Strain Name:

BTBR T+ Itpr3tf-Fbxl3Ovtm/J

Stock Number:

016926

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Availability:

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The ENU induced mutation (Fbxl3Ovtm) on the BTBR inbred background results in an extended circadian period. These mice may be useful for studying circadian rhythm modulation.

Description

Strain Information

Former Names BTBR T+ tf-Fbxl3Ovtm/J    (Changed: 30-OCT-12 )
Type Chemically Induced Mutation; Coisogenic; Mutant Strain;
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Mating SystemHeterozygote x Heterozygote         (Female x Male)   16-DEC-11
Specieslaboratory mouse
Generation?+F4 (22-NOV-13)
Generation Definitions
 
Donating InvestigatorDr. Joseph S. Takahashi,   Univ Texas Southwestern Medical Ctr

Description
Ovtm ENU-induced mutants contain an A to G transition at nucleotide in exon 5 of the F-box and leucine-rich repeat protein 3 (Fbxl3) gene that defines an amino acid change from isoleucine to threonine at residue 364. While homozygous males are viable, fertile, and normal in size, homozygous females are viable and normal in size, but are often infertile. FBXL3 is part of the SKP1-CUL1-F-box-protein (SCF) ubiquitin protein ligase complex which mediates phosphorylation-dependent ubiquitination. Homozygotes have a long circadian period of ~26 hours. These mice may be useful for studying circadian rhythm modulation.

Development
Male BTBR T+ Itpr3tf/J mice (Stock No. 002282) were treated with N-ethyl-N-nitrosourea (ENU) and then bred to BTBR T+ Itpr3tf/J females. The resulting male pups were then bred to BTBR T+ Itpr3tf/J females to obtain second generation female mice, which were subsequently backcrossed to first generation males to obtain third generation mice. A mutagenesis screen was then performed to identify mutations that alter circadian periodicity. One of these mutants, with a 25.8 hour period length length segregates in autosomal semi-dominant-manner was termed Overtime (Ovtm). Further studies revealed the F-box and leucine-rich repeat protein 3 (Fbxl3) gene as a candidate gene for Ovtm. In Ovtm mice, Fbxl3 contains a A to G transition in exon 5 of the coding region that defines an amino acid change from isoleucine to threonine at residue 364. These mice have been backcrossed to BTBR T+ Itpr3tf/J prior to arrival at The Jackson Laboratory.

Control Information

  Control
   Heterozygote from the colony
   Wild-type from the colony
   002282 BTBR T+ Itpr3tf/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Itpr3tf     (5 strains)

Strains carrying   T+ allele
002282   BTBR T+ Itpr3tf/J
View Strains carrying   T+     (1 strain)

Strains carrying other alleles of Fbxl3
016168   B6;129S4-Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/JtJ
View Strains carrying other alleles of Fbxl3     (1 strain)

Strains carrying other alleles of Itpr3
013147   STOCK Itpr3tm1.1Rmnc/Mmjax
View Strains carrying other alleles of Itpr3     (1 strain)

View Strains carrying other alleles of T     (15 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Diabetes Mellitus, Insulin-Dependent; IDDM   (ITPR3)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Fbxl3Ovtm/Fbxl3+

        BTBR T+ Itpr3tf/Itpr3tf-Fbxl3Ovtm/Nwu
  • behavior/neurological phenotype
  • abnormal circadian period
    • heterozygous mutant mice display a longer free running period than that of wild-type mice (23.97 hrs vs.23.27 hrs 0.13 sd)   (MGI Ref ID J:83419)

Fbxl3Ovtm/Fbxl3Ovtm

        BTBR T+ Itpr3tf/Itpr3tf-Fbxl3Ovtm/Nwu
  • behavior/neurological phenotype
  • abnormal circadian period
    • homozygous mutant mice display a longer free running period than that of wild-type mice (25.88 hrs vs.23.27 hrs 0.13 sd)   (MGI Ref ID J:83419)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Fbxl3Ovtm/Fbxl3Ovtm

        involves: BTBR/J * C3H/HeJ * C57BL/6J
  • behavior/neurological phenotype
  • prolonged circadian period
    • circadian period is extended to 26.2 hours compared to 25.8 in wild-type mice   (MGI Ref ID J:122872)

Fbxl3Ovtm/Fbxl3Ovtm

        involves: BTBR * C57BL/6J
  • behavior/neurological phenotype
  • prolonged circadian period
    • period length is 26 hr   (MGI Ref ID J:194037)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cell Biology Research
Post-translational Processing

Neurobiology Research
Circadian Rhythms

Research Tools
Genetics Research
      Mutagenesis and Transgenesis: Production of Chemical Mutations

Itpr3tf related

Dermatology Research
Skin and Hair Texture Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Fbxl3Ovtm
Allele Name overtime
Allele Type Chemically induced (ENU)
Mutation Made ByDr. Joseph Takahashi,   Univ Texas Southwestern Medical Ctr
Strain of OriginBTBR T+ Itpr3tf/J
Gene Symbol and Name Fbxl3, F-box and leucine-rich repeat protein 3
Chromosome 14
Gene Common Name(s) AU041772; AW212966; F-box and leucine-rich repeat protein 3a; FBL3; FBL3A; FBXL3A; Fbxl3a; Ovtm; Play68; expressed sequence AU041772; expressed sequence AW212966; overtime; play 68;
Molecular Note This phenotypic mutant was identified in an ENU mutagenesis screen. Subsequently, a single A to G transition was identified in exon 5. This results in the conversion of amino acid residue 364 from isoleucine to threonine. [MGI Ref ID J:122872]
 
Allele Symbol Itpr3tf
Allele Name tufted
Allele Type Spontaneous
Common Name(s) tf;
Strain of OriginBTBR
Gene Symbol and Name Itpr3, inositol 1,4,5-triphosphate receptor 3
Chromosome 17
Gene Common Name(s) IP3R; IP3R3; IP3R3X; Ip3r3; Itpr-3; inositol 1,4,5-triphosphate receptor, type III; tf; tufted;
General Note This allele was recovered from a Harwell testing stock carrying multiple recessive markers in an undefined background. (J:273)
Molecular Note Complementation mapping was used to demonstrate that this spontaneous mutation was an allele of Itpr3. Sequencing revealed a 12 bp deletion in Exon23 (Chr17: 27238069, Build 38.1) which codes for amino acids 983-986. This mutation arose early in the history of the BTBR strain (in or soon after 1956) and is not found in 18 other strains (129P2/OlaHsd, 129S1/SvImJ, 129S5/SvEvBrd, A/J, AKR/J, BALB/cJ, C3H/HeJ, C57BL/6NJ, CAST/EiJ, CBA/J, DBA/2J, FVB/NJ, LP/J, NOD/ShiLtJ, NZO/HlLtJ, PWK/PhJ, SPRET/EiJ and WSB/EiJ) [MGI Ref ID J:188251] [MGI Ref ID J:201643]
 
Allele Symbol T+
Allele Name wild type
Allele Type Not Applicable
Gene Symbol and Name T, brachyury
Chromosome 17
Gene Common Name(s) Bra; Low; Lr; SAVA; T1; TFT; Tl2; Tl3; brachyury-like 2; brachyury-like 3; cou; coupe; low ratio;

Genotyping

Genotyping Information

Genotyping Protocols

Fbxl3Ovtm, Pyrosequencing
Fbxl3Ovtm-ARMS-alternate2, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Center for Functional Genomics (CFG) at Northwestern University. 2003. Heritable mouse mutants from Neurogenomics Project at Northwestern University MGI Direct Data Submission :.  [MGI Ref ID J:83419]

Additional References

Fbxl3Ovtm related

Shi G; Xing L; Liu Z; Qu Z; Wu X; Dong Z; Wang X; Gao X; Huang M; Yan J; Yang L; Liu Y; Ptacek LJ; Xu Y. 2013. Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock. Proc Natl Acad Sci U S A 110(12):4750-5. [PubMed: 23471982]  [MGI Ref ID J:194250]

Siepka SM; Yoo SH; Park J; Song W; Kumar V; Hu Y; Lee C; Takahashi JS. 2007. Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell 129(5):1011-23. [PubMed: 17462724]  [MGI Ref ID J:122872]

Yoo SH; Mohawk JA; Siepka SM; Shan Y; Huh SK; Hong HK; Kornblum I; Kumar V; Koike N; Xu M; Nussbaum J; Liu X; Chen Z; Chen ZJ; Green CB; Takahashi JS. 2013. Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm. Cell 152(5):1091-105. [PubMed: 23452855]  [MGI Ref ID J:194037]

Itpr3tf related

Amodeo DA; Jones JH; Sweeney JA; Ragozzino ME. 2012. Differences in BTBR T+ tf/J and C57BL/6J mice on probabilistic reversal learning and stereotyped behaviors. Behav Brain Res 227(1):64-72. [PubMed: 22056750]  [MGI Ref ID J:180186]

Borthwell RM; Hunsaker MR; Willemsen R; Berman RF. 2012. Spatiotemporal processing deficits in female CGG KI mice modeling the fragile X premutation. Behav Brain Res 233(1):29-34. [PubMed: 22561129]  [MGI Ref ID J:190501]

Crabbe JC; Cotnam CJ; Cameron AJ; Schlumbohm JP; Rhodes JS; Metten P; Wahlsten D. 2003. Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain Behav 2(4):201-13. [PubMed: 12953786]  [MGI Ref ID J:104878]

Defensor EB; Pearson BL; Pobbe RL; Bolivar VJ; Blanchard DC; Blanchard RJ. 2011. A novel social proximity test suggests patterns of social avoidance and gaze aversion-like behavior in BTBR T+ tf/J mice. Behav Brain Res 217(2):302-8. [PubMed: 21055421]  [MGI Ref ID J:167352]

Ellis HT; Tordoff MG; Parker MR. 2012. Itpr3 Is Responsible for the Mouse Tufted (tf) Locus. J Hered :. [PubMed: 23100490]  [MGI Ref ID J:188251]

Han S; Tai C; Jones CJ; Scheuer T; Catterall WA. 2014. Enhancement of inhibitory neurotransmission by GABAA receptors having alpha2,3-subunits ameliorates behavioral deficits in a mouse model of autism. Neuron 81(6):1282-9. [PubMed: 24656250]  [MGI Ref ID J:213173]

Heo Y; Zhang Y; Gao D; Miller VM; Lawrence DA. 2011. Aberrant immune responses in a mouse with behavioral disorders. PLoS One 6(7):e20912. [PubMed: 21799730]  [MGI Ref ID J:174928]

Karunakaran S; Manji A; Yan CS; Wu ZJ; Clee SM. 2013. Moo1 obesity quantitative trait locus in BTBR T+ Itpr3tf/J mice increases food intake. Physiol Genomics 45(5):191-9. [PubMed: 23341217]  [MGI Ref ID J:195220]

Kusek GK; Wahlsten D; Herron BJ; Bolivar VJ; Flaherty L. 2007. Localization of two new X-linked quantitative trait loci controlling corpus callosum size in the mouse. Genes Brain Behav 6(4):359-63. [PubMed: 16899052]  [MGI Ref ID J:137289]

Lyon MF. 1996. An additional type of male sterility and inherited urinary obstruction in mice with the t-haplotype th7. Genet Res 67(3):249-56. [PubMed: 8690273]  [MGI Ref ID J:34190]

Lyon MF. 1956. Hereditary hair loss in the tufted mutant of the house mouse J Hered 47:101-3.  [MGI Ref ID J:273]

Lyon MF; Bechtol KB. 1977. Derivation of mutant t-haplotypes of the mouse by presumed duplication or deletion. Genet Res 30(1):63-76. [PubMed: 924142]  [MGI Ref ID J:5889]

MacPherson P; McGaffigan R; Wahlsten D; Nguyen PV. 2008. Impaired fear memory, altered object memory and modified hippocampal synaptic plasticity in split-brain mice. Brain Res 1210:179-88. [PubMed: 18417102]  [MGI Ref ID J:136821]

McFarlane HG; Kusek GK; Yang M; Phoenix JL; Bolivar VJ; Crawley JN. 2008. Autism-like behavioral phenotypes in BTBR T+tf/J mice. Genes Brain Behav 7(2):152-63. [PubMed: 17559418]  [MGI Ref ID J:138842]

Mercier F; Cho Kwon Y; Kodama R. 2011. Meningeal/vascular alterations and loss of extracellular matrix in the neurogenic zone of adult BTBR T+ tf/J mice, animal model for autism. Neurosci Lett 498(3):173-8. [PubMed: 21600960]  [MGI Ref ID J:174319]

Mercier F; Kwon YC; Douet V. 2012. Hippocampus/amygdala alterations, loss of heparan sulfates, fractones and ventricle wall reduction in adult BTBR T+ tf/J mice, animal model for autism. Neurosci Lett 506(2):208-13. [PubMed: 22100909]  [MGI Ref ID J:180372]

Meyza KZ; Blanchard DC; Pearson BL; Pobbe RL; Blanchard RJ. 2012. Fractone-associated N-sulfated heparan sulfate shows reduced quantity in BTBR T+tf/J mice: a strong model of autism. Behav Brain Res 228(2):247-53. [PubMed: 22101175]  [MGI Ref ID J:181751]

MouseBookTM. 2005. Information obtained from MouseBook<sup>TM</sup>, Medical Research Council Mammalian Genetics Unit, Harwell, UK. Unpublished :.  [MGI Ref ID J:169366]

Pearson BL; Bettis JK; Meyza KZ; Yamamoto LY; Blanchard DC; Blanchard RJ. 2012. Absence of social conditioned place preference in BTBR T+tf/J mice: relevance for social motivation testing in rodent models of autism. Behav Brain Res 233(1):99-104. [PubMed: 22562042]  [MGI Ref ID J:190500]

Pearson BL; Pobbe RL; Defensor EB; Oasay L; Bolivar VJ; Blanchard DC; Blanchard RJ. 2011. Motor and cognitive stereotypies in the BTBR T+tf/J mouse model of autism. Genes Brain Behav 10(2):228-35. [PubMed: 21040460]  [MGI Ref ID J:183514]

Rutz HL; Rothblat LA. 2012. Intact and impaired executive abilities in the BTBR mouse model of autism. Behav Brain Res 234(1):33-7. [PubMed: 22677272]  [MGI Ref ID J:190470]

Sato-Miyaoka M; Hisatsune C; Ebisui E; Ogawa N; Takahashi-Iwanaga H; Mikoshiba K. 2012. Regulation of hair shedding by the type 3 IP3 receptor. J Invest Dermatol 132(9):2137-47. [PubMed: 22572820]  [MGI Ref ID J:188252]

Scattoni ML; Gandhy SU; Ricceri L; Crawley JN. 2008. Unusual repertoire of vocalizations in the BTBR T+tf/J mouse model of autism. PLoS ONE 3(8):e3067. [PubMed: 18728777]  [MGI Ref ID J:138605]

Scattoni ML; Ricceri L; Crawley JN. 2011. Unusual repertoire of vocalizations in adult BTBR T+tf/J mice during three types of social encounters. Genes Brain Behav 10(1):44-56. [PubMed: 20618443]  [MGI Ref ID J:183525]

Silver LM; Cisek L; Jackson C; Lukralle D. 1985. A new spontaneous mutation at the tufted locus within a mouse t haplotype. Genet Res 45(1):107-12. [PubMed: 3996911]  [MGI Ref ID J:7861]

Silverman JL; Smith DG; Rizzo SJ; Karras MN; Turner SM; Tolu SS; Bryce DK; Smith DL; Fonseca K; Ring RH; Crawley JN. 2012. Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism. Sci Transl Med 4(131):131ra51. [PubMed: 22539775]  [MGI Ref ID J:183984]

Silverman JL; Yang M; Turner SM; Katz AM; Bell DB; Koenig JI; Crawley JN. 2010. Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism. Neuroscience 171(4):1197-208. [PubMed: 20888890]  [MGI Ref ID J:170182]

Tordoff MG; Ellis HT. 2013. Taste dysfunction in BTBR mice due to a mutation of Itpr3, the inositol triphosphate receptor 3 gene. Physiol Genomics 45(18):834-55. [PubMed: 23859941]  [MGI Ref ID J:201643]

Wohr M; Roullet FI; Crawley JN. 2011. Reduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism. Genes Brain Behav 10(1):35-43. [PubMed: 20345893]  [MGI Ref ID J:183527]

Yang M; Clarke AM; Crawley JN. 2009. Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability. Eur J Neurosci 29(8):1663-77. [PubMed: 19419429]  [MGI Ref ID J:148483]

Zou H; Yu Y; Sheikh AM; Malik M; Yang K; Wen G; Chadman KK; Brown WT; Li X. 2011. Association of upregulated Ras/Raf/ERK1/2 signaling with autism. Genes Brain Behav 10(5):615-24. [PubMed: 21595826]  [MGI Ref ID J:185685]

T+ related

Abe K; Yamamura K; Suzuki M. 2000. Molecular and embryological characterization of a new transgene-induced null allele of mouse Brachyury locus. Mamm Genome 11(3):238-40. [PubMed: 10723731]  [MGI Ref ID J:60706]

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Bilinski P; Schimenti J; Gossler A. 1997. A new spontaneous deletion on chromosome 17 including brachyury. Mamm Genome 8(12):932-3. [PubMed: 9383288]  [MGI Ref ID J:44446]

Bogani D; Siggers P; Brixey R; Warr N; Beddow S; Edwards J; Williams D; Wilhelm D; Koopman P; Flavell RA; Chi H; Ostrer H; Wells S; Cheeseman M; Greenfield A. 2009. Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol 7(9):e1000196. [PubMed: 19753101]  [MGI Ref ID J:153050]

Bogani D; Warr N; Elms P; Davies J; Tymowska-Lalanne Z; Goldsworthy M; Cox RD; Keays DA; Flint J; Wilson V; Nolan P; Arkell R. 2004. New semidominant mutations that affect mouse development. Genesis 40(2):109. [PubMed: 15384171]  [MGI Ref ID J:93195]

Bucan M; Herrmann BG; Frischauf AM; Bautch VL; Bode V; Silver LM; Martin GR; Lehrach H. 1987. Deletion and duplication of DNA sequences is associated with the embryonic lethal phenotype of the t9 complementation group of the mouse t complex. Genes Dev 1(4):376-85. [PubMed: 3678828]  [MGI Ref ID J:8922]

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Dunn LC; Bennett D. 1971. Lethal alleles near locus T in the house mouse population on the Jutland Peninsula, Denmark Evolution 25(3):451-53.  [MGI Ref ID J:175677]

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Lyon MF. 1959. A new dominant T-allele in the house mouse. J Hered 50:140-142.  [MGI Ref ID J:13072]

Lyon MF. 1996. An additional type of male sterility and inherited urinary obstruction in mice with the t-haplotype th7. Genet Res 67(3):249-56. [PubMed: 8690273]  [MGI Ref ID J:34190]

Lyon MF. 1990. Search for differences among t haplotypes in distorter and responder genes. Genet Res 55(1):13-9. [PubMed: 2318411]  [MGI Ref ID J:192386]

Lyon MF. 1984. Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell 37(2):621-8. [PubMed: 6722884]  [MGI Ref ID J:7443]

Lyon MF; Bechtol KB. 1977. Derivation of mutant t-haplotypes of the mouse by presumed duplication or deletion. Genet Res 30(1):63-76. [PubMed: 924142]  [MGI Ref ID J:5889]

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The RIKEN BioResource Center. 2006. Information obtained from The RIKEN BioResource Center Unpublished :.  [MGI Ref ID J:104881]

Vojtiskova M; Viklicky V; Voracova B; Lewis SE; Gluecksohn-Waelsch S. 1976. The effects of a t-allele (tAE5) in the mouse on the lymphoid system and reproduction. J Embryol Exp Morphol 36(2):443-51. [PubMed: 1003081]  [MGI Ref ID J:83862]

Washburn LL; Albrecht KH; Eicher EM. 2001. C57BL/6J-T-Associated Sex Reversal in Mice Is Caused by Reduced Expression of a Mus domesticus Sry Allele. Genetics 158(4):1675-81. [PubMed: 11514455]  [MGI Ref ID J:71077]

Washburn LL; Lee BK; Eicher EM. 1990. Inheritance of T-associated sex reversal in mice. Genet Res 56(2-3):185-91. [PubMed: 2272509]  [MGI Ref ID J:10943]

Wu B; Shao Y; Chen B; Liu C; Xue Z; Wu P; Li H. 2010. Identification of a novel mouse brachyury (T) allele causing a short tail mutation in mice. Cell Biochem Biophys 58(3):129-35. [PubMed: 20809182]  [MGI Ref ID J:166619]

Wutz A; Theussl HC; Dausman J; Jaenisch R; Barlow DP; Wagner EF. 2001. Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice. Development 128(10):1881-7. [PubMed: 11311167]  [MGI Ref ID J:68721]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX18

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, heterozygous females may be bred to homozygous males. The donating investigator reports that homozygous females are often infertile.
Mating SystemHeterozygote x Heterozygote         (Female x Male)   16-DEC-11
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHeterozygous for Fbxl3Ovtm  
$239.00Female or MaleHomozygous for Fbxl3Ovtm  
Price per Pair (US dollars $)Pair Genotype
$478.00Heterozygous for Fbxl3Ovtm x Heterozygous for Fbxl3Ovtm  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHeterozygous for Fbxl3Ovtm  
$310.70Female or MaleHomozygous for Fbxl3Ovtm  
Price per Pair (US dollars $)Pair Genotype
$621.40Heterozygous for Fbxl3Ovtm x Heterozygous for Fbxl3Ovtm  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   Heterozygote from the colony
   Wild-type from the colony
   002282 BTBR T+ Itpr3tf/J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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