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Common Names: FcRg-;    
In this knockout strain, exon 2 of the Fcer1g gene is disrupted. These mice develop mild or no symptoms in response to a collagen-induced arthritis challenge. These mice may have applications in studies related to autoimmunity and inflammation.


Strain Information

Type Congenic; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   13-JUN-13
Specieslaboratory mouse
GenerationN14pN1F8 (08-MAY-15)
Generation Definitions
Donating Investigator Sandra Kleinau,   Biomedical Center, Uppsala University

Fc IgE receptors are found on immune effector cells and mediate macrophage phagocytosis, antibody-dependent cell-mediated cytotoxicity, mast cell degranulation, IgE-mediated systemic anaphylaxis and neutrophil recruitment. These mice carry a targeted mutation of the Fcer1g (Fc receptor, IgE, high affinity I, gamma polypeptide ) gene and have been backcrossed onto the autoimmune-susceptible DBA/1 background. In homozygous mice challenged with collagen-induced arthritis, fewer mice develop arthritic symptoms, and the symptoms are mild compared to wildtype controls. Mutant mice that develop collagen-induced arthritis do not exhibit inflammatory cell infiltration in the synovium or cartilage and bone erosion. However, homozygotes produce total IgG anti-collagen antibodies at levels similar to those seen in controls. During backcrossing, the Y chromosome may not have been fixed to the DBA/1 genetic background. Mice that are homozygous for the targeted mutation are viable, fertile and normal in size.

A targeting vector containing a NEO cassette was used to disrupt exon 2, which created a new stop codon 239 bp downstream of the integration site. The construct was electroporated into 129P2/OlaHsd derived E14 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice, and then backcrossed to DBA/1 for 14 generations. Upon arrival at The Jackson Laboratory, the mice were crossed to DBA/1J (Stock No. 000670) at least once to establish the colony.

Control Information

   000670 DBA/1J
  Considerations for Choosing Controls

Related Strains

Strains carrying   Fcer1gtm1Rav allele
002847   B6;129P2-Fcer1gtm1Rav/J
View Strains carrying   Fcer1gtm1Rav     (1 strain)


Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.


        involves: 129P2/OlaHsd * C57BL/6
  • immune system phenotype
  • *normal* immune system phenotype
    • the development of NK T cells is normal in these mice   (MGI Ref ID J:28282)
    • abnormal immune cell physiology   (MGI Ref ID J:39248)
      • abnormal NK cell physiology
        • antibody dependent, cell-mediated cytotoxicity almost totally lost   (MGI Ref ID J:39248)
      • abnormal dendritic cell antigen presentation
        • deficient antigen presentation by bone marrow dendritic cells   (MGI Ref ID J:83995)
      • abnormal immunoglobulin level
        • serum IgG response to OVA challenge of sensitized mice more moderate than in controls (37% increase as opposed to 260%)   (MGI Ref ID J:78659)
        • increased IgE level
          • serum IgE response to OVA challenge of sensitized mice greater than that of controls   (MGI Ref ID J:78659)
      • abnormal mast cell physiology
        • loss of IgE and IgG2a binding   (MGI Ref ID J:39248)
        • IgG1 binding normal   (MGI Ref ID J:39248)
        • degranulation and serotonin release largely suppressed   (MGI Ref ID J:39248)
        • significantly reduced prostaglandin D2 release   (MGI Ref ID J:39248)
      • impaired macrophage phagocytosis
        • phagocytosis blocked regardless of Ig binding   (MGI Ref ID J:39248)
    • decreased susceptibility to experimental autoimmune encephalomyelitis
      • considerably reduced when induced with myelin oligodendrocyte glycoprotein   (MGI Ref ID J:126520)
      • more frequent disease remission   (MGI Ref ID J:126520)
      • completely protected against anaphylaxis from a second dose of myelin oligodendrocyte glycoprotein   (MGI Ref ID J:126520)
      • fewer inflammatory foci in the central nervous system   (MGI Ref ID J:126520)
    • decreased susceptibility to type I hypersensitivity reaction
      • unable to mount a passive cutaneous anaphylactic response   (MGI Ref ID J:39248)
      • IgG1 dependent passive systemic anaphylaxis does not occur   (MGI Ref ID J:78659)
      • sensitized mice survive OVA challenge whereas controls die within 20 minutes   (MGI Ref ID J:78659)
  • cardiovascular system phenotype
  • decreased myocardial infarction size
    • infarct size after coronary occlusion/reperfusion is significantly reduced   (MGI Ref ID J:112819)
    • fewer platelet microthrombi and neutrophils in the capillaries of the myocardium   (MGI Ref ID J:112819)
    • occluded microthrombi in 12% of capillaries as compared to 38% in controls   (MGI Ref ID J:112819)
  • homeostasis/metabolism phenotype
  • abnormal platelet activation
    • while platelets exhibit activation at high shear stress, they form looser aggregates and disintegrate more frequently than wild-type platelets   (MGI Ref ID J:118488)
    • platelet aggregates display reduced annexinV positivity after perfusion unlike wild-type platelets   (MGI Ref ID J:118488)
    • platelet calcium response fluctuates and is lower than in wild-type platelets   (MGI Ref ID J:118488)
    • decreased platelet aggregation
      • reduced aggregation in response to collagen   (MGI Ref ID J:112819)
  • decreased myocardial infarction size
    • infarct size after coronary occlusion/reperfusion is significantly reduced   (MGI Ref ID J:112819)
    • fewer platelet microthrombi and neutrophils in the capillaries of the myocardium   (MGI Ref ID J:112819)
    • occluded microthrombi in 12% of capillaries as compared to 38% in controls   (MGI Ref ID J:112819)
  • decreased platelet calcium level   (MGI Ref ID J:118488)
  • hematopoietic system phenotype
  • abnormal NK cell physiology
    • antibody dependent, cell-mediated cytotoxicity almost totally lost   (MGI Ref ID J:39248)
  • abnormal immunoglobulin level
    • serum IgG response to OVA challenge of sensitized mice more moderate than in controls (37% increase as opposed to 260%)   (MGI Ref ID J:78659)
    • increased IgE level
      • serum IgE response to OVA challenge of sensitized mice greater than that of controls   (MGI Ref ID J:78659)
  • abnormal mast cell physiology
    • loss of IgE and IgG2a binding   (MGI Ref ID J:39248)
    • IgG1 binding normal   (MGI Ref ID J:39248)
    • degranulation and serotonin release largely suppressed   (MGI Ref ID J:39248)
    • significantly reduced prostaglandin D2 release   (MGI Ref ID J:39248)
  • abnormal platelet activation
    • while platelets exhibit activation at high shear stress, they form looser aggregates and disintegrate more frequently than wild-type platelets   (MGI Ref ID J:118488)
    • platelet aggregates display reduced annexinV positivity after perfusion unlike wild-type platelets   (MGI Ref ID J:118488)
    • platelet calcium response fluctuates and is lower than in wild-type platelets   (MGI Ref ID J:118488)
    • decreased platelet aggregation
      • reduced aggregation in response to collagen   (MGI Ref ID J:112819)
  • decreased platelet calcium level   (MGI Ref ID J:118488)
  • impaired macrophage phagocytosis
    • phagocytosis blocked regardless of Ig binding   (MGI Ref ID J:39248)
  • skeleton phenotype
  • *normal* skeleton phenotype
    • mice exhibit normal bone volume and osteoclast function   (MGI Ref ID J:89583)


  • immune system phenotype
  • decreased interleukin-1 beta secretion
    • by BMDCs in response to water-soluble mannans from Serotype A C. albicans   (MGI Ref ID J:160680)
    • by BMDCs stimulated by yeast or hyphae forms of C.albicans   (MGI Ref ID J:160680)
  • decreased interleukin-10 secretion
    • by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans   (MGI Ref ID J:160680)
    • by BMDCs stimulated by yeast or hyphae forms of C.albicans   (MGI Ref ID J:160680)
  • decreased interleukin-12b secretion
    • by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans   (MGI Ref ID J:160680)
    • by BMDCs stimulated by yeast or hyphae forms of C.albicans   (MGI Ref ID J:160680)
  • decreased interleukin-23 secretion
    • by BMDCs stimulated by yeast form of C.albicans   (MGI Ref ID J:160680)
  • decreased interleukin-6 secretion
    • by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans   (MGI Ref ID J:160680)
    • by BMDCs stimulated by yeast or hyphae forms of C.albicans   (MGI Ref ID J:160680)
  • decreased tumor necrosis factor secretion
    • by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans   (MGI Ref ID J:160680)
    • by BMDCs stimulated by yeast or hyphae forms of C.albicans   (MGI Ref ID J:160680)


        involves: 129P2/OlaHsd
  • immune system phenotype
  • increased susceptibility to parasitic infection
    • after second infestation to ticks, mice fail to exhibit resistance (repletion) unlike similarly treated wild-type mice   (MGI Ref ID J:163761)
    • however, transfer of bone marrow from KitW-sh homozygotes restores repletion   (MGI Ref ID J:163761)
  • hematopoietic system phenotype
  • abnormal hemoglobin
    • increased hemisphere hemoglobin content in mouse brains injected with phosphate buffered saline   (MGI Ref ID J:168556)
  • decreased platelet aggregation
    • mutants exhibit a lack of collagen-induced aggregation of platelets   (MGI Ref ID J:165893)
  • cardiovascular system phenotype
  • hematoma
    • greatly enlarged area of experimentally induced hematomas   (MGI Ref ID J:168556)
  • homeostasis/metabolism phenotype
  • decreased platelet aggregation
    • mutants exhibit a lack of collagen-induced aggregation of platelets   (MGI Ref ID J:165893)
  • skeleton phenotype
  • *normal* skeleton phenotype
    • no effect on osteoclast size and number in tibias   (MGI Ref ID J:197378)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
      collagen induced arthritis
      experimentally induced rheumatoid arthritis
      Neutrophil defects
      collagen induced arthritis

Fcer1gtm1Rav related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Fcer1gtm1Rav
Allele Name targeted mutation 1, Jeffrey V Ravetch
Allele Type Targeted (Null/Knockout)
Common Name(s) FcR gamma-; FcR-; FcRKO; FcRg-; FcRgamma-; FcRgamma-chain-; FcRgammanl; FcRgammac-; Fcepsilonrgamma-; Fcer1gtm1; Fcer1gtm1Ra; Fcerg1tm1; FcgammaR-; gamma-;
Mutation Made ByDr. Jeffrey Ravetch,   Memorial Sloan Kettering Cancer Center
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide
Chromosome 1
Gene Common Name(s) AI573376; FCRG; Fc epsilon high affinity receptor gamma; FcR-gamma; FcR[g]; FcRgamma; Fce1g; FcepsilonRI; Ly-50; expressed sequence AI573376; lymphocyte antigen 50;
Molecular Note A neomycin selection cassette was inserted into exon 2, creating a new stop codon 239 bp downstream of the integration site. RT-PCR analysis on RNA isolated from activated macrophages, mast cells and NK cells of homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on lysates derived from activated macrophages, mast cells and NK cells of homozygous mice confirmed that no protein is encoded by this allele. [MGI Ref ID J:39248]


Genotyping Information

Genotyping Protocols

Fcer1gtm1Ravalternate1, MELT

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Takai T; Li M; Sylvestre D; Clynes R; Ravetch JV. 1994. FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell 76(3):519-29. [PubMed: 8313472]  [MGI Ref ID J:39248]

Additional References

Fcer1gtm1Rav related

Abboud G; Staumont-Salle D; Kanda A; Roumier T; Deruytter N; Lavogiez C; Fleury S; Remy P; Papin JP; Capron M; Dombrowicz D. 2009. Fc(epsilon)RI and FcgammaRIII/CD16 differentially regulate atopic dermatitis in mice. J Immunol 182(10):6517-26. [PubMed: 19414806]  [MGI Ref ID J:148317]

Albanesi M; Mancardi DA; Macdonald LE; Iannascoli B; Zitvogel L; Murphy AJ; Leusen JH; Bruhns P. 2012. Cutting Edge: FcgammaRIII (CD16) and FcgammaRI (CD64) Are Responsible for Anti-Glycoprotein 75 Monoclonal Antibody TA99 Therapy for Experimental Metastatic B16 Melanoma. J Immunol 189(12):5513-7. [PubMed: 23150715]  [MGI Ref ID J:190859]

Aloulou M; Ben Mkaddem S; Biarnes-Pelicot M; Boussetta T; Souchet H; Rossato E; Benhamou M; Crestani B; Zhu Z; Blank U; Launay P; Monteiro RC. 2012. IgG1 and IVIg induce inhibitory ITAM signaling through FcgammaRIII controlling inflammatory responses. Blood 119(13):3084-96. [PubMed: 22337713]  [MGI Ref ID J:182509]

Andreu P; Johansson M; Affara NI; Pucci F; Tan T; Junankar S; Korets L; Lam J; Tawfik D; Denardo DG; Naldini L; de Visser KE; De Palma M; Coussens LM. 2010. FcRgamma Activation Regulates Inflammation-Associated Squamous Carcinogenesis. Cancer Cell 17(2):121-134. [PubMed: 20138013]  [MGI Ref ID J:157152]

Ankeny DP; Guan Z; Popovich PG. 2009. B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice. J Clin Invest 119(10):2990-9. [PubMed: 19770513]  [MGI Ref ID J:154634]

Arase H; Ono S; Arase N; Park SY; Wakizaka K; Watanabe H; Ohno H; Saito T. 1995. Developmental arrest of NK1.1+ T cell antigen receptor (TCR)-alpha/beta+ T cells and expansion of NK1.1+ TCR-gamma/delta+ T cell development in CD3 zeta-deficient mice. J Exp Med 182(3):891-5. [PubMed: 7650493]  [MGI Ref ID J:28282]

Aubin E; Lemieux R; Bazin R. 2010. Indirect inhibition of in vivo and in vitro T-cell responses by intravenous immunoglobulins due to impaired antigen presentation. Blood 115(9):1727-34. [PubMed: 19965673]  [MGI Ref ID J:157778]

Aubin E; Proulx DP; Trepanier P; Lemieux R; Bazin R. 2011. Prevention of T cell activation by interference of internalized intravenous immunoglobulin (IVIg) with MHC II-dependent native antigen presentation. Clin Immunol 141(3):273-83. [PubMed: 21824820]  [MGI Ref ID J:178253]

Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204(8):1875-89. [PubMed: 17664287]  [MGI Ref ID J:125951]

Barker TT; Lee PY; Kelly-Scumpia KM; Weinstein JS; Nacionales DC; Kumagai Y; Akira S; Croker BP; Sobel ES; Reeves WH; Satoh M. 2011. Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane. Lab Invest 91(10):1540-50. [PubMed: 21808234]  [MGI Ref ID J:176270]

Barnes N; Gavin AL; Tan PS; Mottram P; Koentgen F; Hogarth PM. 2002. FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses. Immunity 16(3):379-89. [PubMed: 11911823]  [MGI Ref ID J:86281]

Barrett NA; Maekawa A; Rahman OM; Austen KF; Kanaoka Y. 2009. Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J Immunol 182(2):1119-28. [PubMed: 19124755]  [MGI Ref ID J:143482]

Barrow AD; Raynal N; Andersen TL; Slatter DA; Bihan D; Pugh N; Cella M; Kim T; Rho J; Negishi-Koga T; Delaisse JM; Takayanagi H; Lorenzo J; Colonna M; Farndale RW; Choi Y; Trowsdale J. 2011. OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J Clin Invest 121(9):3505-16. [PubMed: 21841309]  [MGI Ref ID J:178250]

Baumann U; Kohl J; Tschernig T; Schwerter-Strumpf K; Verbeek JS; Schmidt RE; Gessner JE. 2000. A codominant role of Fc gamma RI/III and C5aR in the reverse Arthus reaction. J Immunol 164(2):1065-70. [PubMed: 10623857]  [MGI Ref ID J:59290]

Ben Mkaddem S; Hayem G; Jonsson F; Rossato E; Boedec E; Boussetta T; El Benna J; Launay P; Goujon JM; Benhamou M; Bruhns P; Monteiro RC. 2014. Shifting FcgammaRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis. J Clin Invest 124(9):3945-59. [PubMed: 25061875]  [MGI Ref ID J:215667]

Bergthaler A; Flatz L; Verschoor A; Hegazy AN; Holdener M; Fink K; Eschli B; Merkler D; Sommerstein R; Horvath E; Fernandez M; Fitsche A; Senn BM; Verbeek JS; Odermatt B; Siegrist CA; Pinschewer DD. 2009. Impaired antibody response causes persistence of prototypic T cell-contained virus. PLoS Biol 7(4):e1000080. [PubMed: 19355789]  [MGI Ref ID J:150498]

Bergtold A; Desai DD; Gavhane A; Clynes R. 2005. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 23(5):503-14. [PubMed: 16286018]  [MGI Ref ID J:113283]

Bergtold A; Gavhane A; D'Agati V; Madaio M; Clynes R. 2006. FcR-bearing myeloid cells are responsible for triggering murine lupus nephritis. J Immunol 177(10):7287-95. [PubMed: 17082647]  [MGI Ref ID J:140615]

Bevaart L; Jansen MJ; van Vugt MJ; Verbeek JS; van de Winkel JG; Leusen JH. 2006. The high-affinity IgG receptor, FcgammaRI, plays a central role in antibody therapy of experimental melanoma. Cancer Res 66(3):1261-4. [PubMed: 16452176]  [MGI Ref ID J:106686]

Biburger M; Aschermann S; Schwab I; Lux A; Albert H; Danzer H; Woigk M; Dudziak D; Nimmerjahn F. 2011. Monocyte subsets responsible for immunoglobulin g-dependent effector functions in vivo. Immunity 35(6):932-44. [PubMed: 22169040]  [MGI Ref ID J:179288]

Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 106(39):16758-63. [PubMed: 19805369]  [MGI Ref ID J:153217]

Binstadt BA; Patel PR; Alencar H; Nigrovic PA; Lee DM; Mahmood U; Weissleder R; Mathis D; Benoist C. 2006. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7(3):284-92. [PubMed: 16444258]  [MGI Ref ID J:112604]

Blink SE; Fu YX. 2010. IgE regulates T helper cell differentiation through FcgammaRIII mediated dendritic cell cytokine modulation. Cell Immunol 264(1):54-60. [PubMed: 20494341]  [MGI Ref ID J:162109]

Block H; Herter JM; Rossaint J; Stadtmann A; Kliche S; Lowell CA; Zarbock A. 2012. Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med 209(2):407-21. [PubMed: 22291096]  [MGI Ref ID J:181695]

Boilard E; Larabee K; Shnayder R; Jacobs K; Farndale RW; Ware J; Lee DM. 2011. Platelets Participate in Synovitis via Cox-1-Dependent Synthesis of Prostacyclin Independently of Microparticle Generation. J Immunol 186(7):4361-6. [PubMed: 21357261]  [MGI Ref ID J:170699]

Boross P; van Lent PL; Martin-Ramirez J; van der Kaa J; Mulder MH; Claassens JW; van den Berg WB; Arandhara VL; Verbeek JS. 2008. Destructive Arthritis in the Absence of Both Fc{gamma}RI and Fc{gamma}RIII. J Immunol 180(7):5083-91. [PubMed: 18354234]  [MGI Ref ID J:133367]

Boule MW; Broughton C; Mackay F; Akira S; Marshak-Rothstein A; Rifkin IR. 2004. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med 199(12):1631-40. [PubMed: 15197227]  [MGI Ref ID J:120392]

Bournazos S; Chow SK; Abboud N; Casadevall A; Ravetch JV. 2014. Human IgG Fc domain engineering enhances antitoxin neutralizing antibody activity. J Clin Invest 124(2):725-9. [PubMed: 24401277]  [MGI Ref ID J:207991]

Bournazos S; Klein F; Pietzsch J; Seaman MS; Nussenzweig MC; Ravetch JV. 2014. Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity. Cell 158(6):1243-53. [PubMed: 25215485]  [MGI Ref ID J:214949]

Boyle KB; Gyori D; Sindrilaru A; Scharffetter-Kochanek K; Taylor PR; Mocsai A; Stephens LR; Hawkins PT. 2011. Class IA Phosphoinositide 3-Kinase {beta} and {delta} Regulate Neutrophil Oxidase Activation in Response to Aspergillus fumigatus Hyphae. J Immunol 186(5):2978-89. [PubMed: 21257963]  [MGI Ref ID J:169412]

Braun A; Gessner JE; Varga-Szabo D; Syed SN; Konrad S; Stegner D; Vogtle T; Schmidt RE; Nieswandt B. 2009. STIM1 is essential for Fcgamma receptor activation and autoimmune inflammation. Blood 113(5):1097-104. [PubMed: 18941110]  [MGI Ref ID J:144644]

Buhtoiarov IN; Lum HD; Berke G; Sondel PM; Rakhmilevich AL. 2006. Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects. J Immunol 176(1):309-18. [PubMed: 16365423]  [MGI Ref ID J:126263]

Burrer R; Buchmeier MJ; Wolfe T; Ting JP; Feuer R; Iglesias A; von Herrath MG. 2007. Exacerbated pathology of viral encephalitis in mice with central nervous system-specific autoantibodies. Am J Pathol 170(2):557-66. [PubMed: 17255324]  [MGI Ref ID J:117906]

Buxbaum LU; Scott P. 2005. Interleukin 10- and Fcgamma receptor-deficient mice resolve Leishmania mexicana lesions. Infect Immun 73(4):2101-8. [PubMed: 15784551]  [MGI Ref ID J:97206]

Cascio JA; Haymaker CL; Divekar RD; Zaghouani S; Khairallah MT; Wan X; Rowland LM; Dhakal M; Chen W; Zaghouani H. 2013. Antigen-specific effector CD4 T lymphocytes school lamina propria dendritic cells to transfer innate tolerance. J Immunol 190(12):6004-14. [PubMed: 23686493]  [MGI Ref ID J:204839]

Castano AP; Lin SL; Surowy T; Nowlin BT; Turlapati SA; Patel T; Singh A; Li S; Lupher ML Jr; Duffield JS. 2009. Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivo. Sci Transl Med 1(5):5ra13. [PubMed: 20368175]  [MGI Ref ID J:167887]

Chappell CP; Draves KE; Giltiay NV; Clark EA. 2012. Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses. J Exp Med 209(10):1825-40. [PubMed: 22966002]  [MGI Ref ID J:191423]

Charles JF; Humphrey MB; Zhao X; Quarles E; Nakamura MC; Aderem A; Seaman WE; Smith KD. 2008. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Infect Immun 76(6):2439-47. [PubMed: 18391000]  [MGI Ref ID J:136148]

Chiesa S; Mingueneau M; Fuseri N; Malissen B; Raulet DH; Malissen M; Vivier E; Tomasello E. 2006. Multiplicity and plasticity of natural killer cell signaling pathways. Blood 107(6):2364-72. [PubMed: 16291591]  [MGI Ref ID J:125723]

Chou RC; Kim ND; Sadik CD; Seung E; Lan Y; Byrne MH; Haribabu B; Iwakura Y; Luster AD. 2010. Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis. Immunity 33(2):266-78. [PubMed: 20727790]  [MGI Ref ID J:163913]

Chu CL; Yu YL; Shen KY; Lowell CA; Lanier LL; Hamerman JA. 2008. Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma. Eur J Immunol 38(1):166-73. [PubMed: 18081038]  [MGI Ref ID J:130527]

Chu N; Thomas BN; Patel SR; Buxbaum LU. 2010. IgG1 Is Pathogenic in Leishmania mexicana Infection. J Immunol 185(11):6939-46. [PubMed: 21037092]  [MGI Ref ID J:166141]

Clynes R; Calvani N; Croker BP; Richards HB. 2005. Modulation of the immune response in pristane-induced lupus by expression of activation and inhibitory Fc receptors. Clin Exp Immunol 141(2):230-7. [PubMed: 15996187]  [MGI Ref ID J:100855]

Clynes R; Ravetch JV. 1995. Cytotoxic antibodies trigger inflammation through Fc receptors. Immunity 3(1):21-6. [PubMed: 7621075]  [MGI Ref ID J:78887]

Clynes RA; Towers TL; Presta LG; Ravetch JV. 2000. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med 6(4):443-6. [PubMed: 10742152]  [MGI Ref ID J:118052]

Colonna L; Catalano G; Chew C; D'Agati V; Thomas JW; Wong FS; Schmitz J; Masuda ES; Reizis B; Tarakhovsky A; Clynes R. 2010. Therapeutic targeting of Syk in autoimmune diabetes. J Immunol 185(3):1532-43. [PubMed: 20601600]  [MGI Ref ID J:162249]

Corbett AJ; Caminschi I; McKenzie BS; Brady JL; Wright MD; Mottram PL; Hogarth PM; Hodder AN; Zhan Y; Tarlinton DM; Shortman K; Lew AM. 2005. Antigen delivery via two molecules on the CD8- dendritic cell subset induces humoral immunity in the absence of conventional 'danger'. Eur J Immunol 35(10):2815-25. [PubMed: 16143986]  [MGI Ref ID J:113495]

Corr M; Crain B. 2002. The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis. J Immunol 169(11):6604-9. [PubMed: 12444173]  [MGI Ref ID J:124384]

Coxon A; Cullere X; Knight S; Sethi S; Wakelin MW; Stavrakis G; Luscinskas FW; Mayadas TN. 2001. Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity 14(6):693-704. [PubMed: 11420040]  [MGI Ref ID J:78297]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX9

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice can be bred as homozygotes.
Mating SystemHomozygote x Homozygote         (Female x Male)   13-JUN-13

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $205.90Female or MaleHomozygous for Fcer1gtm1Rav  
Price per Pair (US dollars $)Pair Genotype
$411.80Homozygous for Fcer1gtm1Rav x Homozygous for Fcer1gtm1Rav  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $267.70Female or MaleHomozygous for Fcer1gtm1Rav  
Price per Pair (US dollars $)Pair Genotype
$535.40Homozygous for Fcer1gtm1Rav x Homozygous for Fcer1gtm1Rav  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   000670 DBA/1J
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.