| |||||||||||||||
| The Alb1-cre transgene was designed with a Cre recombinase gene under control of Alb promoter/enhancer elements. These mice may be useful for studying the liver specific deletion of target genes. | |||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
Strain Information
Former Names B6.Cg-Tg(Alb1-cre)1Dlr/J (Changed: 14-JUN-11 ) Type Congenic; Mutant Stock; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Noncarrier x Hemizygote (Female x Male) 01-MAY-12 Mating System Hemizygote x Noncarrier (Female x Male) 01-MAY-12 Species laboratory mouse Generation N10+N1+F2 (14-FEB-13)
Generation DefinitionsDonating Investigator Dr. Derek LeRoith, Mount Sinai School of Medicine Description
The Alb1-cre transgene was designed with a Cre recombinase gene under control of albumin (Alb) promoter/enhancer elements. Hemizygous Alb1-cre mice are viable, fertile, and normal in size, with cre expression directed specifically to the liver. When these transgenic mice are bred with mice containing a loxP-flanked sequence, Cre-mediated recombination is expected to result in deletion of the floxed sequences in the Cre recombinase-expressing hepatic cells of the offspring. For example, when these mice are bred to Igf1tm1Dlr-containing mice (Stock No. 012663 or Stock No. 016831), the removal of IGF1 expression in the liver causes a 75% reduction in serum IGF-1levels. These mice may be useful for studying the liver specific deletion of target genes.Development
The Alb1-Cre transgene was designed with a Cre recombinase gene under control of albumin (Alb) promoter/enhancer elements. The construct was microinjected into fertilized FVB/N oocytes, and founder mice were bred to FVB/NJ mice. The resulting mice were then crossed to B6.129-Igf1tm1Dlr mice. The resulting offspring were then backcrossed to an C57BL/6J for at least 9 generations. Upon arrival, the mice were bred to C57BL/6J inbred mice (Stock No. 000664) for one generation and floxed allele was selectively bred out of the line.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(Alb1-cre)1Dlr allele
016833 FVB(Cg)-Tg(Alb1-cre)1Dlr/J View Strains carrying Tg(Alb1-cre)1Dlr (1 strain)
007853 129S/SvEv-Tg(Alb1-Ren)2Unc/CofJ 002226 C57BL/6J-Tg(Alb1HBV)44Bri/J
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedDevelopmental Biology Research
Internal/Organ Defects
liver
Research Tools
Cre-lox System
Cre Recombinase Expression
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Alb1-cre)1Dlr | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Derek LeRoith | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Alb-cre; AlbCre; Albumen-Cre; Albumin-Cre; | ||
| Mutation Made By | Dr. Derek LeRoith, Mount Sinai School of Medicine | ||
| Strain of Origin | FVB/N | ||
| Site of Expression | liver | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Alb1, Albumin , Mouse | ||
| Gene Symbol and Name | Tg(Alb1-cre)1Dlr, transgene insertion 1, Derek LeRoith | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Alb-cre; AlbCre; Albumen-Cre; Albumin-Cre; | ||
| Driver Note | Alb | ||
| Molecular Note | This transgene expresses Cre recombinase in the liver, under the control of an albumin promoter (species not specified). [MGI Ref ID J:69517] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(Alb1-cre)1Dlr, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Yakar S; Liu JL; Stannard B; Butler A; Accili D; Sauer B; LeRoith D. 1999. Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci U S A 96(13):7324-9. [PubMed: 10377413] [MGI Ref ID J:69517]
Additional References
Tg(Alb1-cre)1Dlr relatedAgouni A; Mody N; Owen C; Czopek A; Zimmer D; Bentires-Alj M; Bence KK; Delibegovic M. 2011. Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress. Biochem J 438(2):369-78. [PubMed: 21605081] [MGI Ref ID J:177894]
Anzo M; Cobb LJ; Hwang DL; Mehta H; Said JW; Yakar S; LeRoith D; Cohen P. 2008. Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression. Cancer Res 68(9):3342-9. [PubMed: 18451161] [MGI Ref ID J:134610]
Bonzo JA; Ferry CH; Matsubara T; Kim JH; Gonzalez FJ. 2012. Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4alpha in adult mice. J Biol Chem 287(10):7345-56. [PubMed: 22241473] [MGI Ref ID J:182767]
Chen M; Gavrilova O; Zhao WQ; Nguyen A; Lorenzo J; Shen L; Nackers L; Pack S; Jou W; Weinstein LS. 2005. Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific G(s)alpha deficiency. J Clin Invest 115(11):3217-27. [PubMed: 16239968] [MGI Ref ID J:102504]
Chen M; Mema E; Kelleher J; Nemechek N; Berger A; Wang J; Xie T; Gavrilova O; Drucker DJ; Weinstein LS. 2011. Absence of the glucagon-like peptide-1 receptor does not affect the metabolic phenotype of mice with liver-specific G(s)alpha deficiency. Endocrinology 152(9):3343-50. [PubMed: 21771891] [MGI Ref ID J:177087]
Chong MM; Metcalf D; Jamieson E; Alexander WS; Kay TW. 2005. Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation. Blood 106(5):1668-75. [PubMed: 15899915] [MGI Ref ID J:118492]
Corchero J; Granvil CP; Akiyama TE; Hayhurst GP; Pimprale S; Feigenbaum L; Idle JR; Gonzalez FJ. 2001. The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse. Mol Pharmacol 60(6):1260-7. [PubMed: 11723233] [MGI Ref ID J:104020]
Courtland HW; Elis S; Wu Y; Sun H; Rosen CJ; Jepsen KJ; Yakar S. 2011. Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner. PLoS One 6(3):e14762. [PubMed: 21445249] [MGI Ref ID J:171681]
Croker BA; Krebs DL; Zhang JG; Wormald S; Willson TA; Stanley EG; Robb L; Greenhalgh CJ; Forster I; Clausen BE; Nicola NA; Metcalf D; Hilton DJ; Roberts AW; Alexander WS. 2003. SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol 4(6):540-5. [PubMed: 12754505] [MGI Ref ID J:83645]
Delibegovic M; Zimmer D; Kauffman C; Rak K; Hong EG; Cho YR; Kim JK; Kahn BB; Neel BG; Bence KK. 2009. Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress. Diabetes 58(3):590-9. [PubMed: 19074988] [MGI Ref ID J:146928]
Della Torre S; Rando G; Meda C; Stell A; Chambon P; Krust A; Ibarra C; Magni P; Ciana P; Maggi A. 2011. Amino acid-dependent activation of liver estrogen receptor alpha integrates metabolic and reproductive functions via IGF-1. Cell Metab 13(2):205-14. [PubMed: 21284987] [MGI Ref ID J:169561]
Ding X; Lichti K; Kim I; Gonzalez FJ; Staudinger JL. 2006. Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha. J Biol Chem 281(36):26540-51. [PubMed: 16825189] [MGI Ref ID J:117299]
Ealey KN; Xuan W; Lu S; Archer MC. 2008. Colon carcinogenesis in liver-specific IGF-I-deficient (LID) mice. Int J Cancer 122(2):472-6. [PubMed: 17918153] [MGI Ref ID J:135544]
Endres M; Piriz J; Gertz K; Harms C; Meisel A; Kronenberg G; Torres-Aleman I. 2007. Serum insulin-like growth factor I and ischemic brain injury. Brain Res 1185:328-35. [PubMed: 17961524] [MGI Ref ID J:128923]
Fernandez MC; Venara M; Nowicki S; Chemes HE; Barontini M; Pennisi PA. 2012. Igf-I regulates pheochromocytoma cell proliferation and survival in vitro and in vivo. Endocrinology 153(8):3724-34. [PubMed: 22653556] [MGI Ref ID J:189111]
Fritton JC; Emerton KB; Sun H; Kawashima Y; Mejia W; Wu Y; Rosen CJ; Panus D; Bouxsein M; Majeska RJ; Schaffler MB; Yakar S. 2010. Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1). J Bone Miner Res 25(2):235-46. [PubMed: 19619004] [MGI Ref ID J:179871]
Gao D; Inuzuka H; Tseng A; Chin RY; Toker A; Wei W. 2009. Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nat Cell Biol 11(4):397-408. [PubMed: 19270695] [MGI Ref ID J:158181]
Gavrilova O; Haluzik M; Matsusue K; Cutson JJ; Johnson L; Dietz KR; Nicol CJ; Vinson C; Gonzalez FJ; Reitman ML. 2003. Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J Biol Chem 278(36):34268-76. [PubMed: 12805374] [MGI Ref ID J:85313]
Genetic Resource Sciences at The Jackson Laboratory. 2013. Expression/Specificity Patterns of Cre Alleles, 2013 MGI Direct Data Submission :. [MGI Ref ID J:193672]
Guo D; Sarkar J; Ahmed MR; Viswakarma N; Jia Y; Yu S; Sambasiva Rao M; Reddy JK. 2006. Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver. Biochem Biophys Res Commun 347(2):485-95. [PubMed: 16828057] [MGI Ref ID J:111289]
Guo D; Sarkar J; Suino-Powell K; Xu Y; Matsumoto K; Jia Y; Yu S; Khare S; Haldar K; Rao MS; Foreman JE; Monga SP; Peters JM; Xu HE; Reddy JK. 2007. Induction of Nuclear Translocation of Constitutive Androstane Receptor by Peroxisome Proliferator-activated Receptor {alpha} Synthetic Ligands in Mouse Liver. J Biol Chem 282(50):36766-76. [PubMed: 17962186] [MGI Ref ID J:128919]
Haluzik M; Yakar S; Gavrilova O; Setser J; Boisclair Y; LeRoith D. 2003. Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance. Diabetes 52(10):2483-9. [PubMed: 14514630] [MGI Ref ID J:107186]
Hayhurst GP; Lee YH; Lambert G; Ward JM; Gonzalez FJ. 2001. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol 21(4):1393-403. [PubMed: 11158324] [MGI Ref ID J:67396]
Inoue H; Ogawa W; Asakawa A; Okamoto Y; Nishizawa A; Matsumoto M; Teshigawara K; Matsuki Y; Watanabe E; Hiramatsu R; Notohara K; Katayose K; Okamura H; Kahn CR; Noda T; Takeda K; Akira S; Inui A; Kasuga M. 2006. Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab 3(4):267-75. [PubMed: 16581004] [MGI Ref ID J:109359]
Inoue Y; Inoue J; Lambert G; Yim SH; Gonzalez FJ. 2004. Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis. J Biol Chem 279(43):44740-8. [PubMed: 15292250] [MGI Ref ID J:93982]
Inoue Y; Yu AM; Yim SH; Ma X; Krausz KW; Inoue J; Xiang CC; Brownstein MJ; Eggertsen G; Bjorkhem I; Gonzalez FJ. 2006. Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha. J Lipid Res 47(1):215-27. [PubMed: 16264197] [MGI Ref ID J:106030]
Jia Y; Qi C; Kashireddi P; Surapureddi S; Zhu YJ; Rao MS; Le Roith D; Chambon P; Gonzalez FJ; Reddy JK. 2004. Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver. J Biol Chem 279(23):24427-34. [PubMed: 15150259] [MGI Ref ID J:94123]
Kamileri I; Karakasilioti I; Sideri A; Kosteas T; Tatarakis A; Talianidis I; Garinis GA. 2012. Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A 109(8):2995-3000. [PubMed: 22323595] [MGI Ref ID J:181994]
Kautz L; Meynard D; Monnier A; Darnaud V; Bouvet R; Wang RH; Deng C; Vaulont S; Mosser J; Coppin H; Roth MP. 2008. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 112(4):1503-9. [PubMed: 18539898] [MGI Ref ID J:139214]
Kim HS; Xiao C; Wang RH; Lahusen T; Xu X; Vassilopoulos A; Vazquez-Ortiz G; Jeong WI; Park O; Ki SH; Gao B; Deng CX. 2010. Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab 12(3):224-36. [PubMed: 20816089] [MGI Ref ID J:166368]
Kim I; Ahn SH; Inagaki T; Choi M; Ito S; Guo GL; Kliewer SA; Gonzalez FJ. 2007. Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J Lipid Res 48(12):2664-72. [PubMed: 17720959] [MGI Ref ID J:129978]
Klover P; Hennighausen L. 2007. Postnatal Body Growth Is Dependent on the Transcription Factors Signal Transducers and Activators of Transcription 5a/b in Muscle: A Role for Autocrine/Paracrine Insulin-Like Growth Factor I. Endocrinology 148(4):1489-97. [PubMed: 17158201] [MGI Ref ID J:119237]
Kyrmizi I; Hatzis P; Katrakili N; Tronche F; Gonzalez FJ; Talianidis I. 2006. Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev 20(16):2293-305. [PubMed: 16912278] [MGI Ref ID J:111670]
Laz EV; Holloway MG; Chen CS; Waxman DJ. 2007. Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver. Endocrinology 148(7):3327-37. [PubMed: 17412818] [MGI Ref ID J:129617]
Lee C; Safdie FM; Raffaghello L; Wei M; Madia F; Parrella E; Hwang D; Cohen P; Bianchi G; Longo VD. 2010. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res 70(4):1564-72. [PubMed: 20145127] [MGI Ref ID J:157609]
Liu YL; Yakar S; Otero-Corchon V; Low MJ; Liu JL. 2002. Ghrelin gene expression is age-dependent and influenced by gender and the level of circulating IGF-I. Mol Cell Endocrinol 189(1-2):97-103. [PubMed: 12039068] [MGI Ref ID J:76060]
Lopez-Lopez C; LeRoith D; Torres-Aleman I. 2004. Insulin-like growth factor I is required for vessel remodeling in the adult brain. Proc Natl Acad Sci U S A 101(26):9833-8. [PubMed: 15210967] [MGI Ref ID J:91431]
Martinez-Jimenez CP; Kyrmizi I; Cardot P; Gonzalez FJ; Talianidis I. 2010. Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism. Mol Cell Biol 30(3):565-77. [PubMed: 19933841] [MGI Ref ID J:156389]
Matheny RW; Merritt E; Zannikos SV; Farrar RP; Adamo ML. 2009. Serum IGF-I-deficiency does not prevent compensatory skeletal muscle hypertrophy in resistance exercise. Exp Biol Med (Maywood) 234(2):164-70. [PubMed: 19064939] [MGI Ref ID J:165003]
Matsumoto K; Huang J; Viswakarma N; Bai L; Jia Y; Zhu YT; Yang G; Borensztajn J; Rao MS; Zhu YJ; Reddy JK. 2010. Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse. Carcinogenesis 31(2):318-25. [PubMed: 20007298] [MGI Ref ID J:156765]
Matsumoto K; Yu S; Jia Y; Ahmed MR; Viswakarma N; Sarkar J; Kashireddy PV; Rao MS; Karpus W; Gonzalez FJ; Reddy JK. 2007. Critical role for transcription coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein/TRAP220 in liver regeneration and PPARalpha ligand-induced liver tumor development. J Biol Chem 282(23):17053-60. [PubMed: 17438330] [MGI Ref ID J:123863]
Matsumoto M; Ogawa W; Akimoto K; Inoue H; Miyake K; Furukawa K; Hayashi Y; Iguchi H; Matsuki Y; Hiramatsu R; Shimano H; Yamada N; Ohno S; Kasuga M; Noda T. 2003. PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J Clin Invest 112(6):935-44. [PubMed: 12975478] [MGI Ref ID J:118462]
Matsusue K; Gavrilova O; Lambert G; Brewer HB Jr; Ward JM; Inoue Y; LeRoith D; Gonzalez FJ. 2004. Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice. Mol Endocrinol 18(11):2751-64. [PubMed: 15319454] [MGI Ref ID J:93579]
Matsusue K; Haluzik M; Lambert G; Yim SH; Gavrilova O; Ward JM; Brewer B Jr; Reitman ML; Gonzalez FJ. 2003. Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest 111(5):737-47. [PubMed: 12618528] [MGI Ref ID J:82439]
Matsusue K; Kusakabe T; Noguchi T; Takiguchi S; Suzuki T; Yamano S; Gonzalez FJ. 2008. Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. Cell Metab 7(4):302-11. [PubMed: 18396136] [MGI Ref ID J:134335]
Moore T; Carbajal S; Beltran L; Perkins SN; Yakar S; Leroith D; Hursting SD; Digiovanni J. 2008. Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels. Cancer Res 68(10):3680-8. [PubMed: 18483250] [MGI Ref ID J:135023]
Niu T; Rosen CJ. 2005. The insulin-like growth factor-I gene and osteoporosis: a critical appraisal. Gene 361:38-56. [PubMed: 16183214] [MGI Ref ID J:102683]
Ohguchi H; Tanaka T; Uchida A; Magoori K; Kudo H; Kim I; Daigo K; Sakakibara I; Okamura M; Harigae H; Sasaki T; Osborne TF; Gonzalez FJ; Hamakubo T; Kodama T; Sakai J. 2008. Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9. Mol Cell Biol 28(12):3917-31. [PubMed: 18426912] [MGI Ref ID J:137297]
Okamoto Y; Ogawa W; Nishizawa A; Inoue H; Teshigawara K; Kinoshita S; Matsuki Y; Watanabe E; Hiramatsu R; Sakaue H; Noda T; Kasuga M. 2007. Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1. Diabetes 56(4):1000-9. [PubMed: 17267763] [MGI Ref ID J:122117]
Scacheri PC; Crabtree JS; Kennedy AL; Swain GP; Ward JM; Marx SJ; Spiegel AM; Collins FS. 2004. Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1. Mamm Genome 15(11):872-7. [PubMed: 15672591] [MGI Ref ID J:96272]
Suzuki T; Kelly VP; Motohashi H; Nakajima O; Takahashi S; Nishimura S; Yamamoto M. 2008. Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2. J Biol Chem 283(4):2021-30. [PubMed: 18039655] [MGI Ref ID J:130723]
Tatarakis A; Margaritis T; Martinez-Jimenez CP; Kouskouti A; Mohan WS 2nd; Haroniti A; Kafetzopoulos D; Tora L; Talianidis I. 2008. Dominant and redundant functions of TFIID involved in the regulation of hepatic genes. Mol Cell 31(4):531-43. [PubMed: 18722179] [MGI Ref ID J:138818]
Trejo JL; Piriz J; Llorens-Martin MV; Fernandez AM; Bolos M; LeRoith D; Nunez A; Torres-Aleman I. 2007. Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects. Mol Psychiatry 12(12):1118-28. [PubMed: 17848918] [MGI Ref ID J:147526]
Wallace DF; Summerville L; Subramaniam VN. 2007. Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload. Gastroenterology 132(1):301-10. [PubMed: 17241880] [MGI Ref ID J:127267]
Wang RH; Kim HS; Xiao C; Xu X; Gavrilova O; Deng CX. 2011. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J Clin Invest 121(11):4477-90. [PubMed: 21965330] [MGI Ref ID J:178460]
Wang RH; Li C; Deng CX. 2010. Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition. Int J Biol Sci 6(7):682-90. [PubMed: 21103071] [MGI Ref ID J:179193]
Wang RH; Li C; Xu X; Zheng Y; Xiao C; Zerfas P; Cooperman S; Eckhaus M; Rouault T; Mishra L; Deng CX. 2005. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2(6):399-409. [PubMed: 16330325] [MGI Ref ID J:129666]
Wu Y; Brodt P; Sun H; Mejia W; Novosyadlyy R; Nunez N; Chen X; Mendoza A; Hong SH; Khanna C; Yakar S. 2010. Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis. Cancer Res 70(1):57-67. [PubMed: 20048072] [MGI Ref ID J:155733]
Xiao C; Wang RH; Lahusen TJ; Park O; Bertola A; Maruyama T; Reynolds D; Chen Q; Xu X; Young HA; Chen WJ; Gao B; Deng CX. 2012. Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J Biol Chem 287(50):41903-13. [PubMed: 23076146] [MGI Ref ID J:193418]
Xu X; Kobayashi S; Qiao W; Li C; Xiao C; Radaeva S; Stiles B; Wang RH; Ohara N; Yoshino T; LeRoith D; Torbenson MS; Gores GJ; Wu H; Gao B; Deng CX. 2006. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest 116(7):1843-52. [PubMed: 16767220] [MGI Ref ID J:111718]
Yakar S; Bouxsein ML; Canalis E; Sun H; Glatt V; Gundberg C; Cohen P; Hwang D; Boisclair Y; Leroith D; Rosen CJ. 2006. The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. J Endocrinol 189(2):289-99. [PubMed: 16648296] [MGI Ref ID J:108341]
Yakar S; Canalis E; Sun H; Mejia W; Kawashima Y; Nasser P; Courtland HW; Williams V; Bouxsein M; Rosen C; Jepsen KJ. 2009. Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactions. J Bone Miner Res 24(8):1481-92. [PubMed: 19257833] [MGI Ref ID J:168668]
Yakar S; Liu JL; Fernandez AM; Wu Y; Schally AV; Frystyk J; Chernausek SD; Mejia W; Le Roith D. 2001. Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity. Diabetes 50(5):1110-8. [PubMed: 11334415] [MGI Ref ID J:68986]
Yakar S; Rosen CJ; Beamer WG; Ackert-Bicknell CL; Wu Y; Liu JL; Ooi GT; Setser J; Frystyk J; Boisclair YR; LeRoith D. 2002. Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest 110(6):771-81. [PubMed: 12235108] [MGI Ref ID J:79109]
Yakar S; Setser J; Zhao H; Stannard B; Haluzik M; Glatt V; Bouxsein ML; Kopchick JJ; LeRoith D. 2004. Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice. J Clin Invest 113(1):96-105. [PubMed: 14702113] [MGI Ref ID J:87619]
Yang SH; Chang SY; Tu Y; Lawson GW; Bergo MO; Fong LG; Young SG. 2012. Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases. J Lipid Res 53(1):77-86. [PubMed: 22039581] [MGI Ref ID J:179405]
Yu R; Yakar S; Liu YL; Lu Y; LeRoith D; Miao D; Liu JL. 2003. Liver-specific IGF-I gene deficient mice exhibit accelerated diabetes in response to streptozotocin, associated with early onset of insulin resistance. Mol Cell Endocrinol 204(1-2):31-42. [PubMed: 12850279] [MGI Ref ID J:126277]
Zhang Y; Yin L; Anderson J; Ma H; Gonzalez FJ; Willson TM; Edwards PA. 2010. Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia. J Biol Chem 285(5):3035-43. [PubMed: 19996107] [MGI Ref ID J:159763]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX18
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, homozygous mice may be bred together. Mating System Noncarrier x Hemizygote (Female x Male) 01-MAY-12 Hemizygote x Noncarrier (Female x Male) 01-MAY-12 Diet Information LabDiet® 5K20
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for Tg(Alb1-cre)1Dlr
Price per Pair (US dollars $) Pair Genotype $302.00 Hemizygous for Tg(Alb1-cre)1Dlr x Noncarrier $302.00 Noncarrier x Hemizygous for Tg(Alb1-cre)1Dlr Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for Tg(Alb1-cre)1Dlr
Price per Pair (US dollars $) Pair Genotype $392.60 Hemizygous for Tg(Alb1-cre)1Dlr x Noncarrier $392.60 Noncarrier x Hemizygous for Tg(Alb1-cre)1Dlr Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
|
|
|
Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | (approximate) | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.