Strain Name:

STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#aAhmb/J

Stock Number:

017596

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Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use
These Tg(SMN2)89; Smn1+/-; Tg(SMNΔ7)4299; ROSA26rtTA; "old" Luci-TRE-SMN mice allow high levels of both luciferase and full-length human SMN expression to be regulated by the addition/removal of doxycycline. These may be useful as a fluorescent reporter and/or Tet-On/Tet-Off tool strain for doxycycline-inducible rescue of Type II (moderate) proximal spinal muscular atrophy (SMA).

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Smn1tm1Msd Tg(SMN2)89Ahmb Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#aAhmb/J    (Changed: 18-JUL-13 )
STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Smn1tm1Msd Tg(SMN2)89Ahmb Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN,-luc)#Ahmb/J    (Changed: 24-MAY-12 )
Type Mutant Stock; Targeted Mutation; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Specieslaboratory mouse
Generation+pN1
Generation Definitions
 
Donating Investigator Arthur H.M. Burghes,   The Ohio State University

Description
These Tg(SMN2)89; Smn1+/-; Tg(SMNΔ7)4299; ROSA26rtTA; "old" Luci-TRE-SMN mice harbor multiple mutations/transgenes.
The moderate Type II SMA mouse model (see Stock No. 005025) is defined by mice homozygous for the Tg(SMN2)89 transgene (SMN2+/+), homozygous for the Smn1tm1Msd mutation (Smn1-/-), and homozygous for the Tg(SMNΔ7)4299 transgene (SMNΔ7+/+). At birth, SMN2+/+; Smn1-/-; SMNΔ7+/+ mice are small with neuromuscular defects by 5 days old that progress to abnormal gait, hind limb weakness/immobility, and eventually death at approximately 13 days of age.
The ROSA26rtTA targeted mutation results in widespread reverse tetracycline transactivator (rtTA)-expression. The Luci-TRE-SMN transgene has expression of both luciferase and a full-length (exons 1-8) human SMN under the control of a bi-directional tet-responsive promoter. When together in mice, addition of doxycycline (dox) results in widespread and simultaneous expression of luciferase and full-length human SMN expression. When doxycycline (dox) food is introduced to the dams at pup birth, neonatal brain and spinal cord exhibit high levels of luciferase activity beginning at ~48 hours post-induction and increasing to maximum after 10 days on dox. Similarly, full-length SMN is induced at 3 days post-induction and continues to increase to 10 days post-induction (in a similar manner to endogenous SMN protein). Similar results are observed following dox food administration to 28 day old mice. Following 10 days of dox, western blot shows luciferase and human SMN expression in widespread tissues including muscle, brain, liver, heart, spinal cord, heart, kidney, lung, and spleen. In addition, dox induction results in increased SMN expression in motor neurons as well as gems within those motor neurons. Following 28 days of dox administration, the subsequent removal of dox for 10 days results in luciferase and SMN expression levels dropping to non-induced levels.

These Tg(SMN2)89; Smn1+/-; Tg(SMNΔ7)4299; ROSA26rtTA; "old" Luci-TRE-SMN mice allow high levels of both luciferase and full-length human SMN expression to be regulated by the addition/removal of dox. Mice heterozygous for the Smn1tm1Msd mutation (Smn1+/-) and homozygous for the other mutations/transgenes are viable and fertile with no reported abnormalities or symptoms of neuropathology. The phenotype of mice homozygous for the Tg(SMN2)89 transgene (SMN2+/+), homozygous for the Smn1tm1Msd mutation (Smn1-/-), homozygous for the Tg(SMNΔ7)4299 transgene (SMNΔ7+/+), homozygous for the ROSA26rtTA mutation (ROSA26rtTA+/+), and hemizygous or homozygous for the Luci-TRE-SMN is described below.
In the absence of dox, the SMN2+/+; Smn1-/-; SMNΔ7+/+; ROSA26rtTA+/+; Luci-TRE-SMN mice (called non-induced SMA mice) die on average of 13 days old with no extension of lifespan (no mice live past ~18 days old). As expected, this is the same phenotype as moderate Type II SMA mouse model (see Stock No. 005025). When pregnant dams are given dox beginning coincident with gestating pup embryonic day (E)13, the high levels of full-length human SMN expression over the early postnatal period in SMN2+/+; Smn1-/-; SMNΔ7+/+; ROSA26rtTA+/+; Luci-TRE-SMN mice results in substantial rescue of SMA: the mice have no marked motor deficits, near normal motor neuron electrophysiology/neuromuscular junction (NMJ) function, fully developed NMJs, and average lifespan of 132 days (~30% of mice live over 200 days). Additionally, early postnatal SMN induction followed by removal of dox from 28-58 days of age, result in no morphological or electrophysiological abnormalities at the NMJ and no overt motor phenotype. Later dox administration to nursing dams rescues SMA but to a lesser extent: dox treatment to nursing dams at pup birth/postnatal day 1 (P0/P1) results in average lifespan of 86 days (~15% of mice live over 200 days), while dox treatment to nursing dams at pup postnatal day 2 (P2) leads to average lifespan of 25 days.

The donating investigator reports the following doxycycline approach. For embryonic induction, pregnant females were given water containing 500 mg/ml of doxycycline. At pup birth, doxycycline food (200 mg/kg) was introduced to the cage and the doxycycline water removed. For postnatal induction, high-concentration doxycycline food (6 g/kg) was administered to the mother; thus the pups received doxycycline in the mother's milk. Of note, high-concentration doxycycline food (6 g/kg) was found to severely affect birth rates if administered to pregnant mice.

Development
These Tg(SMN2)89; Smn1+/-; Tg(SMNΔ7)4299; ROSA26rtTA; "old" Luci-TRE-SMN mice harbor several mutations/transgenes, as described below.

Mice homozygous for the Tg(SMN2)89 transgene (SMN2+/+), homozygous for the Smn1tm1Msd mutation (Smn1-/-), and homozygous for the Tg(SMNΔ7)4299 transgene (SMNΔ7+/+) define the moderate type II SMA mouse model. The Tg(SMN2)89; Smn1-/-; Tg(SMNΔ7)4299 mice are described as Stock No. 005025. These mice were bred to and maintained upon an FVB/N genetic background prior to being used for breeding as below.

To generate the widespread rtTa-expressing mutation ROSA26rtTA, mice with the flox-STOP ROSA26-rtTA mutation (ICR;129 background; Stock No. 005572) were bred with Sox2-Cre transgenic mice (FVB;Swiss Webster;C57BL6;CBA background; see Stock No. 004783). The resulting offspring with pan-deletion of the lox-flanked STOP cassette/widespread expression of rtTA were bred to and maintained upon a C57BL/6 genetic background prior to being used as a donor for the Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy allele (see below).

The Luci-TRE-SMN transgene was created by Dr. Arthur HM Burghes (The Ohio State University). The Luci-TRE-SMN transgenic construct used here ["old" pBI-L-SMN] was designed with a luciferase sequence on one side, and a full-length human SMN2 cDNA sequence (encoding exons 1-8) on the other side of the Pbi-1 bi-directional tetracycline-responsive promoter. The 1.37 kb human SMN2 cDNA sequence was derived via RT-PCR performed on total RNA isolated from SMA type 1-derived patient fibroblast cells (Coriell Institute GM 3813; shown to express both full-length and truncated SMN2 transcripts). Compared to the "new" pBI-L-SMN(B) construct, the "old" pBI-L-SMN construct used here retains part of a hemagglutinin epitope tag sequence between the Pbi-1 promoter and 5' end of SMN2 cDNA. The Pbi-1 promoter contains the Tet-responsive element (TRE; seven copies of the 42-bp tet operator sequence [tetO]) placed between two minimal CMV enhancer-less promoters. The "old" Luci-TRE-SMN transgene was microinjected into the male pronucleus of FVB/N embryos. Founder mice were bred with Camk2a-tTA mice (FVB background; see Stock No. 003010) to determine which lines had high dox-inducible levels of luciferase and SMN in brain. The high-expressing "old" Luci-TRE-SMN founder line was identified and used as below.

To generate the Tg(SMN2)89; Smn1+/-; Tg(SMNΔ7)4299; ROSA26rtTA; "old" Luci-TRE-SMN animals, mice from the moderate type II SMA colony (Tg(SMN2)89+/+; Smn1+/-; Tg(SMNΔ7)4299+/+) were bred to ROSA26rtTA mice. Because the ROSA26rtTA mutation and Tg(SMN2)89 transgene insertion lie relatively close to each other on chromosome 6, additional crosses were performed to FVB/N wildtype mice; and a single mouse with a recombinant chromosome containing both Tg(SMN2)89 and ROSA26rtTA was identified. Next, those mice were bred to also harbor the "old" Luci-TRE-SMN transgene. The resulting Tg(SMN2)89; Smn1+/-; Tg(SMNΔ7)4299; ROSA26rtTA; "old" Luci-TRE-SMN mice (on a mixed FVB/N and C57BL/6 genetic background) were sent to The Jackson Laboratory Repository as Stock No. 017596. Upon arrival, males were used to cryopreserve sperm. To establish the living mouse colony, an aliquot of the frozen sperm was used to fertilize oocytes from moderate type II SMA females (Stock No. 005025).

Control Information

  Control
   See control note: The following strain(s) may also be appropriate experimental controls:
--mice from the moderate type II SMA strain (Stock No. 005025).
   001800 FVB/NJ (approximate)
 
  Considerations for Choosing Controls

Related Strains

Spinal Muscular Atrophy (SMA) Models
008849   B6.129(C)-Smn1tm1.1Jme/J
006146   B6.129-Smn1tm1Jme/J
008453   B6.129-Smn1tm4(SMN2)Mrph/J
008714   B6.129-Smn1tm5(Smn1/SMN2)Mrph/J
009378   B6.129-Smn1tm6(SMN2)Mrph/J
010921   B6.129P2(Cg)-Smn1tm1Msd/J
018439   B6.129S6-Tg(CAG-Bgeo,-SMN2)E9Dscd/J
009680   B6.B-Vps54wr/J
007963   B6.Cg-Smn1tm2Mrph/J
007966   B6.Cg-Smn1tm3(SMN2/Smn1)Mrph/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
008629   B6.Cg-Tg(SMN2)11Tro Smn1tm1Msd/J
008631   B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
008630   B6.Cg-Tg(SMN2)46Tro Smn1tm1Msd/J
007222   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/J
006964   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
006773   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
007246   B6;129-Smn1tm2Mrph/J
008383   B6;129-Smn1tm4(SMN2)Mrph/J
008384   B6;129-Smn1tm5(Smn1/SMN2)Mrph/J
008704   B6;129-Smn1tm6(SMN2)Mrph/J
006138   FVB.129(B6)-Smn1tm1Jme/J
008713   FVB.129(B6)-Smn1tm4(SMN2)Mrph/J
008604   FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J
006214   FVB.129P2-Smn1tm1Msd/J
005058   FVB.Cg-Smn1tm1Hung Tg(SMN2)2Hung/J
008206   FVB.Cg-Smn1tm1Msd Tg(SMN2)566Ahmb/J
007955   FVB.Cg-Smn1tm2Mrph/J
007964   FVB.Cg-Smn1tm3(SMN2/Smn1)Mrph/J
009381   FVB.Cg-Smn1tm6(SMN2)Mrph/J
012252   FVB.Cg-Tbcepmn/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
008209   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb/J
016573   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(S100B-EGFP)1Wjt Tg(SMN2*delta7)4299Ahmb/J
007968   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/2J
008782   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*A111G)588Ahmb/J
009134   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*A111G)591Ahmb/J
007952   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/2J
005025   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
005026   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/J
007949   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/2J
005024   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
009682   NMRI-Tbcepmn/J
017597   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#bAhmb/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
008783   STOCK Tg(CAG-cre/Esr1*)5Amc Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
005938   STOCK Tg(Eno2-cre)39Jme/J
008203   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb/J
006553   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(H2-K1-tsA58)6Kio Tg(SMN2*delta7)4299Ahmb/J
006570   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj/J
008212   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Prnp-SMN)92Ahmb/J
018916   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1-SMN2*)16Cll/CllJ
007951   STOCK Tg(SMN2)89Ahmb Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb/J
008359   STOCK Tg(SMN2)89Ahmb Smn1tm3(SMN2/Smn1)Mrph/J
017599   STOCK Tg(tetO-SMN2,-luc)#aAhmb/J
017600   STOCK Tg(tetO-SMN2,-luc)#bAhmb/J
View Spinal Muscular Atrophy (SMA) Models     (58 strains)

View Strains carrying   Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy     (3 strains)

Strains carrying   Smn1tm1Msd allele
010921   B6.129P2(Cg)-Smn1tm1Msd/J
008629   B6.Cg-Tg(SMN2)11Tro Smn1tm1Msd/J
008631   B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
008630   B6.Cg-Tg(SMN2)46Tro Smn1tm1Msd/J
007222   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/J
006964   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
006773   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
006214   FVB.129P2-Smn1tm1Msd/J
008206   FVB.Cg-Smn1tm1Msd Tg(SMN2)566Ahmb/J
008209   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb/J
016573   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(S100B-EGFP)1Wjt Tg(SMN2*delta7)4299Ahmb/J
007968   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/2J
008782   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*A111G)588Ahmb/J
009134   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*A111G)591Ahmb/J
007952   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/2J
005025   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
005026   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/J
007949   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/2J
005024   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
017597   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#bAhmb/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
008203   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb/J
006553   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(H2-K1-tsA58)6Kio Tg(SMN2*delta7)4299Ahmb/J
006570   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj/J
008212   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Prnp-SMN)92Ahmb/J
018916   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1-SMN2*)16Cll/CllJ
View Strains carrying   Smn1tm1Msd     (26 strains)

Strains carrying   Tg(SMN2)89Ahmb allele
007222   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/J
006964   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
006773   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
008209   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb/J
016573   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(S100B-EGFP)1Wjt Tg(SMN2*delta7)4299Ahmb/J
007968   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/2J
008782   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*A111G)588Ahmb/J
009134   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*A111G)591Ahmb/J
007952   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/2J
005025   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
005026   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/J
007949   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/2J
005024   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
017597   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#bAhmb/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
008783   STOCK Tg(CAG-cre/Esr1*)5Amc Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
008203   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb/J
006553   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(H2-K1-tsA58)6Kio Tg(SMN2*delta7)4299Ahmb/J
006570   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj/J
008212   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Prnp-SMN)92Ahmb/J
018916   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1-SMN2*)16Cll/CllJ
007951   STOCK Tg(SMN2)89Ahmb Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb/J
008359   STOCK Tg(SMN2)89Ahmb Smn1tm3(SMN2/Smn1)Mrph/J
View Strains carrying   Tg(SMN2)89Ahmb     (23 strains)

View Strains carrying   Tg(SMN2*delta7)4299Ahmb     (9 strains)

Strains carrying   Tg(tetO-SMN2,-luc)#aAhmb allele
017599   STOCK Tg(tetO-SMN2,-luc)#aAhmb/J
View Strains carrying   Tg(tetO-SMN2,-luc)#aAhmb     (1 strain)

Strains carrying other alleles of GFP
006053   129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J
006067   129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J
006041   129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J
016925   129;B6-Del(10Grin3b-Tmem259)1Zang Tg(Prnp-C19ORF6,-GFP)6Zhang/J
016251   129S.Cg-Tg(Hoxb7-EGFP)33Cos/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
017458   B6(C)-Tg(UAS-EGFP,-SOD1*G37R)135Gsn/J
017460   B6(C)-Tg(UAS-EGFP,-SOD1*G37R)677Gsn/J
008242   B6(Cg)-Gt(ROSA)26Sortm4(Ikbkb)Rsky/J
021011   B6(D2)-Tg(CAG-Brainbow1.0)2Eggn/J
021012   B6(D2)-Tg(CAG-Brainbow1.0)3Eggn/J
021469   B6(D2)-Tg(CAG-GFP,-Uprt)985Cdoe/J
016958   B6.129(Cg)-Foxp3tm3(DTR/GFP)Ayr/J
007676   B6.129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
004178   B6.129(Cg)-Tg(CAG-Bgeo/GFP)21Lbe/J
018979   B6.129(Cg)-Tg(CAG-EGFP)D4Nagy/KnwJ
010635   B6.129(FVB)-Alcamtm1Jawe/J
006071   B6.129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J
008606   B6.129-Gt(ROSA)26Sortm1Joe/J
006080   B6.129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J
006075   B6.129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J
011036   B6.129-Hoxa11tm1Dmwe/J
025880   B6.129-Tg(EEF1A1-SHC1*)1Ravi/J
008451   B6.129P(Cg)-Ptprca Cx3cr1tm1Litt/LittJ
005582   B6.129P-Cx3cr1tm1Litt/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009114   B6.129P2(129S4)-Hprttm14(Ple103-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
009113   B6.129P2(Cg)-Hprttm13(Ple54-EGFP)Ems/Mmjax
009115   B6.129P2(Cg)-Hprttm15(Ple111-EGFP)Ems/Mmjax
009118   B6.129P2(Cg)-Hprttm18(Ple90-EGFP)Ems/Mmjax
009353   B6.129P2(Cg)-Hprttm20(Ple53-EGFP)Ems/Mmjax
009596   B6.129P2(Cg)-Hprttm33(Ple183-EGFP)Ems/Mmjax
010770   B6.129P2(Cg)-Hprttm34(Ple186-EGFP)Ems/Mmjax
008706   B6.129P2(Cg)-Hprttm4(Ple88-EGFP)Ems/Mmjax
010789   B6.129P2(Cg)-Hprttm54(Ple233-EGFP)Ems/Mmjax
008707   B6.129P2(Cg)-Hprttm7(Ple185-EGFP)Ems/Mmjax
008708   B6.129P2(Cg)-Hprttm8(Ple151-EGFP)Ems/Mmjax
007766   B6.129P2(Cg)-Olfr160tm6Mom/MomJ
007572   B6.129P2(Cg)-Rorctm2Litt/J
005693   B6.129P2-Cxcr6tm1Litt/J
008875   B6.129P2-Lgr5tm1(cre/ERT2)Cle/J
016934   B6.129P2-Lgr6tm2.1(cre/ERT2)Cle/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
009380   B6.129S1-Irf4tm1Rdf/J
021930   B6.129S1-Tg(CAG-EGFP)S1C2Tpo/KnwPeaJ
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
007669   B6.129S4-Pdgfratm11(EGFP)Sor/J
013061   B6.129S6-Ccr6tm1(EGFP)Irw/J
008379   B6.129S6-Il10tm1Flv/J
012644   B6.129S7-Pcdhgtm2Xzw/J
008466   B6.129X1(Cg)-Shhtm6Amc/J
009081   B6.129X1-Id1tm1Xhsu/J
006772   B6.Cg-Foxp3tm2Tch/J
005670   B6.Cg-Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
007906   B6.Cg-Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze/J
005491   B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
022486   B6.Cg-Ptprca Tg(UBC-PA-GFP)1Mnz/J
025855   B6.Cg-Ptprca Lag3tm1Doi Tg(CAG-luc,-GFP)L2G85Chco Thy1a/J
013115   B6.Cg-Rag1tm1Mom Tg(UBC-GFP)30Scha/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
007484   B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
008705   B6.Cg-Tg(CAG-DsRed,-EGFP)5Gae/J
007575   B6.Cg-Tg(CAG-Ngb,-EGFP)1Dgrn/J
008111   B6.Cg-Tg(CAG-Ub*G76V/GFP)1Dant/J
008112   B6.Cg-Tg(CAG-Ub*G76V/GFP)2Dant/J
022148   B6.Cg-Tg(CSNK1D*,-EGFP)827Yfu/J
022149   B6.Cg-Tg(CSNK1D,-EGFP)432Yfu/J
023404   B6.Cg-Tg(CSNK1D,-EGFP)433Yfu/J
022787   B6.Cg-Tg(Chst4-EGFP)23Nrud/J
013134   B6.Cg-Tg(Col1a1*2.3-GFP)1Rowe/J
017466   B6.Cg-Tg(Col1a1*3.6-Topaz)2Rowe/J
018306   B6.Cg-Tg(Fos-tTA,Fos-EGFP*)1Mmay/J
014135   B6.Cg-Tg(Fos/EGFP)1-3Brth/J
007673   B6.Cg-Tg(Gad1-EGFP)3Gfng/J
010835   B6.Cg-Tg(Gfap-EGFP)3739Sart/J
007897   B6.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
006069   B6.Cg-Tg(HIST1H2BB/EGFP)1Pa/J
005029   B6.Cg-Tg(Hlxb9-GFP)1Tmj/J
024808   B6.Cg-Tg(Inpp5d-EGFP)DLrr/CprJ
006864   B6.Cg-Tg(Ins1-EGFP)1Hara/J
005244   B6.Cg-Tg(Krt1-15-EGFP)2Cot/J
012643   B6.Cg-Tg(Ly6a-EGFP)G5Dzk/J
008323   B6.Cg-Tg(Mc4r-MAPT/Sapphire)21Rck/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008321   B6.Cg-Tg(Npy-MAPT/Sapphire)1Rck/J
021232   B6.Cg-Tg(Nrl-EGFP)1Asw/J
008324   B6.Cg-Tg(Pmch-MAPT/CFP)1Rck/J
008322   B6.Cg-Tg(Pomc-MAPT/Topaz)1Rck/J
007902   B6.Cg-Tg(RP23-268L19-EGFP)2Mik/J
022086   B6.Cg-Tg(RP24-131B16/EGFP)13Ghan/J
019494   B6.Cg-Tg(RP24-131B16/EGFP)37Ghan/J
007894   B6.Cg-Tg(Rgs4-EGFP)4Lvt/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
012893   B6.Cg-Tg(S100a4-EGFP)M1Egn/YunkJ
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
016998   B6.Cg-Tg(TetO-Axin1,EGFP)TA6Cos/J
007921   B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J
007919   B6.Cg-Tg(Thy1-EGFP)OJrs/GfngJ
021069   B6.Cg-Tg(Thy1-PA-GFP)5Rmpl/J
021070   B6.Cg-Tg(Thy1-PA-GFP)6Rmpl/J
015805   B6.Cg-Tg(UBC-GFP,-TVA)1Clc/J
015806   B6.Cg-Tg(UBC-GFP,-TVA)2Clc/J
015807   B6.Cg-Tg(UBC-GFP,-TVA)3Clc/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
025854   B6.FVB-Ptprca Tg(CAG-luc,-GFP)L2G85Chco Thy1a/J
008226   B6.FVB-Tg(CAG-EGFP,-ALPP)2.6Ggc/J
018056   B6.FVB-Tg(CAG-boNT/B,-EGFP)U75-56Fwp/J
018055   B6.FVB-Tg(H2-K-S100a9,GFP)1Gabr/J
006000   B6.FVB-Tg(ITGAM-DTR/EGFP)34Lan/J
004509   B6.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
006417   B6.FVB-Tg(Npy-hrGFP)1Lowl/J
024033   B6.FVB-Tg(Shank3-EGFP)1Hzo/J
005738   B6.FVB-Tg(tetO-EGFP,-Tgfbr2)8Mcle/J
008126   B6.NOD-Tg(Cd4-EGFP)1Lt/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
024179   B6;129-Gt(ROSA)26Sortm1(Actb-T,-GFP)Dalco/J
008516   B6;129-Gt(ROSA)26Sortm1Joe/J
004077   B6;129-Gt(ROSA)26Sortm2Sho/J
009600   B6;129-Six2tm3(EGFP/cre/ERT2)Amc/J
008678   B6;129-Ubbtm1Rrk/J
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
010985   B6;129P-Klf3tm1(cre/ERT2)Pzg/J
015854   B6;129P2-Foxl2tm1(GFP/cre/ERT2)Pzg/J
008769   B6;129P2-Gpr15tm1.1Litt/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
021162   B6;129P2-Mapttm2Arbr/J
006717   B6;129P2-Olfr124tm1Mom/MomJ
006665   B6;129P2-Olfr151tm13(rI7)Mom/MomJ
006666   B6;129P2-Olfr151tm24(Olfr2)Mom/MomJ
006676   B6;129P2-Olfr151tm26Mom/MomJ
006734   B6;129P2-Olfr151tm35(Adrb2)Mom/MomJ
006714   B6;129P2-Olfr160tm11(Olfr545)Mom/MomJ
006649   B6;129P2-Olfr17tm5(Olfr6)Mom/MomJ
006712   B6;129P2-Olfr545tm1Mom/MomJ
006715   B6;129P2-Olfr545tm3(Olfr160)Mom/MomJ
004946   B6;129P2-Omptm2(spH)Mom/J
006667   B6;129P2-Omptm3Mom/MomJ
006728   B6;129P2-Vmn2r26tm2Mom/MomJ
012735   B6;129S-Gt(ROSA)26Sortm35.1(CAG-aop3/GFP)Hze/J
010987   B6;129S-Sox18tm1(GFP/cre/ERT2)Pzg/J
017592   B6;129S-Sox2tm2Hoch/J
004858   B6;129S1-Tshrtm1Rmar/J
007843   B6;129S4-Efnb2tm2Sor/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
012464   B6;129S4-Foxd1tm2(GFP/cre/ERT2)Amc/J
016836   B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J
008214   B6;129S4-Pou5f1tm2Jae/J
008078   B6;129S4-Tcf3tm5Zhu/J
017495   B6;129S7-Crim1tm1(GFP/cre/ERT2)Pzg/J
012436   B6;129S7-Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/Mmjax
008605   B6;C3-Tg(CAG-DsRed,-EGFP)5Gae/J
008080   B6;C3-Tg(CAG-SAC/EGFP)35Rang/J
010827   B6;C3-Tg(FOXJ1-EGFP)85Leo/J
010930   B6;CB-Tg(Pbsn-Hpn,-GFP)DVv/J
010704   B6;CBA-Tg(ATP6V1B1-EGFP)1Rnel/Mmjax
004966   B6;CBA-Tg(Acrv1-EGFP)2727Redd/J
025820   B6;CBA-Tg(CRH-MAPT/Topaz)1Rck/J
021588   B6;CBA-Tg(Gast-EGFP)1Tcw/J
007986   B6;CBA-Tg(H*/Olfr16-GFP)11Mom/MomJ
007987   B6;CBA-Tg(H*/Olfr16-GFP)25Mom/MomJ
007979   B6;CBA-Tg(H/Olfr16-GFP)3Mom/MomJ
007980   B6;CBA-Tg(H/Olfr16-GFP)4Mom/MomJ
007981   B6;CBA-Tg(H/Olfr16-GFP)6Mom/MomJ
007984   B6;CBA-Tg(H/Olfr16-taumCherry,-tauGFP)11Mom/MomJ
007985   B6;CBA-Tg(H/Olfr16-taumCherry,-tauGFP)13Mom/MomJ
007982   B6;CBA-Tg(H/Olfr16-taumRFP,-tauGFP)8Mom/MomJ
007983   B6;CBA-Tg(H/Olfr16-taumRFP,-tauGFP)9Mom/MomJ
007978   B6;CBA-Tg(Hf/Olfr16-GFP)47Mom/MomJ
007977   B6;CBA-Tg(Hf/Olfr16-GFP)7Mom/MomJ
004654   B6;CBA-Tg(Pou5f1-EGFP)2Mnn/J
011070   B6;CBA-Tg(Thy1-EGFP)SJrs/NdivJ
014651   B6;CBA-Tg(Thy1-spH)21Vnmu/J
015814   B6;CBA-Tg(Thy1-spH)64Vnmu/FrkJ
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
025122   B6;D2-Tg(RP24-330G11-EGFP)1Mik/J
005621   B6;D2-Tg(S100B-EGFP)1Wjt/J
008344   B6;DBA-Tg(Fos-tTA,Fos-EGFP*)1Mmay Tg(tetO-lacZ,tTA*)1Mmay/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
009159   B6;FVB-Tg(Cnp-EGFP/Rpl10a)JD368Htz/J
021187   B6;FVB-Tg(Pbsn-rtTA*M2)42Xy/J
004690   B6;FVB-Tg(Pcp2-EGFP)2Yuza/J
006147   B6;FVB-Tg(Sfpi1,-EGFP)7Dgt/J
019381   B6;FVB-Tg(Zfp423-EGFP)7Brsp/J
021022   B6;SJL-Tg(AMELX-EGFP/RHOA*T19N)13Gibs/Mmjax
006043   B6;SJL-Tg(Oxt/EGFP)AI03Wsy/J
021078   B6N.129S1-Mrgprb4tm4.1(flpo)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
018549   B6N.Cg-Tg(Csf1r-EGFP)1Hume/J
020650   B6N.Cg-Tg(Trpm8-EGFP)1Dmck/J
018913   B6N.Cg-Tg(tetO-GFP,-lacZ)G3Rsp/J
007732   B6SJL-Tg(Dazl-hrGFP)4Gar/J
004190   C.129-Il4tm1Lky/J
005700   C.129P2-Cxcr6tm1Litt/J
011010   C.B6-Tg(Foxp3-DTR/EGFP)23.2Spar/Mmjax
006769   C.Cg-Foxp3tm2Tch/J
010545   C.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
004512   C.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
008591   C57BL/6-Ackr3tm1Litt/J
023520   C57BL/6-Bcrtm1(BCR/ABL)Tsr/J
012343   C57BL/6-Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/J
012361   C57BL/6-Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky/J
010724   C57BL/6-Trim21tm1Hm/J
017469   C57BL/6-Tg(BGLAP-Topaz)1Rowe/J
006567   C57BL/6-Tg(CAG-EGFP)131Osb/LeySopJ
003291   C57BL/6-Tg(CAG-EGFP)1Osb/J
005070   C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck/J
017467   C57BL/6-Tg(Dmp1-Topaz)1Ikal/J
011003   C57BL/6-Tg(Foxp3-DTR/EGFP)23.2Spar/Mmjax
023800   C57BL/6-Tg(Foxp3-GFP)90Pkraj/J
012943   C57BL/6-Tg(Ins2-luc/EGFP/TK)300Kauf/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
012890   C57BL/6-Tg(Scgb1a1-Il17f,GFP)1Cdon/J
007265   C57BL/6-Tg(Sry-EGFP)92Ei Chr YAKR/J/EiJ
007264   C57BL/6-Tg(Sry-EGFP)92Ei Tg(Sry)4Ei Chr YPOS/EiJ
004353   C57BL/6-Tg(UBC-GFP)30Scha/J
022476   C57BL/6-Tg(Uchl1-EGFP)G1Phoz/J
005706   C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
009593   C57BL/6J-Tg(Pomc-EGFP)1Low/J
003927   C57BL/6J-Tg(Sry-EGFP)92Ei/EiJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
024898   C57BL/6J-Tg(tetO-EGFP/Rpl10a)5aReij/J
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
024753   C57BL/6N-Tg(Ddx25*-EGFP)1Mld/J
024752   C57BL/6N-Tg(Ddx25-EGFP)1Mld/J
008234   CB6-Tg(CAG-EGFP/CETN2)3-4Jgg/J
007677   CB6-Tg(Gad1-EGFP)G42Zjh/J
007898   CBy.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
007075   CByJ.B6-Tg(CAG-EGFP)1Osb/J
007076   CByJ.B6-Tg(UBC-GFP)30Scha/J
010548   D1.FVB(Cg)-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
008450   FVB-Tg(CAG-luc,-GFP)L2G85Chco/J
003718   FVB-Tg(GadGFP)45704Swn/J
010947   FVB-Tg(Gstm5-EGFP)1Ilis/J
005515   FVB-Tg(ITGAM-DTR/EGFP)34Lan/J
017484   FVB-Tg(JPH3-GFP,-JPH3*)GXwy/J
006421   FVB-Tg(Pomc1-hrGFP)1Lowl/J
005688   FVB-Tg(Rag2-EGFP)1Mnz/J
024636   FVB.B6-Tg(CAG-cat,-EGFP)1Rbns/KrnzJ
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
003516   FVB.Cg-Tg(CAG-EGFP)B5Nagy/J
022735   FVB.Cg-Tg(Cspg4-EGFP*)HDbe/J
016573   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(S100B-EGFP)1Wjt Tg(SMN2*delta7)4299Ahmb/J
007483   FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
008200   FVB/N-Tg(CAG-EGFP,-ALPP)2.6Ggc/J
018393   FVB/N-Tg(CAG-EGFP,TGFB1*)C8Kul/J
009354   FVB/N-Tg(Dazl-EGFP)10Rarp/J
025062   FVB/N-Tg(Figla-EGFP,-icre)ZP3Dean/Mmjax
018548   FVB/N-Tg(GFAP-Cadm1/EGFP)42Oje/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
025097   NOD.129X1(Cg)-Foxp3tm2Tch/DvsJ
013116   NOD.B6-Tg(Ins2-luc/EGFP/TK)300Kauf/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
006698   NOD.Cg-Il4tm1Lky/JbsJ
021937   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CAG-EGFP)1Osb/SzJ
017619   NOD.Cg-Prkdcscid Tg(CAG-EGFP)1Osb/KupwJ
008173   NOD.Cg-Tg(Ins1-EGFP)1Hara/QtngJ
005076   NOD.Cg-Tg(tetO-EGFP/FADD)1Doi/DoiJ
010542   NOD.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
008547   NOD.FVB-Tg(ITGAM-DTR/EGFP)34Lan/JdkJ
008549   NOD.FVB-Tg(Itgax-DTR/EGFP)57Lan/JdkJ
005082   NOD/ShiLt-Tg(ACTB-Ica1/EGFP)18Mdos/MdosJ
005334   NOD/ShiLt-Tg(Cd4-EGFP)1Lt/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
005282   NOD/ShiLtJ-Tg(Ins1-EGFP/GH1)14Hara/HaraJ
012881   STOCK Ascl1tm1Reed/J
008666   STOCK Fmn1tm1Made/J
016961   STOCK Foxp3tm9(EGFP/cre/ERT2)Ayr/J
006331   STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J
005572   STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
007576   STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
009349   STOCK Hprttm31(Ple67-EGFP)Ems/Mmjax
009594   STOCK Hprttm32(Ple112-EGFP)Ems/Mmjax
017530   STOCK Igs2tm2(ACTB-tdTomato,-EGFP)Luo Trp53tm1Tyj Nf1tm1Par/J
013749   STOCK Iis2tm1(ACTB-EGFP,-tdTomato)Luo/J
013751   STOCK Iis2tm2(ACTB-tdTomato,-EGFP)Luo/J
017932   STOCK Iis3tm1.1(ACTB-EGFP*)Luo/J
017923   STOCK Iis3tm2.1(ACTB-EGFP*,-tdTomato)Luo/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
004779   STOCK Mapttm1(EGFP)Klt/J
005692   STOCK Nphs1tm1Rkl/J
006702   STOCK Ntstm1Mom/MomJ
006622   STOCK Olfr151tm10Mom/MomJ
006646   STOCK Olfr151tm11(Olfr160)Mom/MomJ
006692   STOCK Olfr151tm16(Olfr160/Olfr161)Mom/MomJ
006627   STOCK Olfr151tm4Mom/MomJ
006626   STOCK Olfr151tm6Mom/MomJ
006625   STOCK Olfr151tm7Mom/MomJ
006624   STOCK Olfr151tm8Mom/MomJ
006623   STOCK Olfr151tm9Mom/MomJ
006740   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)AMom/MomJ
006741   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)BMom/MomJ
006647   STOCK Olfr160tm1(Olfr151)Mom/MomJ
006636   STOCK Olfr160tm5(Cnga2)Mom/MomJ
006678   STOCK Olfr160tm6Mom/MomJ
006650   STOCK Olfr17tm6(Olfr713)Mom/MomJ
006669   STOCK Olfr17tm7Mom/MomJ
009061   STOCK Osr1tm1(EGFP/cre/ERT2)Amc/J
022757   STOCK Prg4tm1(GFP/cre/ERT2)Abl/J
006770   STOCK Rag1tm1Mom Tg(TIE2GFP)287Sato/J
006633   STOCK Vmn1r49tm3Mom/MomJ
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
017472   STOCK Tg(Acp5-CFP,Ibsp-YFP,Dmp1-RFP)1Pmay/J
006850   STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006876   STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
003920   STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
003115   STOCK Tg(CAG-EGFP)B5Nagy/J
003116   STOCK Tg(CAG-EGFP)D4Nagy/J
017919   STOCK Tg(CAG-EGFP,-dsRed2/RNAi:Tardbp)6Zxu/J
011106   STOCK Tg(CAG-GFP*)1Hadj/J
013753   STOCK Tg(CAG-KikGR)33Hadj/J
013754   STOCK Tg(CAG-KikGR)75Hadj/J
019082   STOCK Tg(CMV-GFP,-BBS4)4T25Vcs/J
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
026105   STOCK Tg(Cnp-EGFP*)1Qrlu/J
017468   STOCK Tg(Col1a1*3.6-Cyan)2Rowe/J
018322   STOCK Tg(Cp-EGFP)25Gaia/ReyaJ
006334   STOCK Tg(Gad1-EGFP)94Agmo/J
006340   STOCK Tg(Gad1-EGFP)98Agmo/J
007896   STOCK Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
017952   STOCK Tg(Isl1-EGFP*)1Slp/J
023965   STOCK Tg(Krt17-EGFP)#Cou/J
012477   STOCK Tg(Myh6*/tetO-GCaMP2)1Mik/J
008579   STOCK Tg(PSCA-EGFP)1Witt/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
023345   STOCK Tg(Pgk1-Ccnb1/EGFP)1Aklo/J
012276   STOCK Tg(Piwil2/EGFP)1Ghan/J
012277   STOCK Tg(Piwil4/EGFP)1Ghan/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006570   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
018148   STOCK Tg(Slc17a8-EGFP)1Edw/SealJ
013752   STOCK Tg(TCF/Lef1-HIST1H2BB/EGFP)61Hadj/J
003658   STOCK Tg(TIE2GFP)287Sato/J
021226   STOCK Tg(Thy1-Brainbow3.1)18Jrs/J
021225   STOCK Tg(Thy1-Brainbow3.1)3Jrs/J
021227   STOCK Tg(Thy1-Brainbow3.2)7Jrs/J
007788   STOCK Tg(Thy1-EGFP)MJrs/J
016981   STOCK Tg(Uchl1-HIST2H2BE/mCherry/EGFP*)FSout/J
025193   STOCK Tg(Vmn1r232-Mapt/EGFP)1Dlc/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
006129   STOCK Tg(Zp3-EGFP)1Dean/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
017755   STOCK Tg(tetO-GCAMP2)12iRyu/J
005104   STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J
005699   STOCK Tg(tetO-Ipf1,EGFP)956.6Macd/J
017918   STOCK Tg(tetO-MAML1*/EGFP)2Akar/J
017906   STOCK Tg(tetO-hop/EGFP,-COP4/mCherry)6Kftnk/J
012345   STOCK Tg(tetO-tdTomato,-Syp/EGFP*)1.1Luo/J
View Strains carrying other alleles of GFP     (362 strains)

Strains carrying other alleles of Gt(ROSA)26Sor
002292   129-Gt(ROSA)26Sor/J
006053   129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J
006067   129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J
006041   129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J
013205   129S-Gt(ROSA)26Sortm1(NOTCH3)Sat/Mmjax
003310   129S-Gt(ROSA)26Sortm1Sor/J
013207   129S-Gt(ROSA)26Sortm2(NOTCH3*C455R)Sat/Mmjax
009043   129S-Gt(ROSA)26Sortm3(CAG-luc)Tyj/J
007844   129S4/SvJae-Gt(ROSA)26Sortm2(FLP*)Sor/J
003946   129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J
007689   129S4/SvJaeSor-Gt(ROSA)26Sortm4(attB/attP)Sor/J
017626   B6(Cg)-Gt(ROSA)26Sortm1(CAG-GFP/Eif2c2)Zjh/J
010633   B6(Cg)-Gt(ROSA)26Sortm1(CAG-taulacZ)Bene/J
024540   B6(Cg)-Gt(ROSA)26Sortm1(Sstr3/GFP)Bky/J
008242   B6(Cg)-Gt(ROSA)26Sortm4(Ikbkb)Rsky/J
007676   B6.129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
006071   B6.129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J
007708   B6.129-Gt(ROSA)26Sortm1(HD*103Q)Xwy/J
008463   B6.129-Gt(ROSA)26Sortm1(cre/ERT2)Tyj/J
008606   B6.129-Gt(ROSA)26Sortm1Joe/J
006080   B6.129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J
006075   B6.129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J
011008   B6.129P2(Cg)-Gt(ROSA)26Sortm1(tTA)Roos/J
017492   B6.129P2-Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle/J
009669   B6.129P2-Gt(ROSA)26Sortm1(DTA)Lky/J
008513   B6.129P2-Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/J
013586   B6.129P2-Gt(ROSA)26Sortm1Nik/J
013587   B6.129P2-Gt(ROSA)26Sortm3Nik/J
022367   B6.129S4-Gt(ROSA)26Sortm1(CAG-EGFP/Rpl10a,-birA)Wtp/J
009086   B6.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/RainJ
003474   B6.129S4-Gt(ROSA)26Sortm1Sor/J
012930   B6.129S4-Gt(ROSA)26Sortm2(FLP*)Sor/J
009044   B6.129S4-Gt(ROSA)26Sortm3(CAG-luc)Tyj/J
007743   B6.129S4-Gt(ROSA)26Sortm3(phiC31*)Sor/J
009673   B6.129S6(C)-Gt(ROSA)26Sortm3(HIF1A*)Kael/J
022626   B6.129S6(SJL)-Gt(ROSA)26Sortm2.1(mix1b-mCherry)Mgn/Mmjax
002192   B6.129S7-Gt(ROSA)26Sor/J
006148   B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J
026294   B6.Cg(129S)-Gt(ROSA)26Sortm2.2Ksvo/J
017983   B6.Cg-Col1a1tm9(tetO-Dnmt3b_i1)Jae Gt(ROSA)26Sortm1(rtTA*M2)Jae/J
021071   B6.Cg-Gt(ROSA)26Sortm1(CAG-PA-GFP)Rmpl/J
014588   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm6(tetO-MSI2)Jae/J
014602   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-mCherry)Eggn/J
023749   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Tg(tetO-Pou5f1,-Sox2,-Klf4,-Myc)1Srn/J
006965   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae/J
005670   B6.Cg-Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
007914   B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J
007920   B6.Cg-Gt(ROSA)26Sortm2(CAG-EYFP)Hze/J
012567   B6.Cg-Gt(ROSA)26Sortm27.1(CAG-COP4*H134R/tdTomato)Hze/J
007903   B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze/J
024109   B6.Cg-Gt(ROSA)26Sortm32(CAG-COP4*H134R/EYFP)Hze/J
014648   B6.Cg-Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/ZkhuJ
021188   B6.Cg-Gt(ROSA)26Sortm40.1(CAG-aop3/EGFP)Hze/J
007906   B6.Cg-Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze/J
025106   B6.Cg-Gt(ROSA)26Sortm75.1(CAG-tdTomato*)Hze/J
007909   B6.Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J
007897   B6.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
024179   B6;129-Gt(ROSA)26Sortm1(Actb-T,-GFP)Dalco/J
017455   B6;129-Gt(ROSA)26Sortm1(CAG-COP4*E123T*H134R,-tdTomato)Gfng/J
024857   B6;129-Gt(ROSA)26Sortm1(CAG-xstpx-cas9,-EGFP)Fezh/J
010527   B6;129-Gt(ROSA)26Sortm1(DTA)Mrc/J
016262   B6;129-Gt(ROSA)26Sortm1(Foxo1/GFP)Jke/J
017962   B6;129-Gt(ROSA)26Sortm1(RAC1*)Jkis/J
008883   B6;129-Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/TmdJ
004847   B6;129-Gt(ROSA)26Sortm1(cre/ERT)Nat/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
006911   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm2(tetO-Pou5f1)Jae/J
008516   B6;129-Gt(ROSA)26Sortm1Joe/J
003504   B6;129-Gt(ROSA)26Sortm1Sho/J
021847   B6;129-Gt(ROSA)26Sortm1Ytchn/J
008889   B6;129-Gt(ROSA)26Sortm2(SNCA*119)Djmo/TmdJ
009253   B6;129-Gt(ROSA)26Sortm2Nat/J
004077   B6;129-Gt(ROSA)26Sortm2Sho/J
008886   B6;129-Gt(ROSA)26Sortm3(SNCA*E46K)Djmo/TmdJ
010557   B6;129-Gt(ROSA)26Sortm3(rtTA,tetO-cre/ERT)Nat/J
021429   B6;129-Gt(ROSA)26Sortm4(CAG-GFP*)Nat/J
021039   B6;129-Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat/J
010523   B6;129P2-Gt(ROSA)26Sortm1(CAG-ALPP)Fawa/J
024708   B6;129P2-Gt(ROSA)26Sortm1(CAG-RABVgp4,-TVA)Arenk/J
002073   B6;129S-Gt(ROSA)26Sor/J
018385   B6;129S-Gt(ROSA)26Sortm1(CAG-COX8A/Dendra2)Dcc/J
022516   B6;129S-Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/J
013206   B6;129S-Gt(ROSA)26Sortm1(NOTCH3*R1031C)Sat/Mmjax
018397   B6;129S-Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/J
023139   B6;129S-Gt(ROSA)26Sortm1.1Ksvo/J
024846   B6;129S-Gt(ROSA)26Sortm2.1Ksvo/J
012569   B6;129S-Gt(ROSA)26Sortm32(CAG-COP4*H134R/EYFP)Hze/J
012570   B6;129S-Gt(ROSA)26Sortm34.1(CAG-Syp/tdTomato)Hze/J
012735   B6;129S-Gt(ROSA)26Sortm35.1(CAG-aop3/GFP)Hze/J
014538   B6;129S-Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze/J
014539   B6;129S-Gt(ROSA)26Sortm39(CAG-hop/EYFP)Hze/J
021875   B6;129S-Gt(ROSA)26Sortm65.1(CAG-tdTomato)Hze/J
021876   B6;129S-Gt(ROSA)26Sortm66.1(CAG-tdTomato)Hze/J
024105   B6;129S-Gt(ROSA)26Sortm95.1(CAG-GCaMP6f)Hze/J
016836   B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J
003309   B6;129S4-Gt(ROSA)26Sortm1Sor/J
004598   B6;129S4-Gt(ROSA)26Sortm2Dym/J
007670   B6;129S4-Gt(ROSA)26Sortm3(phiC31*)Sor/J
024750   B6;129S4-Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/J
023035   B6;129S6-Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/J
016999   B6;129S6-Gt(ROSA)26Sortm1(xstpx-rtTA2S*M2)Whsu/J
007908   B6;129S6-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J
007905   B6;129S6-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J
024106   B6;129S6-Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/J
019101   B6N.129S4(B6)-Gt(ROSA)26Sortm1Sor/CjDswJ
016226   B6N.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
019016   B6N.129S6(Cg)-Gt(ROSA)26Sortm3(CAG-FLPo/ERT2)Alj/J
023537   B6N.129S6-Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/J
025701   B6N;129S1-Gt(ROSA)26Sortm1(Grem1)Svok/J
019120   BALB/c-Gt(ROSA)26Sortm10(Lmp1)Rsky/J
009670   C.129P2(B6)-Gt(ROSA)26Sortm1(DTA)Lky/J
008603   C.129P2(B6)-Gt(ROSA)26Sortm1(tTA)Roos/J
002955   C.129S7-Gt(ROSA)26Sor/J
007900   C57BL/6-Gt(ROSA)26Sortm1(HBEGF)Awai/J
008517   C57BL/6-Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/J
012637   C57BL/6-Gt(ROSA)26Sortm5(Map3k14)Rsky/J
012638   C57BL/6-Gt(ROSA)26Sortm6(Map3k14*)Rsky/J
012343   C57BL/6-Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/J
012352   C57BL/6-Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/J
012361   C57BL/6-Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky/J
020458   C57BL/6N-Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky/J
005420   C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/GrsrJ
008040   CBy.B6-Gt(ROSA)26Sortm1(HBEGF)Awai/J
007898   CBy.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
009427   FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J
005125   FVB.129S6(B6)-Gt(ROSA)26Sortm1(Luc)Kael/J
016977   FVB.129S6-Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/J
006206   FVB.129S6-Gt(ROSA)26Sortm2(HIF1A/luc)Kael/J
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
010920   FVB;129P2-Gt(ROSA)26Sortm1(birA)Mejr/J
016603   NOD.B6-Gt(ROSA)26Sortm1(HBEGF)Awai/DvsJ
013731   STOCK Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle/J
010675   STOCK Gt(ROSA)26Sortm1(CAG-EGFP)Fsh/Mmjax
006331   STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J
022793   STOCK Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo/J
023451   STOCK Gt(ROSA)26Sortm1(Luc)Kael Tg(UBC-CCR5,-CD4)19Mnz/J
008159   STOCK Gt(ROSA)26Sortm1(Notch1)Dam/J
005130   STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J
018121   STOCK Gt(ROSA)26Sortm1(birA)Mejr Gata4tm3.1Wtp/J
011004   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J
011011   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm4(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J
011013   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm5(tetO-Pou5f1,-Klf4,-Myc)Jae/J
005572   STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
008600   STOCK Gt(ROSA)26Sortm1(tTA)Roos/J
010701   STOCK Gt(ROSA)26Sortm1.1(CAG-EGFP)Fsh/Mmjax
022386   STOCK Gt(ROSA)26Sortm1.1(CAG-EGFP/Rpl10a,-birA)Wtp/J
024858   STOCK Gt(ROSA)26Sortm1.1(CAG-cas9,-EGFP)Fezh/J
010812   STOCK Gt(ROSA)26Sortm1.2(CAG-EGFP)Fsh/Mmjax
017922   STOCK Gt(ROSA)26Sortm10(ACTB-tdTomato)Luo/J
023898   STOCK Gt(ROSA)26Sortm11.1(Setd5-GFP)Mgn/Mmjax
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018906   STOCK Gt(ROSA)26Sortm3(CAG-FLPo/ERT2)Alj/J
013124   STOCK Gt(ROSA)26Sortm3(Gli3)Amc/J
007576   STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
009674   STOCK Gt(ROSA)26Sortm4(HIF2A*)Kael/J
024107   STOCK Gt(ROSA)26Sortm5(ACTB-tTA)Luo Igs7tm93.1(tetO-GCaMP6f)Hze/HzeJ
012266   STOCK Gt(ROSA)26Sortm5(ACTB-tTA)Luo/J
017912   STOCK Gt(ROSA)26Sortm6(ACTB-EGFP*,-tdTomato)Luo/J
013123   STOCK Gt(ROSA)26Sortm6(Gli1)Amc/J
017921   STOCK Gt(ROSA)26Sortm7(ACTB-EGFP*)Luo/J
017909   STOCK Gt(ROSA)26Sortm8(ACTB-EGFP*,-tTA2)Luo/J
007577   STOCK Tg(Gt(ROSA)26Sor-BCHE*G117H)837Loc/J
007896   STOCK Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
View Strains carrying other alleles of Gt(ROSA)26Sor     (164 strains)

View Strains carrying other alleles of SMN2     (20 strains)

View Strains carrying other alleles of Smn1     (22 strains)

Strains carrying other alleles of lacZ
002484   129-Alpltm1Sor/J
002292   129-Gt(ROSA)26Sor/J
006050   129-Sirt6tm1Fwa/J
003451   129-Smad3tm1Par/J
003310   129S-Gt(ROSA)26Sortm1Sor/J
003383   129S-Nogtm1Amc/J
004545   129S-Npytm1Rpa/J
005091   129S-Pnpla6tm1Blw/J
007199   129S-Sgpl1Gt(ROSA)78Sor/J
003082   129S1/SvImJ-Bcl2tm1Mpin/J
010633   B6(Cg)-Gt(ROSA)26Sortm1(CAG-taulacZ)Bene/J
023757   B6(Cg)-Tg(tetO-tetX,lacZ)1Gogo/UmriJ
005085   B6.129(Cg)-Cd44tm1Hbg/J
012239   B6.129(Cg)-Cd44tm1Hbg/SjJ
004178   B6.129(Cg)-Tg(CAG-Bgeo/GFP)21Lbe/J
004478   B6.129-Foxd1tm1Lai/J
006939   B6.129-Fut1tm1Sdo/J
005768   B6.129-Htr5atm1Dgen/J
002938   B6.129-Kdrtm1Jrt/J
004158   B6.129-Maftm1Gsb/J
008233   B6.129-Nrgntm1Kph/J
006497   B6.129-Skiltm2Spw/J
005849   B6.129-Tmprss11atm1Dgen/J
009348   B6.129P2(Cg)-Hprttm17(Ple48-lacZ)Ems/Mmjax
012572   B6.129P2(Cg)-Hprttm19(Ple88-lacZ)Ems/Mmjax
012574   B6.129P2(Cg)-Hprttm38(Ple17-lacZ)Ems/Mmjax
012575   B6.129P2(Cg)-Hprttm39(Ple24-lacZ)Ems/Mmjax
012576   B6.129P2(Cg)-Hprttm40(Ple34-lacZ)Ems/Mmjax
010805   B6.129P2(Cg)-Hprttm41(Ple160-lacZ)Ems/Mmjax
012331   B6.129P2(Cg)-Hprttm42(Ple131-lacZ)Ems/Mmjax
012577   B6.129P2(Cg)-Hprttm43(Ple140-lacZ)Ems/Mmjax
010709   B6.129P2(Cg)-Hprttm44(Ple49-lacZ)Ems/Mmjax
012333   B6.129P2(Cg)-Hprttm45(Ple67-lacZ)Ems/Mmjax
012733   B6.129P2(Cg)-Hprttm53(CAG-lacZ)Ems/Mmjax
012578   B6.129P2(Cg)-Hprttm56(Ple25-lacZ)Ems/Mmjax
012579   B6.129P2(Cg)-Hprttm58(Ple119-lacZ)Ems/Mmjax
012580   B6.129P2(Cg)-Hprttm59(Ple123-lacZ)Ems/Mmjax
012581   B6.129P2(Cg)-Hprttm62(Ple153-lacZ)Ems/Mmjax
012342   B6.129P2(Cg)-Hprttm63(Ple12-lacZ)Ems/Mmjax
012347   B6.129P2(Cg)-Hprttm64(Ple170-lacZ)Ems/Mmjax
012582   B6.129P2(Cg)-Hprttm67(Ple238-lacZ)Ems/Mmjax
012583   B6.129P2(Cg)-Hprttm68(Ple127-lacZ)Ems/Mmjax
012656   B6.129P2(Cg)-Hprttm70(Ple240-lacZ)Ems/Mmjax
012657   B6.129P2(Cg)-Hprttm71(Ple155-lacZ)Ems/Mmjax
012659   B6.129P2(Cg)-Hprttm73(Ple142-lacZ)Ems/Mmjax
012734   B6.129P2(Cg)-Hprttm74(Ple232-lacZ)Ems/Mmjax
008235   B6.129P2-Abcg5tm1Plo/J
005772   B6.129P2-Acvrl1tm1Dgen/J
005770   B6.129P2-Adamts4tm1Dgen/J
005771   B6.129P2-Adamts5tm1Dgen/J
005773   B6.129P2-Adcy3tm1Dgen/J
005774   B6.129P2-Adcy7tm1Dgen/J
005775   B6.129P2-Adipor2tm1Dgen/J
005776   B6.129P2-Avpr1atm1Dgen/J
009120   B6.129P2-Axin2tm1Wbm/J
005777   B6.129P2-Axltm1Dgen/J
005783   B6.129P2-Cacna1ctm1Dgen/J
005780   B6.129P2-Cacna2d3tm1Dgen/J
005781   B6.129P2-Cacng3tm1Dgen/J
005782   B6.129P2-Cacng4tm1Dgen/J
005784   B6.129P2-Capn5tm1Dgen/J
005785   B6.129P2-Capn7tm1Dgen/J
005792   B6.129P2-Ccr1l1tm1Dgen/J
005793   B6.129P2-Ccr6tm1Dgen/J
005794   B6.129P2-Ccr7tm1Dgen/J
005779   B6.129P2-Celsr2tm1Dgen/J
005797   B6.129P2-Chrna2tm1Dgen/J
007566   B6.129P2-Clip2tm1.1Gal/J
005787   B6.129P2-Ctsctm1Dgen/J
005796   B6.129P2-Cxcr3tm1Dgen/J
005798   B6.129P2-Drd5tm1Dgen/J
005800   B6.129P2-Efemp2tm1Dgen/J
005801   B6.129P2-Esrratm1Dgen/J
005802   B6.129P2-Faim2tm1Dgen/J
005803   B6.129P2-Fzd1tm1Dgen/J
005804   B6.129P2-Fzd8tm1Dgen/J
005811   B6.129P2-Gabra3tm1Dgen/J
005812   B6.129P2-Gabra4tm1Dgen/J
005810   B6.129P2-Gabrptm1Dgen/J
005809   B6.129P2-Galr1tm1Dgen/J
005816   B6.129P2-Glra3tm1Dgen/J
005805   B6.129P2-Gpr151tm1Dgen/J
005806   B6.129P2-Gpr37tm1Dgen/J
005807   B6.129P2-Gpr6tm1Dgen/J
005813   B6.129P2-Grik5tm1Dgen/J
005808   B6.129P2-Grk5tm1Dgen/J
005814   B6.129P2-Grm1tm1Dgen/J
005815   B6.129P2-Grm3tm1Dgen/J
005817   B6.129P2-Gsk3btm1Dgen/J
005818   B6.129P2-Hcrtr1tm1Dgen/J
005767   B6.129P2-Htr4tm1Dgen/J
005769   B6.129P2-Htr7tm1Dgen/J
005821   B6.129P2-Lats2tm1Dgen/J
005822   B6.129P2-Lmbr1tm1Dgen/J
005850   B6.129P2-Mapkapk2tm1Dgen/J
005824   B6.129P2-Mmp17tm1Dgen/J
005825   B6.129P2-Mtmr1tm1Dgen/J
005826   B6.129P2-Ntsr1tm1Dgen/J
005829   B6.129P2-Pkd2l2tm1Dgen/J
005828   B6.129P2-Ppardtm1Dgen/J
005831   B6.129P2-Ppm1ftm1Dgen/J
005827   B6.129P2-Ptch2tm1Dgen/J
005832   B6.129P2-Ptprotm1Dgen/J
005799   B6.129P2-S1pr4tm1Dgen/J
005837   B6.129P2-Scn11atm1Dgen/J
005836   B6.129P2-Scn9atm1Dgen/J
005834   B6.129P2-Sema5atm1Dgen/J
005835   B6.129P2-Sema6ctm1Dgen/J
006432   B6.129P2-Slc18a1tm1Dgen/J
005839   B6.129P2-Slc22a12tm1Dgen/J
005838   B6.129P2-Slc22a6tm1Dgen/J
005840   B6.129P2-Slc40a1tm1Dgen/J
005841   B6.129P2-Slc6a9tm1Dgen/J
005842   B6.129P2-Slc7a8tm1Dgen/J
005843   B6.129P2-Slc9a6tm1Dgen/J
005844   B6.129P2-Sstr1tm1Dgen/J
005847   B6.129P2-Tgfbr1tm1Dgen/J
005845   B6.129P2-Thbs4tm1Dgen/J
005790   B6.129P2-Tpp1tm1Dgen/J
005848   B6.129P2-Trpm5tm1Dgen/J
005791   B6.129P2-Xcr1tm1Dgen/J
012377   B6.129S-Cyp19a1tm1.1Shah/J
009089   B6.129S1(Cg)-Ndntm2Stw/J
009387   B6.129S1-Osr1tm1Jian/J
009386   B6.129S1-Osr2tm1Jian/J
010617   B6.129S1-Snai2tm1Grid/J
003474   B6.129S4-Gt(ROSA)26Sortm1Sor/J
006142   B6.129S4-Ppargtm1Rev/J
003754   B6.129S4-Shroom3Gt(ROSA53)Sor/J
005119   B6.129S6-Npas2tm1Slm/J
002741   B6.129S7-Alpltm1Sor/J
005970   B6.129S7-Atoh1tm2Hzo/J
006039   B6.129S7-Efnb2tm1And/J
002192   B6.129S7-Gt(ROSA)26Sor/J
005981   B6.129S7-Rai1tm1Jrl/J
005039   B6.129X1-Adra1atm1Pcs/J
006262   B6.129X1-Fut2tm1Sdo/J
025101   B6.Cg-Avpr1atm1Dgen Tg(AVPR1A)1Bux/BuxJ
014536   B6.Cg-Hprttm75(Ple143-lacZ)Ems/Mmjax
007745   B6.Cg-Mir155tm1.1Rsky/J
005317   B6.Cg-Tg(BAT-lacZ)3Picc/J
003139   B6.Cg-Tg(DBHn-lacZ)8Rpk/J
006229   B6.Cg-Tg(DRE-lacZ)2Gswz/J
024050   B6.Cg-Tg(Hmgcr-lacZ)H253Sest/J
024377   B6.Cg-Tg(TCF/Lef1-lacZ)34Efu/KatmJ
009136   B6.Cg-Tg(tetO-Kcnj2,lacZ)1Gogo/J
002982   B6.Cg-Tg(xstpx-lacZ)32And/J
018625   B6.FVB-Tg(Fabp4-lacZ)4Mosh/J
008615   B6;129-Frzbtm1Nat/J
008621   B6;129-Fzd5tm1Nat/J
016857   B6;129-Itga7tm1Burk/J
005064   B6;129-Slc30a3tm1Rpa/J
009599   B6;129P2-Adam19Gt(Betageo)1Bbl/J
006431   B6;129P2-Adam21tm1Dgen/J
005788   B6;129P2-Cd97tm1Dgen/J
008590   B6;129P2-Cxcl14tm1Litt/J
006703   B6;129P2-Gucy2dtm1Mom/MomJ
021162   B6;129P2-Mapttm2Arbr/J
006665   B6;129P2-Olfr151tm13(rI7)Mom/MomJ
006666   B6;129P2-Olfr151tm24(Olfr2)Mom/MomJ
005833   B6;129P2-Rgs4tm1Dgen/J
002073   B6;129S-Gt(ROSA)26Sor/J
006470   B6;129S-Hopxtm1Eno/J
004153   B6;129S-Map7Gt(ROSABetageo)1Sor/J
006958   B6;129S-Nkd1tm1Kwha/J
006960   B6;129S-Nkd2tm1Kwha/J
010619   B6;129S1-Lfngtm1Grid/J
007208   B6;129S4-Csrnp1Gt(ROSA)80Sor/J
011052   B6;129S4-Ctbp2Gt(ROSA61)Sor/J
003309   B6;129S4-Gt(ROSA)26Sortm1Sor/J
007207   B6;129S4-Zfp640Gt(ROSA)81Sor/J
004365   B6;129S6-Srebf1tm1Mbr/J
002317   B6;129S7-Alpltm1Sor/J
003266   B6;129S7-Epas1tm1Rus/J
006044   B6;129S7-Ephb4tm1And/J
012436   B6;129S7-Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/Mmjax
008618   B6;A-Tg(OPN1LW-lacZ)1Nat/J
006465   B6;CBA-Tg(CAG-lacZ-WGA)330Bbm/J
007975   B6;CBA-Tg(OR8A1-taulacZ)1Mom/MomJ
007972   B6;CBA-Tg(Olfr151-taulacZ)4Mom/MomJ
006680   B6;CBA-Tg(Olfr16*,taulacZ)19Mom/MomJ
006671   B6;CBA-Tg(Olfr16*,taulacZ)5Mom/MomJ
006672   B6;CBA-Tg(Olfr16*,taulacZ)7Mom/MomJ
006673   B6;CBA-Tg(Olfr16,taulacZ)sn2Mom/MomJ
007973   B6;CBA-Tg(Olfr16-taulacZ)1Mom/MomJ
007974   B6;CBA-Tg(Olfr160-taulacZ)V4-7Mom/MomJ
007976   B6;CBA-Tg(Olfr713-taulacZ)4Mom/MomJ
006743   B6;CBA-Tg(P-taulacZ)11Mom/MomJ
006793   B6;CBA-Tg(P-taulacZ)13Mom/MomJ
006742   B6;CBA-Tg(P-taulacZ)8Mom/MomJ
004141   B6;CBA-Tg(UAS-lacZ)65Rth/J
008344   B6;DBA-Tg(Fos-tTA,Fos-EGFP*)1Mmay Tg(tetO-lacZ,tTA*)1Mmay/J
018627   B6;SJL-Tg(Myl1-lacZ)1Ibdml/J
026216   B6;SJL-Tg(Tnnt2-lacZ)497Jl/J
002369   B6;SJL-Tg(c177-lacZ)226Bri/J
002372   B6;SJL-Tg(c177-lacZ)227Bri/J
002621   B6;SJL-Tg(tetop-lacZ)2Mam/J
003299   B6;SWJ-Tg(TIMP3-lacZ)7Jeb/J
002865   B6CBA-Tg(Wnt1-lacZ)206Amc/J
019101   B6N.129S4(B6)-Gt(ROSA)26Sortm1Sor/CjDswJ
018913   B6N.Cg-Tg(tetO-GFP,-lacZ)G3Rsp/J
002955   C.129S7-Gt(ROSA)26Sor/J
009062   C57BL/6-Magel2tm1Stw/J
017955   C57BL/6-Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan/J
002754   C57BL/6-Tg(LacZpl)60Vij/J
013729   C57BL/6-Tg(tetO-EDN1,-lacZ)9Mhus/J
013728   C57BL/6-Tg(tetO-NOS2,-lacZ)240iMhus/J
002193   C57BL/6J-Tg(MTn-lacZ)204Bri/J
005420   C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/GrsrJ
002981   DBA/2-Tg(xstpx-lacZ)36And/J
017333   FVB-Tg(tetO-Gnai2*,-lacZ)382Kndl/J
007225   FVB.129(B6)-Usp18tm1Dzh/J
009427   FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
003487   FVB.Cg-Tg(XGFAP-lacZ)3Mes/J
003140   FVB/N-Tg(PAI1-lacZ)1Jjb/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
005941   FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J
003315   FVB/N-Tg(tetORo1-lacZ)3Conk/J
005878   NOD.129(Cg)-Cd44tm1Hbg/J
003899   STOCK Cd44tm1Hbg/J
008602   STOCK Cdontm2Rsk/J
007912   STOCK En1tm2Alj/J
007925   STOCK En2tm5.1Alj/J
008211   STOCK Gli1tm2Alj/J
007922   STOCK Gli2tm2.1Alj/J
024746   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Hprttm1(tetO-Dkk1)Spdl Tg(TCF/Lef1-lacZ)34Efu/J
006241   STOCK Hhiptm1Amc/J
010707   STOCK Hprttm37(lacZ)Ems/Mmjax
012335   STOCK Hprttm50(Ple55-lacZ)Ems/Mmjax
013764   STOCK Hprttm57(Ple26-lacZ)Ems/Mmjax
012353   STOCK Hprttm65(Ple53-lacZ)Ems/Mmjax
012354   STOCK Hprttm66(Ple5-lacZ)Ems/Mmjax
012584   STOCK Hprttm69(Ple134-lacZ)Ems/Mmjax
006578   STOCK Myoz2tm1Eno/J
006646   STOCK Olfr151tm11(Olfr160)Mom/MomJ
006645   STOCK Olfr151tm12(Olfr16)Mom/MomJ
006691   STOCK Olfr151tm14(Adrb2)Mom/MomJ
006635   STOCK Olfr151tm15(V1rb2)Mom/MomJ
006630   STOCK Olfr151tm1Mom/MomJ
006629   STOCK Olfr151tm2Mom/MomJ
006628   STOCK Olfr151tm3Mom/MomJ
006740   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)AMom/MomJ
006741   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)BMom/MomJ
006651   STOCK Olfr17tm4Mom/MomJ
005707   STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J
006633   STOCK Vmn1r49tm3Mom/MomJ
006634   STOCK Vmn1r49tm4(Olfr151)Mom/MomJ
014092   STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J
006613   STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J
003920   STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
006674   STOCK Tg(Olfr16,taulacZ)2030Mom/MomJ
008477   STOCK Tg(RARE-Hspa1b/lacZ)12Jrt/J
004623   STOCK Tg(TCF/Lef1-lacZ)34Efu/J
005493   STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J
002395   STOCK Tg(Zfy1-lacZ)218Bri/J
003274   STOCK Tg(tetNZL)2Bjd/J
005728   STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J
View Strains carrying other alleles of lacZ     (258 strains)

Strains carrying other alleles of luc
006102   B10.Cg-H2k Tg(Il2/NFAT-luc)83Rinc/J
006100   B10.Cg-H2k Tg(NFkB/Fos-luc)26Rinc/J
006852   B6.129S6-Per2tm1Jt/J
016187   B6.BTBR-Tg(Per1-luc,Per1)1Jt/J
003479   B6.C3-Tg(Fos-luc)1Rnd/J
025855   B6.Cg-Ptprca Lag3tm1Doi Tg(CAG-luc,-GFP)L2G85Chco Thy1a/J
006098   B6.Cg-Tg(Il2/NFAT-luc)83Rinc/J
006851   B6.Cg-Tg(Per1-luc)025Jt/J
016165   B6.Cg-Tg(Per1-luc)128Jt/J
016166   B6.Cg-Tg(Per1-luc)141Jt/J
005999   B6.Cg-Tg(SBE/TK-luc)7Twc/J
006101   B6.Cg-Tg(TRE/Prl-luc)31FlvRinc/J
025854   B6.FVB-Ptprca Tg(CAG-luc,-GFP)L2G85Chco Thy1a/J
011060   B6;129S4-Nanogtm1Jae/J
002709   B6;C3-Tg(TettTALuc)1Dgs/J
013781   B6;FVB-Tg(Myh6/NFAT-luc)1Jmol/J
010545   C.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
012943   C57BL/6-Tg(Ins2-luc/EGFP/TK)300Kauf/J
010548   D1.FVB(Cg)-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
008450   FVB-Tg(CAG-luc,-GFP)L2G85Chco/J
009638   FVB-Tg(GFAP-luc,GAPDH-rluc)172.9Mes/J
010588   FVB-Tg(Myh6/NFAT-luc)1Jmol/J
018167   FVB-Tg(TERT-rluc)DJzhu/J
005125   FVB.129S6(B6)-Gt(ROSA)26Sortm1(Luc)Kael/J
006206   FVB.129S6-Gt(ROSA)26Sortm2(HIF1A/luc)Kael/J
002060   FVB/N-Tg(HIV-luc)326Morr/J
007800   FVB/N-Tg(Ins1-luc)VUPwrs/J
012370   FVB/NJ-Tg(Hspa1a-luc,-EGFP)2Chco/J
013116   NOD.B6-Tg(Ins2-luc/EGFP/TK)300Kauf/J
010542   NOD.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
023451   STOCK Gt(ROSA)26Sortm1(Luc)Kael Tg(UBC-CCR5,-CD4)19Mnz/J
017597   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#bAhmb/J
003275   STOCK Tg(tetL)1Bjd/J
003274   STOCK Tg(tetNZL)2Bjd/J
017600   STOCK Tg(tetO-SMN2,-luc)#bAhmb/J
View Strains carrying other alleles of luc     (35 strains)

Strains carrying other alleles of tetO
008079   129S-Ppargtm2Yba/J
016178   B6(Cg)-Tg(tetO-Cry2)3Jt/J
016176   B6(Cg)-Tg(tetO-Per2)2Jt/J
023757   B6(Cg)-Tg(tetO-tetX,lacZ)1Gogo/UmriJ
009602   B6.129S4(Cg)-Kcnn2tm2Jpad/J
009603   B6.129S4-Kcnn3tm1Jpad/J
023910   B6.Cg-Col1a1tm1(tetO-Lin28a)Gqda/J
023911   B6.Cg-Col1a1tm2(tetO-LIN28B)Gqda/J
023912   B6.Cg-Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/J
017983   B6.Cg-Col1a1tm9(tetO-Dnmt3b_i1)Jae Gt(ROSA)26Sortm1(rtTA*M2)Jae/J
014588   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm6(tetO-MSI2)Jae/J
023749   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Tg(tetO-Pou5f1,-Sox2,-Klf4,-Myc)1Srn/J
014648   B6.Cg-Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/ZkhuJ
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
016998   B6.Cg-Tg(TetO-Axin1,EGFP)TA6Cos/J
003762   B6.Cg-Tg(tetFosb)4468Nes/J
007051   B6.Cg-Tg(tetO-APPSwInd)102Dbo/Mmjax
007052   B6.Cg-Tg(tetO-APPSwInd)107Dbo/Mmjax
007049   B6.Cg-Tg(tetO-APPSwInd)885Dbo/Mmjax
007618   B6.Cg-Tg(tetO-Arntl)1Jt/J
017555   B6.Cg-Tg(tetO-CALY)5Cber/J
024114   B6.Cg-Tg(tetO-CHRM4*)2Blr/J
008277   B6.Cg-Tg(tetO-Clockm1Jt)CL57Jt/J
008468   B6.Cg-Tg(tetO-DTA)1Gfi/J
017791   B6.Cg-Tg(tetO-Hamp)2181Nca/J
009344   B6.Cg-Tg(tetO-Ifng)184Pop/J
009136   B6.Cg-Tg(tetO-Kcnj2,lacZ)1Gogo/J
013583   B6.Cg-Tg(tetO-LRRK2)C7874Cai/J
020652   B6.Cg-Tg(tetO-Mif)279Aren/J
017331   B6.Cg-Tg(tetO-Ppp3ca*)11255Kndl/J
017332   B6.Cg-Tg(tetO-Ppp3ca*)13967Kndl/J
017330   B6.Cg-Tg(tetO-TAg*)175Kndl/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
005738   B6.FVB-Tg(tetO-EGFP,-Tgfbr2)8Mcle/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
006911   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm2(tetO-Pou5f1)Jae/J
011001   B6;129S4-Col1a1tm1(tetO-Pou5f1,-Klf4,-Sox2,-Myc)Hoch/J
016836   B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
002709   B6;C3-Tg(TettTALuc)1Dgs/J
023598   B6;C3-Tg(tetO-AIMP2)630Tmd/J
023642   B6;C3-Tg(tetO-AIMP2)634Tmd/J
016841   B6;C3-Tg(tetO-TARDBP)12Vle/J
014650   B6;C3-Tg(tetO-TARDBP*)4Vle/J
012450   B6;D2-Tg(tetO-SNCA)1Cai/J
008344   B6;DBA-Tg(Fos-tTA,Fos-EGFP*)1Mmay Tg(tetO-lacZ,tTA*)1Mmay/J
024742   B6;DBA-Tg(tetO-GCaMP6s)2Niell/J
024088   B6;FVB-Tg(tetO-AML1/ETO)8Dzh/J
008082   B6;SJL-Tg(Tagln-tTA)1Mrab Tg(tetO-Mcpt1)1Mrab/J
010575   B6;SJL-Tg(tetO-Egfr*)2-9Jek/J
010577   B6;SJL-Tg(tetO-Erbb2*)8-4Jek/J
002621   B6;SJL-Tg(tetop-lacZ)2Mam/J
006004   B6C3-Tg(tetO-APPSwInd)885Dbo/Mmjax
016976   B6C3-Tg(tetO-SNCA*A53T)33Vle/J
018913   B6N.Cg-Tg(tetO-GFP,-lacZ)G3Rsp/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
017719   C3HeB/FeJ-Tg(tetO-TAg)1Efr/J
017955   C57BL/6-Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan/J
025487   C57BL/6-Tg(tetO-Aimp1)29872Mcla/J
005706   C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
006618   C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J
017613   C57BL/6-Tg(tetO-Cdkn1b)1Scpr/J
013729   C57BL/6-Tg(tetO-EDN1,-lacZ)9Mhus/J
016260   C57BL/6-Tg(tetO-Fbxl21)38Jt/J
016179   C57BL/6-Tg(tetO-Fbxl21*)11Jt/J
010713   C57BL/6-Tg(tetO-GFP/tetX)5696Stl/J
013728   C57BL/6-Tg(tetO-NOS2,-lacZ)240iMhus/J
016181   C57BL/6-Tg(tetO-Nr1d1)1Schb/J
016581   C57BL/6J-Tg(tetO-Btrc*)1Jt/J
008278   C57BL/6J-Tg(tetO-Clock)1Jt/J
024898   C57BL/6J-Tg(tetO-EGFP/Rpl10a)5aReij/J
016580   C57BL/6J-Tg(tetO-Usf1)2Jt/J
021065   FVB(C)-Tg(tetO-Npc1/YFP)1Mps/J
017542   FVB-Tg(Myh6/tetO-ATP2B4)1Jmol/J
016571   FVB-Tg(Myh6/tetO-Gata6)2Jmol/J
014155   FVB-Tg(Myh6/tetO-Itpr1)22.3Jmol/J
014153   FVB-Tg(Myh6/tetO-Itpr2)3.11Jmol/J
014154   FVB-Tg(Myh6/tetO-Itpr2)4.9Jmol/J
012684   FVB-Tg(Myh6/tetO-POSTN)22.1Jmol/J
010580   FVB-Tg(Myh6/tetO-PRKCA*)1Jmk/J
013156   FVB-Tg(tetO-CDK5R1*)1Vln/J
013777   FVB-Tg(tetO-Cacna1g)1Jmol/J
013778   FVB-Tg(tetO-Cacnb2)1Jmol/J
013779   FVB-Tg(tetO-Cacnb2)2Jmol/J
013780   FVB-Tg(tetO-Cib1)1Jmol/J
010578   FVB-Tg(tetO-Dusp6)1Jmol/J
017333   FVB-Tg(tetO-Gnai2*,-lacZ)382Kndl/J
008685   FVB-Tg(tetO-Kdr*)4377.5Rwng/J
023397   FVB-Tg(tetO-Lmnb1)AF1Yfu/J
015815   FVB-Tg(tetO-MAPT*P301L)#Kha/JlwsJ
008695   FVB-Tg(tetO-MET)23Rwng/J
012387   FVB-Tg(tetO-Ppargc1a)1Dpk/J
012385   FVB-Tg(tetO-Ppargc1b)7Dpk/J
022979   FVB-Tg(tetO-Thbs4)17.7Jmol/J
006439   FVB-Tg(tetO/CMV-KRAS*G12C)9.1Msmi/J
019038   FVB.Cg-Tg(tetO-GLI1)10Rup/Mmjax
019039   FVB.Cg-Tg(tetO-KLF4)32831Rup/Mmjax
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
012459   FVB/N-Tg(Myh6*/tetO-Capn1)L2Gwd/J
005941   FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J
006202   FVB/N-Tg(tetO-BCR/ABL1)2Dgt/J
014547   FVB/N-Tg(tetO-Fasl)BDepa/J
025672   FVB/N-Tg(tetO-Fgfr2b/Igh)1.3Jaw/J
019376   FVB/N-Tg(tetO-MYC)36aBop/J
026278   FVB/N-Tg(tetO-Ube3a*1)1Svd/J
026279   FVB/N-Tg(tetO-Ube3a*2)884Svd/J
022938   FVB/N-Tg(tetO-Wnt5a)17Rva/J
003315   FVB/N-Tg(tetORo1-lacZ)3Conk/J
005076   NOD.Cg-Tg(tetO-EGFP/FADD)1Doi/DoiJ
006999   STOCK Dbttm1Geh Tg(Cebpb-tTA)5Bjd Tg(tetO-DBT)A1Geh/J
011004   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J
011011   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm4(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J
011013   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm5(tetO-Pou5f1,-Klf4,-Myc)Jae/J
017597   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#bAhmb/J
025671   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(tetO-Fgf10)1Jaw/SpdlJ
024854   STOCK Tg(Camk2a-tTA)1Mmay Tg(tetO-MAPT*P301L)#Kha/J
008755   STOCK Tg(Ins2-rtTA)2Efr Tg(teto-DTA)1Gfi/J
012477   STOCK Tg(Myh6*/tetO-GCaMP2)1Mik/J
016572   STOCK Tg(Myh6/tetO-Gata4)1Jmol/J
014544   STOCK Tg(tetO-ABL1*P242E*P249E)CPdav/J
014093   STOCK Tg(tetO-CHRM3*)1Blr/J
008790   STOCK Tg(tetO-DISC1*)1001Plet/J
008168   STOCK Tg(tetO-DTA)1Gfi/J
017755   STOCK Tg(tetO-GCAMP2)12iRyu/J
024509   STOCK Tg(tetO-Gata6)1Abl/J
016970   STOCK Tg(tetO-HCV)1Mlch/Mmjax
005104   STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J
005699   STOCK Tg(tetO-Ipf1,EGFP)956.6Macd/J
005728   STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J
012441   STOCK Tg(tetO-LRRK2*G2019S)E3Cai/J
017918   STOCK Tg(tetO-MAML1*/EGFP)2Akar/J
017600   STOCK Tg(tetO-SMN2,-luc)#bAhmb/J
012442   STOCK Tg(tetO-SNCA*A53T)E2Cai/J
006224   STOCK Tg(tetO-cre)1Jaw/J
017906   STOCK Tg(tetO-hop/EGFP,-COP4/mCherry)6Kftnk/J
012345   STOCK Tg(tetO-tdTomato,-Syp/EGFP*)1.1Luo/J
012449   STOCK Tg(teto-LRRK2)C7874Cai/J
View Strains carrying other alleles of tetO     (137 strains)

Additional Web Information

Reference Guide to Mouse Models of Spinal Muscular Atrophy manual [.pdf]
Fluorescent Proteins/lacZ Systems

Information about the Rosa26 locus on the Soriano lab web page

Tet Expression Systems

Visit the Spinal Muscular Atrophy (SMA) Mouse Model Resource site for helpful information on SMA Disease and research resources.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Spinal Muscular Atrophy, Type I; SMA1   (SMN1)
Spinal Muscular Atrophy, Type II; SMA2   (SMN1)
Spinal Muscular Atrophy, Type III; SMA3   (SMN1)
Spinal Muscular Atrophy, Type IV; SMA4   (SMN1)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Neurodevelopmental Defects

Neurobiology Research
Ataxia (Movement) Defects
Fluorescent protein expression in neural tissue
Neurodegeneration
Spinal Muscular Atrophy (SMA)
Tet Expression System
      tTA/rtTA Expressing Strains
      tTA/rtTA Responsive Strains

Research Tools
Fluorescent Proteins
Genetics Research
      Mutagenesis and Transgenesis: Tetop Tet System
      Tissue/Cell Markers
      Tissue/Cell Markers: multiple
      Tissue/Cell Markers: neurons
Neurobiology Research
      Tetop Tet System
      cell marker
Tet Expression Systems
      tTA/rtTA Expressing Strains
      tTA/rtTA Responsive Strains

GFP related

Research Tools
Fluorescent Proteins

Smn1tm1Msd related

Neurobiology Research
Spinal Muscular Atrophy (SMA)

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy
Allele Name targeted mutation 1.1, Andras Nagy
Allele Type Targeted (Reporter, Transactivator)
Common Name(s) ROSA26rtTA;
Strain of Origin(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Site of ExpressionWidespread reverse tetracycline transactivator (rtTA)-expression.
Expressed Gene GFP, Green Fluorescent Protein, jellyfish
Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. In some constructs the original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source.
Molecular Note A targeting vector containing a floxed Pgk-neo-pA cassette and a rtTA-IRES-EGFP-pA cassette was inserted into intron 1 of the locus. Cre-mediated recombination removed the floxed neo cassette allowing the ROSA26 promoter to drive expression of rtTA and EGFP. Presence of doxycycline results in the formation of an active transcriptional activator and the activation of the responder transgene. [MGI Ref ID J:174960]
 
Gene Symbol and Name Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano
Chromosome 6
Gene Common Name(s) AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26;
 
Allele Symbol Smn1tm1Msd
Allele Name targeted mutation 1, Michael Sendtner
Allele Type Targeted (Null/Knockout, Reporter)
Common Name(s) SMN-;
Mutation Made By Michael Sendtner,  
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14TG2aIV
ES Cell Line Strain129P2/OlaHsd
Site of ExpressionThe expression of the lacZ gene in tissues where Smn is normally expressed was noted.
Expressed Gene lacZ, beta-galactosidase, E. coli
Molecular Note A lacZ-neo cassette was inserted into exon 2 by homologous recombination resulting in an in-frame fusion of lacZ to exon 2. Homozygous mutant embryos were identified up to 80 hours post coitum. The expression of the lacZ gene in tissues where Smn is normally expressed was noted. [MGI Ref ID J:42813]
 
Gene Symbol and Name Smn1, survival motor neuron 1
Chromosome 13
Gene Common Name(s) AI849087; BCD541; C-BCD541; GEMIN1; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNC; SMNT; Smn; T-BCD541; TDRD16A; TDRD16B; expressed sequence AI849087; survival motor neuron;
 
Allele Symbol Tg(SMN2)89Ahmb
Allele Name transgene insertion 89, Arthur H M Burghes
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) SMN2;
Mutation Made By Arthur Burghes,   Ohio State University
Strain of OriginFVB/N
Site of ExpressionDendrites, axons, and soma of spinal motor neurons display distinct expression of GFP. GFP expression mimics endogenous HLXB9 expression pattern. Fluorscence is detected in axons, dendrites, and processes of spinal motor neurons at embryonic day 9.5 to postnatal day 10 aged mice.
Expressed Gene SMN2, survival of motor neuron 2, centromeric, human
Promoter SMN2, survival of motor neuron 2, centromeric, human
Molecular Note A 35.5 kb genomic fragment containing the human survival motor neuron 2 (SMN2) gene and promoter was used for the transgene. The transgene is ubiquitously expressed in all tissues examined by Northern blot analysis. Line 89 carries 1 copy of the transgene. [MGI Ref ID J:60592]
 
 
Allele Symbol Tg(SMN2*delta7)4299Ahmb
Allele Name transgene insertion 4299, Arthur H M Burghes
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) SMNdelta7; Tg(SMN1*delta7)4299Ahmb;
Mutation Made By Arthur Burghes,   Ohio State University
Strain of OriginFVB/N
Site of ExpressionDendrites, axons, and soma of spinal motor neurons display distinct expression of GFP. GFP expression mimics endogenous HLXB9 expression pattern. Fluorscence is detected in axons, dendrites, and processes of spinal motor neurons at embryonic day 9.5 to postnatal day 10 aged mice.
Expressed Gene SMN2, survival of motor neuron 2, centromeric, human
Promoter SMN2, survival of motor neuron 2, centromeric, human
Molecular Note The transgene contains a human SMN2 promoter and a human SMN2 cDNA (SMNdelta7) that lacks exon 7. [MGI Ref ID J:97103]
 
 
Allele Symbol Tg(tetO-SMN2,-luc)#aAhmb
Allele Name transgene insertion, Arthur H M Burghes
Allele Type Transgenic (Inducible, Inserted expressed sequence, Reporter)
Common Name(s) Luci-TRE-SMN;
Mutation Made By Arthur Burghes,   The Ohio State University
Strain of OriginFVB/N
Site of ExpressionFollowing 10 days of dox, western blot shows luciferase and human SMN expression in widespread tissues including muscle, brain, liver, heart, spinal cord, heart, kidney, lung, and spleen. In addition, dox induction results in increased SMN expression in motor neurons as well as gems within those motor neurons.
Expressed Gene SMN2, survival of motor neuron 2, centromeric, human
Expressed Gene luc, luciferase, firefly
Promoter tetO, tet operator,
Molecular Note The tetracycline response element with two minimal CMV promoters drives inducible expression of human SMN (exons 1 through 7) and a luciferase gene. Two lines were generated. The pound symbol (#) is used when no line is specified and/or lines are pooled. [MGI Ref ID J:174960]
 
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,

Separated MCA


Smn1tm1Msd,

SEPARATED MELT


Smn1tm1Msd, High Resolution Melting
Tg(SMN2)89Ahmb, Melt Curve Analysis
Tg(SMN2*delta7)4299Ahmb, QPCR
Tg(tetO-SMN,-luc)#Ahmb,

Separated MCA


Tg(tetO-SMN,-luc)#Ahmb, High Resolution Melting
Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy, Separated PCR
Smn1tm1Msd, Separated PCR
Tg(SMN2)89Ahmb, Standard PCR
Tg(SMN2*delta7)4299Ahmb, Standard PCR
Tg(tetO-SMN,-luc)#Ahmb, Separated PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Le TT; McGovern VL; Alwine IE; Wang X; Massoni-Laporte A; Rich MM; Burghes AH. 2011. Temporal requirement for high SMN expression in SMA mice. Hum Mol Genet 20(18):3578-91. [PubMed: 21672919]  [MGI Ref ID J:174960]

Additional References

Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy related

Lin X; Suh JH; Go G; Miner JH. 2014. Feasibility of repairing glomerular basement membrane defects in alport syndrome. J Am Soc Nephrol 25(4):687-92. [PubMed: 24262794]  [MGI Ref ID J:207595]

Smn1tm1Msd related

Ahmad S; Wang Y; Shaik GM; Burghes AH; Gangwani L. 2012. The zinc finger protein ZPR1 is a potential modifier of spinal muscular atrophy. Hum Mol Genet 21(12):2745-58. [PubMed: 22422766]  [MGI Ref ID J:184463]

Balasubramaniam V; Ryan SL; Seedorf GJ; Roth EV; Heumann TR; Yoder MC; Ingram DA; Hogan CJ; Markham NE; Abman SH. 2010. Bone marrow-derived angiogenic cells restore lung alveolar and vascular structure after neonatal hyperoxia in infant mice. Am J Physiol Lung Cell Mol Physiol 298(3):L315-23. [PubMed: 20008116]  [MGI Ref ID J:157669]

Baumer D; Lee S; Nicholson G; Davies JL; Parkinson NJ; Murray LM; Gillingwater TH; Ansorge O; Davies KE; Talbot K. 2009. Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy. PLoS Genet 5(12):e1000773. [PubMed: 20019802]  [MGI Ref ID J:161744]

Bebee TW; Dominguez CE; Samadzadeh-Tarighat S; Akehurst KL; Chandler DS. 2012. Hypoxia is a modifier of SMN2 splicing and disease severity in a severe SMA mouse model. Hum Mol Genet 21(19):4301-13. [PubMed: 22763238]  [MGI Ref ID J:187404]

Bevan AK; Hutchinson KR; Foust KD; Braun L; McGovern VL; Schmelzer L; Ward JG; Petruska JC; Lucchesi PA; Burghes AH; Kaspar BK. 2010. Early heart failure in the SMNDelta7 model of spinal muscular atrophy and correction by postnatal scAAV9-SMN delivery. Hum Mol Genet 19(20):3895-905. [PubMed: 20639395]  [MGI Ref ID J:164456]

Bordet T. 2009. Generation of an SMN2 transgene (line 11) MGI Direct Data Submission :.  [MGI Ref ID J:144852]

Bordet T. 2009. Generation of an SMN2 transgene (line 46) MGI Direct Data Submission :.  [MGI Ref ID J:144853]

Bosch-Marce M; Wee CD; Martinez TL; Lipkes CE; Choe DW; Kong L; Van Meerbeke JP; Musaro A; Sumner CJ. 2011. Increased IGF-1 in muscle modulates the phenotype of severe SMA mice. Hum Mol Genet 20(9):1844-53. [PubMed: 21325354]  [MGI Ref ID J:170476]

Bowerman M; Anderson CL; Beauvais A; Boyl PP; Witke W; Kothary R. 2009. SMN, profilin IIa and plastin 3: a link between the deregulation of actin dynamics and SMA pathogenesis. Mol Cell Neurosci 42(1):66-74. [PubMed: 19497369]  [MGI Ref ID J:154248]

Bowerman M; Beauvais A; Anderson CL; Kothary R. 2010. Rho-kinase inactivation prolongs survival of an intermediate SMA mouse model. Hum Mol Genet 19(8):1468-78. [PubMed: 20097679]  [MGI Ref ID J:158345]

Bowerman M; Michalski JP; Beauvais A; Murray LM; DeRepentigny Y; Kothary R. 2014. Defects in pancreatic development and glucose metabolism in SMN-depleted mice independent of canonical spinal muscular atrophy neuromuscular pathology. Hum Mol Genet 23(13):3432-44. [PubMed: 24497575]  [MGI Ref ID J:210674]

Boyer JG; Deguise MO; Murray LM; Yazdani A; De Repentigny Y; Boudreau-Lariviere C; Kothary R. 2014. Myogenic program dysregulation is contributory to disease pathogenesis in spinal muscular atrophy. Hum Mol Genet 23(16):4249-59. [PubMed: 24691550]  [MGI Ref ID J:213423]

Boyer JG; Murray LM; Scott K; De Repentigny Y; Renaud JM; Kothary R. 2013. Early onset muscle weakness and disruption of muscle proteins in mouse models of spinal muscular atrophy. Skelet Muscle 3(1):24. [PubMed: 24119341]  [MGI Ref ID J:202752]

Bricceno KV; Martinez T; Leikina E; Duguez S; Partridge TA; Chernomordik LV; Fischbeck KH; Sumner CJ; Burnett BG. 2014. Survival motor neuron protein deficiency impairs myotube formation by altering myogenic gene expression and focal adhesion dynamics. Hum Mol Genet 23(18):4745-57. [PubMed: 24760765]  [MGI Ref ID J:213599]

Butchbach ME; Edwards JD; Burghes AH. 2007. Abnormal motor phenotype in the SMNDelta7 mouse model of spinal muscular atrophy. Neurobiol Dis 27(2):207-19. [PubMed: 17561409]  [MGI Ref ID J:134824]

Butchbach ME; Rose FF Jr; Rhoades S; Marston J; McCrone JT; Sinnott R; Lorson CL. 2010. Effect of diet on the survival and phenotype of a mouse model for spinal muscular atrophy. Biochem Biophys Res Commun 391(1):835-40. [PubMed: 19945425]  [MGI Ref ID J:156779]

Cobb MS; Rose FF; Rindt H; Glascock JJ; Shababi M; Miller MR; Osman EY; Yen PF; Garcia ML; Martin BR; Wetz MJ; Mazzasette C; Feng Z; Ko CP; Lorson CL. 2013. Development and characterization of an SMN2-based intermediate mouse model of Spinal Muscular Atrophy. Hum Mol Genet 22(9):1843-55. [PubMed: 23390132]  [MGI Ref ID J:194969]

Dachs E; Piedrafita L; Hereu M; Esquerda JE; Caldero J. 2013. Chronic treatment with lithium does not improve neuromuscular phenotype in a mouse model of severe spinal muscular atrophy. Neuroscience 250:417-33. [PubMed: 23876328]  [MGI Ref ID J:207041]

Dale JM; Shen H; Barry DM; Garcia VB; Rose FF Jr; Lorson CL; Garcia ML. 2011. The spinal muscular atrophy mouse model, SMADelta7, displays altered axonal transport without global neurofilament alterations. Acta Neuropathol 122(3):331-41. [PubMed: 21681521]  [MGI Ref ID J:176036]

Dominguez E; Marais T; Chatauret N; Benkhelifa-Ziyyat S; Duque S; Ravassard P; Carcenac R; Astord S; de Moura AP; Voit T; Barkats M. 2011. Intravenous scAAV9 delivery of a codon-optimized SMN1 sequence rescues SMA mice. Hum Mol Genet 20(4):681-93. [PubMed: 21118896]  [MGI Ref ID J:168716]

El-Khodor BF; Edgar N; Chen A; Winberg ML; Joyce C; Brunner D; Suarez-Farinas M; Heyes MP. 2008. Identification of a battery of tests for drug candidate evaluation in the SMNDelta7 neonate model of spinal muscular atrophy. Exp Neurol 212(1):29-43. [PubMed: 18455159]  [MGI Ref ID J:137949]

Farooq F; Abadia-Molina F; Mackenzie D; Hadwen J; Shamim F; O'Reilly S; Holcik M; Mackenzie A. 2013. Celecoxib increases SMN and survival in a severe spinal muscular atrophy mouse model via p38 pathway activation. Hum Mol Genet 22(17):3415-24. [PubMed: 23656793]  [MGI Ref ID J:199128]

Farooq F; Molina FA; Hadwen J; MacKenzie D; Witherspoon L; Osmond M; Holcik M; MacKenzie A. 2011. Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway. J Clin Invest 121(8):3042-50. [PubMed: 21785216]  [MGI Ref ID J:176009]

Fulceri F; Bartalucci A; Paparelli S; Pasquali L; Biagioni F; Ferrucci M; Ruffoli R; Fornai F. 2012. Motor neuron pathology and behavioral alterations at late stages in a SMA mouse model. Brain Res 1442:66-75. [PubMed: 22306031]  [MGI Ref ID J:181868]

Gavrilina TO; McGovern VL; Workman E; Crawford TO; Gogliotti RG; Didonato CJ; Monani UR; Morris GE; Burghes HM. 2008. Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle specific SMN expression has no phenotypic effect. Hum Mol Genet :. [PubMed: 18178576]  [MGI Ref ID J:131663]

Gladman JT; Bebee TW; Edwards C; Wang X; Sahenk Z; Rich MM; Chandler DS. 2010. A humanized Smn gene containing the SMN2 nucleotide alteration in exon 7 mimics SMN2 splicing and the SMA disease phenotype. Hum Mol Genet 19(21):4239-52. [PubMed: 20705738]  [MGI Ref ID J:164889]

Gogliotti RG; Lutz C; Jorgensen M; Huebsch K; Koh S; Didonato CJ. 2011. Characterization of a commonly used mouse model of SMA reveals increased seizure susceptibility and heightened fear response in FVB/N mice. Neurobiol Dis 43(1):142-51. [PubMed: 21396450]  [MGI Ref ID J:174332]

Gogliotti RG; Quinlan KA; Barlow CB; Heier CR; Heckman CJ; Didonato CJ. 2012. Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction. J Neurosci 32(11):3818-29. [PubMed: 22423102]  [MGI Ref ID J:183080]

Hayhurst M; Wagner AK; Cerletti M; Wagers AJ; Rubin LL. 2012. A cell-autonomous defect in skeletal muscle satellite cells expressing low levels of survival of motor neuron protein. Dev Biol 368(2):323-34. [PubMed: 22705478]  [MGI Ref ID J:186551]

Heier CR; Satta R; Lutz C; DiDonato CJ. 2010. Arrhythmia and cardiac defects are a feature of spinal muscular atrophy model mice. Hum Mol Genet 19(20):3906-18. [PubMed: 20693262]  [MGI Ref ID J:164446]

Hunter G; Aghamaleky Sarvestany A; Roche SL; Symes RC; Gillingwater TH. 2014. SMN-dependent intrinsic defects in Schwann cells in mouse models of spinal muscular atrophy. Hum Mol Genet 23(9):2235-50. [PubMed: 24301677]  [MGI Ref ID J:208449]

Jablonka S; Beck M; Lechner BD; Mayer C; Sendtner M. 2007. Defective Ca2+ channel clustering in axon terminals disturbs excitability in motoneurons in spinal muscular atrophy. J Cell Biol 179(1):139-49. [PubMed: 17923533]  [MGI Ref ID J:134807]

Jablonka S; Holtmann B; Meister G; Bandilla M; Rossoll W; Fischer U; Sendtner M. 2002. Gene targeting of Gemin2 in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death. Proc Natl Acad Sci U S A 99(15):10126-31. [PubMed: 12091709]  [MGI Ref ID J:81784]

Jablonka S; Karle K; Sandner B; Andreassi C; von Au K; Sendtner M. 2006. Distinct and overlapping alterations in motor and sensory neurons in a mouse model of spinal muscular atrophy. Hum Mol Genet 15(3):511-8. [PubMed: 16396995]  [MGI Ref ID J:105422]

Jablonka S; Schrank B; Kralewski M; Rossoll W; Sendtner M. 2000. Reduced survival motor neuron (Smn) gene dose in mice leads to motor neuron degeneration: an animal model for spinal muscular atrophy type III. Hum Mol Genet 9(3):341-6. [PubMed: 10655542]  [MGI Ref ID J:60591]

Kariya S; Obis T; Garone C; Akay T; Sera F; Iwata S; Homma S; Monani UR. 2014. Requirement of enhanced Survival Motoneuron protein imposed during neuromuscular junction maturation. J Clin Invest 124(2):785-800. [PubMed: 24463453]  [MGI Ref ID J:208442]

Kariya S; Park GH; Maeno-Hikichi Y; Leykekhman O; Lutz C; Arkovitz MS; Landmesser LT; Monani UR. 2008. Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy. Hum Mol Genet 17(16):2552-69. [PubMed: 18492800]  [MGI Ref ID J:138437]

Kariya S; Re DB; Jacquier A; Nelson K; Przedborski S; Monani UR. 2012. Mutant superoxide dismutase 1 (SOD1), a cause of amyotrophic lateral sclerosis, disrupts the recruitment of SMN, the spinal muscular atrophy protein to nuclear Cajal bodies. Hum Mol Genet 21(15):3421-34. [PubMed: 22581780]  [MGI Ref ID J:185362]

Kong L; Wang X; Choe DW; Polley M; Burnett BG; Bosch-Marce M; Griffin JW; Rich MM; Sumner CJ. 2009. Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice. J Neurosci 29(3):842-51. [PubMed: 19158308]  [MGI Ref ID J:144843]

Kwon DY; Motley WW; Fischbeck KH; Burnett BG. 2011. Increasing expression and decreasing degradation of SMN ameliorate the spinal muscular atrophy phenotype in mice. Hum Mol Genet 20(18):3667-77. [PubMed: 21693563]  [MGI Ref ID J:174791]

Le TT; Pham LT; Butchbach ME; Zhang HL; Monani UR; Coovert DD; Gavrilina TO; Xing L; Bassell GJ; Burghes AH. 2005. SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN. Hum Mol Genet 14(6):845-57. [PubMed: 15703193]  [MGI Ref ID J:97103]

Lee YI; Mikesh M; Smith I; Rimer M; Thompson W. 2011. Muscles in a mouse model of spinal muscular atrophy show profound defects in neuromuscular development even in the absence of failure in neuromuscular transmission or loss of motor neurons. Dev Biol 356(2):432-44. [PubMed: 21658376]  [MGI Ref ID J:175468]

Ling KK; Gibbs RM; Feng Z; Ko CP. 2012. Severe neuromuscular denervation of clinically relevant muscles in a mouse model of spinal muscular atrophy. Hum Mol Genet 21(1):185-95. [PubMed: 21968514]  [MGI Ref ID J:178856]

Ling KK; Lin MY; Zingg B; Feng Z; Ko CP. 2010. Synaptic defects in the spinal and neuromuscular circuitry in a mouse model of spinal muscular atrophy. PLoS One 5(11):e15457. [PubMed: 21085654]  [MGI Ref ID J:166818]

Lotti F; Imlach WL; Saieva L; Beck ES; Hao le T; Li DK; Jiao W; Mentis GZ; Beattie CE; McCabe BD; Pellizzoni L. 2012. An SMN-Dependent U12 Splicing Event Essential for Motor Circuit Function. Cell 151(2):440-54. [PubMed: 23063131]  [MGI Ref ID J:189067]

Lutz CM; Kariya S; Patruni S; Osborne MA; Liu D; Henderson CE; Li DK; Pellizzoni L; Rojas J; Valenzuela DM; Murphy AJ; Winberg ML; Monani UR. 2011. Postsymptomatic restoration of SMN rescues the disease phenotype in a mouse model of severe spinal muscular atrophy. J Clin Invest 121(8):3029-41. [PubMed: 21785219]  [MGI Ref ID J:176007]

McGovern VL; Gavrilina TO; Beattie CE; Burghes AH. 2008. Embryonic motor axon development in the severe SMA mouse. Hum Mol Genet 17(18):2900-9. [PubMed: 18603534]  [MGI Ref ID J:138317]

Meyer K; Marquis J; Trub J; Nlend Nlend R; Verp S; Ruepp MD; Imboden H; Barde I; Trono D; Schumperli D. 2009. Rescue of a severe mouse model for spinal muscular atrophy by U7 snRNA-mediated splicing modulation. Hum Mol Genet 18(3):546-55. [PubMed: 19010792]  [MGI Ref ID J:143540]

Michaud M; Arnoux T; Bielli S; Durand E; Rotrou Y; Jablonka S; Robert F; Giraudon-Paoli M; Riessland M; Mattei MG; Andriambeloson E; Wirth B; Sendtner M; Gallego J; Pruss RM; Bordet T. 2010. Neuromuscular defects and breathing disorders in a new mouse model of spinal muscular atrophy. Neurobiol Dis 38(1):125-35. [PubMed: 20085811]  [MGI Ref ID J:159930]

Monani UR; Pastore MT; Gavrilina TO; Jablonka S; Le TT; Andreassi C; DiCocco JM; Lorson C; Androphy EJ; Sendtner M; Podell M; Burghes AH. 2003. A transgene carrying an A2G missense mutation in the SMN gene modulates phenotypic severity in mice with severe (type I) spinal muscular atrophy. J Cell Biol 160(1):41-52. [PubMed: 12515823]  [MGI Ref ID J:81238]

Monani UR; Sendtner M; Coovert DD; Parsons DW; Andreassi C; Le TT; Jablonka S; Schrank B; Rossol W; Prior TW; Morris GE; Burghes AH. 2000. The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy. Hum Mol Genet 9(3):333-9. [PubMed: 10655541]  [MGI Ref ID J:60592]

Murray LM; Comley LH; Thomson D; Parkinson N; Talbot K; Gillingwater TH. 2008. Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy. Hum Mol Genet 17(7):949-62. [PubMed: 18065780]  [MGI Ref ID J:132467]

Murray LM; Lee S; Baumer D; Parson SH; Talbot K; Gillingwater TH. 2009. Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophy. Hum Mol Genet :. [PubMed: 19884170]  [MGI Ref ID J:155336]

Mutsaers CA; Wishart TM; Lamont DJ; Riessland M; Schreml J; Comley LH; Murray LM; Parson SH; Lochmuller H; Wirth B; Talbot K; Gillingwater TH. 2011. Reversible molecular pathology of skeletal muscle in spinal muscular atrophy. Hum Mol Genet 20(22):4334-44. [PubMed: 21840928]  [MGI Ref ID J:176892]

Nolle A; Zeug A; van Bergeijk J; Tonges L; Gerhard R; Brinkmann H; Al Rayes S; Hensel N; Schill Y; Apkhazava D; Jablonka S; O Fmer J; Kumar Srivastav R; Baasner A; Lingor P; Wirth B; Ponimaskin E; Niedenthal R; Grothe C; Claus P. 2011. The spinal muscular atrophy disease protein SMN is linked to the rho-kinase pathway via profilin. Hum Mol Genet :. [PubMed: 21920940]  [MGI Ref ID J:177764]

Novoyatleva T; Heinrich B; Tang Y; Benderska N; Butchbach ME; Lorson CL; Lorson MA; Ben-Dov C; Fehlbaum P; Bracco L; Burghes AH; Bollen M; Stamm S. 2008. Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing. Hum Mol Genet 17(1):52-70. [PubMed: 17913700]  [MGI Ref ID J:130114]

Osman EY; Miller MR; Robbins KL; Lombardi AM; Atkinson AK; Brehm AJ; Lorson CL. 2014. Morpholino antisense oligonucleotides targeting intronic repressor Element1 improve phenotype in SMA mouse models. Hum Mol Genet 23(18):4832-45. [PubMed: 24781211]  [MGI Ref ID J:213594]

Paez-Colasante X; Seaberg B; Martinez TL; Kong L; Sumner CJ; Rimer M. 2013. Improvement of neuromuscular synaptic phenotypes without enhanced survival and motor function in severe spinal muscular atrophy mice selectively rescued in motor neurons. PLoS One 8(9):e75866. [PubMed: 24086650]  [MGI Ref ID J:206015]

Park GH; Maeno-Hikichi Y; Awano T; Landmesser LT; Monani UR. 2010. Reduced survival of motor neuron (SMN) protein in motor neuronal progenitors functions cell autonomously to cause spinal muscular atrophy in model mice expressing the human centromeric (SMN2) gene. J Neurosci 30(36):12005-19. [PubMed: 20826664]  [MGI Ref ID J:164292]

Porensky PN; Mitrpant C; McGovern VL; Bevan AK; Foust KD; Kaspar BK; Wilton SD; Burghes AH. 2012. A single administration of morpholino antisense oligomer rescues spinal muscular atrophy in mouse. Hum Mol Genet 21(7):1625-38. [PubMed: 22186025]  [MGI Ref ID J:181560]

Riessland M; Ackermann B; Forster A; Jakubik M; Hauke J; Garbes L; Fritzsche I; Mende Y; Blumcke I; Hahnen E; Wirth B. 2010. SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy. Hum Mol Genet 19(8):1492-506. [PubMed: 20097677]  [MGI Ref ID J:158347]

Robbins KL; Glascock JJ; Osman EY; Miller MR; Lorson CL. 2014. Defining the therapeutic window in a severe animal model of spinal muscular atrophy. Hum Mol Genet 23(17):4559-68. [PubMed: 24722206]  [MGI Ref ID J:213616]

Rose FF Jr; Mattis VB; Rindt H; Lorson CL. 2009. Delivery of recombinant follistatin lessens disease severity in a mouse model of spinal muscular atrophy. Hum Mol Genet 18(6):997-1005. [PubMed: 19074460]  [MGI Ref ID J:145746]

Rose FF Jr; Meehan PW; Coady TH; Garcia VB; Garcia ML; Lorson CL. 2008. The Wallerian degeneration slow (Wld(s)) gene does not attenuate disease in a mouse model of spinal muscular atrophy. Biochem Biophys Res Commun 375(1):119-23. [PubMed: 18680723]  [MGI Ref ID J:140130]

Rossoll W; Jablonka S; Andreassi C; Kroning AK; Karle K; Monani UR; Sendtner M. 2003. Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons. J Cell Biol 163(4):801-12. [PubMed: 14623865]  [MGI Ref ID J:86712]

Ruggiu M; McGovern VL; Lotti F; Saieva L; Li DK; Kariya S; Monani UR; Burghes AH; Pellizzoni L. 2012. A role for SMN exon 7 splicing in the selective vulnerability of motor neurons in spinal muscular atrophy. Mol Cell Biol 32(1):126-38. [PubMed: 22037760]  [MGI Ref ID J:183557]

Ruiz R; Casanas JJ; Torres-Benito L; Cano R; Tabares L. 2010. Altered intracellular Ca2+ homeostasis in nerve terminals of severe spinal muscular atrophy mice. J Neurosci 30(3):849-57. [PubMed: 20089893]  [MGI Ref ID J:157700]

Schrank B; Gotz R; Gunnersen JM; Ure JM; Toyka KV; Smith AG ; Sendtner M. 1997. Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos. Proc Natl Acad Sci U S A 94(18):9920-5. [PubMed: 9275227]  [MGI Ref ID J:42813]

See K; Yadav P; Giegerich M; Cheong PS; Graf M; Vyas H; Lee SG; Mathavan S; Fischer U; Sendtner M; Winkler C. 2014. SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy. Hum Mol Genet 23(7):1754-70. [PubMed: 24218366]  [MGI Ref ID J:207140]

Shababi M; Habibi J; Yang HT; Vale SM; Sewell WA; Lorson CL. 2010. Cardiac defects contribute to the pathology of spinal muscular atrophy models. Hum Mol Genet 19(20):4059-71. [PubMed: 20696672]  [MGI Ref ID J:164444]

Sleigh JN; Gillingwater TH; Talbot K. 2011. The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy. Dis Model Mech 4(4):457-67. [PubMed: 21708901]  [MGI Ref ID J:175452]

Subramanian N; Wetzel A; Dombert B; Yadav P; Havlicek S; Jablonka S; Nassar MA; Blum R; Sendtner M. 2012. Role of Nav1.9 in activity-dependent axon growth in motoneurons. Hum Mol Genet 21(16):3655-67. [PubMed: 22641814]  [MGI Ref ID J:185985]

Sumner CJ; Wee CD; Warsing LC; Choe DW; Ng AS; Lutz C; Wagner KR. 2009. Inhibition of myostatin does not ameliorate disease features of severe spinal muscular atrophy mice. Hum Mol Genet 18(17):3145-52. [PubMed: 19477958]  [MGI Ref ID J:151438]

Thomson SR; Nahon JE; Mutsaers CA; Thomson D; Hamilton G; Parson SH; Gillingwater TH. 2012. Morphological characteristics of motor neurons do not determine their relative susceptibility to degeneration in a mouse model of severe spinal muscular atrophy. PLoS One 7(12):e52605. [PubMed: 23285108]  [MGI Ref ID J:195758]

Tisdale S; Lotti F; Saieva L; Van Meerbeke JP; Crawford TO; Sumner CJ; Mentis GZ; Pellizzoni L. 2013. SMN Is Essential for the Biogenesis of U7 Small Nuclear Ribonucleoprotein and 3'-End Formation of Histone mRNAs. Cell Rep 5(5):1187-95. [PubMed: 24332368]  [MGI Ref ID J:204134]

Turner BJ; Parkinson NJ; Davies KE; Talbot K. 2009. Survival motor neuron deficiency enhances progression in an amyotrophic lateral sclerosis mouse model. Neurobiol Dis 34(3):511-7. [PubMed: 19332122]  [MGI Ref ID J:150474]

Walker MP; Rajendra TK; Saieva L; Fuentes JL; Pellizzoni L; Matera AG. 2008. SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain. Hum Mol Genet 17(21):3399-410. [PubMed: 18689355]  [MGI Ref ID J:140332]

Wishart TM; Huang JP; Murray LM; Lamont DJ; Mutsaers CA; Ross J; Geldsetzer P; Ansorge O; Talbot K; Parson SH; Gillingwater TH. 2010. SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy. Hum Mol Genet 19(21):4216-28. [PubMed: 20705736]  [MGI Ref ID J:164890]

Workman E; Saieva L; Carrel TL; Crawford TO; Liu D; Lutz C; Beattie CE; Pellizzoni L; Burghes AH. 2009. A SMN missense mutation complements SMN2 restoring snRNPs and rescuing SMA mice. Hum Mol Genet 18(12):2215-29. [PubMed: 19329542]  [MGI Ref ID J:148541]

Zhang H; Robinson N; Wu C; Wang W; Harrington MA. 2010. Electrophysiological properties of motor neurons in a mouse model of severe spinal muscular atrophy: in vitro versus in vivo development. PLoS One 5(7):e11696. [PubMed: 20657731]  [MGI Ref ID J:163103]

Zhang Z; Pinto AM; Wan L; Wang W; Berg MG; Oliva I; Singh LN; Dengler C; Wei Z; Dreyfuss G. 2013. Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy. Proc Natl Acad Sci U S A 110(48):19348-53. [PubMed: 24191055]  [MGI Ref ID J:202974]

d'Errico P; Boido M; Piras A; Valsecchi V; De Amicis E; Locatelli D; Capra S; Vagni F; Vercelli A; Battaglia G. 2013. Selective vulnerability of spinal and cortical motor neuron subpopulations in delta7 SMA mice. PLoS One 8(12):e82654. [PubMed: 24324819]  [MGI Ref ID J:209739]

Tg(SMN2)89Ahmb related

Ahmad S; Wang Y; Shaik GM; Burghes AH; Gangwani L. 2012. The zinc finger protein ZPR1 is a potential modifier of spinal muscular atrophy. Hum Mol Genet 21(12):2745-58. [PubMed: 22422766]  [MGI Ref ID J:184463]

Avila AM; Burnett BG; Taye AA; Gabanella F; Knight MA; Hartenstein P; Cizman Z; Di Prospero NA; Pellizzoni L; Fischbeck KH; Sumner CJ. 2007. Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy. J Clin Invest 117(3):659-71. [PubMed: 17318264]  [MGI Ref ID J:120738]

Baumer D; Lee S; Nicholson G; Davies JL; Parkinson NJ; Murray LM; Gillingwater TH; Ansorge O; Davies KE; Talbot K. 2009. Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy. PLoS Genet 5(12):e1000773. [PubMed: 20019802]  [MGI Ref ID J:161744]

Bebee TW; Dominguez CE; Samadzadeh-Tarighat S; Akehurst KL; Chandler DS. 2012. Hypoxia is a modifier of SMN2 splicing and disease severity in a severe SMA mouse model. Hum Mol Genet 21(19):4301-13. [PubMed: 22763238]  [MGI Ref ID J:187404]

Bevan AK; Hutchinson KR; Foust KD; Braun L; McGovern VL; Schmelzer L; Ward JG; Petruska JC; Lucchesi PA; Burghes AH; Kaspar BK. 2010. Early heart failure in the SMNDelta7 model of spinal muscular atrophy and correction by postnatal scAAV9-SMN delivery. Hum Mol Genet 19(20):3895-905. [PubMed: 20639395]  [MGI Ref ID J:164456]

Bosch-Marce M; Wee CD; Martinez TL; Lipkes CE; Choe DW; Kong L; Van Meerbeke JP; Musaro A; Sumner CJ. 2011. Increased IGF-1 in muscle modulates the phenotype of severe SMA mice. Hum Mol Genet 20(9):1844-53. [PubMed: 21325354]  [MGI Ref ID J:170476]

Bowerman M; Beauvais A; Anderson CL; Kothary R. 2010. Rho-kinase inactivation prolongs survival of an intermediate SMA mouse model. Hum Mol Genet 19(8):1468-78. [PubMed: 20097679]  [MGI Ref ID J:158345]

Boyer JG; Deguise MO; Murray LM; Yazdani A; De Repentigny Y; Boudreau-Lariviere C; Kothary R. 2014. Myogenic program dysregulation is contributory to disease pathogenesis in spinal muscular atrophy. Hum Mol Genet 23(16):4249-59. [PubMed: 24691550]  [MGI Ref ID J:213423]

Boyer JG; Murray LM; Scott K; De Repentigny Y; Renaud JM; Kothary R. 2013. Early onset muscle weakness and disruption of muscle proteins in mouse models of spinal muscular atrophy. Skelet Muscle 3(1):24. [PubMed: 24119341]  [MGI Ref ID J:202752]

Bricceno KV; Martinez T; Leikina E; Duguez S; Partridge TA; Chernomordik LV; Fischbeck KH; Sumner CJ; Burnett BG. 2014. Survival motor neuron protein deficiency impairs myotube formation by altering myogenic gene expression and focal adhesion dynamics. Hum Mol Genet 23(18):4745-57. [PubMed: 24760765]  [MGI Ref ID J:213599]

Butchbach ME; Edwards JD; Burghes AH. 2007. Abnormal motor phenotype in the SMNDelta7 mouse model of spinal muscular atrophy. Neurobiol Dis 27(2):207-19. [PubMed: 17561409]  [MGI Ref ID J:134824]

Butchbach ME; Rose FF Jr; Rhoades S; Marston J; McCrone JT; Sinnott R; Lorson CL. 2010. Effect of diet on the survival and phenotype of a mouse model for spinal muscular atrophy. Biochem Biophys Res Commun 391(1):835-40. [PubMed: 19945425]  [MGI Ref ID J:156779]

Cobb MS; Rose FF; Rindt H; Glascock JJ; Shababi M; Miller MR; Osman EY; Yen PF; Garcia ML; Martin BR; Wetz MJ; Mazzasette C; Feng Z; Ko CP; Lorson CL. 2013. Development and characterization of an SMN2-based intermediate mouse model of Spinal Muscular Atrophy. Hum Mol Genet 22(9):1843-55. [PubMed: 23390132]  [MGI Ref ID J:194969]

Dachs E; Piedrafita L; Hereu M; Esquerda JE; Caldero J. 2013. Chronic treatment with lithium does not improve neuromuscular phenotype in a mouse model of severe spinal muscular atrophy. Neuroscience 250:417-33. [PubMed: 23876328]  [MGI Ref ID J:207041]

Dale JM; Shen H; Barry DM; Garcia VB; Rose FF Jr; Lorson CL; Garcia ML. 2011. The spinal muscular atrophy mouse model, SMADelta7, displays altered axonal transport without global neurofilament alterations. Acta Neuropathol 122(3):331-41. [PubMed: 21681521]  [MGI Ref ID J:176036]

Dominguez E; Marais T; Chatauret N; Benkhelifa-Ziyyat S; Duque S; Ravassard P; Carcenac R; Astord S; de Moura AP; Voit T; Barkats M. 2011. Intravenous scAAV9 delivery of a codon-optimized SMN1 sequence rescues SMA mice. Hum Mol Genet 20(4):681-93. [PubMed: 21118896]  [MGI Ref ID J:168716]

Farooq F; Abadia-Molina F; Mackenzie D; Hadwen J; Shamim F; O'Reilly S; Holcik M; Mackenzie A. 2013. Celecoxib increases SMN and survival in a severe spinal muscular atrophy mouse model via p38 pathway activation. Hum Mol Genet 22(17):3415-24. [PubMed: 23656793]  [MGI Ref ID J:199128]

Farooq F; Molina FA; Hadwen J; MacKenzie D; Witherspoon L; Osmond M; Holcik M; MacKenzie A. 2011. Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway. J Clin Invest 121(8):3042-50. [PubMed: 21785216]  [MGI Ref ID J:176009]

Fulceri F; Bartalucci A; Paparelli S; Pasquali L; Biagioni F; Ferrucci M; Ruffoli R; Fornai F. 2012. Motor neuron pathology and behavioral alterations at late stages in a SMA mouse model. Brain Res 1442:66-75. [PubMed: 22306031]  [MGI Ref ID J:181868]

Gavrilina TO; McGovern VL; Workman E; Crawford TO; Gogliotti RG; Didonato CJ; Monani UR; Morris GE; Burghes HM. 2008. Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle specific SMN expression has no phenotypic effect. Hum Mol Genet :. [PubMed: 18178576]  [MGI Ref ID J:131663]

Gogliotti RG; Lutz C; Jorgensen M; Huebsch K; Koh S; Didonato CJ. 2011. Characterization of a commonly used mouse model of SMA reveals increased seizure susceptibility and heightened fear response in FVB/N mice. Neurobiol Dis 43(1):142-51. [PubMed: 21396450]  [MGI Ref ID J:174332]

Gogliotti RG; Quinlan KA; Barlow CB; Heier CR; Heckman CJ; Didonato CJ. 2012. Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction. J Neurosci 32(11):3818-29. [PubMed: 22423102]  [MGI Ref ID J:183080]

Hayhurst M; Wagner AK; Cerletti M; Wagers AJ; Rubin LL. 2012. A cell-autonomous defect in skeletal muscle satellite cells expressing low levels of survival of motor neuron protein. Dev Biol 368(2):323-34. [PubMed: 22705478]  [MGI Ref ID J:186551]

Heier CR; Satta R; Lutz C; DiDonato CJ. 2010. Arrhythmia and cardiac defects are a feature of spinal muscular atrophy model mice. Hum Mol Genet 19(20):3906-18. [PubMed: 20693262]  [MGI Ref ID J:164446]

Hunter G; Aghamaleky Sarvestany A; Roche SL; Symes RC; Gillingwater TH. 2014. SMN-dependent intrinsic defects in Schwann cells in mouse models of spinal muscular atrophy. Hum Mol Genet 23(9):2235-50. [PubMed: 24301677]  [MGI Ref ID J:208449]

Jablonka S; Beck M; Lechner BD; Mayer C; Sendtner M. 2007. Defective Ca2+ channel clustering in axon terminals disturbs excitability in motoneurons in spinal muscular atrophy. J Cell Biol 179(1):139-49. [PubMed: 17923533]  [MGI Ref ID J:134807]

Jablonka S; Karle K; Sandner B; Andreassi C; von Au K; Sendtner M. 2006. Distinct and overlapping alterations in motor and sensory neurons in a mouse model of spinal muscular atrophy. Hum Mol Genet 15(3):511-8. [PubMed: 16396995]  [MGI Ref ID J:105422]

Kariya S; Obis T; Garone C; Akay T; Sera F; Iwata S; Homma S; Monani UR. 2014. Requirement of enhanced Survival Motoneuron protein imposed during neuromuscular junction maturation. J Clin Invest 124(2):785-800. [PubMed: 24463453]  [MGI Ref ID J:208442]

Kariya S; Park GH; Maeno-Hikichi Y; Leykekhman O; Lutz C; Arkovitz MS; Landmesser LT; Monani UR. 2008. Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy. Hum Mol Genet 17(16):2552-69. [PubMed: 18492800]  [MGI Ref ID J:138437]

Kong L; Wang X; Choe DW; Polley M; Burnett BG; Bosch-Marce M; Griffin JW; Rich MM; Sumner CJ. 2009. Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice. J Neurosci 29(3):842-51. [PubMed: 19158308]  [MGI Ref ID J:144843]

Le TT; Pham LT; Butchbach ME; Zhang HL; Monani UR; Coovert DD; Gavrilina TO; Xing L; Bassell GJ; Burghes AH. 2005. SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN. Hum Mol Genet 14(6):845-57. [PubMed: 15703193]  [MGI Ref ID J:97103]

Lee AJ; Awano T; Park GH; Monani UR. 2012. Limited phenotypic effects of selectively augmenting the SMN protein in the neurons of a mouse model of severe spinal muscular atrophy. PLoS One 7(9):e46353. [PubMed: 23029491]  [MGI Ref ID J:191961]

Lee YI; Mikesh M; Smith I; Rimer M; Thompson W. 2011. Muscles in a mouse model of spinal muscular atrophy show profound defects in neuromuscular development even in the absence of failure in neuromuscular transmission or loss of motor neurons. Dev Biol 356(2):432-44. [PubMed: 21658376]  [MGI Ref ID J:175468]

Ling KK; Gibbs RM; Feng Z; Ko CP. 2012. Severe neuromuscular denervation of clinically relevant muscles in a mouse model of spinal muscular atrophy. Hum Mol Genet 21(1):185-95. [PubMed: 21968514]  [MGI Ref ID J:178856]

Ling KK; Lin MY; Zingg B; Feng Z; Ko CP. 2010. Synaptic defects in the spinal and neuromuscular circuitry in a mouse model of spinal muscular atrophy. PLoS One 5(11):e15457. [PubMed: 21085654]  [MGI Ref ID J:166818]

Lotti F; Imlach WL; Saieva L; Beck ES; Hao le T; Li DK; Jiao W; Mentis GZ; Beattie CE; McCabe BD; Pellizzoni L. 2012. An SMN-Dependent U12 Splicing Event Essential for Motor Circuit Function. Cell 151(2):440-54. [PubMed: 23063131]  [MGI Ref ID J:189067]

Lutz CM; Kariya S; Patruni S; Osborne MA; Liu D; Henderson CE; Li DK; Pellizzoni L; Rojas J; Valenzuela DM; Murphy AJ; Winberg ML; Monani UR. 2011. Postsymptomatic restoration of SMN rescues the disease phenotype in a mouse model of severe spinal muscular atrophy. J Clin Invest 121(8):3029-41. [PubMed: 21785219]  [MGI Ref ID J:176007]

McGovern VL; Gavrilina TO; Beattie CE; Burghes AH. 2008. Embryonic motor axon development in the severe SMA mouse. Hum Mol Genet 17(18):2900-9. [PubMed: 18603534]  [MGI Ref ID J:138317]

Meyer K; Marquis J; Trub J; Nlend Nlend R; Verp S; Ruepp MD; Imboden H; Barde I; Trono D; Schumperli D. 2009. Rescue of a severe mouse model for spinal muscular atrophy by U7 snRNA-mediated splicing modulation. Hum Mol Genet 18(3):546-55. [PubMed: 19010792]  [MGI Ref ID J:143540]

Monani UR; Pastore MT; Gavrilina TO; Jablonka S; Le TT; Andreassi C; DiCocco JM; Lorson C; Androphy EJ; Sendtner M; Podell M; Burghes AH. 2003. A transgene carrying an A2G missense mutation in the SMN gene modulates phenotypic severity in mice with severe (type I) spinal muscular atrophy. J Cell Biol 160(1):41-52. [PubMed: 12515823]  [MGI Ref ID J:81238]

Monani UR; Sendtner M; Coovert DD; Parsons DW; Andreassi C; Le TT; Jablonka S; Schrank B; Rossol W; Prior TW; Morris GE; Burghes AH. 2000. The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy. Hum Mol Genet 9(3):333-9. [PubMed: 10655541]  [MGI Ref ID J:60592]

Murray LM; Comley LH; Thomson D; Parkinson N; Talbot K; Gillingwater TH. 2008. Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy. Hum Mol Genet 17(7):949-62. [PubMed: 18065780]  [MGI Ref ID J:132467]

Murray LM; Lee S; Baumer D; Parson SH; Talbot K; Gillingwater TH. 2009. Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophy. Hum Mol Genet :. [PubMed: 19884170]  [MGI Ref ID J:155336]

Mutsaers CA; Wishart TM; Lamont DJ; Riessland M; Schreml J; Comley LH; Murray LM; Parson SH; Lochmuller H; Wirth B; Talbot K; Gillingwater TH. 2011. Reversible molecular pathology of skeletal muscle in spinal muscular atrophy. Hum Mol Genet 20(22):4334-44. [PubMed: 21840928]  [MGI Ref ID J:176892]

Nolle A; Zeug A; van Bergeijk J; Tonges L; Gerhard R; Brinkmann H; Al Rayes S; Hensel N; Schill Y; Apkhazava D; Jablonka S; O Fmer J; Kumar Srivastav R; Baasner A; Lingor P; Wirth B; Ponimaskin E; Niedenthal R; Grothe C; Claus P. 2011. The spinal muscular atrophy disease protein SMN is linked to the rho-kinase pathway via profilin. Hum Mol Genet :. [PubMed: 21920940]  [MGI Ref ID J:177764]

Novoyatleva T; Heinrich B; Tang Y; Benderska N; Butchbach ME; Lorson CL; Lorson MA; Ben-Dov C; Fehlbaum P; Bracco L; Burghes AH; Bollen M; Stamm S. 2008. Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing. Hum Mol Genet 17(1):52-70. [PubMed: 17913700]  [MGI Ref ID J:130114]

Osman EY; Miller MR; Robbins KL; Lombardi AM; Atkinson AK; Brehm AJ; Lorson CL. 2014. Morpholino antisense oligonucleotides targeting intronic repressor Element1 improve phenotype in SMA mouse models. Hum Mol Genet 23(18):4832-45. [PubMed: 24781211]  [MGI Ref ID J:213594]

Paez-Colasante X; Seaberg B; Martinez TL; Kong L; Sumner CJ; Rimer M. 2013. Improvement of neuromuscular synaptic phenotypes without enhanced survival and motor function in severe spinal muscular atrophy mice selectively rescued in motor neurons. PLoS One 8(9):e75866. [PubMed: 24086650]  [MGI Ref ID J:206015]

Park GH; Maeno-Hikichi Y; Awano T; Landmesser LT; Monani UR. 2010. Reduced survival of motor neuron (SMN) protein in motor neuronal progenitors functions cell autonomously to cause spinal muscular atrophy in model mice expressing the human centromeric (SMN2) gene. J Neurosci 30(36):12005-19. [PubMed: 20826664]  [MGI Ref ID J:164292]

Porensky PN; Mitrpant C; McGovern VL; Bevan AK; Foust KD; Kaspar BK; Wilton SD; Burghes AH. 2012. A single administration of morpholino antisense oligomer rescues spinal muscular atrophy in mouse. Hum Mol Genet 21(7):1625-38. [PubMed: 22186025]  [MGI Ref ID J:181560]

Riessland M; Ackermann B; Forster A; Jakubik M; Hauke J; Garbes L; Fritzsche I; Mende Y; Blumcke I; Hahnen E; Wirth B. 2010. SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy. Hum Mol Genet 19(8):1492-506. [PubMed: 20097677]  [MGI Ref ID J:158347]

Robbins KL; Glascock JJ; Osman EY; Miller MR; Lorson CL. 2014. Defining the therapeutic window in a severe animal model of spinal muscular atrophy. Hum Mol Genet 23(17):4559-68. [PubMed: 24722206]  [MGI Ref ID J:213616]

Rose FF Jr; Mattis VB; Rindt H; Lorson CL. 2009. Delivery of recombinant follistatin lessens disease severity in a mouse model of spinal muscular atrophy. Hum Mol Genet 18(6):997-1005. [PubMed: 19074460]  [MGI Ref ID J:145746]

Rossoll W; Jablonka S; Andreassi C; Kroning AK; Karle K; Monani UR; Sendtner M. 2003. Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons. J Cell Biol 163(4):801-12. [PubMed: 14623865]  [MGI Ref ID J:86712]

Ruggiu M; McGovern VL; Lotti F; Saieva L; Li DK; Kariya S; Monani UR; Burghes AH; Pellizzoni L. 2012. A role for SMN exon 7 splicing in the selective vulnerability of motor neurons in spinal muscular atrophy. Mol Cell Biol 32(1):126-38. [PubMed: 22037760]  [MGI Ref ID J:183557]

Ruiz R; Casanas JJ; Torres-Benito L; Cano R; Tabares L. 2010. Altered intracellular Ca2+ homeostasis in nerve terminals of severe spinal muscular atrophy mice. J Neurosci 30(3):849-57. [PubMed: 20089893]  [MGI Ref ID J:157700]

Sanchez G; Dury AY; Murray LM; Biondi O; Tadesse H; El Fatimy R; Kothary R; Charbonnier F; Khandjian EW; Cote J. 2013. A novel function for the survival motoneuron protein as a translational regulator. Hum Mol Genet 22(4):668-84. [PubMed: 23136128]  [MGI Ref ID J:191211]

See K; Yadav P; Giegerich M; Cheong PS; Graf M; Vyas H; Lee SG; Mathavan S; Fischer U; Sendtner M; Winkler C. 2014. SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy. Hum Mol Genet 23(7):1754-70. [PubMed: 24218366]  [MGI Ref ID J:207140]

Shababi M; Habibi J; Yang HT; Vale SM; Sewell WA; Lorson CL. 2010. Cardiac defects contribute to the pathology of spinal muscular atrophy models. Hum Mol Genet 19(20):4059-71. [PubMed: 20696672]  [MGI Ref ID J:164444]

Sleigh JN; Gillingwater TH; Talbot K. 2011. The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy. Dis Model Mech 4(4):457-67. [PubMed: 21708901]  [MGI Ref ID J:175452]

Subramanian N; Wetzel A; Dombert B; Yadav P; Havlicek S; Jablonka S; Nassar MA; Blum R; Sendtner M. 2012. Role of Nav1.9 in activity-dependent axon growth in motoneurons. Hum Mol Genet 21(16):3655-67. [PubMed: 22641814]  [MGI Ref ID J:185985]

Sumner CJ; Wee CD; Warsing LC; Choe DW; Ng AS; Lutz C; Wagner KR. 2009. Inhibition of myostatin does not ameliorate disease features of severe spinal muscular atrophy mice. Hum Mol Genet 18(17):3145-52. [PubMed: 19477958]  [MGI Ref ID J:151438]

Taylor AS; Glascock JJ; Rose FF Jr; Lutz C; Lorson CL. 2013. Restoration of SMN to Emx-1 expressing cortical neurons is not sufficient to provide benefit to a severe mouse model of Spinal Muscular Atrophy. Transgenic Res 22(5):1029-36. [PubMed: 23512182]  [MGI Ref ID J:213313]

Thomson SR; Nahon JE; Mutsaers CA; Thomson D; Hamilton G; Parson SH; Gillingwater TH. 2012. Morphological characteristics of motor neurons do not determine their relative susceptibility to degeneration in a mouse model of severe spinal muscular atrophy. PLoS One 7(12):e52605. [PubMed: 23285108]  [MGI Ref ID J:195758]

Tisdale S; Lotti F; Saieva L; Van Meerbeke JP; Crawford TO; Sumner CJ; Mentis GZ; Pellizzoni L. 2013. SMN Is Essential for the Biogenesis of U7 Small Nuclear Ribonucleoprotein and 3'-End Formation of Histone mRNAs. Cell Rep 5(5):1187-95. [PubMed: 24332368]  [MGI Ref ID J:204134]

Torres-Benito L; Neher MF; Cano R; Ruiz R; Tabares L. 2011. SMN requirement for synaptic vesicle, active zone and microtubule postnatal organization in motor nerve terminals. PLoS One 6(10):e26164. [PubMed: 22022549]  [MGI Ref ID J:179582]

Turner BJ; Parkinson NJ; Davies KE; Talbot K. 2009. Survival motor neuron deficiency enhances progression in an amyotrophic lateral sclerosis mouse model. Neurobiol Dis 34(3):511-7. [PubMed: 19332122]  [MGI Ref ID J:150474]

Walker MP; Rajendra TK; Saieva L; Fuentes JL; Pellizzoni L; Matera AG. 2008. SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain. Hum Mol Genet 17(21):3399-410. [PubMed: 18689355]  [MGI Ref ID J:140332]

Wishart TM; Huang JP; Murray LM; Lamont DJ; Mutsaers CA; Ross J; Geldsetzer P; Ansorge O; Talbot K; Parson SH; Gillingwater TH. 2010. SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy. Hum Mol Genet 19(21):4216-28. [PubMed: 20705736]  [MGI Ref ID J:164890]

Wishart TM; Mutsaers CA; Riessland M; Reimer MM; Hunter G; Hannam ML; Eaton SL; Fuller HR; Roche SL; Somers E; Morse R; Young PJ; Lamont DJ; Hammerschmidt M; Joshi A; Hohenstein P; Morris GE; Parson SH; Skehel PA; Becker T; Robinson IM; Becker CG; Wirth B; Gillingwater TH. 2014. Dysregulation of ubiquitin homeostasis and beta-catenin signaling promote spinal muscular atrophy. J Clin Invest 124(4):1821-34. [PubMed: 24590288]  [MGI Ref ID J:209625]

Workman E; Saieva L; Carrel TL; Crawford TO; Liu D; Lutz C; Beattie CE; Pellizzoni L; Burghes AH. 2009. A SMN missense mutation complements SMN2 restoring snRNPs and rescuing SMA mice. Hum Mol Genet 18(12):2215-29. [PubMed: 19329542]  [MGI Ref ID J:148541]

Zhang H; Robinson N; Wu C; Wang W; Harrington MA. 2010. Electrophysiological properties of motor neurons in a mouse model of severe spinal muscular atrophy: in vitro versus in vivo development. PLoS One 5(7):e11696. [PubMed: 20657731]  [MGI Ref ID J:163103]

Zhang Z; Pinto AM; Wan L; Wang W; Berg MG; Oliva I; Singh LN; Dengler C; Wei Z; Dreyfuss G. 2013. Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy. Proc Natl Acad Sci U S A 110(48):19348-53. [PubMed: 24191055]  [MGI Ref ID J:202974]

d'Errico P; Boido M; Piras A; Valsecchi V; De Amicis E; Locatelli D; Capra S; Vagni F; Vercelli A; Battaglia G. 2013. Selective vulnerability of spinal and cortical motor neuron subpopulations in delta7 SMA mice. PLoS One 8(12):e82654. [PubMed: 24324819]  [MGI Ref ID J:209739]

Tg(SMN2*delta7)4299Ahmb related

Ahmad S; Wang Y; Shaik GM; Burghes AH; Gangwani L. 2012. The zinc finger protein ZPR1 is a potential modifier of spinal muscular atrophy. Hum Mol Genet 21(12):2745-58. [PubMed: 22422766]  [MGI Ref ID J:184463]

Avila AM; Burnett BG; Taye AA; Gabanella F; Knight MA; Hartenstein P; Cizman Z; Di Prospero NA; Pellizzoni L; Fischbeck KH; Sumner CJ. 2007. Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy. J Clin Invest 117(3):659-71. [PubMed: 17318264]  [MGI Ref ID J:120738]

Baumer D; Lee S; Nicholson G; Davies JL; Parkinson NJ; Murray LM; Gillingwater TH; Ansorge O; Davies KE; Talbot K. 2009. Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy. PLoS Genet 5(12):e1000773. [PubMed: 20019802]  [MGI Ref ID J:161744]

Bebee TW; Dominguez CE; Samadzadeh-Tarighat S; Akehurst KL; Chandler DS. 2012. Hypoxia is a modifier of SMN2 splicing and disease severity in a severe SMA mouse model. Hum Mol Genet 21(19):4301-13. [PubMed: 22763238]  [MGI Ref ID J:187404]

Bosch-Marce M; Wee CD; Martinez TL; Lipkes CE; Choe DW; Kong L; Van Meerbeke JP; Musaro A; Sumner CJ. 2011. Increased IGF-1 in muscle modulates the phenotype of severe SMA mice. Hum Mol Genet 20(9):1844-53. [PubMed: 21325354]  [MGI Ref ID J:170476]

Boyer JG; Deguise MO; Murray LM; Yazdani A; De Repentigny Y; Boudreau-Lariviere C; Kothary R. 2014. Myogenic program dysregulation is contributory to disease pathogenesis in spinal muscular atrophy. Hum Mol Genet 23(16):4249-59. [PubMed: 24691550]  [MGI Ref ID J:213423]

Bricceno KV; Martinez T; Leikina E; Duguez S; Partridge TA; Chernomordik LV; Fischbeck KH; Sumner CJ; Burnett BG. 2014. Survival motor neuron protein deficiency impairs myotube formation by altering myogenic gene expression and focal adhesion dynamics. Hum Mol Genet 23(18):4745-57. [PubMed: 24760765]  [MGI Ref ID J:213599]

Bricceno KV; Sampognaro PJ; Van Meerbeke JP; Sumner CJ; Fischbeck KH; Burnett BG. 2012. Histone deacetylase inhibition suppresses myogenin-dependent atrogene activation in spinal muscular atrophy mice. Hum Mol Genet 21(20):4448-59. [PubMed: 22798624]  [MGI Ref ID J:187753]

Butchbach ME; Edwards JD; Burghes AH. 2007. Abnormal motor phenotype in the SMNDelta7 mouse model of spinal muscular atrophy. Neurobiol Dis 27(2):207-19. [PubMed: 17561409]  [MGI Ref ID J:134824]

Butchbach ME; Rose FF Jr; Rhoades S; Marston J; McCrone JT; Sinnott R; Lorson CL. 2010. Effect of diet on the survival and phenotype of a mouse model for spinal muscular atrophy. Biochem Biophys Res Commun 391(1):835-40. [PubMed: 19945425]  [MGI Ref ID J:156779]

Cobb MS; Rose FF; Rindt H; Glascock JJ; Shababi M; Miller MR; Osman EY; Yen PF; Garcia ML; Martin BR; Wetz MJ; Mazzasette C; Feng Z; Ko CP; Lorson CL. 2013. Development and characterization of an SMN2-based intermediate mouse model of Spinal Muscular Atrophy. Hum Mol Genet 22(9):1843-55. [PubMed: 23390132]  [MGI Ref ID J:194969]

Dachs E; Piedrafita L; Hereu M; Esquerda JE; Caldero J. 2013. Chronic treatment with lithium does not improve neuromuscular phenotype in a mouse model of severe spinal muscular atrophy. Neuroscience 250:417-33. [PubMed: 23876328]  [MGI Ref ID J:207041]

Dale JM; Shen H; Barry DM; Garcia VB; Rose FF Jr; Lorson CL; Garcia ML. 2011. The spinal muscular atrophy mouse model, SMADelta7, displays altered axonal transport without global neurofilament alterations. Acta Neuropathol 122(3):331-41. [PubMed: 21681521]  [MGI Ref ID J:176036]

Dominguez E; Marais T; Chatauret N; Benkhelifa-Ziyyat S; Duque S; Ravassard P; Carcenac R; Astord S; de Moura AP; Voit T; Barkats M. 2011. Intravenous scAAV9 delivery of a codon-optimized SMN1 sequence rescues SMA mice. Hum Mol Genet 20(4):681-93. [PubMed: 21118896]  [MGI Ref ID J:168716]

Farooq F; Abadia-Molina F; Mackenzie D; Hadwen J; Shamim F; O'Reilly S; Holcik M; Mackenzie A. 2013. Celecoxib increases SMN and survival in a severe spinal muscular atrophy mouse model via p38 pathway activation. Hum Mol Genet 22(17):3415-24. [PubMed: 23656793]  [MGI Ref ID J:199128]

Farooq F; Molina FA; Hadwen J; MacKenzie D; Witherspoon L; Osmond M; Holcik M; MacKenzie A. 2011. Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway. J Clin Invest 121(8):3042-50. [PubMed: 21785216]  [MGI Ref ID J:176009]

Heier CR; Satta R; Lutz C; DiDonato CJ. 2010. Arrhythmia and cardiac defects are a feature of spinal muscular atrophy model mice. Hum Mol Genet 19(20):3906-18. [PubMed: 20693262]  [MGI Ref ID J:164446]

Kariya S; Park GH; Maeno-Hikichi Y; Leykekhman O; Lutz C; Arkovitz MS; Landmesser LT; Monani UR. 2008. Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy. Hum Mol Genet 17(16):2552-69. [PubMed: 18492800]  [MGI Ref ID J:138437]

Kong L; Wang X; Choe DW; Polley M; Burnett BG; Bosch-Marce M; Griffin JW; Rich MM; Sumner CJ. 2009. Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice. J Neurosci 29(3):842-51. [PubMed: 19158308]  [MGI Ref ID J:144843]

Kwon DY; Motley WW; Fischbeck KH; Burnett BG. 2011. Increasing expression and decreasing degradation of SMN ameliorate the spinal muscular atrophy phenotype in mice. Hum Mol Genet 20(18):3667-77. [PubMed: 21693563]  [MGI Ref ID J:174791]

Le TT; Pham LT; Butchbach ME; Zhang HL; Monani UR; Coovert DD; Gavrilina TO; Xing L; Bassell GJ; Burghes AH. 2005. SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN. Hum Mol Genet 14(6):845-57. [PubMed: 15703193]  [MGI Ref ID J:97103]

Lee YI; Mikesh M; Smith I; Rimer M; Thompson W. 2011. Muscles in a mouse model of spinal muscular atrophy show profound defects in neuromuscular development even in the absence of failure in neuromuscular transmission or loss of motor neurons. Dev Biol 356(2):432-44. [PubMed: 21658376]  [MGI Ref ID J:175468]

Ling KK; Gibbs RM; Feng Z; Ko CP. 2012. Severe neuromuscular denervation of clinically relevant muscles in a mouse model of spinal muscular atrophy. Hum Mol Genet 21(1):185-95. [PubMed: 21968514]  [MGI Ref ID J:178856]

Ling KK; Lin MY; Zingg B; Feng Z; Ko CP. 2010. Synaptic defects in the spinal and neuromuscular circuitry in a mouse model of spinal muscular atrophy. PLoS One 5(11):e15457. [PubMed: 21085654]  [MGI Ref ID J:166818]

Lotti F; Imlach WL; Saieva L; Beck ES; Hao le T; Li DK; Jiao W; Mentis GZ; Beattie CE; McCabe BD; Pellizzoni L. 2012. An SMN-Dependent U12 Splicing Event Essential for Motor Circuit Function. Cell 151(2):440-54. [PubMed: 23063131]  [MGI Ref ID J:189067]

Lutz CM; Kariya S; Patruni S; Osborne MA; Liu D; Henderson CE; Li DK; Pellizzoni L; Rojas J; Valenzuela DM; Murphy AJ; Winberg ML; Monani UR. 2011. Postsymptomatic restoration of SMN rescues the disease phenotype in a mouse model of severe spinal muscular atrophy. J Clin Invest 121(8):3029-41. [PubMed: 21785219]  [MGI Ref ID J:176007]

Murray LM; Comley LH; Thomson D; Parkinson N; Talbot K; Gillingwater TH. 2008. Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy. Hum Mol Genet 17(7):949-62. [PubMed: 18065780]  [MGI Ref ID J:132467]

Murray LM; Lee S; Baumer D; Parson SH; Talbot K; Gillingwater TH. 2009. Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophy. Hum Mol Genet :. [PubMed: 19884170]  [MGI Ref ID J:155336]

Osman EY; Miller MR; Robbins KL; Lombardi AM; Atkinson AK; Brehm AJ; Lorson CL. 2014. Morpholino antisense oligonucleotides targeting intronic repressor Element1 improve phenotype in SMA mouse models. Hum Mol Genet 23(18):4832-45. [PubMed: 24781211]  [MGI Ref ID J:213594]

Paez-Colasante X; Seaberg B; Martinez TL; Kong L; Sumner CJ; Rimer M. 2013. Improvement of neuromuscular synaptic phenotypes without enhanced survival and motor function in severe spinal muscular atrophy mice selectively rescued in motor neurons. PLoS One 8(9):e75866. [PubMed: 24086650]  [MGI Ref ID J:206015]

Porensky PN; Mitrpant C; McGovern VL; Bevan AK; Foust KD; Kaspar BK; Wilton SD; Burghes AH. 2012. A single administration of morpholino antisense oligomer rescues spinal muscular atrophy in mouse. Hum Mol Genet 21(7):1625-38. [PubMed: 22186025]  [MGI Ref ID J:181560]

Robbins KL; Glascock JJ; Osman EY; Miller MR; Lorson CL. 2014. Defining the therapeutic window in a severe animal model of spinal muscular atrophy. Hum Mol Genet 23(17):4559-68. [PubMed: 24722206]  [MGI Ref ID J:213616]

Rose FF Jr; Mattis VB; Rindt H; Lorson CL. 2009. Delivery of recombinant follistatin lessens disease severity in a mouse model of spinal muscular atrophy. Hum Mol Genet 18(6):997-1005. [PubMed: 19074460]  [MGI Ref ID J:145746]

Ruggiu M; McGovern VL; Lotti F; Saieva L; Li DK; Kariya S; Monani UR; Burghes AH; Pellizzoni L. 2012. A role for SMN exon 7 splicing in the selective vulnerability of motor neurons in spinal muscular atrophy. Mol Cell Biol 32(1):126-38. [PubMed: 22037760]  [MGI Ref ID J:183557]

Ruiz R; Casanas JJ; Torres-Benito L; Cano R; Tabares L. 2010. Altered intracellular Ca2+ homeostasis in nerve terminals of severe spinal muscular atrophy mice. J Neurosci 30(3):849-57. [PubMed: 20089893]  [MGI Ref ID J:157700]

Sanchez G; Dury AY; Murray LM; Biondi O; Tadesse H; El Fatimy R; Kothary R; Charbonnier F; Khandjian EW; Cote J. 2013. A novel function for the survival motoneuron protein as a translational regulator. Hum Mol Genet 22(4):668-84. [PubMed: 23136128]  [MGI Ref ID J:191211]

Shababi M; Habibi J; Ma L; Glascock JJ; Sowers JR; Lorson CL. 2012. Partial restoration of cardio-vascular defects in a rescued severe model of spinal muscular atrophy. J Mol Cell Cardiol 52(5):1074-82. [PubMed: 22285962]  [MGI Ref ID J:183695]

Shababi M; Habibi J; Yang HT; Vale SM; Sewell WA; Lorson CL. 2010. Cardiac defects contribute to the pathology of spinal muscular atrophy models. Hum Mol Genet 19(20):4059-71. [PubMed: 20696672]  [MGI Ref ID J:164444]

Sleigh JN; Gillingwater TH; Talbot K. 2011. The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy. Dis Model Mech 4(4):457-67. [PubMed: 21708901]  [MGI Ref ID J:175452]

Sumner CJ; Wee CD; Warsing LC; Choe DW; Ng AS; Lutz C; Wagner KR. 2009. Inhibition of myostatin does not ameliorate disease features of severe spinal muscular atrophy mice. Hum Mol Genet 18(17):3145-52. [PubMed: 19477958]  [MGI Ref ID J:151438]

Taylor AS; Glascock JJ; Rose FF Jr; Lutz C; Lorson CL. 2013. Restoration of SMN to Emx-1 expressing cortical neurons is not sufficient to provide benefit to a severe mouse model of Spinal Muscular Atrophy. Transgenic Res 22(5):1029-36. [PubMed: 23512182]  [MGI Ref ID J:213313]

Tisdale S; Lotti F; Saieva L; Van Meerbeke JP; Crawford TO; Sumner CJ; Mentis GZ; Pellizzoni L. 2013. SMN Is Essential for the Biogenesis of U7 Small Nuclear Ribonucleoprotein and 3'-End Formation of Histone mRNAs. Cell Rep 5(5):1187-95. [PubMed: 24332368]  [MGI Ref ID J:204134]

Torres-Benito L; Neher MF; Cano R; Ruiz R; Tabares L. 2011. SMN requirement for synaptic vesicle, active zone and microtubule postnatal organization in motor nerve terminals. PLoS One 6(10):e26164. [PubMed: 22022549]  [MGI Ref ID J:179582]

Zhang Z; Pinto AM; Wan L; Wang W; Berg MG; Oliva I; Singh LN; Dengler C; Wei Z; Dreyfuss G. 2013. Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy. Proc Natl Acad Sci U S A 110(48):19348-53. [PubMed: 24191055]  [MGI Ref ID J:202974]

d'Errico P; Boido M; Piras A; Valsecchi V; De Amicis E; Locatelli D; Capra S; Vagni F; Vercelli A; Battaglia G. 2013. Selective vulnerability of spinal and cortical motor neuron subpopulations in delta7 SMA mice. PLoS One 8(12):e82654. [PubMed: 24324819]  [MGI Ref ID J:209739]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryFor routine maintenance of the live colony, mice of the following genotype may be bred together: homozygous for Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy, heterozygous or homozygous for Smn1tm1Msd, homozygous for Tg(SMN2)89, homozygous for the Tg(SMNΔ7)4299, and hemizygous or homozygous for Tg(tetO-SMN2,-luc)#a.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   See control note: The following strain(s) may also be appropriate experimental controls:
--mice from the moderate type II SMA strain (Stock No. 005025).
   001800 FVB/NJ (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
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- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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