Strain Name:


Stock Number:



On Hold

Use Restrictions Apply, see Terms of Use
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These mMof floxed mutant mice possess loxP sites flanking exons 1-3 of the K(lysine) acetyltransferase 8 (Kat8) gene. This strain may be useful for studying the role of histone H4 acetylation of lysine 16 on embryogenesis and organogenesis.


Strain Information

Type Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Mating SystemHeterozygote x Heterozygote         (Female x Male)   10-JUL-13
Specieslaboratory mouse
Donating Investigator Tej Pandita,   Houston Methodist Research Institute

These conditional mMof mice possess loxP sites flanking exons 1-3 of the K(lysine) acetyltransferase 8 (Kat8) gene. Kat8, also called mMOF (murine, males absent on the first), encodes a histone H4 lysine 16 (H4K16)-specific acetyltransferase. Acetylation of H4K16 is required for cellular growth and proliferation during embryogenesis and organogenesis. Overexpression of MOF results in increased H4K16ac levels, increased cellular proliferation, oncogenic transformation, and tumor growth. Mice that are homozygous for this allele are viable and fertile. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exons 1-3 deleted in cre-expressing tissues. Complete mMOF deficiency results in embryonic lethality and cell death.

For example, when crossed to B6.129-Tg(Pcp2-cre)2Mpin/J mice (Stock No. 004146) expressing Cre recombinase in Purkinje cells, mMof-deficient mice display impaired motor coordination, ataxia, a backward-walking phenotype, and a reduced life span.

A targeting vector was designed to insert a frt-flanked neomycin resistance (neo) cassette with a 5' loxP site upstream of exon 1, and a single loxP site downstream of exon 3 of the K(lysine) acetyltransferase 8 (Kat8) gene. The construct was electroporated into 129S1/Sv-Oca2+ Tyr+ Kitl+-derived W9.5 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts and resulting chimeric males were bred with C57BL/6J females. These mMof mice were maintained on a mixed background. Upon arrival, mice were bred to C57BL/6J inbred mice (Stock No. 000664) for at least one generation to establish the colony.

Control Information

   101045 B6129SF2/J (approximate)
  Considerations for Choosing Controls


Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cell Biology Research
Genes Regulating Growth and Proliferation

Developmental Biology Research
Internal/Organ Defects

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Kat8tm1Thl
Allele Name targeted mutation 1, Thomas Ludwig
Allele Type Targeted (Conditional ready (e.g. floxed), No functional change)
Common Name(s) Mofflox; mMofflox;
Strain of Origin129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Gene Symbol and Name Kat8, K(lysine) acetyltransferase 8
Chromosome 7
Gene Common Name(s) 2010203C02Rik; 5830450F21Rik; D7Ertd629e; DNA segment, Chr 7, ERATO Doi 629, expressed; MOF; MYST histone acetyltransferase 1; MYST1; Myst1; RIKEN cDNA 2010203C02 gene; RIKEN cDNA 5830450F21 gene; ZC2HC8; hMOF;
Molecular Note An frt-flanked neo cassette with a 5' loxP site was inserted upstream of intron 1 and an additional loxP site was inserted downstream of exon 3. [MGI Ref ID J:128936]


Genotyping Information

Genotyping Protocols

Generic Neo Melt Curve Analysis,


Generic Neo Quantitative PCR-QPCR- 1.2, QPCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Gupta A; Guerin-Peyrou TG; Sharma GG; Park C; Agarwal M; Ganju RK; Pandita S; Choi K; Sukumar S; Pandita RK; Ludwig T; Pandita TK. 2008. The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis. Mol Cell Biol 28(1):397-409. [PubMed: 17967868]  [MGI Ref ID J:128936]

Additional References

Kat8tm1Thl related

Gupta A; Hunt CR; Pandita RK; Pae J; Komal K; Singh M; Shay JW; Kumar R; Ariizumi K; Horikoshi N; Hittelman WN; Guha C; Ludwig T; Pandita TK. 2013. T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice. Mutagenesis 28(3):263-70. [PubMed: 23386701]  [MGI Ref ID J:210129]

Kumar R; Hunt CR; Gupta A; Nannepaga S; Pandita RK; Shay JW; Bachoo R; Ludwig T; Burns DK; Pandita TK. 2011. Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice. Proc Natl Acad Sci U S A 108(9):3636-41. [PubMed: 21321203]  [MGI Ref ID J:170483]

Health & husbandry

Health & Colony Maintenance Information

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, mice homozygous for the floxed allele may be bred together.
Mating SystemHeterozygote x Heterozygote         (Female x Male)   10-JUL-13

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


This strain is currently On Hold.
Register Interest

To request more information use the Customer Support Contact Form or call 1-800-422-6423 or 1-207-288-5845

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Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $232.00Female or MaleHeterozygous for Kat8tm1Thl  
$232.00Female or MaleHomozygous for Kat8tm1Thl  
Price per Pair (US dollars $)Pair Genotype
$464.00Heterozygous for Kat8tm1Thl x Heterozygous for Kat8tm1Thl  

Standard Supply

This strain is currently on HOLD - Contact Customer Service for more information.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $301.60Female or MaleHeterozygous for Kat8tm1Thl  
$301.60Female or MaleHomozygous for Kat8tm1Thl  
Price per Pair (US dollars $)Pair Genotype
$603.20Heterozygous for Kat8tm1Thl x Heterozygous for Kat8tm1Thl  

Standard Supply

This strain is currently on HOLD - Contact Customer Service for more information.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

This strain is currently on HOLD - Contact Customer Service for more information.

General Supply Notes

  • 4/14/14: This strain is currently on hold. We are currently trying to re-import this stock.

Control Information

   101045 B6129SF2/J (approximate)
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

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