Strain Name:


Stock Number:



Awaiting Transfer from the Donor

On 09-JAN-13 this strain was accepted for import and is now awaiting transfer to our campus.
Use Restrictions Apply, see Terms of Use
Register Interest
YFP-labeled NPC1 (Niemann Pick type C1) protein expression is conditionally directed via a tetracycline-inducible minimal cytomegalovirus (tetO-CMVmin) promoter in this transgenic strain. When bred with mice expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), NPC1-YFP expression can be regulated with the tetracycline analog doxycycline (dox) in the resulting double mutant offspring.


Strain Information

Type Mutant Strain; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Specieslaboratory mouse
Donating InvestigatorDr. Matthew Scott,   Stanford University School of Medicine

Loss of NPC1 (Niemann Pick type C1) protein function is a known cause of Niemann-Pick type C disease, a fatal lysosomal storage disorder associated with progressive, widespread neurological deterioration. Symptoms include, but are not limited to, dementia, ataxia, dysarthria, dystonia, and epilepsy.

In this transgenic strain, expression of YFP-labeled and FLAG-tagged NPC1 is conditionally directed via a tetracycline-inducible minimal cytomegalovirus (tetO-CMVmin) promoter. When bred with mice expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), NPC1-YFP expression can be regulated with the tetracycline analog doxycycline (dox) in the resulting double mutant offspring. Expression of the transgene is undetectable in heterozygotes in the absence of a tTA/rtTA driver.

Founder lines were test-crossed with Pcp2-tTA (Purkinje cell protein 2 (L7)) driver animals (see Stock No. 005625) to select a transgenic line that best exhibited induction of NPC1-YFP in Purkinje neuron layer of the mouse cerebellum.

When tetO/tTA (or tetO/rtTA) double mutants are further combined with an Npc1 knockout (see Stock No. 021755), cell type-specific rescue of NPC1 loss can be tested. NPC1-YFP produced in cerebellar Purkinje neurons of Npc1 knockout mice prevents neuron degeneration, slows reactive glial activity, and ameliorates disease. These mice show reduced ataxia, increased weight, and prolonged life, but the transgene does not prevent the eventual decline and premature death of knockout mice. Cell types responsible for disease pathogenesis can be traced through the fluorescent signal.

Robust expression of NPC1-YFP in skin and visceral tissue is observed in offspring generated through crosses with B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae (see Stock No. 006965) and treated with dox.

A transgenic vector containing Npc1-6xHis-YFP-2xFLAG driven by a tet operon-cytomegalovirus minimal promoter (tetO-CMVmin) was introduced to FVB/N embryos. Founder animals were test-crossed with FVB-Tg(Pcp2-tTA)3Horr/J driver animals (see Stock No. 005625) to select a transgenic line that best exhibited induction of NPC1-YFP in the Purkinje neuron (PN) layer of the mouse cerebellum. Pcp2-tTA was subsequently bred away from this strain.

Transgenic animals were crossed with FVB.C-Npc1m1N (Stock No. 021755) heterozygotes (background then N5-6 FVB). The compound mutant mice were backcrossed crossed 2-3 times to FVB/NJ. Animals lacking the Npc1m1N knockout mutation were selected from the donating lab's (Tg Homozygous, m1N Heterozygous) colony to generate this single-mutation transgenic line.

The transgenic insertion site was mapped by 3' end genome walking. The 3' end is directly before a PstI restriction enzyme site at Chr4:36,629,314. A HindIII site is located nearby at position Chr4:36,631,149. The 5' integration end is not known, nor is the transgenic copy number.

Control Information

   Wild-type from the colony
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Npc1
003092   BALB/cNctr-Npc1m1N/J
004817   C57BL/6J-Npc1nmf164/J
002760   C57BLKS/J-Npc1spm/J
021755   FVB.C-Npc1m1N/J
View Strains carrying other alleles of Npc1     (4 strains)

Strains carrying other alleles of YFP
005483   129-Tg(CAG-EYFP)7AC5Nagy/J
021011   B6(D2)-Tg(CAG-Brainbow1.0)2Eggn/J
021012   B6(D2)-Tg(CAG-Brainbow1.0)3Eggn/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
010818   B6.129-Ifnb1tm1Lky/J
006412   B6.129-Il12btm1Lky/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
006148   B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J
007920   B6.Cg-Gt(ROSA)26Sortm2(CAG-EYFP)Hze/J
007903   B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze/J
014545   B6.Cg-Tg(Chat-COP4*H134R/EYFP,Slc18a3)5Gfng/J
014546   B6.Cg-Tg(Chat-COP4*H134R/EYFP,Slc18a3)6Gfng/J
008829   B6.Cg-Tg(Itgax-Venus)1Mnz/J
008299   B6.Cg-Tg(NEFL-EYFP/Nefh)40Gsn/J
008828   B6.Cg-Tg(Prdm1-EYFP)1Mnz/J
014548   B6.Cg-Tg(Slc32a1-COP4*H134R/EYFP)8Gfng/J
007901   B6.Cg-Tg(Thy1-Brainbow1.0)HLich/J
007911   B6.Cg-Tg(Thy1-Brainbow1.1)MLich/J
007921   B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J
007612   B6.Cg-Tg(Thy1-COP4/EYFP)18Gfng/J
007615   B6.Cg-Tg(Thy1-COP4/EYFP)9Gfng/J
013161   B6.Cg-Tg(Thy1-Clomeleon)1Gjau/J
005630   B6.Cg-Tg(Thy1-EYFP)15Jrs/J
003709   B6.Cg-Tg(Thy1-YFP)16Jrs/J
003782   B6.Cg-Tg(Thy1-YFP)HJrs/J
005627   B6.Cg-Tg(Thy1-YFP/Syp)10Jrs/J
007606   B6.Cg-Tg(Thy1-cre/ERT2,-EYFP)AGfng/J
013081   B6.FVB-Tg(Per1-Venus)33Obr/Mmjax
006716   B6;129P2-Olfr545tm4Mom/MomJ
008774   B6;129P2-Runx3tm1Litt/J
014539   B6;129S-Gt(ROSA)26Sortm39(CAG-hop/EYFP)Hze/J
008636   B6;C-Tg(Prnp-APP695*/EYFP)49Gsn/J
007910   B6;CBA-Tg(Thy1-Brainbow1.0)LLich/J
014130   B6;CBA-Tg(Thy1-YFP)GJrs/GfngJ
005620   B6;D2-Tg(S100B-EYFP)1Wjt/J
012355   B6;SJL-Tg(Pvalb-COP4*H134R/EYFP)15Gfng/J
012341   B6;SJL-Tg(Thy1-COP3/EYFP)1Gfng/J
012344   B6;SJL-Tg(Thy1-COP3/EYFP)4Gfng/J
012348   B6;SJL-Tg(Thy1-COP3/EYFP)8Gfng/J
012350   B6;SJL-Tg(Thy1-COP4*H134R/EYFP)20Gfng/J
007610   B6;SJL-Tg(Thy1-cre/ERT2,-EYFP)VGfng/J
012332   B6;SJL-Tg(Thy1-hop/EYFP)2Gfng/J
012334   B6;SJL-Tg(Thy1-hop/EYFP)4Gfng/J
014555   B6;SJL-Tg(Tph2-COP4*H134R/EYFP)5Gfng/J
007880   B6SJL-Tg(Thy1-Stx1a/EYFP)1Sud/J
015864   C.129S4(B6)-Il12btm1Lky/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
008830   C.Cg-Tg(Itgax-Venus)1Mnz/J
017978   C57BL/6-Tg(Slc17a6-COP4*H134R/EYFP)2Oki/J
006618   C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J
006362   C57BL/6J-Tg(CMV-Cox8a/EYFP)17J/J
007857   C57BL/6J-Tg(Eno2-YFP/Cox8a)YRwb/J
007860   C57BL/6J-Tg(Eno2-YFP/Cox8a)ZRwb/J
025018   D2.Cg-Gpnmb+Tg(Thy1-YFP)HJrs/SjJ
024705   D2.Cg-Tg(Thy1-YFP)HJrs/SjJ
025019   D2.Cg-Tg(Thy1-YFP/Syp)10Jrs/SjJ
018067   FVB-Tg(Prism)1849Htz/J
018071   FVB-Tg(Prism)1861Htz/J
018068   FVB-Tg(Prism)1989Htz/J
009618   NOD.129(B6)-Il12btm1Lky/JbsJ
009422   NOD.Cg-Tg(Itgax-Venus)1Mnz/QtngJ
005130   STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J
017472   STOCK Tg(Acp5-CFP,Ibsp-YFP,Dmp1-RFP)1Pmay/J
011107   STOCK Tg(CAG-Venus)1Hadj/J
020942   STOCK Tg(Cp-HIST1H2BB/Venus)47Hadj/J
016252   STOCK Tg(Hoxb7-Venus*)17Cos/J
021226   STOCK Tg(Thy1-Brainbow3.1)18Jrs/J
021225   STOCK Tg(Thy1-Brainbow3.1)3Jrs/J
021227   STOCK Tg(Thy1-Brainbow3.2)7Jrs/J
013162   STOCK Tg(Thy1-Clomeleon)12Gjau/J
013163   STOCK Tg(Thy1-Clomeleon)13Gjau/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
View Strains carrying other alleles of YFP     (73 strains)

Strains carrying other alleles of tetO
008079   129S-Ppargtm2Yba/J
016176   B6(Cg)-Tg(tetO-Per2)2Jt/J
023757   B6(Cg)-Tg(tetO-tetX,lacZ)1Gogo/UmriJ
009602   B6.129S4(Cg)-Kcnn2tm2Jpad/J
009603   B6.129S4-Kcnn3tm1Jpad/J
017983   B6.Cg-Col1a1tm9(tetO-Dnmt3b_i1)Jae Gt(ROSA)26Sortm1(rtTA*M2)Jae/J
014588   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm6(tetO-MSI2)Jae/J
023749   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Tg(tetO-Pou5f1,-Sox2,-Klf4,-Myc)1Srn/J
014648   B6.Cg-Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/ZkhuJ
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
016998   B6.Cg-Tg(TetO-Axin1,EGFP)TA6Cos/J
003762   B6.Cg-Tg(tetFosb)4468Nes/J
007051   B6.Cg-Tg(tetO-APPSwInd)102Dbo/Mmjax
007052   B6.Cg-Tg(tetO-APPSwInd)107Dbo/Mmjax
007049   B6.Cg-Tg(tetO-APPSwInd)885Dbo/Mmjax
007618   B6.Cg-Tg(tetO-Arntl)1Jt/J
017555   B6.Cg-Tg(tetO-CALY)5Cber/J
024114   B6.Cg-Tg(tetO-CHRM4*)2Blr/J
008277   B6.Cg-Tg(tetO-Clockm1Jt)CL57Jt/J
008468   B6.Cg-Tg(tetO-DTA)1Gfi/J
017791   B6.Cg-Tg(tetO-Hamp)2181Nca/J
009344   B6.Cg-Tg(tetO-Ifng)184Pop/J
009136   B6.Cg-Tg(tetO-Kcnj2,lacZ)1Gogo/J
013583   B6.Cg-Tg(tetO-LRRK2)C7874Cai/J
020652   B6.Cg-Tg(tetO-Mif)279Aren/J
017331   B6.Cg-Tg(tetO-Ppp3ca*)11255Kndl/J
017332   B6.Cg-Tg(tetO-Ppp3ca*)13967Kndl/J
017330   B6.Cg-Tg(tetO-TAg*)175Kndl/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
005738   B6.FVB-Tg(tetO-EGFP,-Tgfbr2)8Mcle/J
006911   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm2(tetO-Pou5f1)Jae/J
011001   B6;129S4-Col1a1tm1(tetO-Pou5f1,-Klf4,-Sox2,-Myc)Hoch/J
016836   B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
002709   B6;C3-Tg(TettTALuc)1Dgs/J
023598   B6;C3-Tg(tetO-AIMP2)630Tmd/J
016841   B6;C3-Tg(tetO-TARDBP)12Vle/J
014650   B6;C3-Tg(tetO-TARDBP*)4Vle/J
012450   B6;D2-Tg(tetO-SNCA)1Cai/J
008344   B6;DBA-Tg(Fos-tTA,Fos-EGFP*)1Mmay Tg(tetO-lacZ,tTA*)1Mmay/J
008082   B6;SJL-Tg(Tagln-tTA)1Mrab Tg(tetO-Mcpt1)1Mrab/J
010575   B6;SJL-Tg(tetO-Egfr*)2-9Jek/J
010577   B6;SJL-Tg(tetO-Erbb2*)8-4Jek/J
002621   B6;SJL-Tg(tetop-lacZ)2Mam/J
006004   B6C3-Tg(tetO-APPSwInd)885Dbo/Mmjax
016976   B6C3-Tg(tetO-SNCA*A53T)33Vle/J
018913   B6N.Cg-Tg(tetO-GFP,-lacZ)G3Rsp/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
017719   C3HeB/FeJ-Tg(tetO-TAg)1Efr/J
017955   C57BL/6-Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan/J
005706   C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
006618   C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J
017613   C57BL/6-Tg(tetO-Cdkn1b)1Scpr/J
013729   C57BL/6-Tg(tetO-EDN1,-lacZ)9Mhus/J
016260   C57BL/6-Tg(tetO-Fbxl21)38Jt/J
016179   C57BL/6-Tg(tetO-Fbxl21*)11Jt/J
010713   C57BL/6-Tg(tetO-GFP/tetX)5696Stl/J
013728   C57BL/6-Tg(tetO-NOS2,-lacZ)240iMhus/J
016181   C57BL/6-Tg(tetO-Nr1d1)1Schb/J
008278   C57BL/6J-Tg(tetO-Clock)1Jt/J
016580   C57BL/6J-Tg(tetO-Usf1)2Jt/J
017542   FVB-Tg(Myh6/tetO-ATP2B4)1Jmol/J
016571   FVB-Tg(Myh6/tetO-Gata6)2Jmol/J
014155   FVB-Tg(Myh6/tetO-Itpr1)22.3Jmol/J
014153   FVB-Tg(Myh6/tetO-Itpr2)3.11Jmol/J
014154   FVB-Tg(Myh6/tetO-Itpr2)4.9Jmol/J
012684   FVB-Tg(Myh6/tetO-POSTN)22.1Jmol/J
010580   FVB-Tg(Myh6/tetO-PRKCA*)1Jmk/J
013156   FVB-Tg(tetO-CDK5R1*)1Vln/J
013777   FVB-Tg(tetO-Cacna1g)1Jmol/J
013778   FVB-Tg(tetO-Cacnb2)1Jmol/J
013779   FVB-Tg(tetO-Cacnb2)2Jmol/J
013780   FVB-Tg(tetO-Cib1)1Jmol/J
010578   FVB-Tg(tetO-Dusp6)1Jmol/J
017333   FVB-Tg(tetO-Gnai2*,-lacZ)382Kndl/J
008685   FVB-Tg(tetO-Kdr*)4377.5Rwng/J
023397   FVB-Tg(tetO-Lmnb1)AF1Yfu/J
015815   FVB-Tg(tetO-MAPT*P301L)#Kha/JlwsJ
008695   FVB-Tg(tetO-MET)23Rwng/J
012387   FVB-Tg(tetO-Ppargc1a)1Dpk/J
012385   FVB-Tg(tetO-Ppargc1b)7Dpk/J
022979   FVB-Tg(tetO-Thbs4)17.7Jmol/J
006439   FVB-Tg(tetO/CMV-KRAS*G12C)9.1Msmi/J
019038   FVB.Cg-Tg(tetO-GLI1)10Rup/Mmjax
019039   FVB.Cg-Tg(tetO-KLF4)32831Rup/Mmjax
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
012459   FVB/N-Tg(Myh6*/tetO-Capn1)L2Gwd/J
005941   FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J
006202   FVB/N-Tg(tetO-BCR/ABL1)2Dgt/J
014547   FVB/N-Tg(tetO-Fasl)BDepa/J
019376   FVB/N-Tg(tetO-MYC)36aBop/J
022938   FVB/N-Tg(tetO-Wnt5a)17Rva/J
003315   FVB/N-Tg(tetORo1-lacZ)3Conk/J
005076   NOD.Cg-Tg(tetO-EGFP/FADD)1Doi/DoiJ
006999   STOCK Dbttm1Geh Tg(Cebpb-tTA)5Bjd Tg(tetO-DBT)A1Geh/J
011004   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J
011011   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm4(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J
011013   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm5(tetO-Pou5f1,-Klf4,-Myc)Jae/J
018999   STOCK Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/J
017596   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#aAhmb/J
017597   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#bAhmb/J
024854   STOCK Tg(Camk2a-tTA)1Mmay Tg(tetO-MAPT*P301L)#Kha/J
008755   STOCK Tg(Ins2-rtTA)2Efr Tg(teto-DTA)1Gfi/J
012477   STOCK Tg(Myh6*/tetO-GCaMP2)1Mik/J
016572   STOCK Tg(Myh6/tetO-Gata4)1Jmol/J
014544   STOCK Tg(tetO-ABL1*P242E*P249E)CPdav/J
014093   STOCK Tg(tetO-CHRM3*)1Blr/J
008790   STOCK Tg(tetO-DISC1*)1001Plet/J
008168   STOCK Tg(tetO-DTA)1Gfi/J
017755   STOCK Tg(tetO-GCAMP2)12iRyu/J
016970   STOCK Tg(tetO-HCV)1Mlch/Mmjax
005104   STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J
005699   STOCK Tg(tetO-Ipf1,EGFP)956.6Macd/J
005728   STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J
012441   STOCK Tg(tetO-LRRK2*G2019S)E3Cai/J
017918   STOCK Tg(tetO-MAML1*/EGFP)2Akar/J
017599   STOCK Tg(tetO-SMN2,-luc)#aAhmb/J
017600   STOCK Tg(tetO-SMN2,-luc)#bAhmb/J
012442   STOCK Tg(tetO-SNCA*A53T)E2Cai/J
006224   STOCK Tg(tetO-cre)1Jaw/J
017906   STOCK Tg(tetO-hop/EGFP,-COP4/mCherry)6Kftnk/J
012345   STOCK Tg(tetO-tdTomato,-Syp/EGFP*)1.1Luo/J
012449   STOCK Tg(teto-LRRK2)C7874Cai/J
View Strains carrying other alleles of tetO     (123 strains)


Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on transgenic expression of a human gene that is associated with this disease. Phenotypic similarity to the human disease has not been tested.
Niemann-Pick Disease, Type C1; NPC1   (NPC1)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Fluorescent protein expression in neural tissue
Tet Expression System
      tTA/rtTA Expressing Strains

Research Tools
Fluorescent Proteins
Neurobiology Research
      Tetop Tet System
      cell marker
Tet Expression Systems
      tTA/rtTA Expressing Strains

YFP related

Research Tools
Fluorescent Proteins

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Tg(tetO-Npc1/YFP)1Mps
Allele Name transgene insertion 1, Matthew Scott
Allele Type Transgenic (random, expressed)
Common Name(s) Tg(tetO-Npc1-YFP);
Strain of OriginFVB/N
Site of ExpressionIn this transgenic strain, expression of YFP-labeled and FLAG-tagged NPC1 is conditionally directed via a tetracycline-inducible minimal cytomegalovirus (tetO-CMVmin) promoter. When bred with mice expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), NPC1-YFP expression can be regulated with the tetracycline analog doxycycline (dox) in the resulting double mutant offspring. For example, bred with mice carrying the Eno2-tTA trans-gene drives reporter expression in neurons throughout the central nervous system.
Expressed Gene YFP, Yellow Fluorescent Protein, jellyfish
Yellow Fluorescent Protein (YFP) is a derivative of Green Fluorescent Protein (GFP), a versatile reporter molecule which has found use in many biological applications. The original molecule has been modified in order to enhance fluorescence intensity and shift the wavelength emitted when excited. When YFP is utilized in a transgenic construct, tissue expressing sufficient amounts of YFP will fluoresce yellowish-green when exposed to a 513 nm light source.
Expressed Gene Npc1, Niemann-Pick type C1, mouse, laboratory
Promoter tetO, tet operator,
Molecular Note The transgenic vector contains a Npc1-6xHis-YFP-2xFLAG driven by a tet operon-cytomegalovirus minimal promoter (tetO-CMVmin). Line 1 was generated. [MGI Ref ID J:170312]


Genotyping Information

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Lopez ME; Klein AD; Dimbil UJ; Scott MP. 2011. Anatomically defined neuron-based rescue of neurodegenerative niemann-pick type C disorder. J Neurosci 31(12):4367-78. [PubMed: 21430138]  [MGI Ref ID J:170312]

Health & husbandry

Health & Colony Maintenance Information

Colony Maintenance

Breeding & HusbandryHemizygotes and homozygotes are viable and fertile. When maintaining a live colony, hemizygous mice are bred with wildtype (noncarrier) mice from the colony or with FVB/NJ inbred mice (Stock No. 001800).

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


This strain is currently Awaiting Transfer from the Donor.

On 09-JAN-13 this strain was accepted for import and is now awaiting transfer to our campus.

Register Interest

View All Strains Awaiting Transfer from the Donor, In Progress and On Hold

Control Information

   Wild-type from the colony
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.