Strain Name:

B6.129(Cg)-Axin2tm1(cre/ERT2)Rnu/J

Stock Number:

018867

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Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
Common Names: Axin2-CreERT2;    
In this inducible Axin2 (axin2) knock-in/knockout strain, Cre-ERT2 protein expression affects cells with active Wnt/β-catenin pathway signaling. Crosses with floxed reporter strains enable conditional stem cell-specific labeling.

Description

Strain Information

Former Names B6.Cg-Axin2tm1(cre/ERT2)Rnu/J    (Changed: 11-SEP-12 )
Type Congenic; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemWild-type x Heterozygote         (Female x Male)   29-SEP-14
Mating SystemHeterozygote x Wild-type         (Female x Male)   29-SEP-14
Specieslaboratory mouse
GenerationN5+pN1F4 (04-MAY-15)
Generation Definitions
 
Donating Investigator Roel Nusse,   Stanford University

Description
The Axin2 (axin2) gene plays an integral role in the Wnt /β-catenin signaling pathway that is involved in stem cell maintenance. As such, it is a frequently-used marker of functional stem cells and a target for analyzing the pathway in a variety of tissues.

In this inducible knock-in/knockout strain, Cre-ERT2 protein expression is driven by the endogenous Axin2 promoter and enhancer sequences, affecting cells with active Wnt/β-catenin signaling. Expression of the targeted Axin2 is ablated and Cre activity is only detected upon treatment with tamoxifen, thereby offering both spatial and temporal control. Heterozygous mice have no phenotype and show normal fertility.

Upon crossing these mice to Cre-reporter strains (e.g. floxed lacZ or GFP), Wnt/β-catenin responsive cells may be labeled for lineage tracing. Animals derived from crosses with B6.129(Cg)-Gt(ROSA)26Sor/J (see Stock No. 007676) or B6.129S4-Gt(ROSA)26Sortm1Sor/J (see Stock No. 003474) can be treated with tamoxifen to label stem cells of the intestinal crypt and the mammary epithelium.

Homozygous Axin2-CreERT2 mice in The Jackson Laboratory colony are born at a significantly reduced frequency (~5% in heterozygous crosses). Due to the disruption of the targeted gene, animals may display minor phenotypes similar to Stock No. 009120, an Axin-lacZ mutant targeted to the same genetic location. Homozygotes may display malformations of skull structures, a phenotype resembling craniosynostosis in humans.

Development
CreERT2 (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain) and an FRT-flanked puromycin resistance cassette were knocked into exon 2 of the Axin2 gene. The mutation was created in (129X1/SvJ x 129S1/Sv)F1- Kitl+-derived R1 embryonic stem (ES) cells and chimeric mice were backcrossed to C57BL/6 for more than 5 generations by the donating laboratory (see SNP note below). Attempts to excise the puromycin cassette by transient FLP expression in ES cells and by crossing to a FLP strain were unsuccessful, but the cassette does not appear to cause any negative side effects.

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, all 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a C57BL/6N genetic background.

Control Information

  Control
   Wild-type from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Axin2
009120   B6.129P2-Axin2tm1Wbm/J
016997   B6.Cg-Tg(Axin2-rtTA2S*M2)7Cos/J
View Strains carrying other alleles of Axin2     (2 strains)

Strains carrying other alleles of cre/ERT2
017611   129-Mcm2tm1(cre/ERT2)Scpr/J
009575   B6(129S4)-Et(cre/ERT2)119Rdav/J
009580   B6(129S4)-Et(cre/ERT2)1382Rdav/J
012688   B6(129S4)-Et(cre/ERT2)13866Rdav/J
009581   B6(129S4)-Et(cre/ERT2)1642Rdav/J
009582   B6(129S4)-Et(cre/ERT2)1645Rdav/J
009583   B6(129S4)-Et(cre/ERT2)1957Rdav/J
009584   B6(129S4)-Et(cre/ERT2)2007Rdav/J
009585   B6(129S4)-Et(cre/ERT2)2047Rdav/J
009574   B6(129S4)-Et(cre/ERT2)21Rdav/J
009577   B6(129S4)-Et(cre/ERT2)296Rdav/J
009578   B6(129S4)-Et(cre/ERT2)398Rdav/J
009573   B6(129S4)-Et(cre/ERT2)4Rdav/J
010688   B6(129S4)-Et(cre/ERT2)6691Rdav/J
010689   B6(129S4)-Et(cre/ERT2)6959Rdav/J
010690   B6(129S4)-Et(cre/ERT2)7089Rdav/J
010691   B6(129S4)-Et(cre/ERT2)7149Rdav/J
010692   B6(129S4)-Et(cre/ERT2)7381Rdav/J
010693   B6(129S4)-Et(cre/ERT2)8120Rdav/J
010694   B6(129S4)-Et(cre/ERT2)8131Rdav/J
009579   B6(129S4)-Et(cre/ERT2)837Rdav/J
010695   B6(129S4)-Et(cre/ERT2)9699Rdav/J
010696   B6(129S4)-Et(icre/ERT2)10596Rdav/J
010697   B6(129S4)-Et(icre/ERT2)10727Rdav/J
012689   B6(129S4)-Et(icre/ERT2)14163Rdav/J
012690   B6(129S4)-Et(icre/ERT2)14208Rdav/J
012694   B6(129S4)-Et(icre/ERT2)14915Rdav/J
022356   B6(129X1)-Tg(Cd4-cre/ERT2)11Gnri/J
013730   B6(Cg)-Calb2tm2.1(cre/ERT2)Zjh/J
010705   B6(Cg)-Dlx5tm1(cre/ERT2)Zjh/J
013048   B6(Cg)-Etv1tm1.1(cre/ERT2)Zjh/J
010776   B6(Cg)-Lhx6tm1(cre/ERT2)Zjh/J
010777   B6(Cg)-Pvalbtm1(cre/ERT2)Zjh/J
010708   B6(Cg)-Ssttm1(cre/ERT2)Zjh/J
026512   B6(Cg)-Tg(TPO-cre/ERT2)1139Tyj/J
021881   B6.129(Cg)-Arctm1.1(cre/ERT2)Luo/J
021882   B6.129(Cg)-Fostm1.1(cre/ERT2)Luo/J
008463   B6.129-Gt(ROSA)26Sortm1(cre/ERT2)Tyj/J
020940   B6.129P2(C)-Cx3cr1tm2.1(cre/ERT2)Jung/J
021160   B6.129P2(Cg)-Cx3cr1tm2.1(cre/ERT)Litt/WganJ
027116   B6.129P2-Cd19tm1(cre/ERT2)Rsky/J
008875   B6.129P2-Lgr5tm1(cre/ERT2)Cle/J
016934   B6.129P2-Lgr6tm2.1(cre/ERT2)Cle/J
016222   B6.129S(Cg)-Id2tm1.1(cre/ERT2)Blh/ZhuJ
005623   B6.129S6-Shhtm2(cre/ERT2)Cjt/J
019148   B6.Cg-Acantm1(cre/ERT2)Crm/J
012360   B6.Cg-Erbb4tm1.1(cre/ERT2)Aibs/J
023676   B6.Cg-Hprttm331(Ple275-icre/ERT2)Ems/Mmjax
023677   B6.Cg-Hprttm332(Ple272-icre/ERT2)Ems/Mmjax
023678   B6.Cg-Hprttm333(Ple281-icre/ERT2)Ems/Mmjax
023679   B6.Cg-Hprttm334(Ple279-icre/ERT2)Ems/Mmjax
023680   B6.Cg-Hprttm335(Ple277-icre/ERT2)Ems/Mmjax
023681   B6.Cg-Hprttm336(Ple134-icre/ERT2)Ems/Mmjax
023682   B6.Cg-Hprttm337(Ple285-icre/ERT2)Ems/Mmjax
023683   B6.Cg-Hprttm338(Ple284-icre/ERT2)Ems/Mmjax
023684   B6.Cg-Hprttm339(Ple280-icre/ERT2)Ems/Mmjax
023685   B6.Cg-Hprttm340(Ple252-icre/ERT2)Ems/Mmjax
023686   B6.Cg-Hprttm341(Ple273-icre/ERT2)Ems/Mmjax
023687   B6.Cg-Hprttm342(Ple282-icre/ERT2)Ems/Mmjax
023688   B6.Cg-Hprttm343(Ple270-icre/ERT2)Ems/Mmjax
023689   B6.Cg-Hprttm344(Ple5-icre/ERT2)Ems/Mmjax
023690   B6.Cg-Hprttm345(icre/ERT2)Ems/Mmjax
023691   B6.Cg-Hprttm346(Ple264-icre/ERT2)Ems/Mmjax
023692   B6.Cg-Hprttm347(Ple155-icre/ERT2)Ems/Mmjax
023693   B6.Cg-Hprttm348(Ple265-icre/ERT2)Ems/Mmjax
023694   B6.Cg-Hprttm349(Ple293-icre/ERT2)Ems/Mmjax
023695   B6.Cg-Hprttm350(Ple232-icre/ERT2)Ems/Mmjax
023696   B6.Cg-Hprttm351(Ple198-icre/ERT2)Ems/Mmjax
023697   B6.Cg-Hprttm352(Ple291-icre/ERT2)Ems/Mmjax
022861   B6.Cg-Nxph4tm1.1(cre/ERT2)Hze/J
017763   B6.Cg-Pax7tm1(cre/ERT2)Gaka/J
022862   B6.Cg-Penktm1.1(cre/ERT2)Hze/J
021189   B6.Cg-Pvalbtm1.1(cre/ERT2)Hze/J
022865   B6.Cg-Trib2tm1.1(cre/ERT2)Hze/J
022357   B6.Cg-Tg(Arc-cre/ERT2)MRhn/CdnyJ
026516   B6.Cg-Tg(Avil-cre/ERT2)AJwo/J
022390   B6.Cg-Tg(CDX2-Cre/ERT2)752Erf/J
016241   B6.Cg-Tg(Col1a1-cre/ERT2)1Crm/J
024709   B6.Cg-Tg(Ins1-cre/ERT)1Lphi/J
007606   B6.Cg-Tg(Thy1-cre/ERT2,-EYFP)AGfng/J
019079   B6.FVB-Tg(Myh11-cre/ERT2)1Soff/J
021961   B6;129-Abcg2tm3.1(cre/ERT2)Bsor/J
010531   B6;129-Bmi1tm1(cre/ERT)Mrc/J
012476   B6;129-Pax7tm2.1(cre/ERT2)Fan/J
009600   B6;129-Six2tm3(EGFP/cre/ERT2)Amc/J
010985   B6;129P-Klf3tm1(cre/ERT2)Pzg/J
015854   B6;129P2-Foxl2tm1(GFP/cre/ERT2)Pzg/J
014541   B6;129S-Nos1tm1.1(cre/ERT2)Zjh/J
010987   B6;129S-Sox18tm1(GFP/cre/ERT2)Pzg/J
017593   B6;129S-Sox2tm1(cre/ERT2)Hoch/J
014551   B6;129S4-Dlx1tm1(cre/ERT2)Zjh/J
012464   B6;129S4-Foxd1tm2(GFP/cre/ERT2)Amc/J
009576   B6;129S4-Et(cre/ERT2)278Rdav/J
024948   B6;129S6-Gdnftm1(cre/ERT2)Cos/J
012362   B6;129S6-Tg(Camk2a-cre/ERT2)1Aibs/J
017495   B6;129S7-Crim1tm1(GFP/cre/ERT2)Pzg/J
014638   B6;129X1-Cldn6tm1(cre/ERT2)Dam/J
018937   B6;C-Tg(Erv4-cre/ERT2*)657Slp/J
025809   B6;CBA-Tg(Fgfr3-icre/ERT2)4-2Wdr/J
025808   B6;CBA-Tg(Nkx2-1-cre/ERT2)1Kess/J
024768   B6;CBA-Tg(Upk2-icre/ERT2)1Ccc/J
017496   B6;D-Tg(Lfng-TagRFP/cre/ERT2)8Amc/J
018682   B6;D-Tg(Meox1-TagRFP/cre/ERT2)30Amc/J
018683   B6;D-Tg(Wnt11-TagRFP/cre/ERT2)28Amc/J
007610   B6;SJL-Tg(Thy1-cre/ERT2,-EYFP)VGfng/J
010550   B6N.FVB-Tg(Penk-glc-2-cre/ERT2)2And/J
017743   B6N;129S-Prom1tm1(cre/ERT2)Gilb/J
025124   C57BL/6-Tg(Adipoq-cre/ERT2)1Soff/J
025867   C57BL/6J-Tg(Neurod1-cre/ERT2)M1Fcal/J
024760   FVB/N-Tg(Ddx4-cre/ERT2)1Dcas/J
012882   STOCK Ascl1tm1.1(Cre/ERT2)Jejo/J
012710   STOCK Ccktm2.1(cre/ERT2)Zjh/J
007924   STOCK En2tm4(cre/ERT2)Alj/J
016961   STOCK Foxp3tm9(EGFP/cre/ERT2)Ayr/J
010702   STOCK Gad2tm1(cre/ERT2)Zjh/J
022135   STOCK Gbx2tm1.1(cre/ERT2)Jyhl/J
007913   STOCK Gli1tm3(cre/ERT2)Alj/J
024283   STOCK Hcn4tm2.1(cre/ERT2)Sev/J
017606   STOCK Hopxtm2.1(cre/ERT2)Joe/J
018418   STOCK Lrig1tm1.1(cre/ERT2)Rjc/J
014552   STOCK Nkx2-1tm1.1(cre/ERT2)Zjh/J
017536   STOCK Nkx6-2tm1(cre/ERT2)Fsh/J
009061   STOCK Osr1tm1(EGFP/cre/ERT2)Amc/J
017569   STOCK Polr2atm1(cre/ERT2)Bbd E4f1tm1.1Llca/J
017585   STOCK Polr2atm1(cre/ERT2)Bbd/J
022757   STOCK Prg4tm1(GFP/cre/ERT2)Abl/J
010912   STOCK Wt1tm2(cre/ERT2)Wtp/J
012691   STOCK Et(icre/ERT2)14374Rdav/J
012692   STOCK Et(icre/ERT2)14602Rdav/J
012693   STOCK Et(icre/ERT2)14624Rdav/J
008861   STOCK Tg(Ela1-Cre/ERT2)1Stof/J
022763   STOCK Tg(Eno2-cre/ERT2)1Pohlk/J
027681   STOCK Tg(Hnf1b-cre/ERT2)1Jfer/J
019380   STOCK Tg(IVL-cre/ERT2)1Blpn/J
017948   STOCK Tg(KRT18-cre/ERT2)23Blpn/J
017947   STOCK Tg(Krt8-cre/ERT2)17Blpn/J
018829   STOCK Tg(Sox9-cre/ERT2)1Msan/J
025520   STOCK Tg(T-cre/ERT2)1Lwd/J
View Strains carrying other alleles of cre/ERT2     (138 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Oligodontia-Colorectal Cancer Syndrome; ODCRCS   (AXIN2)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Axin2tm1(cre/ERT2)Rnu/Axin2+

        involves: 129S1/Sv * 129X1/SvJ
  • no phenotypic analysis
  • *normal* no phenotypic analysis
    • no details are available   (MGI Ref ID J:186834)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cell Biology Research
Signal Transduction

Developmental Biology Research
Craniofacial and Palate Defects
Growth Defects
      Growth Defects (homozygous)
Internal/Organ Defects
      brain

Research Tools
Cell Biology Research
Cre-lox System
      Cre Recombinase Expression
      Cre Recombinase Expression: Inducible

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Axin2tm1(cre/ERT2)Rnu
Allele Name targeted mutation 1, Roel Nusse
Allele Type Targeted (Inducible, cre- or Flp-expressing)
Common Name(s) Axin2creERT2;
Mutation Made By Roel Nusse,   Stanford University
Strain of Origin(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Site of Expressionmammary epithelium
Expressed Gene cre/ERT2, Cre recombinase and estrogen receptor 1 (human) fusion gene,
Gene Symbol and Name Axin2, axin2
Chromosome 11
Gene Common Name(s) AXIL; Conductin; ODCRCS;
Driver Note Axin2
Inducible Note induced by tamoxifen
Molecular Note A cre/ERT2 sequence (cre recombinase fused to a G400V/M543A/L544A triple mutation ofthe human estrogen receptor ligand binding domain) and an FRT-flanked puromycin resistance cassette were knocked into exon 2 of the Axin2 gene. Transient flp expression in ES cells and crosses to flp-expressing strains were unsuccessful at excising the selection cassette, but its presence does not seem to have negative side effects. [MGI Ref ID J:186834] [MGI Ref ID J:74286]
 

Genotyping

Genotyping Information

Genotyping Protocols

Axin2tm1(cre/ERT2)Rnu Alternate1, MELT

Nusse Lab PCR Protocol

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Lustig B; Jerchow B; Sachs M; Weiler S; Pietsch T; Karsten U; van de Wetering M; Clevers H; Schlag PM; Birchmeier W; Behrens J. 2002. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol 22(4):1184-93. [PubMed: 11809809]  [MGI Ref ID J:74286]

van Amerongen R; Bowman AN; Nusse R. 2012. Developmental Stage and Time Dictate the Fate of Wnt/beta-Catenin-Responsive Stem Cells in the Mammary Gland. Cell Stem Cell 11(3):387-400. [PubMed: 22863533]  [MGI Ref ID J:186834]

Additional References

Axin2tm1(cre/ERT2)Rnu related

Bowman AN; van Amerongen R; Palmer TD; Nusse R. 2013. Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/beta-catenin-responsive neural stem cells. Proc Natl Acad Sci U S A 110(18):7324-9. [PubMed: 23589866]  [MGI Ref ID J:196132]

Jan TA; Chai R; Sayyid ZN; van Amerongen R; Xia A; Wang T; Sinkkonen ST; Zeng YA; Levin JR; Heller S; Nusse R; Cheng AG. 2013. Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells. Development 140(6):1196-206. [PubMed: 23444352]  [MGI Ref ID J:194845]

Lim X; Tan SH; Koh WL; Chau RM; Yan KS; Kuo CJ; van Amerongen R; Klein AM; Nusse R. 2013. Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science 342(6163):1226-30. [PubMed: 24311688]  [MGI Ref ID J:205263]

Rinkevich Y; Montoro DT; Contreras-Trujillo H; Harari-Steinberg O; Newman AM; Tsai JM; Lim X; Van-Amerongen R; Bowman A; Januszyk M; Pleniceanu O; Nusse R; Longaker MT; Weissman IL; Dekel B. 2014. In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration. Cell Rep 7(4):1270-83. [PubMed: 24835991]  [MGI Ref ID J:211793]

Tan SH; Senarath-Yapa K; Chung MT; Longaker MT; Wu JY; Nusse R. 2014. Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation. Proc Natl Acad Sci U S A 111(49):E5262-71. [PubMed: 25422448]  [MGI Ref ID J:216799]

Volkenstein S; Oshima K; Sinkkonen ST; Corrales CE; Most SP; Chai R; Jan TA; Cheng AG; Heller S. 2013. Transient, afferent input-dependent, postnatal niche for neural progenitor cells in the cochlear nucleus. Proc Natl Acad Sci U S A 110(35):14456-61. [PubMed: 23940359]  [MGI Ref ID J:200743]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX9

Colony Maintenance

Breeding & HusbandryHeterozygous mice have no phenotype and show normal fertility. Homozygous Axin2-CreERT2 mice are born at a significantly reduced frequency (~5% in heterozygous crosses). Due to the disruption of the targeted gene, animals may display minor phenotypes similar to Stock No. 009120, an Axin-lacZ mutant targeted to the same genetic location. Homozygotes may display malformations of skull structures, a phenotype resembling craniosynostosis in humans.
Mating SystemWild-type x Heterozygote         (Female x Male)   29-SEP-14
Heterozygote x Wild-type         (Female x Male)   29-SEP-14

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHeterozygous for Axin2tm1(cre/ERT2)Rnu  
Price per Pair (US dollars $)Pair Genotype
$313.00Heterozygous for Axin2tm1(cre/ERT2)Rnu x Wild-type for Axin2tm1(cre/ERT2)Rnu  
$313.00Wild-type for Axin2tm1(cre/ERT2)Rnu x Heterozygous for Axin2tm1(cre/ERT2)Rnu  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHeterozygous for Axin2tm1(cre/ERT2)Rnu  
Price per Pair (US dollars $)Pair Genotype
$406.90Heterozygous for Axin2tm1(cre/ERT2)Rnu x Wild-type for Axin2tm1(cre/ERT2)Rnu  
$406.90Wild-type for Axin2tm1(cre/ERT2)Rnu x Heterozygous for Axin2tm1(cre/ERT2)Rnu  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   Wild-type from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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