Strain Name:

B10ScSn.Cg-Prkdcscid Dmdmdx/J

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Common Names: MDX/SCID;    
MDX/SCID mice exhibit necrosis, centrally located nuclei and and the muscle degeneration characteristic of DMD and may be used a dystrophic model for the transplantation of human donor cells to evaluate skeletal muscle regeneration.


Strain Information

Type Congenic; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemSee Breeding & Husbandry under the Health & Care tab         (Female x Male)   22-JUN-12
Specieslaboratory mouse
GenerationN10+N1F5 (01-MAY-15)
Generation Definitions
Donating Investigator Johnny Huard,   University of Pittsburgh

The X-linked dystrophin gene (Dmd) is highly expressed in muscle cells and encodes a cytoskeletal protein which localizes to the inner face of the sarcolemma. Dystrophin molecules bind to cytoskeletal F-actin and transmembrane beta-dystroglycan as part of a complex, multimolecular unit that mediates signaling between the intracellular cytoskeleton and the extracellular matrix. The structure and localization also suggest that dystrophin is important for stabilizing the plasma membrane, particularly during contraction. Like human patients who suffer from one of the most common neuromuscular diseases, Duchenne muscular dystrophy (DMD), the Dmdmdx mutants do not express dystrophin and therefore have been routinely used as an animal model of the disease even though the resultant myopathology is much less severe compared to the human disease course. When combined with the Prkdcscid allele, there is some amelioration of the mdx phenotype including a reduction in the rate of muscle fibrosis, higher endurance and decreased expression of active TGFB1. However, MDX/SCID mice continue to exhibit necrosis, centrally located nuclei and and the muscle degeneration characteristic of DMD. The MDX/SCID mouse may be used a dystrophic model for the transplantation of human donor cells to evaluate skeletal muscle regeneration.

The spontaneous mutation Dmdmdx arose just prior to 1977 at the Agricultural Research Council's Poultry Research Centre, U.K., in C57BL/10ScSn mice obtained from M. Festing (MRC Laboratory Animals Centre, Carshalton, Surrey, U.K.). Mice carrying the mdx allele were imported to The Jackson Laboratory in 1984 by Dr. Thomas Roderick, who received them from Dr. Karen Moore (Department of Genetics, University of California, Berkley). In 2000, under the direction of James Cummins at the University of Pittsburgh and Children's Hospital of Pittsburgh, the Prkdcscid allele from B6.CB17-Prkdcscid/SzJ was introgressed into C57BL/10ScSn-Dmdmdx/J for at least 10 generations. This strain is maintained as homozygous for Prkdcscid allele and by sibling mating homozygous Dmdmdx females with hemizygous Dmdmdx males; mice can breed up to six months of age.

Control Information

   000476 C57BL/10ScSnJ (approximate)
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Dmdmdx     (7 strains)

Strains carrying   Prkdcscid allele
001913   B6.CB17-Prkdcscid/SzJ
017917   B6.Cg-Dysfprmd Prkdcscid/J
021146   B6.Cg-Fcgrttm1Dcr Prkdcscid Tg(CAG-FCGRT)276Dcr/DcrJ
018441   B6.Cg-Fcgrttm1Dcr Prkdcscid Tg(FCGRT)32Dcr/DcrJ
018541   B6.Cg-Fcgrttm1Dcr Prkdcscid/DcrJ
010816   B6;C-Ghrhrlit Prkdcscid/BmJ
001131   C3SnSmn.CB17-Prkdcscid/J
001803   CBySmn.CB17-Prkdcscid/J
004083   NOD.129(B6)-Prkdcscid Iduatm1Clk/J
001303   NOD.CB17-Prkdcscid/J
002571   NOD.Cg Prkdcscid-B2mb/Dvs
004644   NOD.Cg Prkdcscid-Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy/YgyJ
010636   NOD.Cg-B2mtm1Unc Prkdcscid Il2rgtm1Wjl/SzJ
005345   NOD.Cg-Cd38tm1Lnd Prkdcscid/LtJ
014553   NOD.Cg-Hgftm1.1(HGF)Aveo Prkdcscid Il2rgtm1Wjl/J
026622   NOD.Cg-KitW-41J Tyr + Prkdcscid Il2rgtm1Wjl/ThomJ
004262   NOD.Cg-Prkdcscid Tg(HLA-A2.1)1Enge/Dvs
012478   NOD.Cg-Prkdcscid Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/GckJ
004346   NOD.Cg-Prkdcscid Tg(Ins2-CD80)3B7Flv/DvsJ
004230   NOD.Cg-Prkdcscid Tg(Ins2-E3)1Dvs/DvsJ
003843   NOD.Cg-Prkdcscid Tg(Ins2-GAD2)1Lt/LtJ
003844   NOD.Cg-Prkdcscid Tg(Ins2-GAD2)2Lt/LtJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/DvsJ
016148   NOD.Cg-Prkdcscid Alox15tm1Fun/NadlJ
002570   NOD.Cg-Prkdcscid B2mtm1Unc/J
006605   NOD.Cg-Prkdcscid Emv30b Tg(HLA-A/H2-D/B2M)1Dvs/DvsJ
002313   NOD.Cg-Prkdcscid Emv30b/Dvs
005053   NOD.Cg-Prkdcscid Gusbmps/SndsJ
004606   NOD.Cg-Prkdcscid H2-Ab1tm1Doi Tg(HLA-DQA1,HLA-DQB1)1Dv/SzJ
005589   NOD.Cg-Prkdcscid H2-Ab1tm1Doi/SzJ
021885   NOD.Cg-Prkdcscid H2-Ab1tm1Gru Il2rgtm1Wjl/SzJ
023848   NOD.Cg-Prkdcscid H2-K1tm1Bpe H2-D1tm1Bpe Il2rgtm1Wjl/SzJ
026222   NOD.Cg-Prkdcscid Hprtem1Mvw Il2rgtm1Wjl/MvwJ
014570   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(HLA-A/H2-D/B2M)1Dvs/SzJ
012479   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/GckRolyJ
017637   NOD.Cg-Prkdcscid Il2rgtm1Wjl H2-Ab1tm1Gru Tg(HLA-DRB1)31Dmz/SzJ
012480   NOD.Cg-Prkdcscid Il2rgtm1Wjl Hprtb-m3/EshJ
021937   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CAG-EGFP)1Osb/SzJ
013062   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ
009617   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(HLA-A2.1)1Enge/SzJ
017830   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(PGK1-KITLG*220)441Daw/SzJ
005557   NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
011066   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy/YgyJGckRolyJ
017620   NOD.Cg-Prkdcscid Tg(CAG-DsRed*MST)1Nagy/KupwJ
017619   NOD.Cg-Prkdcscid Tg(CAG-EGFP)1Osb/KupwJ
006609   NOD.Cg-Prkdcscid Tg(HLA-A2.1)1Enge/DvsJ
007840   NOD.Cg-Prkdcscid Tg(Ins2-CD86)12B70Flv/FswJ
002380   NOD.Cg-Tg(Ins2-TAg)1Lt Prkdcscid/DvsJ
022396   NOR.CB17(NOD)-Prkdcscid/JsdJ
014543   STOCK Hgftm1.1(HGF)Aveo Prkdcscid/J
010605   STOCK Prkdcscid Gnrh1hpg/BmJ
View Strains carrying   Prkdcscid     (51 strains)

Strains carrying other alleles of Dmd
002377   B6.Cg-Dmdmdx-3Cv/J
023535   B6.Cg-Terctm1Rdp Dmdmdx-4Cv/BlauJ
002388   B6Ros.Cg-Dmdmdx-2Cv/J
002378   B6Ros.Cg-Dmdmdx-4Cv/J
002379   B6Ros.Cg-Dmdmdx-5Cv/J
View Strains carrying other alleles of Dmd     (5 strains)


Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Cardiomyopathy, Dilated, 3b; CMD3B   (DMD)
Immunodeficiency 26 with or without Neurologic Abnormalities; IMD26   (PRKDC)
Muscular Dystrophy, Becker Type; BMD   (DMD)
Muscular Dystrophy, Duchenne Type; DMD   (DMD)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Dmdmdx/Dmdmdx Prkdcscid/Prkdcscid

        involves: C57BL/10ScSn * CB17
  • hematopoietic system phenotype
  • absent CD4-positive, alpha beta T cells
    • no expression of CD4+ cells as determined by cytofluorimetric analysis   (MGI Ref ID J:125527)
  • absent CD8-positive, alpha-beta T cells
    • no expression of CD8+ cells as determined by cytofluorimetric analysis   (MGI Ref ID J:125527)
  • decreased B cell number
    • 9.3% of total blood derived cells express B220+ and no expression of CD19+ cells as determined by cytofluorimetric analysis   (MGI Ref ID J:125527)
  • homeostasis/metabolism phenotype
  • decreased transforming growth factor level
    • costal diaphragm (DIA) has a lower quantity of active TGFB1 in comparison to Dmdmdx mutant although total quantity is similar   (MGI Ref ID J:125527)
    • tibialis anterior (TA) and quadricepts (QA) muscles have a lower quantity of total TGFB1 in comparison to Dmdmdx mutant   (MGI Ref ID J:125527)
  • impaired exercise endurance
    • mice exhibit a shorter time to exhaustion than wild type controls   (MGI Ref ID J:125527)
    • higher endurance on treadmill in double mutant than Dmdmdx mutants   (MGI Ref ID J:125527)
  • immune system phenotype
  • absent CD4-positive, alpha beta T cells
    • no expression of CD4+ cells as determined by cytofluorimetric analysis   (MGI Ref ID J:125527)
  • absent CD8-positive, alpha-beta T cells
    • no expression of CD8+ cells as determined by cytofluorimetric analysis   (MGI Ref ID J:125527)
  • decreased B cell number
    • 9.3% of total blood derived cells express B220+ and no expression of CD19+ cells as determined by cytofluorimetric analysis   (MGI Ref ID J:125527)
  • muscle phenotype
  • centrally nucleated skeletal muscle fibers
    • small, centrally nucleated, regenerating muscle fibers are found in 2 and 12 month old mice   (MGI Ref ID J:125527)
    • 46-52% of muscle fibers exhibit centrally located nuclei   (MGI Ref ID J:125527)
  • impaired skeletal muscle contractility
    • loss of normalized tetanic force in the costal diaphragm (DIA) strips is observed in 2 and 12 month old mice as compared to wild type   (MGI Ref ID J:125527)
    • change appears lower in double mutant than in Dmdmdx mutants   (MGI Ref ID J:125527)
    • a similar decrease in normalized tetanic force occurs in the tibialis anterior (TA)   (MGI Ref ID J:125527)
  • increased skeletal muscle fiber diameter
    • area of muscle fibers is 1500-1800 um2 and coefficient of variance is 55-65   (MGI Ref ID J:125527)
  • skeletal muscle fiber degeneration
    • degenerating muscle fibers are found in 2 and 12 month old mice   (MGI Ref ID J:125527)
  • skeletal muscle fibrosis
    • aged 12 month old double mutant mice exhibit fibrosis, but less than in age-matched Dmdmdx mice   (MGI Ref ID J:125527)
  • reproductive system phenotype
  • reduced fertility
    • double mutant mice are less fertile than Dmdmdx mice   (MGI Ref ID J:125527)
  • skeleton phenotype
  • abnormal vertebral column morphology
    • progressive spinal deformity   (MGI Ref ID J:125527)
  • behavior/neurological phenotype
  • impaired exercise endurance
    • mice exhibit a shorter time to exhaustion than wild type controls   (MGI Ref ID J:125527)
    • higher endurance on treadmill in double mutant than Dmdmdx mutants   (MGI Ref ID J:125527)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
      B and T cell deficiency
T Cell Receptor Signaling Defects
      B and T cell deficiency, xenograft/transplant host

Neurobiology Research
Neuromuscular Defects

Dmdmdx related

Cell Biology Research
Signal Transduction

Neurobiology Research
Muscular Dystrophy
      Duchenne type

Sensorineural Research

Prkdcscid related

Immunology, Inflammation and Autoimmunity Research
      B and T cell deficiency

Internal/Organ Research
Lymphoid Tissue Defects
      B and T cell deficiency

Research Tools
Cancer Research
      B and T cell deficiency, xenograft/transplant host
Toxicology Research
      xenograft/transplant host

Virology Research
B and T Cell Deficiency
      AIDS research tool

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Dmdmdx
Allele Name X linked muscular dystrophy
Allele Type Spontaneous
Common Name(s) mdx; pke; pvruvate kinase expression;
Strain of OriginC57BL/10ScSn
Gene Symbol and Name Dmd, dystrophin, muscular dystrophy
Chromosome X
Gene Common Name(s) BMD; CMD3B; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272; Dp427; Dp71; Duchenne muscular dystrophy; MRX85; X-linked muscular dystrophy; dys; mdx; pke; pyruvate kinase expression;
Molecular Note This mutation arose in 1981 in a C57BL/10ScSn colony at University of Leicester. A C-to-T transition occurred at position 3185, resulting in a termination codon in place of a glutamine codon. This mutation is predicted to produce a truncated protein. [MGI Ref ID J:102707] [MGI Ref ID J:40541] [MGI Ref ID J:9866]
Allele Symbol Prkdcscid
Allele Name severe combined immunodeficiency
Allele Type Spontaneous
Common Name(s) SCID;
Strain of OriginC.B-17
Gene Symbol and Name Prkdc, protein kinase, DNA activated, catalytic polypeptide
Chromosome 16
Gene Common Name(s) AI326420; AU019811; DNA-PK; DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH; HYRC; HYRC1; IMD26; XRCC7; doxorubicin nephropathy; dxnph; expressed sequence AI326420; expressed sequence AU019811; p350; scid; severe combined immunodeficiency; slip;
Molecular Note A T-to-A transversion point mutation at a position corresponding to codon 4095 created a premature stop codon. [MGI Ref ID J:35393] [MGI Ref ID J:39329]


Genotyping Information

Genotyping Protocols

DmdmdxEnd Point, End Point Analysis
Prkdcscid End Point, End Point Analysis

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Chirieleison SM; Feduska JM; Schugar RC; Askew Y; Deasy BM. 2012. Human muscle-derived cell populations isolated by differential adhesion rates: phenotype and contribution to skeletal muscle regeneration in Mdx/SCID mice. Tissue Eng Part A 18(3-4):232-41. [PubMed: 21854253]  [MGI Ref ID J:181239]

Park TS; Gavina M; Chen CW; Sun B; Teng PN; Huard J; Deasy BM; Zimmerlin L; Peault B. 2011. Placental perivascular cells for human muscle regeneration. Stem Cells Dev 20(3):451-63. [PubMed: 20923371]  [MGI Ref ID J:181240]

Additional References

Dmdmdx related

't Hoen PA; de Meijer EJ; Boer JM; Vossen RH; Turk R; Maatman RG; Davies KE; van Ommen GJ; van Deutekom JC; den Dunnen JT. 2008. Generation and characterization of transgenic mice with the full-length human DMD gene. J Biol Chem 283(9):5899-907. [PubMed: 18083704]  [MGI Ref ID J:132320]

Abmayr S; Crawford RW; Chamberlain JS. 2004. Characterization of ARC, apoptosis repressor interacting with CARD, in normal and dystrophin-deficient skeletal muscle. Hum Mol Genet 13(2):213-21. [PubMed: 14645204]  [MGI Ref ID J:87688]

Acharyya S; Butchbach ME; Sahenk Z; Wang H; Saji M; Carathers M; Ringel MD; Skipworth RJ; Fearon KC; Hollingsworth MA; Muscarella P; Burghes AH; Rafael-Fortney JA; Guttridge DC. 2005. Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia. Cancer Cell 8(5):421-32. [PubMed: 16286249]  [MGI Ref ID J:103953]

Acharyya S; Villalta SA; Bakkar N; Bupha-Intr T; Janssen PM; Carathers M; Li ZW; Beg AA; Ghosh S; Sahenk Z; Weinstein M; Gardner KL; Rafael-Fortney JA; Karin M; Tidball JG; Baldwin AS; Guttridge DC. 2007. Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest 117(4):889-901. [PubMed: 17380205]  [MGI Ref ID J:121279]

Acuna MJ; Pessina P; Olguin H; Cabrera D; Vio CP; Bader M; Munoz-Canoves P; Santos RA; Cabello-Verrugio C; Brandan E. 2014. Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-beta signalling. Hum Mol Genet 23(5):1237-49. [PubMed: 24163134]  [MGI Ref ID J:206216]

Agbulut O; Noirez P; Butler-Browne G; Jockusch H. 2004. Specific isomyosin proportions in hyperexcitable and physiologically denervated mouse muscle. FEBS Lett 561(1-3):191-4. [PubMed: 15013776]  [MGI Ref ID J:117992]

Ahmad A; Brinson M; Hodges BL; Chamberlain JS; Amalfitano A. 2000. Mdx mice inducibly expressing dystrophin provide insights into the potential of gene therapy for duchenne muscular dystrophy Hum Mol Genet 9(17):2507-15. [PubMed: 11030755]  [MGI Ref ID J:65413]

Al-Rewashdy H; Ljubicic V; Lin W; Renaud JM; Jasmin BJ. 2015. Utrophin A is essential in mediating the functional adaptations of mdx mouse muscle following chronic AMPK activation. Hum Mol Genet 24(5):1243-55. [PubMed: 25324540]  [MGI Ref ID J:219231]

Alameddine HS; Quantin B; Cartaud A; Dehaupas M; Mandel JL; Fardeau M. 1994. Expression of a recombinant dystrophin in mdx mice using adenovirus vector. Neuromuscul Disord 4(3):193-203. [PubMed: 7919968]  [MGI Ref ID J:19384]

Alfaro LA; Dick SA; Siegel AL; Anonuevo AS; McNagny KM; Megeney LA; Cornelison DD; Rossi FM. 2011. CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration. Stem Cells 29(12):2030-41. [PubMed: 21997891]  [MGI Ref ID J:190197]

Altamirano F; Valladares D; Henriquez-Olguin C; Casas M; Lopez JR; Allen PD; Jaimovich E. 2013. Nifedipine treatment reduces resting calcium concentration, oxidative and apoptotic gene expression, and improves muscle function in dystrophic mdx mice. PLoS One 8(12):e81222. [PubMed: 24349043]  [MGI Ref ID J:209732]

Amenta AR; Yilmaz A; Bogdanovich S; McKechnie BA; Abedi M; Khurana TS; Fallon JR. 2011. Biglycan recruits utrophin to the sarcolemma and counters dystrophic pathology in mdx mice. Proc Natl Acad Sci U S A 108(2):762-7. [PubMed: 21187385]  [MGI Ref ID J:170566]

Amirouche A; Tadesse H; Lunde JA; Belanger G; Cote J; Jasmin BJ. 2013. Activation of p38 signaling increases utrophin A expression in skeletal muscle via the RNA-binding protein KSRP and inhibition of AU-rich element-mediated mRNA decay: implications for novel DMD therapeutics. Hum Mol Genet 22(15):3093-111. [PubMed: 23575223]  [MGI Ref ID J:198527]

Anderson JE. 2000. A role for nitric oxide in muscle repair: nitric oxide-mediated activation of muscle satellite cells. Mol Biol Cell 11(5):1859-74. [PubMed: 10793157]  [MGI Ref ID J:120497]

Anderson JE. 1991. Dystrophic changes in mdx muscle regenerating from denervation and devascularization. Muscle Nerve 14(3):268-79. [PubMed: 2041548]  [MGI Ref ID J:116345]

Anderson JE; Bressler BH; Ovalle WK. 1988. Functional regeneration in the hindlimb skeletal muscle of the mdx mouse. J Muscle Res Cell Motil 9(6):499-515. [PubMed: 3209690]  [MGI Ref ID J:152749]

Anderson JE; Garrett K; Moor A; McIntosh L; Penner K. 1998. Dystrophy and myogenesis in mdx diaphragm muscle. Muscle Nerve 21(9):1153-65. [PubMed: 9703441]  [MGI Ref ID J:116331]

Anderson JE; Kao L; Bressler BH; Gruenstein E. 1990. Analysis of dystrophin in fast- and slow-twitch skeletal muscles from mdx and dy2J mice at different ages. Muscle Nerve 13(1):6-11. [PubMed: 2183046]  [MGI Ref ID J:116019]

Anderson JE; Lentz DL; Johnson RB. 1993. Recovery from disuse osteopenia coincident to restoration of muscle strength in mdx mice. Bone 14(4):625-34. [PubMed: 8274305]  [MGI Ref ID J:17563]

Anderson JE; Liu L; Kardami E. 1994. The effects of hyperthyroidism on muscular dystrophy in the mdx mouse: greater dystrophy in cardiac and soleus muscle. Muscle Nerve 17(1):64-73. [PubMed: 8264704]  [MGI Ref ID J:115865]

Anderson JE; Liu L; Kardami E; Murphy LJ. 1994. The pituitary-muscle axis in mdx dystrophic mice. J Neurol Sci 123(1-2):80-7. [PubMed: 8064326]  [MGI Ref ID J:18080]

Anderson JE; McIntosh LM; Moor AN; Yablonka-Reuveni Z. 1998. Levels of MyoD protein expression following injury of mdx and normal limb muscle are modified by thyroid hormone. J Histochem Cytochem 46(1):59-67. [PubMed: 9407021]  [MGI Ref ID J:45263]

Anderson JL; Head SI; Morley JW. 2003. Altered inhibitory input to Purkinje cells of dystrophin-deficient mice. Brain Res 982(2):280-3. [PubMed: 12915262]  [MGI Ref ID J:85437]

Anderson JL; Head SI; Morley JW. 2004. Long-term depression is reduced in cerebellar Purkinje cells of dystrophin-deficient mdx mice. Brain Res 1019(1-2):289-92. [PubMed: 15306266]  [MGI Ref ID J:91994]

Angoli D; Corona P; Baresi R; Mora M; Wanke E. 1997. Laminin-alpha2 but not -alpha1-mediated adhesion of human (Duchenne) and murine (mdx) dystrophic myotubes is seriously defective. FEBS Lett 408(3):341-4. [PubMed: 9188790]  [MGI Ref ID J:40762]

Ardite E; Perdiguero E; Vidal B; Gutarra S; Serrano AL; Munoz-Canoves P. 2012. PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy. J Cell Biol 196(1):163-75. [PubMed: 22213800]  [MGI Ref ID J:179966]

Asai A; Sahani N; Kaneki M; Ouchi Y; Martyn JA; Yasuhara SE. 2007. Primary role of functional ischemia, quantitative evidence for the two-hit mechanism, and phosphodiesterase-5 inhibitor therapy in mouse muscular dystrophy. PLoS ONE 2(8):e806. [PubMed: 17726536]  [MGI Ref ID J:129397]

Ascah A; Khairhallah M; Daussin F; Bourcier-Lucas C; Godin R; Allen BG; Petrof BJ; Des Rosiers C; Burelle Y. 2010. STRESS-INDUCED OPENING OF THE PERMEABILITY TRANSITION PORE IN THE DYSTROPHIN-DEFICIENT HEART IS ATTENUATED BY ACUTE TREATMENT WITH SILDENAFIL. Am J Physiol Heart Circ Physiol :. [PubMed: 20971771]  [MGI Ref ID J:166227]

Asselin I; Tremblay M; Vilquin JT; Guerette B; Roy R; Tremblay JP. 1995. Quantification of normal dystrophin mRNA following myoblast transplantation in mdx mice. Muscle Nerve 18(9):980-6. [PubMed: 7643878]  [MGI Ref ID J:28866]

Asselin I; Tremblay M; Vilquin JT; Guerette B; Tremblay JP. 1994. Polymerase chain reaction-based assay to assess the success of myoblast transplantation in mdx mice. Transplant Proc 26(6):3389. [PubMed: 7527970]  [MGI Ref ID J:21945]

Attal P; Lambert F; Marchand-Adam S; Bobin S; Pourny JC; Chemla D; Lecarpentier Y; Coirault C. 2000. Severe mechanical dysfunction in pharyngeal muscle from adult mdx mice. Am J Respir Crit Care Med 162(1):278-81. [PubMed: 10903254]  [MGI Ref ID J:103161]

Auda-Boucher G; Rouaud T; Lafoux A; Levitsky D; Huchet-Cadiou C; Feron M; Guevel L; Talon S; Fontaine-Perus J; Gardahaut MF. 2007. Fetal muscle-derived cells can repair dystrophic muscles in mdx mice. Exp Cell Res 313(5):997-1007. [PubMed: 17275812]  [MGI Ref ID J:119767]

Augustin M; Klopp N; Ewald K; Jockusch H. 1998. A multicopy c-Myc transgene as a nuclear label: overgrowth of Myctg50 cells in allophenic mice. Cell Biol Int 22(6):401-11. [PubMed: 10328848]  [MGI Ref ID J:127669]

Austin L; Bower JJ; Bennett TM; Lynch GS; Kapsa R; White JD; Barnard W; Gregorevic P; Byrne E. 2000. Leukemia inhibitory factor ameliorates muscle fiber degeneration in the mdx mouse. Muscle Nerve 23(11):1700-5. [PubMed: 11054748]  [MGI Ref ID J:116201]

Azzena GB; Mancinelli R. 1999. Nitric oxide regenerates the normal colonic peristaltic activity in mdx dystrophic mouse. Neurosci Lett 261(1-2):9-12. [PubMed: 10081914]  [MGI Ref ID J:107984]

Baccari MC; Romagnani P; Calamai F. 2000. Impaired nitrergic relaxations in the gastric fundus of dystrophic (mdx) mice. Neurosci Lett 282(1-2):105-8. [PubMed: 10713407]  [MGI Ref ID J:107938]

Badalamente MA; Stracher A. 2000. Delay of muscle degeneration and necrosis in mdx mice by calpain inhibition. Muscle Nerve 23(1):106-11. [PubMed: 10590413]  [MGI Ref ID J:116195]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX18

Colony Maintenance

Breeding & HusbandryWhile maintaining a live colony, these mice are bred as homozygotes for both alleles.
Mating SystemSee Breeding & Husbandry under the Health & Care tab         (Female x Male)   22-JUN-12
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $205.90MaleHomozygous for Prkdcscid, Hemizygous for Dmdmdx  
$205.90FemaleHomozygous for Prkdcscid, Homozygous for Dmdmdx  
Price per Pair (US dollars $)Pair Genotype
$411.80Homozygous for Prkdcscid, Homozygous for Dmdmdx x Homozygous for Prkdcscid, Hemizygous for Dmdmdx  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $267.70MaleHomozygous for Prkdcscid, Hemizygous for Dmdmdx  
$267.70FemaleHomozygous for Prkdcscid, Homozygous for Dmdmdx  
Price per Pair (US dollars $)Pair Genotype
$535.40Homozygous for Prkdcscid, Homozygous for Dmdmdx x Homozygous for Prkdcscid, Hemizygous for Dmdmdx  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

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Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   000476 C57BL/10ScSnJ (approximate)
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.