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| These transgenic mice express the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain-specific calcium-calmodulin-dependent kinase II (Camk2a) promoter. These mice are a "Tet-Off" tool that allow the inducible expression of genes in forebrain neurons, and may be useful in studying brain disorders such as Alzheimer's disease, Parkinson's disease, or other neurodegenerative diseases. | |||||||||||||||||||
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Description
Strain Information
Former Names 129S6-Tg(Camk2a-tTA)1Mmay/JlwsJ (Changed: 31-AUG-11 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Noncarrier x Hemizygote (Female x Male) 29-AUG-11 Mating System Hemizygote x Noncarrier (Female x Male) 20-OCT-11 Species laboratory mouse Generation N12+ (19-DEC-11)
Generation DefinitionsDonating Investigator Jada Lewis, Description
Transgenic mice expressing the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain-specific calcium-calmodulin-dependent kinase II (Camk2a) promoter are viable and fertile. When hemizygotes are mated to a second strain carrying a gene of interest under the regulatory control of a tetracycline-responsive promoter element (TRE; tetO), expression of the target gene can be blocked by administration of the tetracycline analog, doxycycline (dox). These mice are a "Tet-Off" tool that allow the inducible expression of genes in forebrain neurons, and may be useful in studying brain disorders such as Alzheimer's disease, Parkinson's disease, or other neurodegenerative diseases.In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
A transgenic construct was designed with 8.5 kb of the mouse CaMKIIalpha promoter placed upstream of the tetracycline-regulated transactivator (tTA or "Tet-Off") gene (flanked by an artificial intron and splice sites at the 5' end and by a polyadenylation signal from SV40 at the 3' end). Founder line B was established and maintained on a mixed B6;CBA genetic background. These mice were obtained by Dr. Jada Lewis (Mayo Clinic) and then backcrossed to 129S6/SvEvTac inbred mice. Upon arrival, transgenic mice were bred to 129S6/SvEvTac inbred mice for at least one generation to establish the colony.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
Related Strains
Alzheimer's Disease Models
View Alzheimer's Disease Models (108 strains)
007004 B6.Cg-Tg(Camk2a-tTA)1Mmay/DboJ 003010 B6;CBA-Tg(Camk2a-tTA)1Mmay/J 015838 STOCK Tg(Camk2a-tTA)1Mmay Tg(tetO-ABL1*P242E*P249E)CPdav/J
002362 B6.129P2-Camk2atm1Sva/J 007574 B6.Cg-Tg(Camk2a-Crebbp*)1364Tabe/J 005855 B6.Cg-Tg(Camk2a-Prkaca)426Tabe/J 005359 B6.Cg-Tg(Camk2a-cre)T29-1Stl/J 012362 B6;129S6-Tg(Camk2a-cre/ERT2)1Aibs/J 004995 C3H-Tg(Camk2a-Creb1/ESR1)3Sva/J 006575 C57BL/6-Camk2atm1Vyb/J 013760 C57BL/6-Tg(Camk2a-AIDPak)21Stl/J 006579 C57BL/6-Tg(Camk2a-Bdnf)A9Stl/J 008088 C57BL/6-Tg(Camk2a-ESR1/Disc1*)2698.1Sva/J 005087 C57BL/6-Tg(Camk2a-IDE)1Selk/J 005086 C57BL/6-Tg(Camk2a-MME)3Selk/J 008833 C57BL/6-Tg(Camk2a-UBB)3413-1Fwvl/J 010712 C57BL/6-Tg(Camk2a-tTA)1Stl/J 008716 FVB/N-Tg(Myh6-AIP/PLN*)46Jded/J
Additional Web Information
Tet Expression Systems
Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.
Visit the Parkinson's Disease Resource site for helpful information on Parkinson's and research resources.
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x C3H/HeJ)F1
- nervous system phenotype
- abnormal dentate gyrus morphology
- width of granule cell layer is 14% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- width of granule cell layer is 14% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x CBA/J)F1
- nervous system phenotype
- abnormal dentate gyrus morphology
- width of granule cell layer is 30% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- width of granule cell layer is 30% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x 129X1/SvJ)F1
- behavior/neurological phenotype
- impaired contextual conditioning behavior
- freezing in response to unsignaled foot shock decreases in mutant and increases in control during final minutes of 5 minute test (MGI Ref ID J:185792)
- nervous system phenotype
- abnormal dentate gyrus morphology
- width of granule cell layer is 27% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- width of granule cell layer is 27% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x DBA/1J)F1
- nervous system phenotype
- abnormal dentate gyrus morphology
- width of granule cell layer is 17% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- width of granule cell layer is 17% thinner than controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x FVB/NJ)F1
- nervous system phenotype
- abnormal dentate gyrus morphology
- hippocampal neuron degeneration
Tg(Camk2a-tTA)1Mmay/0
involves: C3H/HeJ * C57BL/6 * CBA
- nervous system phenotype
- abnormal dentate gyrus morphology
- granule cell layer of the dentate gyrus is reduced and disorganized in 2 month old mice as compared to non-transgenic controls and the C57BL/6 congenic background (MGI Ref ID J:185792)
- cell loss is not observed in 2 week old mice (MGI Ref ID J:185792)
- width of granule cell layer is 42% thinner than controls by 2-4 months (MGI Ref ID J:185792)
- width of granule cell layer is 68% thinner than controls by 6-9 months (MGI Ref ID J:185792)
- however, when mice are reared on doxycycline, cell loss is not observed (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- neuronal degeneration is progressive (MGI Ref ID J:185792)
Tg(Camk2a-tTA)1Mmay/0
(B6.Cg-Tg(Camk2a-tTA)1Mmay x C3H/HeJ)F1 X C3H/HeJ
- nervous system phenotype
- abnormal dentate gyrus morphology
- width of granule cell layer is 29% thinner than controls and C57BL/6 congenic background (MGI Ref ID J:185792)
- hippocampal neuron degeneration
- width of granule cell layer is 29% thinner than controls and C57BL/6 congenic background (MGI Ref ID J:185792)
Tg(Camk2a-tTA)1Mmay/?
B6.Cg-Tg(Camk2a-tTA)1Mmay
- behavior/neurological phenotype
- abnormal long term spatial reference memory
- mice swim less distance in the target quadrant than controls when tested for long-term recall suggesting a memory consolidation impairment (MGI Ref ID J:185792)
- nervous system phenotype
- *normal* nervous system phenotype
This mouse can be used to support research in many areas including:
Neurobiology Research
Alzheimer's Disease
Behavioral and Learning Defects
Parkinson's Disease
Tet Expression System
tTA/rtTA Expressing Strains
Research Tools
Neurobiology Research
Tetop Tet System
Tet Expression Systems
tTA/rtTA Expressing Strains
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Camk2a-tTA)1Mmay | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Mark Mayford | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | CAMK-rTA; CaMKII-tTA; CaMKIIalpha-tTA; CamDAT; Tg(CaMKIItTA)Mmay; Tgalpha-CaMkII-tTA; line B; pCaMKII-tTA; | ||
| Mutation Made By | Dr. Mark Mayford, The Scripps Research Institute | ||
| Site of Expression | Expresses tTA in forebrain neurons. | ||
| Expressed Gene | tTA, tetracycline-controlled transactivator, E. coli | ||
| The tetracycline-resistance gene (TetR), arose from chemically mutated Escherichia coli genome which was screened for tetracycline dependence (Gossen and Bujard, 1992). TetR was fused at the C-terminus with the viral co-activator, virion protein 16 of the herpes simplex virus (VP-16). The tetracycline-inhibitable transcription factor is a component of a bigenic system that allows doxycycline (a tetracycline analog) regulatable expression of genes that are under the direction of the tetracycline responsive promoter (TetOp)promoter. | |||
| Promoter | Camk2a, calcium/calmodulin-dependent protein kinase II alpha, mouse, laboratory | ||
| General Note |
This transgene is line B. Transgenic mice are viable, fertile, and display no overt phenotypic defects. Administration of tetracycline analogs such as doxycycline blocks transgene expression. | ||
| Molecular Note | The transgene contains the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain specific calcium/calmodulin-dependent kinase II promoter. [MGI Ref ID J:37107] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(tTA), Melt Curve Analysis
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Mayford M; Bach ME; Huang YY; Wang L; Hawkins RD; Kandel ER. 1996. Control of memory formation through regulated expression of a CaMKII transgene. Science 274(5293):1678-83. [PubMed: 8939850] [MGI Ref ID J:37107]
Santacruz K; Lewis J; Spires T; Paulson J; Kotilinek L; Ingelsson M; Guimaraes A; DeTure M; Ramsden M; McGowan E; Forster C; Yue M; Orne J; Janus C; Mariash A; Kuskowski M; Hyman B; Hutton M; Ashe KH. 2005. Tau suppression in a neurodegenerative mouse model improves memory function. Science 309(5733):476-81. [PubMed: 16020737] [MGI Ref ID J:99626]
Additional References
Tg(Camk2a-tTA)1Mmay relatedAgeta H; Ikegami S; Miura M; Masuda M; Migishima R; Hino T; Takashima N; Murayama A; Sugino H; Setou M; Kida S; Yokoyama M; Hasegawa Y; Tsuchida K; Aosaki T; Inokuchi K. 2010. Activin plays a key role in the maintenance of long-term memory and late-LTP. Learn Mem 17(4):176-85. [PubMed: 20332189] [MGI Ref ID J:185839]
Aleksic T; Baumann B; Wagner M; Adler G; Wirth T; Weber CK. 2007. Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2. Gut 56(2):227-36. [PubMed: 16870717] [MGI Ref ID J:130547]
Alexander GM; Rogan SC; Abbas AI; Armbruster BN; Pei Y; Allen JA; Nonneman RJ; Hartmann J; Moy SS; Nicolelis MA; McNamara JO; Roth BL. 2009. Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron 63(1):27-39. [PubMed: 19607790] [MGI Ref ID J:154952]
Alvarez-Saavedra M; Saez MA; Kang D; Zoghbi HY; Young JI. 2007. Cell-specific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis. Hum Mol Genet 16(19):2315-25. [PubMed: 17635839] [MGI Ref ID J:124365]
Badanich KA; Doremus-Fitzwater TL; Mulholland PJ; Randall PK; Delpire E; Becker HC. 2011. NR2B-deficient mice are more sensitive to the locomotor stimulant and depressant effects of ethanol. Genes Brain Behav 10(7):805-16. [PubMed: 21762461] [MGI Ref ID J:188172]
Barco A; Patterson S; Alarcon JM; Gromova P; Mata-Roig M; Morozov A; Kandel ER. 2005. Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture. Neuron 48(1):123-37. [PubMed: 16202713] [MGI Ref ID J:105355]
Bedford L; Hay D; Devoy A; Paine S; Powe DG; Seth R; Gray T; Topham I; Fone K; Rezvani N; Mee M; Soane T; Layfield R; Sheppard PW; Ebendal T; Usoskin D; Lowe J; Mayer RJ. 2008. Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies. J Neurosci 28(33):8189-98. [PubMed: 18701681] [MGI Ref ID J:138991]
Bejar R; Yasuda R; Krugers H; Hood K; Mayford M. 2002. Transgenic calmodulin-dependent protein kinase II activation: dose-dependent effects on synaptic plasticity, learning, and memory. J Neurosci 22(13):5719-26. [PubMed: 12097524] [MGI Ref ID J:112443]
Bertocchi I; Oberto A; Longo A; Mele P; Sabetta M; Bartolomucci A; Palanza P; Sprengel R; Eva C. 2011. Regulatory functions of limbic Y1 receptors in body weight and anxiety uncovered by conditional knockout and maternal care. Proc Natl Acad Sci U S A 108(48):19395-400. [PubMed: 22084082] [MGI Ref ID J:180396]
Chandrasekaran K; Hazelton JL; Wang Y; Fiskum G; Kristian T. 2006. Neuron-specific conditional expression of a mitochondrially targeted fluorescent protein in mice. J Neurosci 26(51):13123-7. [PubMed: 17182763] [MGI Ref ID J:118452]
Chang KH; Multani PS; Sun KH; Vincent F; de Pablo Y; Ghosh S; Gupta R; Lee HP; Lee HG; Smith MA; Shah K. 2011. Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death. Mol Biol Cell 22(9):1452-62. [PubMed: 21389115] [MGI Ref ID J:182975]
Chen AP; Ohno M; Giese KP; Kuhn R; Chen RL; Silva AJ. 2006. Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory. J Neurosci Res 83(1):28-38. [PubMed: 16342120] [MGI Ref ID J:107042]
Chen L; Ding Y; Cagniard B; Van Laar AD; Mortimer A; Chi W; Hastings TG; Kang UJ; Zhuang X. 2008. Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice. J Neurosci 28(2):425-33. [PubMed: 18184785] [MGI Ref ID J:131093]
Cheng HY; Dziema H; Papp J; Mathur DP; Koletar M; Ralph MR; Penninger JM; Obrietan K. 2006. The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock. J Neurosci 26(50):12984-95. [PubMed: 17167088] [MGI Ref ID J:116668]
Cheng N; Cai H; Belluscio L. 2011. In Vivo Olfactory Model of APP-Induced Neurodegeneration Reveals a Reversible Cell-Autonomous Function. J Neurosci 31(39):13699-704. [PubMed: 21957232] [MGI Ref ID J:176127]
Chiu C; Reid CA; Tan HO; Davies PJ; Single FN; Koukoulas I; Berkovic SF; Tan SS; Sprengel R; Jones MV; Petrou S. 2008. Developmental impact of a familial GABAA receptor epilepsy mutation. Ann Neurol 64(3):284-93. [PubMed: 18825662] [MGI Ref ID J:194736]
Chuhma N; Tanaka KF; Hen R; Rayport S. 2011. Functional connectome of the striatal medium spiny neuron. J Neurosci 31(4):1183-92. [PubMed: 21273403] [MGI Ref ID J:188102]
Crook ZR; Housman D. 2011. Huntington's disease: can mice lead the way to treatment? Neuron 69(3):423-35. [PubMed: 21315254] [MGI Ref ID J:174750]
Cruz JC; Tseng HC; Goldman JA; Shih H; Tsai LH. 2003. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 40(3):471-83. [PubMed: 14642273] [MGI Ref ID J:104240]
Diaz-Hernandez M; Diez-Zaera M; Sanchez-Nogueiro J; Gomez-Villafuertes R; Canals JM; Alberch J; Miras-Portugal MT; Lucas JJ. 2009. Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration. FASEB J 23(6):1893-906. [PubMed: 19171786] [MGI Ref ID J:150552]
DuBoff B; Gotz J; Feany MB. 2012. Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron 75(4):618-32. [PubMed: 22920254] [MGI Ref ID J:188334]
Eckermann K; Mocanu MM; Khlistunova I; Biernat J; Nissen A; Hofmann A; Schonig K; Bujard H; Haemisch A; Mandelkow E; Zhou L; Rune G; Mandelkow EM. 2007. The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. J Biol Chem 282(43):31755-65. [PubMed: 17716969] [MGI Ref ID J:126788]
Engel T; Goni-Oliver P; Gomez-Ramos P; Moran MA; Lucas JJ; Avila J; Hernandez F. 2008. Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta. Neuroscience 157(4):772-80. [PubMed: 18951953] [MGI Ref ID J:144874]
Engel T; Lucas JJ; Gomez-Ramos P; Moran MA; Avila J; Hernandez F. 2006. Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration. Neurobiol Aging 27(9):1258-68. [PubMed: 16054268] [MGI Ref ID J:113439]
Favilla C; Abel T; Kelly MP. 2008. Chronic Galphas signaling in the striatum increases anxiety-related behaviors independent of developmental effects. J Neurosci 28(51):13952-6. [PubMed: 19091983] [MGI Ref ID J:143516]
Fridmacher V; Kaltschmidt B; Goudeau B; Ndiaye D; Rossi FM; Pfeiffer J; Kaltschmidt C; Israel A; Memet S. 2003. Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection. J Neurosci 23(28):9403-8. [PubMed: 14561868] [MGI Ref ID J:86217]
Fukui H; Moraes CT. 2009. Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons. Hum Mol Genet 18(6):1028-36. [PubMed: 19095717] [MGI Ref ID J:145737]
Fuster-Matanzo A; Llorens-Martin M; Sirerol-Piquer MS; Garcia-Verdugo JM; Avila J; Hernandez F. 2013. Dual effects of increased glycogen synthase kinase-3beta activity on adult neurogenesis. Hum Mol Genet 22(7):1300-15. [PubMed: 23257288] [MGI Ref ID J:193849]
Giusti-Rodriguez P; Gao J; Graff J; Rei D; Soda T; Tsai LH. 2011. Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of beta-Secretase (BACE1). J Neurosci 31(44):15751-6. [PubMed: 22049418] [MGI Ref ID J:177847]
Gomez de Barreda E; Perez M; Gomez Ramos P; de Cristobal J; Martin-Maestro P; Moran A; Dawson HN; Vitek MP; Lucas JJ; Hernandez F; Avila J. 2010. Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. Neurobiol Dis 37(3):622-9. [PubMed: 20004245] [MGI Ref ID J:158536]
Gomez-Sintes R; Hernandez F; Bortolozzi A; Artigas F; Avila J; Zaratin P; Gotteland JP; Lucas JJ. 2007. Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice. EMBO J 26(11):2743-54. [PubMed: 17510631] [MGI Ref ID J:122627]
Gross C; Zhuang X; Stark K; Ramboz S; Oosting R; Kirby L; Santarelli L; Beck S; Hen R. 2002. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 416(6879):396-400. [PubMed: 11919622] [MGI Ref ID J:75722]
Gruart A; Benito E; Delgado-Garcia JM; Barco A. 2012. Enhanced cAMP response element-binding protein activity increases neuronal excitability, hippocampal long-term potentiation, and classical eyeblink conditioning in alert behaving mice. J Neurosci 32(48):17431-41. [PubMed: 23197734] [MGI Ref ID J:193114]
Han HJ; Allen CC; Buchovecky CM; Yetman MJ; Born HA; Marin MA; Rodgers SP; Song BJ; Lu HC; Justice MJ; Probst FJ; Jankowsky JL. 2012. Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator. J Neurosci 32(31):10574-86. [PubMed: 22855807] [MGI Ref ID J:185792]
Hansen KF; Sakamoto K; Wayman GA; Impey S; Obrietan K. 2010. Transgenic miR132 alters neuronal spine density and impairs novel object recognition memory. PLoS One 5(11):e15497. [PubMed: 21124738] [MGI Ref ID J:167123]
Hasan MT; Schonig K; Berger S; Graewe W; Bujard H. 2001. Long-term, noninvasive imaging of regulated gene expression in living mice. Genesis 29(3):116-22. [PubMed: 11252052] [MGI Ref ID J:127660]
Hawk JD; Bookout AL; Poplawski SG; Bridi M; Rao AJ; Sulewski ME; Kroener BT; Manglesdorf DJ; Abel T. 2012. NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors. J Clin Invest 122(10):3593-602. [PubMed: 22996661] [MGI Ref ID J:191754]
Hidvegi T; Schmidt BZ; Hale P; Perlmutter DH. 2005. Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response. J Biol Chem 280(47):39002-15. [PubMed: 16183649] [MGI Ref ID J:104112]
Igaz LM; Kwong LK; Lee EB; Chen-Plotkin A; Swanson E; Unger T; Malunda J; Xu Y; Winton MJ; Trojanowski JQ; Lee VM. 2011. Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. J Clin Invest 121(2):726-38. [PubMed: 21206091] [MGI Ref ID J:170756]
Isiegas C; McDonough C; Huang T; Havekes R; Fabian S; Wu LJ; Xu H; Zhao MG; Kim JI; Lee YS; Lee HR; Ko HG; Lee N; Choi SL; Lee JS; Son H; Zhuo M; Kaang BK; Abel T. 2008. A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval. J Neurosci 28(24):6220-30. [PubMed: 18550764] [MGI Ref ID J:137375]
Jankowsky JL; Slunt HH; Gonzales V; Savonenko AV; Wen JC; Jenkins NA; Copeland NG; Younkin LH; Lester HA; Younkin SG; Borchelt DR. 2005. Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. PLoS Med 2(12):e355. [PubMed: 16279840] [MGI Ref ID J:109829]
Jerecic J; Schulze CH; Jonas P; Sprengel R; Seeburg PH; Bischofberger J. 2001. Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression. Brain Res Mol Brain Res 94(1-2):96-104. [PubMed: 11597769] [MGI Ref ID J:130561]
Kaltschmidt B; Ndiaye D; Korte M; Pothion S; Arbibe L; Prullage M; Pfeiffer J; Lindecke A; Staiger V; Israel A; Kaltschmidt C; Memet S. 2006. NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling. Mol Cell Biol 26(8):2936-46. [PubMed: 16581769] [MGI Ref ID J:107412]
Karlen A; Karlsson TE; Mattsson A; Lundstromer K; Codeluppi S; Pham TM; Backman CM; Ogren SO; Aberg E; Hoffman AF; Sherling MA; Lupica CR; Hoffer BJ; Spenger C; Josephson A; Brene S; Olson L. 2009. Nogo receptor 1 regulates formation of lasting memories. Proc Natl Acad Sci U S A 106(48):20476-81. [PubMed: 19915139] [MGI Ref ID J:155587]
Kelly MP; Stein JM; Vecsey CG; Favilla C; Yang X; Bizily SF; Esposito MF; Wand G; Kanes SJ; Abel T. 2009. Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Galphas, a G-protein subunit genetically linked to schizophrenia. Mol Psychiatry 14(4):398-415, 347. [PubMed: 19030002] [MGI Ref ID J:166114]
Kholodilov N; Kim SR; Yarygina O; Kareva T; Cho JW; Baohan A; Burke RE. 2011. Glial cell line-derived neurotrophic factor receptor-alpha1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra. J Neurochem 116(4):486-98. [PubMed: 21133924] [MGI Ref ID J:170428]
Klug JR; Mathur BN; Kash TL; Wang HD; Matthews RT; Robison AJ; Anderson ME; Deutch AY; Lovinger DM; Colbran RJ; Winder DG. 2012. Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability. PLoS One 7(9):e45323. [PubMed: 23028932] [MGI Ref ID J:191787]
Kolber BJ; Boyle MP; Wieczorek L; Kelley CL; Onwuzurike CC; Nettles SA; Vogt SK; Muglia LJ. 2010. Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice. J Neurosci 30(7):2571-81. [PubMed: 20164342] [MGI Ref ID J:157835]
Kopeikina KJ; Carlson GA; Pitstick R; Ludvigson AE; Peters A; Luebke JI; Koffie RM; Frosch MP; Hyman BT; Spires-Jones TL. 2011. Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. Am J Pathol 179(4):2071-82. [PubMed: 21854751] [MGI Ref ID J:176290]
Krestel HE; Mihaljevic AL; Hoffman DA; Schneider A. 2004. Neuronal co-expression of EGFP and beta-galactosidase in mice causes neuropathology and premature death. Neurobiol Dis 17(2):310-8. [PubMed: 15474368] [MGI Ref ID J:93090]
Krestel HE; Shimshek DR; Jensen V; Nevian T; Kim J; Geng Y; Bast T; Depaulis A; Schonig K; Schwenk F; Bujard H; Hvalby O; Sprengel R; Seeburg PH. 2004. A genetic switch for epilepsy in adult mice. J Neurosci 24(46):10568-78. [PubMed: 15548671] [MGI Ref ID J:96556]
Kvajo M; McKellar H; Gogos JA. 2012. Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models. Neuroscience 211:136-64. [PubMed: 21821099] [MGI Ref ID J:184660]
Larsen RS; Corlew RJ; Henson MA; Roberts AC; Mishina M; Watanabe M; Lipton SA; Nakanishi N; Perez-Otano I; Weinberg RJ; Philpot BD. 2011. NR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity. Nat Neurosci 14(3):338-44. [PubMed: 21297630] [MGI Ref ID J:170349]
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Health & husbandry
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Colony Maintenance
Breeding & Husbandry When maintaining a live colony, hemizygous mice can be bred to wildtype (noncarrier) mice from the colony. Mating System Noncarrier x Hemizygote (Female x Male) 29-AUG-11 Hemizygote x Noncarrier (Female x Male) 20-OCT-11 Diet Information LabDiet® 5K20
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Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for Tg(Camk2a-tTA)1Mmay
Price per Pair (US dollars $) Pair Genotype $296.00 Hemizygous for Tg(Camk2a-tTA)1Mmay x Noncarrier $296.00 Noncarrier x Hemizygous for Tg(Camk2a-tTA)1Mmay Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for Tg(Camk2a-tTA)1Mmay
Price per Pair (US dollars $) Pair Genotype $384.80 Hemizygous for Tg(Camk2a-tTA)1Mmay x Noncarrier $384.80 Noncarrier x Hemizygous for Tg(Camk2a-tTA)1Mmay Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.