Description

Strain Information

Former Names BXSB-Chr YC57BL/6/MobJDcrJ    (Changed: 02-APR-13 ) Type Consomic; Additional information on Consomic Mice. Visit our online Nomenclature tutorial. Mating System Wild-type x Hemizygote         (Female x Male)   02-APR-13 Species laboratory mouse Background Strain BXSB.B6-Yaa+/J Background Strain C3H/HeSnJSmn Donor Strain C57BL/6J   Donating Investigator Dr. Derry Roopenian,   The Jackson Laboratory

Important Note
BXSB.B6-Yaa⁺ consomic males carry the C57BL/6-derived Y chromosome in place of the mutant Yaa-containing Y chromosome of BXSB/MpJ inbred male mice. BXSB.B6-Yaa⁺ consomic mice are available with different amounts of backcrossing to BXSB/MpJ inbred females: Stock No. 021330 are backcrossed at least 40 generations, Stock No. 001925 are backcrossed at least 22 generations, and Stock No. 000742 are backcrossed at least 10 generations.

Description
These BXSB.B6-Yaa⁺ mice are a BXSB-consomic strain that carries the C57BL/6-derived Y chromosome in place of the mutant Yaa-containing Y chromosome of BXSB/MpJ inbred male mice (Stock No. 000740). Male as well as female BXSB.B6-Yaa⁺ mice do not develop the severe systemic lupus erythematosus (SLE)-like autoimmune disease that spontaneously develops in BXSB/MpJ male mice. BXSB.B6-Yaa⁺ male mice are a sex-matched, autoimmune disease-resistant control strain for BXSB/MpJ male mice.

Development
The Y-linked autoimmune acceleration (Yaa) locus on the Y chromosome of BXSB inbred male mice is the result of a duplication of an ~4 Mbp telomeric segment near the pseudoautosomal region of the X chromosome onto the Y chromosome. The duplicated segment contains 19 genes, including toll-like receptor 7 (Tlr7) and phosphoribosyl pyrophosphate synthetase 2 (Prps2). The BXSB-derived Yaa locus is attributed to the systemic lupus erythematosus (SLE)-like autoimmune disease characteristics observed in BXSB/MpJ inbred male mice.

These BXSB.B6-Yaa⁺ mice (Stock No. 021330) are a BXSB-consomic control strain that was bred to harbor the C57BL/6-derived wildtype allele of Yaa in place of the BXSB/MpJ-derived Yaa allele. The strain history is shown below.
First, BXSB/MpJ inbred females (Stock No. 000740) were bred to C57BL/6J inbred males (Stock No. 000664). Each successive generation, male offspring with the C57BL/6J-derived Y chromosome were bred with BXSB/MpJ inbred females. The congenic strain after ten generations of backcrossing is BXSB.B6-Yaa⁺/J (N10; Stock No. 000742).
Around 1998, Drs. Larry E. Mobraaten and Derry C. Roopenian (The Jackson Laboratory) obtained some BXSB.B6-Yaa⁺/J males from The Jackson Laboratory Repository and continued the backcrossing for additional generations. The congenic strain after at least 22 generations of backcrossing is BXSB.B6-Yaa⁺/MobJDcr (N22; Stock No. 001925).
In 2013, Dr. Roopenian sent some mice at generation N40 to The Jackson Laboratory Repository to establish Stock No. 012330.

Control Information

	Control
	Wild-type female from the colony
	000742 BXSB.B6-Yaa+/J	(approximate)
	001925 BXSB.B6-Yaa+/MobJ	(approximate)
	000740 BXSB/MpJ
Considerations for Choosing Controls

Related Strains

BXSB Strain

000740

BXSB/MpJ

View BXSB Strain     (1 strain)

Y Chromosomal Aberrations

000552	B6.Cg-Aw-J EdaTa-6J Sxr
001730	B6.Cg-Aw-J EdaTa-6J Sxrb Hya-/J
002021	B6Ei.LT-Y(IsXPAR;Y)Ei/EiJ
000787	BALB/cByJ-Chr YMET/J
000908	C57BL/6J-Chr YMET/J

View Y Chromosomal Aberrations     (5 strains)

Strains carrying   Yaa⁺ allele

000742	BXSB.B6-Yaa+/J
001925	BXSB.B6-Yaa+/MobJ

View Strains carrying   Yaa⁺     (2 strains)

Strains carrying other alleles of Yaa

000483	B6.SB-Yaa/J
000740	BXSB/MpJ

View Strains carrying other alleles of Yaa     (2 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      lupus erythematosus
      lupus erythematosus, control

Yaa⁺ related

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      lupus erythematosus, control

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Yaa+
Allele Name		wild type
Allele Type		Not Applicable
Gene Symbol and Name		Yaa, accelerated autoimmunity and lymphoproliferation transposition
Chromosome		Y
Gene Common Name(s)		Tp(X;Y)1Ekw;

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Bubier JA; Sproule TJ; Foreman O; Spolski R; Shaffer DJ; Morse HC 3rd; Leonard WJ; Roopenian DC. 2009. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci U S A 106(5):1518-23. [PubMed: 19164519]  [MGI Ref ID J:144484]

Health & husbandry

Health & Colony Maintenance Information

Colony Maintenance

Breeding & Husbandry	To maintain the live BXSB.B6-Yaa+ colony (Stock No. 021330), BXSB/MpJ inbred females (Stock No. 000740) are bred with males hemizygous for the Y-linked C57BL/6-derived Yaa+ every generation.
Mating System	Wild-type x Hemizygote         (Female x Male)   02-APR-13

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

 

This strain is currently Under Development - Now Accepting Orders.
Estimated Available for Distribution Date: 15-JUL-13

Please note: You may now place orders for this strain although it is not yet ready for distribution. Estimated available for distribution dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for distribution depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain.

Control Information

	Control
	Wild-type female from the colony
	000742 BXSB.B6-Yaa+/J	(approximate)
	001925 BXSB.B6-Yaa+/MobJ	(approximate)
	000740 BXSB/MpJ
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

Important Note

BXSB.B6-Yaa⁺ consomic males carry the C57BL/6-derived Y chromosome in place of the mutant Yaa-containing Y chromosome of BXSB/MpJ inbred male mice. BXSB.B6-Yaa⁺ consomic mice are available with different amounts of backcrossing to BXSB/MpJ inbred females: Stock No. 021330 are backcrossed at least 40 generations, Stock No. 001925 are backcrossed at least 22 generations, and Stock No. 000742 are backcrossed at least 10 generations.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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