Strain Name:

FVB.129S7(B6)-Prnptm1Cwe/J

Stock Number:

018122

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Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use
These prion protein-deficient mice are resistant to prion disease and serve as a PrP-deficient background for mouse models of spongiform encephalopathies and neurologic prion disorders.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Specieslaboratory mouse
GenerationN?pN1+F3pN1
Generation Definitions
 
Donating Investigator Stanley Prusiner,   University of California, San Francisco

Description
A neo cassette replaces part of exon 3 of the prion protein (Prnp) gene in this strain, abolishing gene function. Prnp encodes the glycoprotein PrPC which is attached to the external surface of central nervous system (CNS) neurons by a glycosylphosphatidyl inositol (GPI) anchor. Conformational changes in PrPC to an infectious form, PrPSc, either by exogenous introduction or as a result of spontaneous mutation, have been linked to the development of spongiform encephalopathies such as scrapie in sheep and Creutzfeld-Jakob disease or GerstmannStraussler-Scheinker syndrome in man. These PrP0/0 mice are viable and fertile. They exhibit decreased copper levels in the brain, impaired synaptic transmission, defective sleep-wake cycles, and altered circadian rhythms. When inoculated with PrPSc, PrP0/0 mice are resistant to prion disease and do not replicate the infectious proteins. These mice serve as a PrPC-deficient background for transgenic mice expressing GPI anchor defects (see (Stock No. 018124).

Development
A targeting vector was designed to replace part of exon 3 of the prion protein (Prnp) gene with a neomycin resistance (neo) cassette. The construct was electroporated into 129S7/SvEvBrd-Hprt+-derived AB1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts and the resulting chimeric males were bred to C57BL/6J females. These Prnp0/0 mice were backcrossed to C57BL/6J mice and subsequently to FVB/NCrl mice for 10 generations. Zygotes from these mice were microinjected with a transgene expressing PRNP lacking the GPI anchor signal Tg(Prnp-tTA)F959Sbp/J. Upon arrival at The Jackson Laboratory, Tg959/Prnp0/0 mice were bred to FVB/NJ (Stock No. 001800) for at least one generation. The Tg(Prnp-tTA)F959Sbp transgene was bred out of some mice, and a colony of mice containing only the Prnp0/0 allele was established. Mice containing the Tg(Prnp-tTA)F959Sbp allele are maintained as Stock No. 018124.

Control Information

  Control
   001800 FVB/NJ (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Prnp
012938   129-Prnptm2Edin/J
016925   129;B6-Grin3b/Tmem259tm1Zhang Tg(Prnp-C19ORF6,-GFP)6Zhang/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
005866   B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax
006006   B6.Cg-Tg(Prnp-APP)A-2Dbo/J
008596   B6.Cg-Tg(Prnp-Abca1)EHol/J
006005   B6.Cg-Tg(Prnp-App/APPswe)E1-2Dbo/Mmjax
007180   B6.Cg-Tg(Prnp-ITM2B/APP695*40)1Emcg/J
007182   B6.Cg-Tg(Prnp-ITM2B/APP695*42)A12Emcg/J
006823   B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J
010700   B6.Cg-Tg(Prnp-TARDBP*A315T)95Balo/J
009337   B6.FVB-Tg(Prnp-RTN3)2Yanr/J
007002   B6;C3-Tg(Prnp-ITM2B/APP695*42)A12Emcg/Mmjax
008169   B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J
004479   B6;C3-Tg(Prnp-SNCA*A53T)83Vle/J
018917   B6;SJL-Tg(Prnp-CCS)17Jlel/J
003378   B6C3-Tg(APP695)3Dbo Tg(PSEN1)5Dbo/J
008216   B6CBA(FVB)-Tg(Prnp-TBP*)71-16Xjl/J
008075   B6CBA-Tg(Prnp-TBP*)105Xjl/J
008083   B6CBA-Tg(Prnp-TBP*)13Xjl/J
003741   B6D2-Tg(Prnp-MAPT)43Vle/J
024841   B6N.Cg-Tg(Prnp-MAPT*P301S)PS19Vle/J
017907   B6N.Cg-Tg(Prnp-TARDBP)96Dwc/J
017933   B6N.Cg-Tg(Prnp-TARDBP*Q331K)103Dwc/J
017930   B6N.Cg-Tg(Prnp-TARDBP*Q331K)109Dwc/J
016201   B6SJL-Tg(Prnp-TARDBP)4Jlel/J
016203   B6SJL-Tg(Prnp-TARDBP*A315T)23Jlel/J
016608   C57BL/6-Tg(Prnp-TARDBP)3cPtrc/J
017604   C57BL/6-Tg(Prnp-TARDBP*M337V)4Ptrc/J
019517   FVB-Tg(Prnp-HSPB1)1Kolb/J
019482   FVB-Tg(Prnp-HSPB1*R136W)1Kolb/J
017678   FVB;129-Pink1tm1Aub Tg(Prnp-SNCA*A53T)AAub/J
017744   FVB;129-Tg(Prnp-SNCA*A53T)AAub/J
017916   STOCK Tg(Prnp-FUS)WT3Cshw/J
016144   STOCK Tg(Prnp-TARDBP)4Jlel/J
016143   STOCK Tg(Prnp-TARDBP*A315T)23Jlel/J
008212   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Prnp-SMN)92Ahmb/J
View Strains carrying other alleles of Prnp     (37 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- No similarity to the expected human disease phenotype was found. One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of these genes, but the phenotype did not resemble the disease.
Creutzfeldt-Jakob Disease; CJD
Gerstmann-Straussler Disease; GSD
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Fatal Familial Insomnia; FFI   (PRNP)
Huntington Disease-Like 1; HDL1   (PRNP)
Kuru, Susceptibility to   (PRNP)
Spongiform Encephalopathy with Neuropsychiatric Features   (PRNP)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Prnptm1Cwe/Prnptm1Cwe

        involves: 129S7/SvEvBrd * C57BL/6
  • behavior/neurological phenotype
  • *normal* behavior/neurological phenotype
    • normal behavior   (MGI Ref ID J:472)
    • no ataxia or Purkinje cell loss observed   (MGI Ref ID J:67593)
  • nervous system phenotype
  • abnormal CNS synaptic transmission
    • GABA(A) receptor-mediated fast inhibition is weaker in hippocampal slices of mutants than in wild-type mice, indicating impaired synaptic inhibition   (MGI Ref ID J:19448)
    • abnormal inhibitory postsynaptic currents
      • inhibitory postsynaptic currents (ipscs) have significantly slower rising phases and are slower   (MGI Ref ID J:19448)
    • abnormal inhibitory postsynaptic potential
      • fast inhibitory postsynaptic potentials (ipsps) appear weaker in hippocampal slices than in wild-type, however excitatory postsynaptic potentials are normal   (MGI Ref ID J:19448)
    • reduced long term potentiation
      • long term potentiation in CA1 of hippocampal slices is weaker in both the absence and presence of bicuculline   (MGI Ref ID J:19448)
  • decreased brain copper level
    • after 12 months, copper levels in the brain fail to increase with age unlike in wild-type mice   (MGI Ref ID J:126728)
    • copper levels in the synaptosomes are decreased compared to in wild-type mice   (MGI Ref ID J:126728)
  • homeostasis/metabolism phenotype
  • decreased brain copper level
    • after 12 months, copper levels in the brain fail to increase with age unlike in wild-type mice   (MGI Ref ID J:126728)
    • copper levels in the synaptosomes are decreased compared to in wild-type mice   (MGI Ref ID J:126728)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cell Biology Research
Protein Processing

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Prnptm1Cwe
Allele Name targeted mutation 1, Charles Weissmann
Allele Type Targeted (Null/Knockout)
Common Name(s) PrP0; PrPC Zrch-1; PrPC-KO; Prn-p0; Prnp trn1Zrch; Prnp-; Prnp0; Prnp0 Zurich I; Prnptm1Zrch; PrnpZH1; Zrch 1 Prnp0; Zrch Prnp0; ZrchI Prnp-; Zurich line;
Mutation Made By Stanley Prusiner,   University of California, San Francisco
Strain of Origin129S7/SvEvBrd-Hprt<+>
Gene Symbol and Name Prnp, prion protein
Chromosome 2
Gene Common Name(s) AA960666; AI325101; ASCR; AltPrP; CD230; CJD; GSS; KURU; PRIP; PrP; PrP27-30; PrP33-35C; PrPC; PrPSc; Prn; Prn-i; Prn-p; Sinc; expressed sequence AA960666; expressed sequence AI325101; p27-30; prion protein, scrapie incubation time regulation; prion protein, structural locus; scrapie incubation period;
Molecular Note A 552 bp fragment of the coding region contained within exon 3 was replaced with a 1.1 kb cassette containing the TK promoter followed by the neomycin gene. [MGI Ref ID J:472] [MGI Ref ID J:83401]

Genotyping

Genotyping Information

Genotyping Protocols

Prnptm1Cwe,

Separated MCA


Prnptm1Cwe, Separated PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Bueler H; Fischer M; Lang Y; Bluethmann H; Lipp HP; DeArmond SJ; Prusiner SB; Aguet M; Weissmann C. 1992. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein [see comments] Nature 356(6370):577-82. [PubMed: 1373228]  [MGI Ref ID J:472]

Additional References

Prnptm1Cwe related

Albanese V; Lawson VA; Hill AF; Cappai R; Di Guardo G; Staikopoulos V; Thacker M; Furness JB; Chiocchetti R. 2008. Evidence for prion protein expression in enteroglial cells of the myenteric plexus of mouse intestine. Auton Neurosci 140(1-2):17-23. [PubMed: 18358791]  [MGI Ref ID J:140002]

Alvarez-Laviada A; Kadurin I; Senatore A; Chiesa R; Dolphin AC. 2014. The inhibition of functional expression of calcium channels by prion protein demonstrates competition with alpha2delta for GPI-anchoring pathways. Biochem J 458(2):365-74. [PubMed: 24329154]  [MGI Ref ID J:210494]

Anaya ZE; Savistchenko J; Massonneau V; Lacroux C; Andreoletti O; Vilette D. 2011. Recovery of small infectious PrP(res) aggregates from prion-infected cultured cells. J Biol Chem 286(10):8141-8. [PubMed: 21212268]  [MGI Ref ID J:170530]

Arantes C; Nomizo R; Lopes MH; Hajj GN; Lima FR; Martins VR. 2009. Prion protein and its ligand stress inducible protein 1 regulate astrocyte development. Glia 57(13):1439-49. [PubMed: 19243016]  [MGI Ref ID J:156202]

Arsac JN; Betemps D; Morignat E; Feraudet C; Bencsik A; Aubert D; Grassi J; Baron T. 2009. Transmissibility of atypical scrapie in ovine transgenic mice: major effects of host prion protein expression and donor prion genotype. PLoS One 4(10):e7300. [PubMed: 19806224]  [MGI Ref ID J:154107]

Asante EA; Li YG; Gowland I; Jefferys JG; Collinge J. 2004. Pathogenic human prion protein rescues PrP null phenotype in transgenic mice. Neurosci Lett 360(1-2):33-6. [PubMed: 15082172]  [MGI Ref ID J:89280]

Asante EA; Linehan JM; Desbruslais M; Joiner S; Gowland I; Wood AL; Welch J; Hill AF; Lloyd SE; Wadsworth JD; Collinge J. 2002. BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein. EMBO J 21(23):6358-66. [PubMed: 12456643]  [MGI Ref ID J:131494]

Balducci C; Beeg M; Stravalaci M; Bastone A; Sclip A; Biasini E; Tapella L; Colombo L; Manzoni C; Borsello T; Chiesa R; Gobbi M; Salmona M; Forloni G. 2010. Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein. Proc Natl Acad Sci U S A 107(5):2295-300. [PubMed: 20133875]  [MGI Ref ID J:157527]

Barmada S; Piccardo P; Yamaguchi K; Ghetti B; Harris DA. 2004. GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice. Neurobiol Dis 16(3):527-37. [PubMed: 15262264]  [MGI Ref ID J:91817]

Baumann F; Pahnke J; Radovanovic I; Rulicke T; Bremer J; Tolnay M; Aguzzi A. 2009. Functionally relevant domains of the prion protein identified in vivo. PLoS One 4(9):e6707. [PubMed: 19738901]  [MGI Ref ID J:153629]

Baumann F; Tolnay M; Brabeck C; Pahnke J; Kloz U; Niemann HH; Heikenwalder M; Rulicke T; Burkle A; Aguzzi A. 2007. Lethal recessive myelin toxicity of prion protein lacking its central domain. EMBO J 26(2):538-47. [PubMed: 17245436]  [MGI Ref ID J:117485]

Benvegnu S; Gasperini L; Legname G. 2011. Aged PrP null mice show defective processing of neuregulins in the peripheral nervous system. Mol Cell Neurosci 47(1):28-35. [PubMed: 21334441]  [MGI Ref ID J:177965]

Benvegnu S; Poggiolini I; Legname G. 2010. Neurodevelopmental expression and localization of the cellular prion protein in the central nervous system of the mouse. J Comp Neurol 518(11):1879-91. [PubMed: 20394048]  [MGI Ref ID J:174473]

Benvegnu S; Roncaglia P; Agostini F; Casalone C; Corona C; Gustincich S; Legname G. 2011. Developmental influence of the cellular prion protein on the gene expression profile in mouse hippocampus. Physiol Genomics 43(12):711-25. [PubMed: 21406608]  [MGI Ref ID J:174633]

Beraldo FH; Soares IN; Goncalves DF; Fan J; Thomas AA; Santos TG; Mohammad AH; Roffe M; Calder MD; Nikolova S; Hajj GN; Guimaraes AL; Massensini AR; Welch I; Betts DH; Gros R; Drangova M; Watson AJ; Bartha R; Prado VF; Martins VR; Prado MA. 2013. Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein. FASEB J 27(9):3594-607. [PubMed: 23729591]  [MGI Ref ID J:201097]

Bertuchi FR; Bourgeon DM; Landemberger MC; Martins VR; Cerchiaro G. 2012. PrPC displays an essential protective role from oxidative stress in an astrocyte cell line derived from PrPC knockout mice. Biochem Biophys Res Commun 418(1):27-32. [PubMed: 22222374]  [MGI Ref ID J:181227]

Biasini E; Turnbaugh JA; Massignan T; Veglianese P; Forloni G; Bonetto V; Chiesa R; Harris DA. 2012. The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells. PLoS One 7(3):e33472. [PubMed: 22428057]  [MGI Ref ID J:187051]

Boudinot E; Tremblay P; Champagnat J; Foutz AS. 2002. Respiratory function in mice lacking or overexpressing the prion protein. Neurosci Lett 323(2):89-92. [PubMed: 11950500]  [MGI Ref ID J:107946]

Boy J; Schmidt T; Wolburg H; Mack A; Nuber S; Bottcher M; Schmitt I; Holzmann C; Zimmermann F; Servadio A; Riess O. 2009. Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3. Hum Mol Genet 18(22):4282-95. [PubMed: 19666958]  [MGI Ref ID J:154079]

Brandner S; Isenmann S; Raeber A; Fischer M; Sailer A; Kobayashi Y; Marino S; Weissmann C; Aguzzi A. 1996. Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature 379(6563):339-43. [PubMed: 8552188]  [MGI Ref ID J:31134]

Brandner S; Raeber A; Sailer A; Blattler T; Fischer M; Weissmann C; Aguzzi A. 1996. Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system. Proc Natl Acad Sci U S A 93(23):13148-51. [PubMed: 8917559]  [MGI Ref ID J:36560]

Bremer J; Baumann F; Tiberi C; Wessig C; Fischer H; Schwarz P; Steele AD; Toyka KV; Nave KA; Weis J; Aguzzi A. 2010. Axonal prion protein is required for peripheral myelin maintenance. Nat Neurosci 13(3):310-8. [PubMed: 20098419]  [MGI Ref ID J:158343]

Bribian A; Fontana X; Llorens F; Gavin R; Reina M; Garcia-Verdugo JM; Torres JM; de Castro F; del Rio JA. 2012. Role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse CNS. PLoS One 7(4):e33872. [PubMed: 22529900]  [MGI Ref ID J:187211]

Brown DR. 2003. Prion protein expression modulates neuronal copper content. J Neurochem 87(2):377-85. [PubMed: 14511115]  [MGI Ref ID J:126728]

Brown DR. 1999. Prion protein peptide neurotoxicity can be mediated by astrocytes. J Neurochem 73(3):1105-13. [PubMed: 10461901]  [MGI Ref ID J:56932]

Brown DR; Nicholas RS; Canevari L. 2002. Lack of prion protein expression results in a neuronal phenotype sensitive to stress. J Neurosci Res 67(2):211-24. [PubMed: 11782965]  [MGI Ref ID J:113181]

Brown DR; Schmidt B; Kretzschmar HA. 1998. Effects of copper on survival of prion protein knockout neurons and glia. J Neurochem 70(4):1686-93. [PubMed: 9523587]  [MGI Ref ID J:46891]

Bueler H; Aguzzi A; Sailer A; Greiner RA; Autenried P; Aguet M; Weissmann C. 1993. Mice devoid of PrP are resistant to scrapie. Cell 73(7):1339-47. [PubMed: 8100741]  [MGI Ref ID J:12900]

Bueler H; Raeber A; Sailer A; Fischer M; Aguzzi A; Weissmann C. 1994. High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene. Mol Med 1(1):19-30. [PubMed: 8790598]  [MGI Ref ID J:26616]

Campeau JL; Wu G; Bell JR; Rasmussen J; Sim VL. 2013. Early increase and late decrease of purkinje cell dendritic spine density in prion-infected organotypic mouse cerebellar cultures. PLoS One 8(12):e81776. [PubMed: 24312586]  [MGI Ref ID J:209747]

Chadi S; Young R; Le Guillou S; Tilly G; Bitton F; Martin-Magniette ML; Soubigou-Taconnat L; Balzergue S; Vilotte M; Peyre C; Passet B; Beringue V; Renou JP; Le Provost F; Laude H; Vilotte JL. 2010. Brain transcriptional stability upon prion protein-encoding gene invalidation in zygotic or adult mouse. BMC Genomics 11:448. [PubMed: 20649983]  [MGI Ref ID J:162768]

Christensen HM; Dikranian K; Li A; Baysac KC; Walls KC; Olney JW; Roth KA; Harris DA. 2010. A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal death. Am J Pathol 176(6):2695-706. [PubMed: 20472884]  [MGI Ref ID J:161315]

Cisse M; Sanchez PE; Kim DH; Ho K; Yu GQ; Mucke L. 2011. Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the j20 line of human amyloid precursor protein transgenic mice. J Neurosci 31(29):10427-31. [PubMed: 21775587]  [MGI Ref ID J:174512]

Cohen E; Avrahami D; Frid K; Canello T; Levy Lahad E; Zeligson S; Perlberg S; Chapman J; Cohen OS; Kahana E; Lavon I; Gabizon R. 2013. Snord 3A: a molecular marker and modulator of prion disease progression. PLoS One 8(1):e54433. [PubMed: 23349890]  [MGI Ref ID J:195806]

Coitinho AS; Dietrich MO; Hoffmann A; Dall'Igna OP; Souza DO; R Martins V; R Brentani R; Izquierdo I; Lara DR. 2002. Decreased hyperlocomotion induced by MK-801, but not amphetamine and caffeine in mice lacking cellular prion protein (PrP(C)). Brain Res Mol Brain Res 107(2):190-4. [PubMed: 12425947]  [MGI Ref ID J:80440]

Coitinho AS; Roesler R; Martins VR; Brentani RR; Izquierdo I. 2003. Cellular prion protein ablation impairs behavior as a function of age. Neuroreport 14(10):1375-9. [PubMed: 12876477]  [MGI Ref ID J:89766]

Colling SB; Collinge J; Jefferys JG. 1996. Hippocampal slices from prion protein null mice: disrupted Ca(2+)-activated K+ currents. Neurosci Lett 209(1):49-52. [PubMed: 8734907]  [MGI Ref ID J:36183]

Collinge J; Whittington MA; Sidle KC; Smith CJ; Palmer MS; Clarke AR; Jefferys JG. 1994. Prion protein is necessary for normal synaptic function. Nature 370(6487):295-7. [PubMed: 8035877]  [MGI Ref ID J:19448]

Cordier C; Bencsik A; Philippe S; Betemps D; Ronzon F; Calavas D; Crozet C; Baron T. 2006. Transmission and characterization of bovine spongiform encephalopathy sources in two ovine transgenic mouse lines (TgOvPrP4 and TgOvPrP59). J Gen Virol 87(Pt 12):3763-71. [PubMed: 17098996]  [MGI Ref ID J:136473]

Coulpier M; Messiaen S; Boucreaux D; Eloit M. 2006. Axotomy-induced motoneuron death is delayed in mice overexpressing PrPc. Neuroscience 141(4):1827-34. [PubMed: 16843609]  [MGI Ref ID J:113164]

Crecelius AC; Helmstetter D; Strangmann J; Mitteregger G; Frohlich T; Arnold GJ; Kretzschmar HA. 2008. The brain proteome profile is highly conserved between Prnp-/- and Prnp+/+ mice. Neuroreport 19(10):1027-31. [PubMed: 18580573]  [MGI Ref ID J:137870]

Crozet C; Flamant F; Bencsik A; Aubert D; Samarut J; Baron T. 2001. Efficient transmission of two different sheep scrapie isolates in transgenic mice expressing the ovine PrP gene. J Virol 75(11):5328-34. [PubMed: 11333913]  [MGI Ref ID J:69368]

Curtis J; Errington M; Bliss T; Voss K; MacLeod N. 2003. Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice. Neurobiol Dis 13(1):55-62. [PubMed: 12758067]  [MGI Ref ID J:126706]

Daude N; Wohlgemuth S; Brown R; Pitstick R; Gapeshina H; Yang J; Carlson GA; Westaway D. 2012. Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrPC-deficiency. Proc Natl Acad Sci U S A 109(23):9035-40. [PubMed: 22619325]  [MGI Ref ID J:184837]

Devanathan V; Jakovcevski I; Santuccione A; Li S; Lee HJ; Peles E; Leshchyns'ka I; Sytnyk V; Schachner M. 2010. Cellular form of prion protein inhibits Reelin-mediated shedding of Caspr from the neuronal cell surface to potentiate Caspr-mediated inhibition of neurite outgrowth. J Neurosci 30(27):9292-305. [PubMed: 20610764]  [MGI Ref ID J:161770]

Diez M; Groth D; DeArmond SJ; Prusiner SB; Hokfelt T. 2007. Changes in neuropeptide expression in mice infected with prions. Neurobiol Aging 28(5):748-65. [PubMed: 16621165]  [MGI Ref ID J:121978]

Dong J; Li A; Yamaguchi N; Sakaguchi S; Harris DA. 2007. Doppel induces degeneration of cerebellar Purkinje cells independently of Bax. Am J Pathol 171(2):599-607. [PubMed: 17569776]  [MGI Ref ID J:142939]

Dossena S; Imeri L; Mangieri M; Garofoli A; Ferrari L; Senatore A; Restelli E; Balducci C; Fiordaliso F; Salio M; Bianchi S; Fioriti L; Morbin M; Pincherle A; Marcon G; Villani F; Carli M; Tagliavini F; Forloni G; Chiesa R. 2008. Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model. Neuron 60(4):598-609. [PubMed: 19038218]  [MGI Ref ID J:142098]

Falsig J; Julius C; Margalith I; Schwarz P; Heppner FL; Aguzzi A. 2008. A versatile prion replication assay in organotypic brain slices. Nat Neurosci 11(1):109-17. [PubMed: 18066056]  [MGI Ref ID J:130808]

Falsig J; Sonati T; Herrmann US; Saban D; Li B; Arroyo K; Ballmer B; Liberski PP; Aguzzi A. 2012. Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures. PLoS Pathog 8(11):e1002985. [PubMed: 23133383]  [MGI Ref ID J:195363]

Fioriti L; Quaglio E; Massignan T; Colombo L; Stewart RS; Salmona M; Harris DA; Forloni G; Chiesa R. 2005. The neurotoxicity of prion protein (PrP) peptide 106-126 is independent of the expression level of PrP and is not mediated by abnormal PrP species. Mol Cell Neurosci 28(1):165-76. [PubMed: 15607951]  [MGI Ref ID J:132459]

Fischer M; Rulicke T; Raeber A; Sailer A; Moser M; Oesch B; Brandner S; Aguzzi A; Weissmann C. 1996. Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J 15(6):1255-64. [PubMed: 8635458]  [MGI Ref ID J:32214]

Flechsig E; Hegyi I; Leimeroth R; Zuniga A; Rossi D; Cozzio A; Schwarz P; Rulicke T; Gotz J; Aguzzi A; Weissmann C. 2003. Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia. EMBO J 22(12):3095-101. [PubMed: 12805223]  [MGI Ref ID J:83952]

Flechsig E; Shmerling D; Hegyi I; Raeber AJ; Fischer M; Cozzio A; von Mering C; Aguzzi A; Weissmann C. 2000. Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice Neuron 27(2):399-408. [PubMed: 10985358]  [MGI Ref ID J:64131]

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Passet B; Young R; Makhzami S; Vilotte M; Jaffrezic F; Halliez S; Bouet S; Marthey S; Khalife M; Kanellopoulos-Langevin C; Beringue V; Le Provost F; Laude H; Vilotte JL. 2012. Prion protein and Shadoo are involved in overlapping embryonic pathways and trophoblastic development. PLoS One 7(7):e41959. [PubMed: 22860039]  [MGI Ref ID J:189679]

Pereira GS; Walz R; Bonan CD; Battastini AM; Izquierdo I; Martins VR; Brentani RR; Sarkis JJ. 2001. Changes in cortical and hippocampal ectonucleotidase activities in mice lacking cellular prion protein. Neurosci Lett 301(1):72-4. [PubMed: 11239719]  [MGI Ref ID J:107955]

Petrosino S; Menard B; Zsurger N; Di Marzo V; Chabry J. 2011. Alteration of the endocannabinoid system in mouse brain during prion disease. Neuroscience 177:292-7. [PubMed: 21195746]  [MGI Ref ID J:170556]

Powell AD; Toescu EC; Collinge J; Jefferys JG. 2008. Alterations in Ca2+-buffering in prion-null mice: association with reduced afterhyperpolarizations in CA1 hippocampal neurons. J Neurosci 28(15):3877-86. [PubMed: 18400886]  [MGI Ref ID J:149385]

Prestori F; Rossi P; Bearzatto B; Laine J; Necchi D; Diwakar S; Schiffmann SN; Axelrad H; D'Angelo E. 2008. Altered neuron excitability and synaptic plasticity in the cerebellar granular layer of juvenile prion protein knock-out mice with impaired motor control. J Neurosci 28(28):7091-103. [PubMed: 18614678]  [MGI Ref ID J:137960]

Prinz M; Montrasio F; Furukawa H; van der Haar ME; Schwarz P; Rulicke T; Giger OT; Hausler KG; Perez D; Glatzel M; Aguzzi A. 2004. Intrinsic resistance of oligodendrocytes to prion infection. J Neurosci 24(26):5974-81. [PubMed: 15229245]  [MGI Ref ID J:97275]

Prusiner SB; Groth D; Serban A; Koehler R; Foster D; Torchia M; Burton D; Yang SL; DeArmond SJ. 1993. Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies. Proc Natl Acad Sci U S A 90(22):10608-12. [PubMed: 7902565]  [MGI Ref ID J:16120]

Quaglio E; Restelli E; Garofoli A; Dossena S; De Luigi A; Tagliavacca L; Imperiale D; Migheli A; Salmona M; Sitia R; Forloni G; Chiesa R. 2011. Expression of Mutant or Cytosolic PrP in Transgenic Mice and Cells Is Not Associated with Endoplasmic Reticulum Stress or Proteasome Dysfunction. PLoS One 6(4):e19339. [PubMed: 21559407]  [MGI Ref ID J:172342]

Radovanovic I; Braun N; Giger OT; Mertz K; Miele G; Prinz M; Navarro B; Aguzzi A. 2005. Truncated prion protein and Doppel are myelinotoxic in the absence of oligodendrocytic PrPC. J Neurosci 25(19):4879-88. [PubMed: 15888663]  [MGI Ref ID J:98738]

Rangel A; Madronal N; Gruart i Masso A; Gavin R; Llorens F; Sumoy L; Torres JM; Delgado-Garcia JM; Del Rio JA. 2009. Regulation of GABA(A) and glutamate receptor expression, synaptic facilitation and long-term potentiation in the hippocampus of prion mutant mice. PLoS One 4(10):e7592. [PubMed: 19855845]  [MGI Ref ID J:154035]

Ratte S; Prescott SA; Collinge J; Jefferys JG. 2008. Hippocampal bursts caused by changes in NMDA receptor-dependent excitation in a mouse model of variant CJD. Neurobiol Dis 32(1):96-104. [PubMed: 18638557]  [MGI Ref ID J:140361]

Ratte S; Vreugdenhil M; Boult JK; Patel A; Asante EA; Collinge J; Jefferys JG. 2011. Threshold for epileptiform activity is elevated in prion knockout mice. Neuroscience 179:56-61. [PubMed: 21277354]  [MGI Ref ID J:170112]

Rial D; Duarte FS; Xikota JC; Schmitz AE; Dafre AL; Figueiredo CP; Walz R; Prediger RD. 2009. Cellular prion protein modulates age-related behavioral and neurochemical alterations in mice. Neuroscience 164(3):896-907. [PubMed: 19747526]  [MGI Ref ID J:155136]

Rial D; Piermartiri TC; Duarte FS; Tasca CI; Walz R; Prediger RD. 2012. Overexpression of cellular prion protein (PrP(C)) prevents cognitive dysfunction and apoptotic neuronal cell death induced by amyloid-beta (Abeta(1)(-)(4)(0)) administration in mice. Neuroscience 215:79-89. [PubMed: 22537845]  [MGI Ref ID J:192442]

Roesler R; Walz R; Quevedo J; de-Paris F; Zanata SM; Graner E; Izquierdo I; Martins VR; Brentani RR. 1999. Normal inhibitory avoidance learning and anxiety, but increased locomotor activity in mice devoid of PrP(C). Brain Res Mol Brain Res 71(2):349-53. [PubMed: 10521590]  [MGI Ref ID J:57672]

Rosenmann H; Talmor G; Halimi M; Yanai A; Gabizon R; Meiner Z. 2001. Prion protein with an E200K mutation displays properties similar to those of the cellular isoform PrP(C). J Neurochem 76(6):1654-62. [PubMed: 11259483]  [MGI Ref ID J:136430]

Rossi D; Cozzio A; Flechsig E; Klein MA; Rulicke T; Aguzzi A; Weissmann C. 2001. Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain. EMBO J 20(4):694-702. [PubMed: 11179214]  [MGI Ref ID J:67593]

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Seelig DM; Mason GL; Telling GC; Hoover EA. 2011. Chronic wasting disease prion trafficking via the autonomic nervous system. Am J Pathol 179(3):1319-28. [PubMed: 21777560]  [MGI Ref ID J:176313]

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Senatore A; Colleoni S; Verderio C; Restelli E; Morini R; Condliffe SB; Bertani I; Mantovani S; Canovi M; Micotti E; Forloni G; Dolphin AC; Matteoli M; Gobbi M; Chiesa R. 2012. Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC alpha(2)delta-1 Subunit. Neuron 74(2):300-13. [PubMed: 22542184]  [MGI Ref ID J:188385]

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Singh A; Kong Q; Luo X; Petersen RB; Meyerson H; Singh N. 2009. Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport. PLoS One 4(7):e6115. [PubMed: 19568430]  [MGI Ref ID J:151641]

Sonati T; Reimann RR; Falsig J; Baral PK; O'Connor T; Hornemann S; Yaganoglu S; Li B; Herrmann US; Wieland B; Swayampakula M; Rahman MH; Das D; Kav N; Riek R; Liberski PP; James MN; Aguzzi A. 2013. The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature 501(7465):102-6. [PubMed: 23903654]  [MGI Ref ID J:205018]

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Stewart RS; Harris DA. 2005. A transmembrane form of the prion protein is localized in the Golgi apparatus of neurons. J Biol Chem 280(16):15855-64. [PubMed: 15671025]  [MGI Ref ID J:128889]

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Tremblay P; Ball HL; Kaneko K; Groth D; Hegde RS; Cohen FE; DeArmond SJ; Prusiner SB; Safar JG. 2004. Mutant PrPSc conformers induced by a synthetic peptide and several prion strains. J Virol 78(4):2088-99. [PubMed: 14747574]  [MGI Ref ID J:88452]

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Turnbaugh JA; Unterberger U; Saa P; Massignan T; Fluharty BR; Bowman FP; Miller MB; Supattapone S; Biasini E; Harris DA. 2012. The N-Terminal, Polybasic Region of PrPC Dictates the Efficiency of Prion Propagation by Binding to PrPSc. J Neurosci 32(26):8817-30. [PubMed: 22745483]  [MGI Ref ID J:185649]

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Viegas P; Chaverot N; Enslen H; Perriere N; Couraud PO; Cazaubon S. 2006. Junctional expression of the prion protein PrPC by brain endothelial cells: a role in trans-endothelial migration of human monocytes. J Cell Sci 119(Pt 22):4634-43. [PubMed: 17062642]  [MGI Ref ID J:117368]

Wadsworth JD; Asante EA; Desbruslais M; Linehan JM; Joiner S; Gowland I; Welch J; Stone L; Lloyd SE; Hill AF; Brandner S; Collinge J. 2004. Human prion protein with valine 129 prevents expression of variant CJD phenotype. Science 306(5702):1793-6. [PubMed: 15539564]  [MGI Ref ID J:133712]

Wadsworth JD; Joiner S; Linehan JM; Desbruslais M; Fox K; Cooper S; Cronier S; Asante EA; Mead S; Brandner S; Hill AF; Collinge J. 2008. Kuru prions and sporadic Creutzfeldt-Jakob disease prions have equivalent transmission properties in transgenic and wild-type mice. Proc Natl Acad Sci U S A 105(10):3885-90. [PubMed: 18316717]  [MGI Ref ID J:132790]

Wang X; Wang F; Arterburn L; Wollmann R; Ma J. 2006. The interaction between cytoplasmic prion protein and the hydrophobic lipid core of membrane correlates with neurotoxicity. J Biol Chem 281(19):13559-65. [PubMed: 16537534]  [MGI Ref ID J:113115]

Watts JC; Drisaldi B; Ng V; Yang J; Strome B; Horne P; Sy MS; Yoong L; Young R; Mastrangelo P; Bergeron C; Fraser PE; Carlson GA; Mount HT; Schmitt-Ulms G; Westaway D. 2007. The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections. EMBO J 26(17):4038-50. [PubMed: 17703189]  [MGI Ref ID J:124925]

Watts JC; Stohr J; Bhardwaj S; Wille H; Oehler A; Dearmond SJ; Giles K; Prusiner SB. 2011. Protease-resistant prions selectively decrease Shadoo protein. PLoS Pathog 7(11):e1002382. [PubMed: 22163178]  [MGI Ref ID J:183163]

Weise J; Sandau R; Schwarting S; Crome O; Wrede A; Schulz-Schaeffer W; Zerr I; Bahr M. 2006. Deletion of cellular prion protein results in reduced Akt activation, enhanced postischemic caspase-3 activation, and exacerbation of ischemic brain injury. Stroke 37(5):1296-300. [PubMed: 16574930]  [MGI Ref ID J:129246]

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Westergard L; Turnbaugh JA; Harris DA. 2011. A nine amino Acid domain is essential for mutant prion protein toxicity. J Neurosci 31(39):14005-17. [PubMed: 21957261]  [MGI Ref ID J:176121]

White AR; Collins SJ; Maher F; Jobling MF; Stewart LR; Thyer JM; Beyreuther K; Masters CL; Cappai R. 1999. Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity. Am J Pathol 155(5):1723-30. [PubMed: 10550328]  [MGI Ref ID J:58339]

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Williams SK; Fairless R; Weise J; Kalinke U; Schulz-Schaeffer W; Diem R. 2011. Neuroprotective effects of the cellular prion protein in autoimmune optic neuritis. Am J Pathol 178(6):2823-31. [PubMed: 21641403]  [MGI Ref ID J:173470]

Windl O; Buchholz M; Neubauer A; Schulz-Schaeffer W; Groschup M; Walter S; Arendt S; Neumann M; Voss AK; Kretzschmar HA. 2005. Breaking an absolute species barrier: transgenic mice expressing the mink PrP gene are susceptible to transmissible mink encephalopathy. J Virol 79(23):14971-5. [PubMed: 16282497]  [MGI Ref ID J:102912]

Xikota JC; Rial D; Ruthes D; Pereira R; Figueiredo CP; Prediger RD; Walz R. 2008. Mild cognitive deficits associated to neocortical microgyria in mice with genetic deletion of cellular prion protein. Brain Res 1241:148-56. [PubMed: 18840415]  [MGI Ref ID J:147621]

Yamaguchi N; Sakaguchi S; Shigematsu K; Okimura N; Katamine S. 2004. Doppel-induced Purkinje cell death is stoichiometrically abrogated by prion protein. Biochem Biophys Res Commun 319(4):1247-52. [PubMed: 15194501]  [MGI Ref ID J:90762]

Yamaguchi Y; Miyata H; Uchiyama K; Ootsuyama A; Inubushi S; Mori T; Muramatsu N; Katamine S; Sakaguchi S. 2012. Biological and biochemical characterization of mice expressing prion protein devoid of the octapeptide repeat region after infection with prions. PLoS One 7(8):e43540. [PubMed: 22927985]  [MGI Ref ID J:191684]

Yang W; Cook J; Rassbach B; Lemus A; DeArmond SJ; Mastrianni JA. 2009. A New Transgenic Mouse Model of Gerstmann-Straussler-Scheinker Syndrome Caused by the A117V Mutation of PRNP. J Neurosci 29(32):10072-80. [PubMed: 19675240]  [MGI Ref ID J:151934]

Yoshikawa D; Yamaguchi N; Ishibashi D; Yamanaka H; Okimura N; Yamaguchi Y; Mori T; Miyata H; Shigematsu K; Katamine S; Sakaguchi S. 2008. Dominant-negative effects of the N-terminal half of prion protein on neurotoxicity of prion protein-like protein/doppel in mice. J Biol Chem 283(35):24202-11. [PubMed: 18562311]  [MGI Ref ID J:140370]

You H; Tsutsui S; Hameed S; Kannanayakal TJ; Chen L; Xia P; Engbers JD; Lipton SA; Stys PK; Zamponi GW. 2012. Abeta neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A 109(5):1737-42. [PubMed: 22307640]  [MGI Ref ID J:182028]

Young R; Bouet S; Polyte J; Le Guillou S; Passet B; Vilotte M; Castille J; Beringue V; Le Provost F; Laude H; Vilotte JL. 2011. Expression of the prion-like protein Shadoo in the developing mouse embryo. Biochem Biophys Res Commun 416(1-2):184-7. [PubMed: 22093825]  [MGI Ref ID J:179204]

Young R; Le Guillou S; Tilly G; Passet B; Vilotte M; Castille J; Beringue V; Le Provost F; Laude H; Vilotte JL. 2011. Generation of Sprn-regulated reporter mice reveals gonadic spatial expression of the prion-like protein Shadoo in mice. Biochem Biophys Res Commun 412(4):752-6. [PubMed: 21871438]  [MGI Ref ID J:177535]

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Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, homozygous mice may be bred together.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


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Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   001800 FVB/NJ (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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