew M. Lowy, University of California, San Diego Description
Mice hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express Cre recombinase under the control of the mouse Pdx1 (pancreatic and duodenal homeobox 1) promoter. Mosaic Cre recombinase activity is detected in the pancreatic epithelium, antral stomach and duodenum in neonates and in pancreatic beta islet cells in adults. No Cre recombinase activity is detected ectopically to the Pdx1 expression domain. When crossed with a strain containing loxP site-flanked sequences, Cre-mediated recombination results in deletion of the floxed sequences in the cre-expressing tissues of the offspring. It is not known if homozygotes are viable.Development
A transgenic construct containing sequence encoding Cre recombinase under the control of a 4.5 kb promoter fragment of mouse Pdx1 was introduced into FVB/N donor eggs. Founder line 6 was subsequently established. The mice were backcrossed for 15 generations onto the C57BL/6 background. Upon arrival at The Jackson Laboratory Repository, the mice were crossed to C57BL/6J (Stock No. 000664) at least once to establish the colony.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Pdx1
005701 STOCK Pdx1tm1Macd/J View Strains carrying other alleles of Pdx1 (1 strain)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Ipf1-cre)6Tuv | ||
|---|---|---|---|
| Allele Name | transgene insertion 6, David A Tuveson | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | PDX-1-Cre; Pdx1-cre; Tg(Ipf1-cre)1Tuv; | ||
| Strain of Origin | FVB/N | ||
| Site of Expression | Cre expression is directed to islet cells of the pancreas. | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Pdx1, pancreatic and duodenal homeobox 1, mouse, laboratory | ||
| Driver Note | Pdx1 | ||
| Molecular Note | The transgenic construct is composed of a Cre recombinase coding sequence under the control of the Ipf1 promoter. Cre expression is thus directed to islet cells of the pancreas. [MGI Ref ID J:87973] | ||
| Gene Symbol and Name | Tg(Ipf1-cre)6Tuv, transgene insertion 6, David A Tuveson | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Pdx-1-cre; Pdx1-cre; Tg(Ipf1-cre)1Tuv; transgene insertion 1, David A Tuveson; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Hingorani SR; Petricoin EF; Maitra A; Rajapakse V; King C; Jacobetz MA; Ross S; Conrads TP; Veenstra TD; Hitt BA; Kawaguchi Y; Johann D; Liotta LA; Crawford HC; Putt ME; Jacks T; Wright CV; Hruban RH; Lowy AM; Tuveson DA. 2003. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4(6):437-50. [PubMed: 14706336] [MGI Ref ID J:87973]
Additional References
Tg(Ipf1-cre)6Tuv relatedAn W; Han JS; Schrum CM; Maitra A; Koentgen F; Boeke JD. 2008. Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis 46(7):373-83. [PubMed: 18615728] [MGI Ref ID J:138548]
Avila JL; Troutman S; Durham A; Kissil JL. 2012. Notch1 is not required for acinar-to-ductal metaplasia in a model of Kras-induced pancreatic ductal adenocarcinoma. PLoS One 7(12):e52133. [PubMed: 23284900] [MGI Ref ID J:195622]
Bayne LJ; Beatty GL; Jhala N; Clark CE; Rhim AD; Stanger BZ; Vonderheide RH. 2012. Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer Cell 21(6):822-35. [PubMed: 22698406] [MGI Ref ID J:189283]
Carpenter AC; Rao S; Wells JM; Campbell K; Lang RA. 2010. Generation of mice with a conditional null allele for Wntless. Genesis 48(9):554-8. [PubMed: 20614471] [MGI Ref ID J:164701]
Carrasco M; Delgado I; Soria B; Martin F; Rojas A. 2012. GATA4 and GATA6 control mouse pancreas organogenesis. J Clin Invest 122(10):3504-15. [PubMed: 23006330] [MGI Ref ID J:192746]
Chen G; Zou X; Watanabe H; van Deursen JM; Shen J. 2010. CREB binding protein is required for both short-term and long-term memory formation. J Neurosci 30(39):13066-77. [PubMed: 20881124] [MGI Ref ID J:164878]
Chugh R; Sangwan V; Patil SP; Dudeja V; Dawra RK; Banerjee S; Schumacher RJ; Blazar BR; Georg GI; Vickers SM; Saluja AK. 2012. A preclinical evaluation of minnelide as a therapeutic agent against pancreatic cancer. Sci Transl Med 4(156):156ra139. [PubMed: 23076356] [MGI Ref ID J:189216]
Clark CE; Hingorani SR; Mick R; Combs C; Tuveson DA; Vonderheide RH. 2007. Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Cancer Res 67(19):9518-27. [PubMed: 17909062] [MGI Ref ID J:125575]
Collins MA; Brisset JC; Zhang Y; Bednar F; Pierre J; Heist KA; Galban CJ; Galban S; di Magliano MP. 2012. Metastatic pancreatic cancer is dependent on oncogenic Kras in mice. PLoS One 7(12):e49707. [PubMed: 23226501] [MGI Ref ID J:195686]
Collisson EA; Trejo CL; Silva JM; Gu S; Korkola JE; Heiser LM; Charles RP; Rabinovich BA; Hann B; Dankort D; Spellman PT; Phillips WA; Gray JW; McMahon M. 2012. A central role for RAF-->MEK-->ERK signaling in the genesis of pancreatic ductal adenocarcinoma. Cancer Discov 2(8):685-93. [PubMed: 22628411] [MGI Ref ID J:193065]
Colvin EK; Susanto JM; Kench JG; Ong VN; Mawson A; Pinese M; Chang DK; Rooman I; O'Toole SA; Segara D; Musgrove EA; Sutherland RL; Apte MV; Scarlett CJ; Biankin AV. 2011. Retinoid signaling in pancreatic cancer, injury and regeneration. PLoS One 6(12):e29075. [PubMed: 22220202] [MGI Ref ID J:182325]
Cook N; Frese KK; Bapiro TE; Jacobetz MA; Gopinathan A; Miller JL; Rao SS; Demuth T; Howat WJ; Jodrell DI; Tuveson DA. 2012. Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma. J Exp Med 209(3):437-44. [PubMed: 22351932] [MGI Ref ID J:182504]
Dufresne M; Clerc P; Dieng M; Edir A; Couvelard A; Delisle MB; Fourmy D; Gigoux V. 2011. Id3 modulates cellular localization of bHLH Ptf1-p48 protein. Int J Cancer 129(2):295-306. [PubMed: 20830706] [MGI Ref ID J:173813]
Fendrich V; Esni F; Garay MV; Feldmann G; Habbe N; Jensen JN; Dor Y; Stoffers D; Jensen J; Leach SD; Maitra A. 2008. Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology 135(2):621-31. [PubMed: 18515092] [MGI Ref ID J:141804]
Fendrich V; Schneider R; Maitra A; Jacobsen ID; Opfermann T; Bartsch DK. 2011. Detection of precursor lesions of pancreatic adenocarcinoma in PET-CT in a genetically engineered mouse model of pancreatic cancer. Neoplasia 13(2):180-6. [PubMed: 21403843] [MGI Ref ID J:171634]
Frese KK; Neesse A; Cook N; Bapiro TE; Lolkema MP; Jodrell DI; Tuveson DA. 2012. nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer. Cancer Discov 2(3):260-9. [PubMed: 22585996] [MGI Ref ID J:193075]
Gades NM; Ohash A; Mills LD; Rowley MA; Predmore KS; Marler RJ; Couch FJ. 2008. Spontaneous vulvar papillomas in a colony of mice used for pancreatic cancer research. Comp Med 58(3):271-5. [PubMed: 18589869] [MGI Ref ID J:140431]
George NM; Day CE; Boerner BP; Johnson RL; Sarvetnick NE. 2012. Hippo signaling regulates pancreas development through inactivation of Yap. Mol Cell Biol 32(24):5116-28. [PubMed: 23071096] [MGI Ref ID J:192856]
Hanlon L; Avila JL; Demarest RM; Troutman S; Allen M; Ratti F; Rustgi AK; Stanger BZ; Radtke F; Adsay V; Long F; Capobianco AJ; Kissil JL. 2010. Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma. Cancer Res 70(11):4280-6. [PubMed: 20484026] [MGI Ref ID J:160687]
Hingorani SR; Wang L; Multani AS; Combs C; Deramaudt TB; Hruban RH; Rustgi AK; Chang S; Tuveson DA. 2005. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7(5):469-83. [PubMed: 15894267] [MGI Ref ID J:98936]
Izeradjene K; Combs C; Best M; Gopinathan A; Wagner A; Grady WM; Deng CX; Hruban RH; Adsay NV; Tuveson DA; Hingorani SR. 2007. Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. Cancer Cell 11(3):229-43. [PubMed: 17349581] [MGI Ref ID J:119990]
Kang R; Loux T; Tang D; Schapiro NE; Vernon P; Livesey KM; Krasinskas A; Lotze MT; Zeh HJ 3rd. 2012. The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia. Proc Natl Acad Sci U S A 109(18):7031-6. [PubMed: 22509024] [MGI Ref ID J:183916]
Kelber JA; Reno T; Kaushal S; Metildi C; Wright T; Stoletov K; Weems JM; Park FD; Mose E; Wang Y; Hoffman RM; Lowy AM; Bouvet M; Klemke RL. 2012. KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer. Cancer Res 72(10):2554-64. [PubMed: 22589274] [MGI Ref ID J:189307]
Kent OA; Chivukula RR; Mullendore M; Wentzel EA; Feldmann G; Lee KH; Liu S; Leach SD; Maitra A; Mendell JT. 2010. Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway. Genes Dev 24(24):2754-9. [PubMed: 21159816] [MGI Ref ID J:166737]
Lampson BL; Kendall SD; Ancrile BB; Morrison MM; Shealy MJ; Barrientos KS; Crowe MS; Kashatus DF; White RR; Gurley SB; Cardona DM; Counter CM. 2012. Targeting eNOS in pancreatic cancer. Cancer Res 72(17):4472-82. [PubMed: 22738914] [MGI Ref ID J:191028]
Lo B; Strasser G; Sagolla M; Austin CD; Junttila M; Mellman I. 2012. Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways. J Cell Biol 199(7):1117-30. [PubMed: 23266956] [MGI Ref ID J:195229]
Maniati E; Bossard M; Cook N; Candido JB; Emami-Shahri N; Nedospasov SA; Balkwill FR; Tuveson DA; Hagemann T. 2011. Crosstalk between the canonical NF-kappaB and Notch signaling pathways inhibits Ppargamma expression and promotes pancreatic cancer progression in mice. J Clin Invest 121(12):4685-99. [PubMed: 22056382] [MGI Ref ID J:184026]
Mastracci TL; Wilcox CL; Arnes L; Panea C; Golden JA; May CL; Sussel L. 2011. Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol 359(1):1-11. [PubMed: 21856296] [MGI Ref ID J:178173]
Mazur PK; Einwachter H; Lee M; Sipos B; Nakhai H; Rad R; Zimber-Strobl U; Strobl LJ; Radtke F; Kloppel G; Schmid RM; Siveke JT. 2010. Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma. Proc Natl Acad Sci U S A 107(30):13438-43. [PubMed: 20624967] [MGI Ref ID J:162569]
Morton JP; Timpson P; Karim SA; Ridgway RA; Athineos D; Doyle B; Jamieson NB; Oien KA; Lowy AM; Brunton VG; Frame MC; Evans TR; Sansom OJ. 2010. Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci U S A 107(1):246-51. [PubMed: 20018721] [MGI Ref ID J:156461]
Olive KP; Jacobetz MA; Davidson CJ; Gopinathan A; McIntyre D; Honess D; Madhu B; Goldgraben MA; Caldwell ME; Allard D; Frese KK; Denicola G; Feig C; Combs C; Winter SP; Ireland-Zecchini H; Reichelt S; Howat WJ; Chang A; Dhara M; Wang L; Ruckert F; Grutzmann R; Pilarsky C; Izeradjene K; Hingorani SR; Huang P; Davies SE; Plunkett W; Egorin M; Hruban RH; Whitebread N; McGovern K; Adams J; Iacobuzio-Donahue C; Griffiths J; Tuveson DA. 2009. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324(5933):1457-61. [PubMed: 19460966] [MGI Ref ID J:149213]
Perez-Mancera PA; Rust AG; van der Weyden L; Kristiansen G; Li A; Sarver AL; Silverstein KA; Grutzmann R; Aust D; Rummele P; Knosel T; Herd C; Stemple DL; Kettleborough R; Brosnan JA; Li A; Morgan R; Knight S; Yu J; Stegeman S; Collier LS; ten Hoeve JJ; de Ridder J; Klein AP; Goggins M; Hruban RH; Chang DK; Biankin AV; Grimmond SM; Wessels LF; Wood SA; Iacobuzio-Donahue CA; Pilarsky C; Largaespada DA; Adams DJ; Tuveson DA. 2012. The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature 486(7402):266-70. [PubMed: 22699621] [MGI Ref ID J:186717]
Plank JL; Frist AY; LeGrone AW; Magnuson MA; Labosky PA. 2011. Loss of Foxd3 results in decreased beta-cell proliferation and glucose intolerance during pregnancy. Endocrinology 152(12):4589-600. [PubMed: 21952247] [MGI Ref ID J:179100]
Provenzano PP; Cuevas C; Chang AE; Goel VK; Von Hoff DD; Hingorani SR. 2012. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 21(3):418-29. [PubMed: 22439937] [MGI Ref ID J:189345]
Reichert M; Takano S; von Burstin J; Kim SB; Lee JS; Ihida-Stansbury K; Hahn C; Heeg S; Schneider G; Rhim AD; Stanger BZ; Rustgi AK. 2013. The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis. Genes Dev 27(3):288-300. [PubMed: 23355395] [MGI Ref ID J:193476]
Seeley ES; Carriere C; Goetze T; Longnecker DS; Korc M. 2009. Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia. Cancer Res 69(2):422-30. [PubMed: 19147554] [MGI Ref ID J:143713]
Seux M; Peuget S; Montero MP; Siret C; Rigot V; Clerc P; Gigoux V; Pellegrino E; Pouyet L; N'guessan P; Garcia S; Dufresne M; Iovanna JL; Carrier A; Andre F; Dusetti NJ. 2011. TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression. Oncogene 30(27):3049-61. [PubMed: 21339733] [MGI Ref ID J:174642]
Shakya R; Gonda T; Quante M; Salas M; Kim S; Brooks J; Hirsch S; Davies J; Cullo A; Olive K; Wang TC; Szabolcs M; Tycko B; Ludwig T. 2013. Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma. Cancer Res 73(2):885-96. [PubMed: 23204224] [MGI Ref ID J:194376]
Shankar S; Nall D; Tang SN; Meeker D; Passarini J; Sharma J; Srivastava RK. 2011. Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition. PLoS One 6(1):e16530. [PubMed: 21304978] [MGI Ref ID J:169546]
Shields DJ; Murphy EA; Desgrosellier JS; Mielgo A; Lau SK; Barnes LA; Lesperance J; Huang M; Schmedt C; Tarin D; Lowy AM; Cheresh DA. 2011. Oncogenic Ras/Src cooperativity in pancreatic neoplasia. Oncogene 30(18):2123-34. [PubMed: 21242978] [MGI Ref ID J:173715]
Skoulidis F; Cassidy LD; Pisupati V; Jonasson JG; Bjarnason H; Eyfjord JE; Karreth FA; Lim M; Barber LM; Clatworthy SA; Davies SE; Olive KP; Tuveson DA; Venkitaraman AR. 2010. Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer. Cancer Cell 18(5):499-509. [PubMed: 21056012] [MGI Ref ID J:166678]
Spence JR; Lange AW; Lin SC; Kaestner KH; Lowy AM; Kim I; Whitsett JA; Wells JM. 2009. Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell 17(1):62-74. [PubMed: 19619492] [MGI Ref ID J:151981]
Talchai C; Xuan S; Kitamura T; DePinho RA; Accili D. 2012. Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet 44(4):406-12, S1. [PubMed: 22406641] [MGI Ref ID J:183890]
Tian H; Callahan CA; DuPree KJ; Darbonne WC; Ahn CP; Scales SJ; de Sauvage FJ. 2009. Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci U S A 106(11):4254-9. [PubMed: 19246386] [MGI Ref ID J:146777]
Timpson P; McGhee EJ; Morton JP; von Kriegsheim A; Schwarz JP; Karim SA; Doyle B; Quinn JA; Carragher NO; Edward M; Olson MF; Frame MC; Brunton VG; Sansom OJ; Anderson KI. 2011. Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res 71(3):747-57. [PubMed: 21266354] [MGI Ref ID J:169401]
Vernon PJ; Loux TJ; Schapiro NE; Kang R; Muthuswamy R; Kalinski P; Tang D; Lotze MT; Zeh HJ 3rd. 2013. The receptor for advanced glycation end products promotes pancreatic carcinogenesis and accumulation of myeloid-derived suppressor cells. J Immunol 190(3):1372-9. [PubMed: 23269246] [MGI Ref ID J:192593]
Wells JM; Esni F; Boivin GP; Aronow BJ; Stuart W; Combs C; Sklenka A; Leach SD; Lowy AM. 2007. Wnt/beta-catenin signaling is required for development of the exocrine pancreas. BMC Dev Biol 7:4. [PubMed: 17222338] [MGI Ref ID J:119908]
Wicksteed B; Brissova M; Yan W; Opland DM; Plank JL; Reinert RB; Dickson LM; Tamarina NA; Philipson LH; Shostak A; Bernal-Mizrachi E; Elghazi L; Roe MW; Labosky PA; Myers MG Jr; Gannon M; Powers AC; Dempsey PJ. 2010. Conditional gene targeting in mouse pancreatic ss-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes 59(12):3090-8. [PubMed: 20802254] [MGI Ref ID J:169727]
Xuan S; Borok MJ; Decker KJ; Battle MA; Duncan SA; Hale MA; Macdonald RJ; Sussel L. 2012. Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. J Clin Invest 122(10):3516-28. [PubMed: 23006325] [MGI Ref ID J:192748]
Zhu L; Shi G; Schmidt CM; Hruban RH; Konieczny SF. 2007. Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol 171(1):263-73. [PubMed: 17591971] [MGI Ref ID J:122825]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice can be bred as hemizygotes. It is not known if homozygotes are viable. Mating System Noncarrier x Hemizygote (Female x Male) 18-OCT-11 Hemizygote x Noncarrier (Female x Male) 18-OCT-11 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for Tg(lpfl-cre)6Tuv
Price per Pair (US dollars $) Pair Genotype $296.00 Hemizygous for Tg(lpfl-cre)6Tuv x Noncarrier $296.00 Noncarrier x Hemizygous for Tg(lpfl-cre)6Tuv Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for Tg(lpfl-cre)6Tuv
Price per Pair (US dollars $) Pair Genotype $384.80 Hemizygous for Tg(lpfl-cre)6Tuv x Noncarrier $384.80 Noncarrier x Hemizygous for Tg(lpfl-cre)6Tuv Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.