Strain Name:

BXSB.B6-Yaa+/MobJDcrJ

Stock Number:

021330

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Availability:

Repository- Live

Common Names: BXSB-wt;     BXSB.B6-Yaa+;     BXSB.B6-Yaa+;     BXSB.YaaB6;     BXSB.YaaC57BL/6;     BXSB.YaaB6;     BXSB.YaaC57BL/6;    
BXSB.B6-Yaa+ mice are a BXSB-consomic strain that carries the C57BL/6-derived Y chromosome in place of the mutant Yaa-containing Y chromosome of BXSB/MpJ inbred male mice (Stock No. 000740). As such, BXSB.B6-Yaa+ male mice are a sex-matched, autoimmune disease-resistant control strain for BXSB/MpJ male mice.

Description

Strain Information

Former Names BXSB-Chr YC57BL/6/MobJDcrJ    (Changed: 02-APR-13 )
Type Consomic;
Additional information on Consomic Mice.
Visit our online Nomenclature tutorial.
Mating SystemWild-type x Hemizygote         (Female x Male)   02-APR-13
Specieslaboratory mouse
Background Strain BXSB.B6-Yaa+/J
Background Strain C3H/HeSnJSmn
Donor Strain C57BL/6J
 
Donating InvestigatorDr. Derry Roopenian,   The Jackson Laboratory

Important Note
BXSB.B6-Yaa+ consomic males carry the C57BL/6-derived Y chromosome in place of the mutant Yaa-containing Y chromosome of BXSB/MpJ inbred male mice. BXSB.B6-Yaa+ consomic mice are available with different amounts of backcrossing to BXSB/MpJ inbred females: Stock No. 021330 are backcrossed at least 40 generations, Stock No. 001925 are backcrossed at least 22 generations, and Stock No. 000742 are backcrossed at least 10 generations.

Description
These BXSB.B6-Yaa+ mice are a BXSB-consomic strain that carries the C57BL/6-derived Y chromosome in place of the mutant Yaa-containing Y chromosome of BXSB/MpJ inbred male mice (Stock No. 000740). Male as well as female BXSB.B6-Yaa+ mice do not develop the severe systemic lupus erythematosus (SLE)-like autoimmune disease that spontaneously develops in BXSB/MpJ male mice. BXSB.B6-Yaa+ male mice are a sex-matched, autoimmune disease-resistant control strain for BXSB/MpJ male mice.

Development
The Y-linked autoimmune accelerator locus (Yaa) on the Y chromosome of BXSB inbred male mice is the result of a duplication of an ~4 Mbp telomeric segment near the pseudoautosomal region of the X chromosome onto the Y chromosome. The duplicated segment contains 19 genes, including toll-like receptor 7 (Tlr7) and phosphoribosyl pyrophosphate synthetase 2 (Prps2). The BXSB-derived Yaa locus is attributed to the systemic lupus erythematosus (SLE)-like autoimmune disease characteristics observed in BXSB/MpJ inbred male mice.

These BXSB.B6-Yaa+ mice (Stock No. 021330) are a BXSB-consomic control strain that was bred to harbor the C57BL/6-derived wildtype allele of Yaa in place of the BXSB/MpJ-derived Yaa allele. The strain history is shown below.
First, BXSB/MpJ inbred females (Stock No. 000740) were bred to C57BL/6J inbred males (Stock No. 000664). Each successive generation, male offspring with the C57BL/6J-derived Y chromosome were bred with BXSB/MpJ inbred females. The congenic strain after ten generations of backcrossing is BXSB.B6-Yaa+/J (N10; Stock No. 000742).
Around 1998, Drs. Larry E. Mobraaten and Derry C. Roopenian (The Jackson Laboratory) obtained some BXSB.B6-Yaa+/J males from The Jackson Laboratory Repository and continued the backcrossing for additional generations. The congenic strain after at least 22 generations of backcrossing is BXSB.B6-Yaa+/MobJDcr (N22; Stock No. 001925).
In 2013, Dr. Roopenian sent some mice at generation N40 to The Jackson Laboratory Repository to establish Stock No. 021330.

Control Information

  Control
   Wild-type female from the colony
   000742 BXSB.B6-Yaa+/J (approximate)
   001925 BXSB.B6-Yaa+/MobJ (approximate)
   000740 BXSB/MpJ
 
  Considerations for Choosing Controls

Related Strains

View Autoimmune Resource     (13 strains)

View BXSB Strain     (13 strains)

View Y Chromosomal Aberrations     (17 strains)

Strains carrying   + allele
000742   BXSB.B6-Yaa+/J
001925   BXSB.B6-Yaa+/MobJ
View Strains carrying   +     (2 strains)

View Strains carrying other alleles of Yaa     (8 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      lupus erythematosus
      lupus erythematosus, control

+ related

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      lupus erythematosus, control

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol +
Allele Name wild type
Allele Type Not Applicable
Gene Symbol and Name Yaa, accelerated autoimmunity and lymphoproliferation transposition
Chromosome Y
Gene Common Name(s) Tp(X;Y)1Ekw;

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Bubier JA; Sproule TJ; Foreman O; Spolski R; Shaffer DJ; Morse HC 3rd; Leonard WJ; Roopenian DC. 2009. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci U S A 106(5):1518-23. [PubMed: 19164519]  [MGI Ref ID J:144484]

Additional References

+ related

MGD Nomenclature Committee. 1995. :.  [MGI Ref ID J:23000]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryTo maintain the live BXSB.B6-Yaa+ colony (Stock No. 021330), BXSB/MpJ inbred females (Stock No. 000740) are bred with males hemizygous for the Y-linked C57BL/6-derived Yaa+ every generation.
Mating SystemWild-type x Hemizygote         (Female x Male)   02-APR-13

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90MaleHemizygous  
Price per Pair (US dollars $)Pair Genotype
$271.90Wild-type x Hemizygous  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90MaleHemizygous  
Price per Pair (US dollars $)Pair Genotype
$353.50Wild-type x Hemizygous  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   Wild-type female from the colony
   000742 BXSB.B6-Yaa+/J (approximate)
   001925 BXSB.B6-Yaa+/MobJ (approximate)
   000740 BXSB/MpJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

BXSB.B6-Yaa+ consomic males carry the C57BL/6-derived Y chromosome in place of the mutant Yaa-containing Y chromosome of BXSB/MpJ inbred male mice. BXSB.B6-Yaa+ consomic mice are available with different amounts of backcrossing to BXSB/MpJ inbred females: Stock No. 021330 are backcrossed at least 40 generations, Stock No. 001925 are backcrossed at least 22 generations, and Stock No. 000742 are backcrossed at least 10 generations.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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