Strain Name:

B6N.Cg-Tg(ACTFLPe)9205Dym/CjDswJ

Stock Number:

019100

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Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
ACTBFLPe mice are useful for deletion of Frt-flanked sequences in a variety of tissues.

Description

Strain Information

Type Congenic; Mutant Strain; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemNoncarrier x Hemizygote         (Female x Male)   09-APR-13
Mating SystemHemizygote x Noncarrier         (Female x Male)   09-APR-13
Specieslaboratory mouse
GenerationN10+pN1 (14-JUL-13)
Generation Definitions
 
Donating Investigator Terry Van Dyke,   NIH

Description
This transgenic strain expresses a variant of the Saccharomyces cerevisiae FLP1 recombinase gene under the direction of the human ACTB promoter. The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being four-fold and ten-fold that of wildtype FLP at 37oC and 40oC, respectively. Mice that are hemizygous or homozygous for the transgenic allele are viable and fertile. Recombinase activity is detected in a wide variety of tissues (spinal cord, heart, gonad, adrenal) as early as embryonic day 10.5. This deleter strain is a suitable alternative to, and complement with the Cre-loxP system for in vivo genetic engineering.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Development
A transgenic construct designed by Dr. Susan Dymecki (Harvard University) containing a FLP1 recombinase variant controlled by the human ACTB promoter (3 kb flanking sequence, 78-bp 5' untranslated region, 832-bp of exon 1) was injected into fertilized eggs from B6SJLF2 mice. Founder line 9205 animals were subsequently obtained. The mice were transferred to the laboratory of Drs. Neal Copeland & Nancy Jenkins and backcrossed to C57BL6/Ncr for 10 generations. Upon arrival at The Jackson Laboratory, the mice were crossed to C57BL/6NJ (Stock No. 005304) at least once to establish the colony.

Control Information

  Control
   005304 C57BL/6NJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tg(ACTFLPe)9205Dym allele
005703   B6.Cg-Tg(ACTFLPe)9205Dym/J
003800   B6;SJL-Tg(ACTFLPe)9205Dym/J
View Strains carrying   Tg(ACTFLPe)9205Dym     (2 strains)

View Strains carrying other alleles of ACTB     (13 strains)

View Strains carrying other alleles of FLP1     (8 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
FLP-FRT System
      FLP Recombinase Expression: Germline/Embryonic Expression
Genetics Research
      Mutagenesis and Transgenesis: FLP recombinase

FLP1 related

Research Tools
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: FLP recombinase

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(ACTFLPe)9205Dym
Allele Name transgene insertion 9205, Susan Dymecki
Allele Type Transgenic (Cre/Flp)
Common Name(s) ACT-FLPe; ACTB::FLPe; ACTB:FLPe; ACTFlpe; CAGG-Flpr; CAGGS-flp; FLPe; Flp; Flp deleter; TgaFlpe; TgpCAG-flpe; actin-FLPe; beta-actinFLPe; hACTB-FLPe; hACTB::FLPe;
Mutation Made By Susan Dymecki,   Harvard Medical School
Strain of Origin(C57BL/6 x SJL)F2
Site of Expressionexpression of the enhanced FLP1 recombinase variant (FLPe) is detected in a wide variety of tissues (spinal cord, heart, gonad, adrenal) as early as embryonic day 10.5
Expressed Gene FLP1, FLP1 recombinase, Saccharomyces cerevisiae
FLP1 recombinase is an enzyme derived from Saccharomyces cerevisiae that specifically recognizes a 34 base pair FLP1 recombinase target (FRT) sequence. FLP1 has been shown to effectively mediate the excision of DNA located between similarly oriented FRT sites. After the excision event, DNA ends recombine leaving a single FRT site in place of the intervening sequence. DNA located between oppositely orientated FRT sites is inverted rather than deleted.
Promoter ACTB, actin, beta, human
Gene Symbol and Name Tg(ACTFLPe)9205Dym, transgene insertion 9205, Susan Dymecki
Chromosome UN
Gene Common Name(s) ACT-FLPe; ACTB:FLPe; CAGG-Flpr; FLPe; Flp; Flp deleter; TgpCAG-flpe; actin-FLPe; beta-actinFLPe; hACTB-FLPe; hACTB::FLPe;
Driver Note ACTB
General Note The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being 4X and 10X that of wildtype FLP at 37C and 40C, respectively. Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
Molecular Note Sequence encoding FLP1 was adjoined to human ACTB promoter sequence, including 3 kb of promoter sequence and an 0.8 kb portion of exon 1. The promoter region drives expression in the germline. Recombinase activity is detected in a wide variety of tissues (spinal cord, heart, gonad, adrenal) as early as embryonic day 10.5. [MGI Ref ID J:78660]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Tg(ACTFLPe), High Resolution Melting
Tg(ACTFLPe), Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Rodriguez CI; Buchholz F; Galloway J; Sequerra R; Kasper J; Ayala R; Stewart AF; Dymecki SM. 2000. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet 25(2):139-40. [PubMed: 10835623]  [MGI Ref ID J:78660]

Additional References

Tg(ACTFLPe)9205Dym related

Aanhaanen WT; Brons JF; Dominguez JN; Rana MS; Norden J; Airik R; Wakker V; de Gier-de Vries C; Brown NA; Kispert A; Moorman AF; Christoffels VM. 2009. The Tbx2+ primary myocardium of the atrioventricular canal forms the atrioventricular node and the base of the left ventricle. Circ Res 104(11):1267-74. [PubMed: 19423846]  [MGI Ref ID J:155719]

Adams JW; Wang J; Davis JR; Liaw C; Gaidarov I; Gatlin J; Dalton ND; Gu Y; Ross J Jr; Behan D; Chien K; Connolly D. 2008. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Am J Physiol Heart Circ Physiol 295(2):H509-21. [PubMed: 18539757]  [MGI Ref ID J:138227]

Agarwal A; Dibaj P; Kassmann CM; Goebbels S; Nave KA; Schwab MH. 2011. In Vivo Imaging and Noninvasive Ablation of Pyramidal Neurons in Adult NEX-CreERT2 Mice. Cereb Cortex :. [PubMed: 21880656]  [MGI Ref ID J:181084]

Ahmadian M; Abbott MJ; Tang T; Hudak CS; Kim Y; Bruss M; Hellerstein MK; Lee HY; Samuel VT; Shulman GI; Wang Y; Duncan RE; Kang C; Sul HS. 2011. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metab 13(6):739-48. [PubMed: 21641555]  [MGI Ref ID J:176083]

Aizawa R; Yamada A; Suzuki D; Iimura T; Kassai H; Harada T; Tsukasaki M; Yamamoto G; Tachikawa T; Nakao K; Yamamoto M; Yamaguchi A; Aiba A; Kamijo R. 2012. Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development. Mech Dev 129(1-4):38-50. [PubMed: 22387309]  [MGI Ref ID J:184022]

Akiyama H; Kim JE; Nakashima K; Balmes G; Iwai N; Deng JM; Zhang Z; Martin JF; Behringer RR; Nakamura T; de Crombrugghe B. 2005. Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci U S A 102(41):14665-70. [PubMed: 16203988]  [MGI Ref ID J:102495]

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Artner I; Hang Y; Mazur M; Yamamoto T; Guo M; Lindner J; Magnuson MA; Stein R. 2010. MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes 59(10):2530-9. [PubMed: 20627934]  [MGI Ref ID J:169626]

Aust JG; Gays F; Hussain F; Butcher GW; Kist R; Peters H; Brooks CG. 2011. Mice lacking Ly49E show normal NK cell development and provide evidence for probabilistic expression of Ly49E in NK cells and T cells. J Immunol 186(4):2013-23. [PubMed: 21248256]  [MGI Ref ID J:169142]

Baba M; Furihata M; Hong SB; Tessarollo L; Haines DC; Southon E; Patel V; Igarashi P; Alvord WG; Leighty R; Yao M; Bernardo M; Ileva L; Choyke P; Warren MB; Zbar B; Linehan WM; Schmidt LS. 2008. Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. J Natl Cancer Inst 100(2):140-54. [PubMed: 18182616]  [MGI Ref ID J:130978]

Backman CM; Malik N; Zhang Y; Shan L; Grinberg A; Hoffer BJ; Westphal H; Tomac AC. 2006. Characterization of a mouse strain expressing Cre recombinase from the 3' untranslated region of the dopamine transporter locus. Genesis 44(8):383-90. [PubMed: 16865686]  [MGI Ref ID J:114466]

Backs J; Backs T; Neef S; Kreusser MM; Lehmann LH; Patrick DM; Grueter CE; Qi X; Richardson JA; Hill JA; Katus HA; Bassel-Duby R; Maier LS; Olson EN. 2009. The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Proc Natl Acad Sci U S A 106(7):2342-7. [PubMed: 19179290]  [MGI Ref ID J:146285]

Balderes DA; Magnuson MA; Sussel L. 2013. Nkx2.2:Cre knock-in mouse line: A novel tool for pancreas- and CNS-specific gene deletion. Genesis 51(12):844-51. [PubMed: 23996959]  [MGI Ref ID J:204532]

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Bardeesy N; Cheng KH; Berger JH; Chu GC; Pahler J; Olson P; Hezel AF; Horner J; Lauwers GY; Hanahan D; DePinho RA. 2006. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev 20(22):3130-46. [PubMed: 17114584]  [MGI Ref ID J:116130]

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Baydyuk M; Russell T; Liao GY; Zang K; An JJ; Reichardt LF; Xu B. 2011. TrkB receptor controls striatal formation by regulating the number of newborn striatal neurons. Proc Natl Acad Sci U S A 108(4):1669-74. [PubMed: 21205893]  [MGI Ref ID J:168326]

Beaudoin GM 3rd; Schofield CM; Nuwal T; Zang K; Ullian EM; Huang B; Reichardt LF. 2012. Afadin, a ras/rap effector that controls cadherin function, promotes spine and excitatory synapse density in the hippocampus. J Neurosci 32(1):99-110. [PubMed: 22219273]  [MGI Ref ID J:179366]

Beck L; Leroy C; Beck-Cormier S; Forand A; Salaun C; Paris N; Bernier A; Urena-Torres P; Prie D; Ollero M; Coulombel L; Friedlander G. 2010. The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development. PLoS One 5(2):e9148. [PubMed: 20161774]  [MGI Ref ID J:157997]

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Borghese CM; Blednov YA; Quan Y; Iyer SV; Xiong W; Mihic SJ; Zhang L; Lovinger DM; Trudell JR; Homanics GE; Harris RA. 2012. Characterization of two mutations, M287L and Q266I, in the alpha1 glycine receptor subunit that modify sensitivity to alcohols. J Pharmacol Exp Ther 340(2):304-16. [PubMed: 22037201]  [MGI Ref ID J:199352]

Borghese CM; Werner DF; Topf N; Baron NV; Henderson LA; Boehm SL 2nd; Blednov YA; Saad A; Dai S; Pearce RA; Harris RA; Homanics GE; Harrison NL. 2006. An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice. J Pharmacol Exp Ther 319(1):208-18. [PubMed: 16807363]  [MGI Ref ID J:144692]

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Breiderhoff T; Himmerkus N; Stuiver M; Mutig K; Will C; Meij IC; Bachmann S; Bleich M; Willnow TE; Muller D. 2012. Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis. Proc Natl Acad Sci U S A 109(35):14241-6. [PubMed: 22891322]  [MGI Ref ID J:188580]

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Camerer E; Barker A; Duong DN; Ganesan R; Kataoka H; Cornelissen I; Darragh MR; Hussain A; Zheng YW; Srinivasan Y; Brown C; Xu SM; Regard JB; Lin CY; Craik CS; Kirchhofer D; Coughlin SR. 2010. Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell 18(1):25-38. [PubMed: 20152175]  [MGI Ref ID J:157446]

Cao Y; Pahlberg J; Sarria I; Kamasawa N; Sampath AP; Martemyanov KA. 2012. Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons. Proc Natl Acad Sci U S A 109(20):7905-10. [PubMed: 22547806]  [MGI Ref ID J:184794]

Carobbio S; Frigerio F; Rubi B; Vetterli L; Bloksgaard M; Gjinovci A; Pournourmohammadi S; Herrera PL; Reith W; Mandrup S; Maechler P. 2009. Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis. J Biol Chem 284(2):921-9. [PubMed: 19015267]  [MGI Ref ID J:145558]

Carpenter AC; Rao S; Wells JM; Campbell K; Lang RA. 2010. Generation of mice with a conditional null allele for Wntless. Genesis 48(9):554-8. [PubMed: 20614471]  [MGI Ref ID J:164701]

Caruso N; Herberth B; Bartoli M; Puppo F; Dumonceaux J; Zimmermann A; Denadai S; Lebosse M; Roche S; Geng L; Magdinier F; Attarian S; Bernard R; Maina F; Levy N; Helmbacher F. 2013. Deregulation of the Protocadherin Gene FAT1 Alters Muscle Shapes: Implications for the Pathogenesis of Facioscapulohumeral Dystrophy. PLoS Genet 9(6):e1003550. [PubMed: 23785297]  [MGI Ref ID J:199157]

Casola S; Cattoretti G; Uyttersprot N; Koralov SB; Segal J; Hao Z; Waisman A; Egert A; Ghitza D; Rajewsky K. 2006. Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Proc Natl Acad Sci U S A 103(19):7396-401. [PubMed: 16651521]  [MGI Ref ID J:109583]

Chalaris A; Adam N; Sina C; Rosenstiel P; Lehmann-Koch J; Schirmacher P; Hartmann D; Cichy J; Gavrilova O; Schreiber S; Jostock T; Matthews V; Hasler R; Becker C; Neurath MF; Reiss K; Saftig P; Scheller J; Rose-John S. 2010. Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med 207(8):1617-24. [PubMed: 20603312]  [MGI Ref ID J:163380]

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Zecharia AY; Yu X; Gotz T; Ye Z; Carr DR; Wulff P; Bettler B; Vyssotski AL; Brickley SG; Franks NP; Wisden W. 2012. GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness. J Neurosci 32(38):13062-75. [PubMed: 22993424]  [MGI Ref ID J:188103]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX18

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice may be bred as homozygotes. Coat color expected from breeding is Black.
Mating SystemNoncarrier x Hemizygote         (Female x Male)   09-APR-13
Hemizygote x Noncarrier         (Female x Male)   09-APR-13
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $232.00Female or MaleHemizygous for Tg(ACTFLPe)9205Dym  
Price per Pair (US dollars $)Pair Genotype
$302.00Hemizygous for Tg(ACTFLPe)9205Dym x Noncarrier  
$302.00Noncarrier x Hemizygous for Tg(ACTFLPe)9205Dym  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $301.60Female or MaleHemizygous for Tg(ACTFLPe)9205Dym  
Price per Pair (US dollars $)Pair Genotype
$392.60Hemizygous for Tg(ACTFLPe)9205Dym x Noncarrier  
$392.60Noncarrier x Hemizygous for Tg(ACTFLPe)9205Dym  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Control Information

  Control
   005304 C57BL/6NJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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