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Common Names: CAGGCre-ERTM;    
These CAGGCre-ERTM transgenic mice have widespread expression of a tamoxifen-inducible Cre recombinase.


Strain Information

Type Congenic; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemInbred x Hemizygote         (Female x Male)   23-JAN-12
Mating SystemHemizygote x Inbred         (Female x Male)   05-MAR-13
Specieslaboratory mouse
GenerationN10 (17-JUN-15)
Generation Definitions
Donating Investigator IMR Colony,   The Jackson Laboratory

These CAGGCre-ERTM transgenic mice have a tamoxifen-inducible cre-mediated recombination system driven by the chicken beta actin promoter/enhancer coupled with the cytomegalovirus (CMV) immediate-early enhancer. When bred with mice containing loxP-flanked sequences, tamoxifen-inducible Cre-mediated recombination results in deletion of the floxed sequences in widespread cells/tissues of the offspring. Tamoxifen administration will also induce Cre recombination in developing embryos of treated mothers and in cultured cells derived from transgenic mice. Homozygous mice are not viable or fertile. Heterozygous mutant mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.

The CreERTM fusion protein consists of Cre recombinase fused to a G525R mutant form of the mouse estrogen receptor; which does not bind its natural ligand (17β-estradiol) at physiological concentrations but will bind the synthetic estrogen receptor ligands 4-hydroxytamoxifen (OHT or tamoxifen) and, with lesser sensitivity, ICI 182780. Restricted to the cytoplasm, Cre-ERT can only gain access to the nuclear compartment after exposure to tamoxifen. To counteract the mixed estrogen agonist effects of tamoxifen injections, which can result in late fetal abortions in pregnant mice, progesterone may be coadministered.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for these FVB/N-congenic CAGGCre-ERTM mice. It should be noted that the phenotype of these mice could vary from that originally described. We may modify the FVB/N-congenic CAGGCre-ERTM strain description if necessary as published results become available.

The pCAGGCre-ERTM transgene was designed with the CMV-IE enhancer/chicken β-actin/rabbit β-globin hybrid promoter (CAG; originally from the pCAGGS vector) and CreERTM fusion gene (CreERTM; Cre recombinase fused to a G525R mutant form of the mouse estrogen receptor ligand binding domain). The transgene was introduced into B6CBF1 donor eggs. The resulting transgenic males were backcrossed for two generations on the SWR background. In 2002, transgenic mice were sent to The Jackson Laboratory Repository (as Stock No. 004453). In 2003, some of the transgenic mice were backcrossed to C57BL/6J inbred mice (Stock No. 000664) for at least five generations to generate a C57BL/6J-congenic line (Stock No. 004682). In 2012, some of the C57BL/6J-congenic mice were subsequently backcrossed to FVB/NJ inbred mice (Stock No. 001800) for several generations using a marker-assisted, speed congenic approach to generate this FVB/NJ-congenic strain (Stock No. 017595).

Control Information

   001800 FVB/NJ
  Considerations for Choosing Controls

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View Spinal Muscular Atrophy (SMA) Models     (57 strains)

View Strains carrying   Tg(CAG-cre/Esr1*)5Amc     (5 strains)

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View Strains carrying other alleles of cre/Esr1     (10 strains)

Additional Web Information

Introduction to Cre-lox technology


Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.


        involves: C57BL/6 * CBA
  • tumorigenesis
  • *normal* tumorigenesis
    • no tumors are observed up to 12 months of age   (MGI Ref ID J:114992)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cre-lox System
      Cre Recombinase Expression
      Cre Recombinase Expression: Inducible
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Tg(CAG-cre/Esr1*)5Amc
Allele Name transgene insertion 5, Andrew P McMahon
Allele Type Transgenic (Inducible, cre- or Flp-expressing)
Common Name(s) CAG-CreERT2; CAGG-Cre; CAGG-CreERT2; CAGGCre-ER; CAGGCre-ERTM; CAGGCre-ERtm line 5.8; CAGGS-CreER; CAGGS-CreErT; CMV-creERT; CaggCreER; Cre-ER; Cre-ERTM; CreESRT; ER-cre; Tg(CAG-cre/Esr1)5Amc; Tg(cre/Esr1)5Amc; TgCreER; TgCAGGCreER; uCreERT;
Mutation Made By Shigemi Hayashi,   Columbia University
Strain of Origin(C57BL/6 x CBA)F1
Site of Expressiontamoxifen-inducible cre; widespread pattern of expression; tamoxifen administration will also induce Cre recombination in developing embryos of treated mothers and in cultured cells derived from transgenic mice
Expressed Gene cre/Esr1, Cre recombinase and estrogen receptor 1 fusion gene,
Promoter ACTB, actin, beta, chicken
Driver Note CAG
General Note Homozygous transgenic mice are not viable or fertile. Hemizygous transgenic mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.

In transgenic mice the mutant mouse estrogen receptor does not bind natural ligand at physiological concentrations but will bind the synthetic ligand, 4-hydroxytamoxifen. Restricted to the cytoplasm, the Cre/Esr1 fusion protein can only gain access to the nuclear compartment after exposure to tamoxifen. When crossed with a strain containing loxP sites flanking a sequence of interest, tamoxifen induced, Cre-mediated targeted deletions are generated in the offspring. Tamoxifen administration will induce Cre recombination in developing embryos of treated mothers and in cultured cells derived from transgenic mice.

Inducible Note Induced by tamoxifen.
Molecular Note This transgene expresses a fusion protein consisting of Cre recombinase joined to the ligand-binding domain of a mouse estrogen receptor modified to bind to 4-hydroxytamoxifen, but not to endogenous estrogen. The CAG promoter, containing a chicken beta actin promoter/enhancer coupled with the cytomegalovirus immediate-early (CMV-IE) enhancer, drives high levels of expression in most tissues. In the presence of tamoxifen, the fusion protein is transported into the nucleus, where cre can excise loxP-flanked segments from conditionally modified genes. [MGI Ref ID J:76130]


Genotyping Information

Genotyping Protocols

Generic Cre Melt Curve Analysis, Probe
Generic Cre, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Hayashi S; McMahon AP. 2002. Efficient recombination in diverse tissues by a tamoxifen-inducible form of cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol 244(2):305-18. [PubMed: 11944939]  [MGI Ref ID J:76130]

Additional References

Tg(CAG-cre/Esr1*)5Amc related

Bale LK; Chakraborty S; Conover CA. 2014. Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice. Endocrinology 155(4):1184-7. [PubMed: 24506074]  [MGI Ref ID J:210171]

Basch ML; Ohyama T; Segil N; Groves AK. 2011. Canonical Notch Signaling Is Not Necessary for Prosensory Induction in the Mouse Cochlea: Insights from a Conditional Mutant of RBPj{kappa}. J Neurosci 31(22):8046-58. [PubMed: 21632926]  [MGI Ref ID J:173382]

Batlle R; Alba-Castellon L; Loubat-Casanovas J; Armenteros E; Franci C; Stanisavljevic J; Banderas R; Martin-Caballero J; Bonilla F; Baulida J; Casal JI; Gridley T; Garcia de Herreros A. 2013. Snail1 controls TGF-beta responsiveness and differentiation of mesenchymal stem cells. Oncogene 32(28):3381-9. [PubMed: 22869142]  [MGI Ref ID J:199985]

Beedle AM; Turner AJ; Saito Y; Lueck JD; Foltz SJ; Fortunato MJ; Nienaber PM; Campbell KP. 2012. Mouse fukutin deletion impairs dystroglycan processing and recapitulates muscular dystrophy. J Clin Invest 122(9):3330-42. [PubMed: 22922256]  [MGI Ref ID J:187144]

Berbari NF; Pasek RC; Malarkey EB; Yazdi SM; McNair AD; Lewis WR; Nagy TR; Kesterson RA; Yoder BK. 2013. Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice. Proc Natl Acad Sci U S A 110(19):7796-801. [PubMed: 23599282]  [MGI Ref ID J:197356]

Berezniuk I; Sironi JJ; Wardman J; Pasek RC; Berbari NF; Yoder BK; Fricker LD. 2013. Quantitative peptidomics of Purkinje cell degeneration mice. PLoS One 8(4):e60981. [PubMed: 23593366]  [MGI Ref ID J:200027]

Bhaskara S; Chyla BJ; Amann JM; Knutson SK; Cortez D; Sun ZW; Hiebert SW. 2008. Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell 30(1):61-72. [PubMed: 18406327]  [MGI Ref ID J:134665]

Bialecka M; Young T; Chuva de Sousa Lopes S; ten Berge D; Sanders A; Beck F; Deschamps J. 2012. Cdx2 contributes to the expansion of the early primordial germ cell population in the mouse. Dev Biol 371(2):227-34. [PubMed: 22960234]  [MGI Ref ID J:190539]

Braunger BM; Leimbeck SV; Schlecht A; Volz C; Jagle H; Tamm ER. 2015. Deletion of Ocular Transforming Growth Factor beta Signaling Mimics Essential Characteristics of Diabetic Retinopathy. Am J Pathol 185(6):1749-68. [PubMed: 25857227]  [MGI Ref ID J:221181]

Brenner-Anantharam A; Cebrian C; Guillaume R; Hurtado R; Sun TT; Herzlinger D. 2007. Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling. Development 134(10):1967-75. [PubMed: 17442697]  [MGI Ref ID J:121412]

Briggs LE; Takeda M; Cuadra AE; Wakimoto H; Marks MH; Walker AJ; Seki T; Oh SP; Lu JT; Sumners C; Raizada MK; Horikoshi N; Weinberg EO; Yasui K; Ikeda Y; Chien KR; Kasahara H. 2008. Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects. Circ Res 103(6):580-90. [PubMed: 18689573]  [MGI Ref ID J:143802]

Brower CS; Varshavsky A. 2009. Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations. PLoS One 4(11):e7757. [PubMed: 19915679]  [MGI Ref ID J:155421]

Brydges SD; Broderick L; McGeough MD; Pena CA; Mueller JL; Hoffman HM. 2013. Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies. J Clin Invest :. [PubMed: 24084736]  [MGI Ref ID J:203992]

Brydges SD; Mueller JL; McGeough MD; Pena CA; Misaghi A; Gandhi C; Putnam CD; Boyle DL; Firestein GS; Horner AA; Soroosh P; Watford WT; O'Shea JJ; Kastner DL; Hoffman HM. 2009. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30(6):875-87. [PubMed: 19501000]  [MGI Ref ID J:150054]

Bumaschny VF; Yamashita M; Casas-Cordero R; Otero-Corchon V; de Souza FS; Rubinstein M; Low MJ. 2012. Obesity-programmed mice are rescued by early genetic intervention. J Clin Invest 122(11):4203-12. [PubMed: 23093774]  [MGI Ref ID J:194013]

Bunnell TM; Burbach BJ; Shimizu Y; Ervasti JM. 2011. beta-Actin specifically controls cell growth, migration, and the G-actin pool. Mol Biol Cell 22(21):4047-58. [PubMed: 21900491]  [MGI Ref ID J:183016]

Burgess K; Xu T; Brown R; Han B; Welle S. 2011. Effect of myostatin depletion on weight gain, hyperglycemia, and hepatic steatosis during five months of high-fat feeding in mice. PLoS One 6(2):e17090. [PubMed: 21390326]  [MGI Ref ID J:171042]

Burnley P; Rahman M; Wang H; Zhang Z; Sun X; Zhuge Q; Su DM. 2013. Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging. Cell Death Dis 4:e932. [PubMed: 24263106]  [MGI Ref ID J:205598]

Cai J; Chen Y; Cai WH; Hurlock EC; Wu H; Kernie SG; Parada LF; Lu QR. 2007. A crucial role for Olig2 in white matter astrocyte development. Development 134(10):1887-99. [PubMed: 17428828]  [MGI Ref ID J:121422]

Carotta S; Dakic A; D'Amico A; Pang SH; Greig KT; Nutt SL; Wu L. 2010. The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner. Immunity 32(5):628-41. [PubMed: 20510871]  [MGI Ref ID J:160816]

Cerani A; Tetreault N; Menard C; Lapalme E; Patel C; Sitaras N; Beaudoin F; Leboeuf D; De Guire V; Binet F; Dejda A; Rezende FA; Miloudi K; Sapieha P. 2013. Neuron-derived semaphorin 3A is an early inducer of vascular permeability in diabetic retinopathy via neuropilin-1. Cell Metab 18(4):505-18. [PubMed: 24093675]  [MGI Ref ID J:206005]

Chan G; Kalaitzidis D; Usenko T; Kutok JL; Yang W; Mohi MG; Neel BG. 2009. Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis. Blood 113(18):4414-24. [PubMed: 19179468]  [MGI Ref ID J:148430]

Chan SY; Zhang YY; Hemann C; Mahoney CE; Zweier JL; Loscalzo J. 2009. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab 10(4):273-84. [PubMed: 19808020]  [MGI Ref ID J:153662]

Chandana EP; Maeda Y; Ueda A; Kiyonari H; Oshima N; Yamamoto M; Kondo S; Oh J; Takahashi R; Yoshida Y; Kawashima S; Alexander DB; Kitayama H; Takahashi C; Tabata Y; Matsuzaki T; Noda M. 2010. Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice. BMC Dev Biol 10:84. [PubMed: 20691046]  [MGI Ref ID J:163845]

Chang H; Gao F; Guillou F; Taketo MM; Huff V; Behringer RR. 2008. Wt1 negatively regulates {beta}-catenin signaling during testis development. Development 135(10):1875-85. [PubMed: 18403409]  [MGI Ref ID J:134687]

Chang I; Bramall AN; Baynash AG; Rattner A; Rakheja D; Post M; Joza S; McKerlie C; Stewart DJ; McInnes RR; Yanagisawa M. 2013. Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest 123(6):2643-53. [PubMed: 23676500]  [MGI Ref ID J:201436]

Chen JA; Huang YP; Mazzoni EO; Tan GC; Zavadil J; Wichterle H. 2011. Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop. Neuron 69(4):721-35. [PubMed: 21338882]  [MGI Ref ID J:174745]

Chen L; Mupo A; Huynh T; Cioffi S; Woods M; Jin C; McKeehan W; Thompson-Snipes L; Baldini A; Illingworth E. 2010. Tbx1 regulates Vegfr3 and is required for lymphatic vessel development. J Cell Biol 189(3):417-24. [PubMed: 20439995]  [MGI Ref ID J:159824]

Chen M; Wang X; Wang Y; Zhang L; Xu B; Lv L; Cui X; Li W; Gao F. 2014. Wt1 is involved in leydig cell steroid hormone biosynthesis by regulating paracrine factor expression in mice. Biol Reprod 90(4):71. [PubMed: 24571983]  [MGI Ref ID J:210334]

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Sun S; Shi G; Han X; Francisco AB; Ji Y; Mendonca N; Liu X; Locasale JW; Simpson KW; Duhamel GE; Kersten S; Yates JR 3rd; Long Q; Qi L. 2014. Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. Proc Natl Acad Sci U S A 111(5):E582-91. [PubMed: 24453213]  [MGI Ref ID J:206568]

Surzenko N; Crowl T; Bachleda A; Langer L; Pevny L. 2013. SOX2 maintains the quiescent progenitor cell state of postnatal retinal Muller glia. Development 140(7):1445-56. [PubMed: 23462474]  [MGI Ref ID J:194918]

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Suzuki N; Kunishima S; Ikejiri M; Maruyama S; Sone M; Takagi A; Ikawa M; Okabe M; Kojima T; Saito H; Naoe T; Matsushita T. 2013. Establishment of mouse model of MYH9 disorders: heterozygous R702C mutation provokes macrothrombocytopenia with leukocyte inclusion bodies, renal glomerulosclerosis and hearing disability. PLoS One 8(8):e71187. [PubMed: 23976996]  [MGI Ref ID J:204923]

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Xue Y; Lim S; Yang Y; Wang Z; Jensen LD; Hedlund EM; Andersson P; Sasahara M; Larsson O; Galter D; Cao R; Hosaka K; Cao Y. 2012. PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells. Nat Med 18(1):100-10. [PubMed: 22138754]  [MGI Ref ID J:180808]

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Yang B; Zhao D; Qian L; Verkman AS. 2006. Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion. Am J Physiol Renal Physiol 291(2):F465-72. [PubMed: 16434568]  [MGI Ref ID J:110648]

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Yang X; Harkins LK; Zubanova O; Harrington A; Kovalenko D; Nadeau RJ; Chen PY; Toher JL; Lindner V; Liaw L; Friesel R. 2008. Overexpression of Spry1 in chondrocytes causes attenuated FGFR ubiquitination and sustained ERK activation resulting in chondrodysplasia. Dev Biol 321(1):64-76. [PubMed: 18582454]  [MGI Ref ID J:138616]

Yasuhara R; Ohta Y; Yuasa T; Kondo N; Hoang T; Addya S; Fortina P; Pacifici M; Iwamoto M; Enomoto-Iwamoto M. 2011. Roles of beta-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells. Lab Invest 91(12):1739-52. [PubMed: 21968810]  [MGI Ref ID J:180101]

Yingling J; Youn YH; Darling D; Toyo-Oka K; Pramparo T; Hirotsune S; Wynshaw-Boris A. 2008. Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division. Cell 132(3):474-86. [PubMed: 18267077]  [MGI Ref ID J:135521]

Youn YH; Pramparo T; Hirotsune S; Wynshaw-Boris A. 2009. Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice. J Neurosci 29(49):15520-30. [PubMed: 20007476]  [MGI Ref ID J:156181]

Young AP; Schlisio S; Minamishima YA; Zhang Q; Li L; Grisanzio C; Signoretti S; Kaelin WG Jr. 2008. VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400. Nat Cell Biol 10(3):361-9. [PubMed: 18297059]  [MGI Ref ID J:145670]

Yu L; Su B; Hollomon M; Deng Y; Facchinetti V; Kleinerman ES. 2010. Vasculogenesis Driven by Bone Marrow-Derived Cells Is Essential for Growth of Ewing's Sarcomas. Cancer Res 70(4):1334-43. [PubMed: 20124484]  [MGI Ref ID J:157154]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryThese mice were bred to FVB/NJ inbred mice (Stock No. 001800) for many generations using a marker-assisted, speed congenic approach to generate this FVB/NJ-congenic strain. When maintaining the live congenic colony, carrier mice may be bred with wildtype (noncarrier) mice from the colony or with FVB/NJ inbred mice.
Mating SystemInbred x Hemizygote         (Female x Male)   23-JAN-12
Hemizygote x Inbred         (Female x Male)   05-MAR-13

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHemizygous for Tg(CAG-cre/Esr1*)5Amc  
Price per Pair (US dollars $)Pair Genotype
$313.00Hemizygous for Tg(CAG-cre/Esr1*)5Amc x Noncarrier  
$313.00Noncarrier x Hemizygous for Tg(CAG-cre/Esr1*)5Amc  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHemizygous for Tg(CAG-cre/Esr1*)5Amc  
Price per Pair (US dollars $)Pair Genotype
$406.90Hemizygous for Tg(CAG-cre/Esr1*)5Amc x Noncarrier  
$406.90Noncarrier x Hemizygous for Tg(CAG-cre/Esr1*)5Amc  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   001800 FVB/NJ
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Mice are subject to US Patent 6040430.

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.