Strain Name:


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Register Interest
Common Names: FcRn-;    
FCGRT-deficient BXSB.Yaa mice (BXSB.Yaa FCGRT-/- or BXSB.Yaa FcRn-/-) are a BXSB-congenic strain carrying an FcRn null mutation. These mice may be useful in studying the role of the FcRn pathway in spontaneous lupus-like autoimmune syndrome.


Strain Information

Type Congenic; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Donating InvestigatorDr. Derry Roopenian,   The Jackson Laboratory

FCGRT-deficient BXSB.Yaa mice (BXSB.Yaa FCGRT-/- or BXSB.Yaa FcRn-/-) are a BXSB-congenic strain carrying an FcRn null mutation. Homozygous (FCGRT-/-) mice lack the Fc receptor (FcRn), which normally functions to enhance the presentation of immune-complexed antigens by MHC class II molecules and is critical for maintaining normal concentrations of immunoglobulin G (IgG) antibodies and serum albumin.

Homozygous mice are viable and fertile. Both homozygous and heterozygous mice develop spontaneous lupus-like autoimmune syndrome similarly to BXSB/MpJ inbred mice (Stock No. 000740): mortality in males starts at ~13 weeks of age with 50% lethality by ~30 weeks and 76% lethality by ~40 weeks. Females develop a greatly attenuated form of autoimmune disease because they lack Yaa. The donating investigator also reports that FcRn-/- mice exhibit ~50% reduction in IgG.

C57BL/6J-congenic mice harboring the FcRn null allele are described and available from The Jackson Laboratory Repository as Stock No. 003982.

The FcRn null allele (Fcgrttm1Dcr) was designed by Dr. Derry C. Roopenian (The Jackson Laboratory) with a PGK-neomycin cassette replacing exons 1-2 of the Fcgrt gene (Fc receptor, IgG, alpha chain transporter) on chromosome 7. C57BL/6J-congenic mice harboring this FcRn null allele are described and available from The Jackson Laboratory Repository as Stock No. 003982.
Dr. Roopenian backcrossed mice harboring the FcRn null mutation with BXSB/MpJ inbred mice (Stock No. 000740) for 11 generations, and then maintained the colony by breeding homozygous mice together. In 2012, Dr. Roopenian froze sperm from BXSB.Yaa FCGRT-/- mice at generation N11F30. In 2013, this frozen sperm was transferred to The Jackson Laboratory Repository (Autoimmune Resource) to establish Stock No. 021455. Male mice have the BXSB/MpJ-derived Y chromosome that contains the Y-linked autoimmune accelerator locus (Yaa).

Control Information

   000740 BXSB/MpJ
  Considerations for Choosing Controls

Related Strains

View Autoimmune Resource     (13 strains)

View BXSB Strain     (13 strains)

View Y Chromosomal Aberrations     (17 strains)

View Strains carrying   Fcgrttm1Dcr     (14 strains)

View Strains carrying   Yaa     (7 strains)

Strains carrying other alleles of Yaa
000742   BXSB.B6-Yaa+/J
001925   BXSB.B6-Yaa+/MobJ
021330   BXSB.B6-Yaa+/MobJDcrJ
View Strains carrying other alleles of Yaa     (3 strains)


Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
      lupus erythematosus
      lupus erythematosus, control
CD Antigens, Antigen Receptors, and Histocompatibility Markers
      genes regulating susceptibility to infectious disease and endotoxin
Growth Factors/Receptors/Cytokines
      defects in humoral immune responses

Research Tools
Immunology, Inflammation and Autoimmunity Research
      genes regulating susceptibility to infectious disease and endotoxin

Fcgrttm1Dcr related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
      genes regulating susceptibility to infectious disease and endotoxin
      defects in humoral immune responses

Research Tools
Immunology, Inflammation and Autoimmunity Research
      genes regulating susceptibility to infectious disease and endotoxin

Yaa related

Immunology, Inflammation and Autoimmunity Research
      lupus erythematosus

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Fcgrttm1Dcr
Allele Name targeted mutation 1, Derry C Roopenian
Allele Type Targeted (Null/Knockout)
Common Name(s) FcRn-;
Strain of Origin129X1/SvJ
ES Cell Line NameRW-4
ES Cell Line Strain129X1/SvJ
Gene Symbol and Name Fcgrt, Fc receptor, IgG, alpha chain transporter
Chromosome 7
Gene Common Name(s) FCRN; alpha-chain; neonatal Fc receptor;
Molecular Note Sequence from exon 1 and part of exon2 was replaced with a PGK-neo cassette. Quantitative PCR of liver cDNA indicated the absence of mRNA. Western blot analysis of neonatal intestinal extracts failed to reveal protein product. [MGI Ref ID J:94189]
Allele Symbol Yaa
Allele Name accelerated autoimmunity and lymphoproliferation
Allele Type Spontaneous
Common Name(s) Is(XOfd1-Mid1;Y)1Mp; Tp(X;Y)1Ekw;
Strain of OriginSB/Le
Gene Symbol and Name Yaa, accelerated autoimmunity and lymphoproliferation transposition
Chromosome Y
Gene Common Name(s) Tp(X;Y)1Ekw;
Molecular Note An approximately 4 MB region of the X chromosome that includes at least 13 known genes (spanning from Ofd1 to Mid1) was translocated to the Y chromosome adjacent to the pseudoautosomal region. Increased RNA expression of Msl3, Tlr7, Tmsb4x and Rab9 was detected in follicular B cells. [MGI Ref ID J:109758] [MGI Ref ID J:111064] [MGI Ref ID J:140028]


Genotyping Information

Genotyping Protocols

Fcgrttm1Dcr Alternate1, High Resolution Melting
Fcgrttm1Dcr, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

McPhee CG; Sproule TJ; Shin DM; Bubier JA; Schott WH; Steinbuck MP; Avenesyan L; Morse HC 3rd; Roopenian DC. 2011. MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis. J Immunol 187(9):4695-704. [PubMed: 21964024]  [MGI Ref ID J:179430]

Additional References

Fcgrttm1Dcr related

Akilesh S; Christianson GJ; Roopenian DC; Shaw AS. 2007. Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism. J Immunol 179(7):4580-8. [PubMed: 17878355]  [MGI Ref ID J:152349]

Akilesh S; Huber TB; Wu H; Wang G; Hartleben B; Kopp JB; Miner JH; Roopenian DC; Unanue ER; Shaw AS. 2008. Podocytes use FcRn to clear IgG from the glomerular basement membrane. Proc Natl Acad Sci U S A 105(3):967-72. [PubMed: 18198272]  [MGI Ref ID J:131366]

Akilesh S; Petkova S; Sproule TJ; Shaffer DJ; Christianson GJ; Roopenian D. 2004. The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease. J Clin Invest 113(9):1328-33. [PubMed: 15124024]  [MGI Ref ID J:95104]

Andersen JT; Foss S; Kenanova VE; Olafsen T; Leikfoss IS; Roopenian DC; Wu AM; Sandlie I. 2012. Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life. J Biol Chem 287(27):22927-37. [PubMed: 22570488]  [MGI Ref ID J:188378]

Bai Y; Ye L; Tesar DB; Song H; Zhao D; Bjorkman PJ; Roopenian DC; Zhu X. 2011. Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport. Proc Natl Acad Sci U S A 108(45):18406-11. [PubMed: 22042859]  [MGI Ref ID J:180229]

Baker K; Qiao SW; Kuo TT; Aveson VG; Platzer B; Andersen JT; Sandlie I; Chen Z; de Haar C; Lencer WI; Fiebiger E; Blumberg RS. 2011. Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells. Proc Natl Acad Sci U S A 108(24):9927-32. [PubMed: 21628593]  [MGI Ref ID J:173310]

Baker K; Rath T; Flak MB; Arthur JC; Chen Z; Glickman JN; Zlobec I; Karamitopoulou E; Stachler MD; Odze RD; Lencer WI; Jobin C; Blumberg RS. 2013. Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer. Immunity 39(6):1095-107. [PubMed: 24290911]  [MGI Ref ID J:209206]

Binstadt BA; Patel PR; Alencar H; Nigrovic PA; Lee DM; Mahmood U; Weissleder R; Mathis D; Benoist C. 2006. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7(3):284-92. [PubMed: 16444258]  [MGI Ref ID J:112604]

Chaudhury C; Kim J; Mehnaz S; Wani MA; Oberyszyn TM; Bronson CL; Mohanty S; Hayton WL; Robinson JM; Anderson CL. 2006. Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation. J Nutr 136(12):2993-8. [PubMed: 17116709]  [MGI Ref ID J:117735]

Chaudhury C; Mehnaz S; Robinson JM; Hayton WL; Pearl DK; Roopenian DC; Anderson CL. 2003. The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med 197(3):315-22. [PubMed: 12566415]  [MGI Ref ID J:110885]

Chen P; Li C; Lang S; Zhu G; Reheman A; Spring CM; Freedman J; Ni H. 2010. Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy. Blood 116(18):3660-8. [PubMed: 20647570]  [MGI Ref ID J:166478]

Crow AR; Suppa SJ; Chen X; Mott PJ; Lazarus AH. 2011. The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody-mediated amelioration of murine immune thrombocytopenia. Blood 118(24):6403-6. [PubMed: 22001393]  [MGI Ref ID J:179078]

Crowley H; Alroy J; Sproule TJ; Roopenian D; Huber BT. 2006. The MHC class I-related FcRn ameliorates murine Lyme arthritis. Int Immunol 18(3):409-14. [PubMed: 16415101]  [MGI Ref ID J:106617]

Deane R; Sagare A; Hamm K; Parisi M; LaRue B; Guo H; Wu Z; Holtzman DM; Zlokovic BV. 2005. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci 25(50):11495-503. [PubMed: 16354907]  [MGI Ref ID J:103998]

Dumont JA; Liu T; Low SC; Zhang X; Kamphaus G; Sakorafas P; Fraley C; Drager D; Reidy T; McCue J; Franck HW; Merricks EP; Nichols TC; Bitonti AJ; Pierce GF; Jiang H. 2012. Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs. Blood 119(13):3024-30. [PubMed: 22246033]  [MGI Ref ID J:182551]

Kim J; Bronson CL; Hayton WL; Radmacher MD; Roopenian DC; Robinson JM; Anderson CL. 2006. Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces. Am J Physiol Gastrointest Liver Physiol 290(2):G352-60. [PubMed: 16210471]  [MGI Ref ID J:106048]

Kim J; Mohanty S; Ganesan LP; Hua K; Jarjoura D; Hayton WL; Robinson JM; Anderson CL. 2009. FcRn in the yolk sac endoderm of mouse is required for IgG transport to fetus. J Immunol 182(5):2583-9. [PubMed: 19234152]  [MGI Ref ID J:146267]

Koltun M; Nikolovski J; Strong K; Nikolic-Paterson D; Comper WD. 2005. Mechanism of hypoalbuminemia in rodents. Am J Physiol Heart Circ Physiol 288(4):H1604-10. [PubMed: 15539420]  [MGI Ref ID J:97362]

Letourneau S; van Leeuwen EM; Krieg C; Martin C; Pantaleo G; Sprent J; Surh CD; Boyman O. 2010. IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25. Proc Natl Acad Sci U S A 107(5):2171-6. [PubMed: 20133862]  [MGI Ref ID J:157531]

Li N; Zhao M; Hilario-Vargas J; Prisayanh P; Warren S; Diaz LA; Roopenian DC; Liu Z. 2005. Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases. J Clin Invest 115(12):3440-50. [PubMed: 16284651]  [MGI Ref ID J:104709]

Martin CE; van Leeuwen EM; Im SJ; Roopenian DC; Sung YC; Surh CD. 2013. IL-7/anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R. Blood 121(22):4484-92. [PubMed: 23610371]  [MGI Ref ID J:198495]

Mezo AR; McDonnell KA; Hehir CA; Low SC; Palombella VJ; Stattel JM; Kamphaus GD; Fraley C; Zhang Y; Dumont JA; Bitonti AJ. 2008. Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn. Proc Natl Acad Sci U S A 105(7):2337-42. [PubMed: 18272495]  [MGI Ref ID J:132181]

Nakata K; Kobayashi K; Ishikawa Y; Yamamoto M; Funada Y; Kotani Y; Blumberg RS; Karasuyama H; Yoshida M; Nishimura Y. 2010. The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner. Biochem Biophys Res Commun 395(2):238-43. [PubMed: 20362552]  [MGI Ref ID J:160346]

Patel DA; Puig-Canto A; Challa DK; Perez Montoyo H; Ober RJ; Ward ES. 2011. Neonatal Fc receptor blockade by Fc engineering ameliorates arthritis in a murine model. J Immunol 187(2):1015-22. [PubMed: 21690327]  [MGI Ref ID J:178025]

Petkova SB; Akilesh S; Sproule TJ; Christianson GJ; Al Khabbaz H; Brown AC; Presta LG; Meng YG; Roopenian DC. 2006. Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol 18(12):1759-69. [PubMed: 17077181]  [MGI Ref ID J:133048]

Petro C; Gonzalez PA; Cheshenko N; Jandl T; Khajoueinejad N; Benard A; Sengupta M; Herold BC; Jacobs WR. 2015. Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease. Elife 4:. [PubMed: 25756612]  [MGI Ref ID J:220691]

Roopenian DC; Christianson GJ; Sproule TJ. 2010. Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies. Methods Mol Biol 602:93-104. [PubMed: 20012394]  [MGI Ref ID J:170668]

Roopenian DC; Christianson GJ; Sproule TJ; Brown AC; Akilesh S; Jung N; Petkova S; Avanessian L; Choi EY; Shaffer DJ; Eden PA; Anderson CL. 2003. The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs. J Immunol 170(7):3528-33. [PubMed: 12646614]  [MGI Ref ID J:94189]

Roopenian DC; Low BE; Christianson GJ; Proetzel G; Sproule TJ; Wiles MV. 2015. Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs. MAbs 7(2):344-51. [PubMed: 25654695]  [MGI Ref ID J:220803]

Sarav M; Wang Y; Hack BK; Chang A; Jensen M; Bao L; Quigg RJ. 2009. Renal FcRn reclaims albumin but facilitates elimination of IgG. J Am Soc Nephrol 20(9):1941-52. [PubMed: 19661163]  [MGI Ref ID J:166328]

Stein C; Kling L; Proetzel G; Roopenian DC; de Angelis MH; Wolf E; Rathkolb B. 2011. Clinical chemistry of human FcRn transgenic mice. Mamm Genome :. [PubMed: 22193411]  [MGI Ref ID J:179989]

Stoklasek TA; Colpitts SL; Smilowitz HM; Lefrancois L. 2010. MHC Class I and TCR Avidity Control the CD8 T Cell Response to IL-15/IL-15R{alpha} Complex. J Immunol 185(11):6857-65. [PubMed: 21041729]  [MGI Ref ID J:166134]

The Jackson Laboratory. 2005. Information obtained from The Jackson Laboratory, Bar Harbor, ME Unpublished :.  [MGI Ref ID J:101977]

Vidarsson G; Stemerding AM; Stapleton NM; Spliethoff SE; Janssen H; Rebers FE; de Haas M; van de Winkel JG. 2006. FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis. Blood 108(10):3573-9. [PubMed: 16849638]  [MGI Ref ID J:140454]

Wang W; Vlasak J; Li Y; Pristatsky P; Fang Y; Pittman T; Roman J; Wang Y; Prueksaritanont T; Ionescu R. 2011. Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies. Mol Immunol 48(6-7):860-6. [PubMed: 21256596]  [MGI Ref ID J:170957]

Yoshida M; Kobayashi K; Kuo TT; Bry L; Glickman JN; Claypool SM; Kaser A; Nagaishi T; Higgins DE; Mizoguchi E; Wakatsuki Y; Roopenian DC; Mizoguchi A; Lencer WI; Blumberg RS. 2006. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Invest 116(8):2142-2151. [PubMed: 16841095]  [MGI Ref ID J:113122]

Zalevsky J; Chamberlain AK; Horton HM; Karki S; Leung IW; Sproule TJ; Lazar GA; Roopenian DC; Desjarlais JR. 2010. Enhanced antibody half-life improves in vivo activity. Nat Biotechnol 28(2):157-9. [PubMed: 20081867]  [MGI Ref ID J:161273]

Yaa related

Anders HJ; Krug A; Pawar RD. 2008. Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus. Eur J Immunol 38(7):1795-9. [PubMed: 18581336]  [MGI Ref ID J:137453]

Arabo A; Costa O; Tron F; Caston J. 2005. Spatial and motor abilities during the course of autoimmune disease in (NZW x BXSB)F1 lupus-prone mice. Behav Brain Res 165(1):126-37. [PubMed: 16168499]  [MGI Ref ID J:115747]

Baccala R; Gonzalez-Quintial R; Schreiber RD; Lawson BR; Kono DH; Theofilopoulos AN. 2012. Anti-IFN-alpha/beta Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice. J Immunol 189(12):5976-84. [PubMed: 23175700]  [MGI Ref ID J:190844]

Boehm GW; Sherman GF; Hoplight BJ 2nd; Hyde LA; Bradway DM; Galaburda AM; Ahmed SA; Denenberg VH. 1998. Learning in year-old female autoimmune BXSB mice. Physiol Behav 64(1):75-82. [PubMed: 9661985]  [MGI Ref ID J:49007]

Boross P; Arandhara VL; Martin-Ramirez J; Santiago-Raber ML; Carlucci F; Flierman R; van der Kaa J; Breukel C; Claassens JW; Camps M; Lubberts E; Salvatori D; Rastaldi MP; Ossendorp F; Daha MR; Cook HT; Izui S; Botto M; Verbeek JS. 2011. The inhibiting Fc receptor for IgG, FcgammaRIIB, is a modifier of autoimmune susceptibility. J Immunol 187(3):1304-13. [PubMed: 21724994]  [MGI Ref ID J:179175]

Bubier JA; Sproule TJ; Foreman O; Spolski R; Shaffer DJ; Morse HC 3rd; Leonard WJ; Roopenian DC. 2009. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci U S A 106(5):1518-23. [PubMed: 19164519]  [MGI Ref ID J:144484]

Deane JA; Pisitkun P; Barrett RS; Feigenbaum L; Town T; Ward JM; Flavell RA; Bolland S. 2007. Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation. Immunity 27(5):801-10. [PubMed: 17997333]  [MGI Ref ID J:127600]

Denenberg VH; Hoplight B; Sherman GF; Mobraaten LE. 2001. Effects of the uterine environment and neocortical ectopias upon behavior of BXSB-Yaa+mice. Dev Psychobiol 38(3):154-63. [PubMed: 11279592]  [MGI Ref ID J:72331]

Denenberg VH; Sherman G; Schrott LM; Waters NS; Boehm GW; Galaburda AM; Mobraaten LE. 1996. Effects of embryo transfer and cortical ectopias upon the behavior of BXSB-Yaa and BXSB-Yaa + mice. Brain Res Dev Brain Res 93(1-2):100-8. [PubMed: 8804696]  [MGI Ref ID J:33655]

Eisenberg RA; Izui S; McConahey PJ; Hang L; Peters CJ; Theofilopoulos AN; Dixon FJ. 1980. Male determined accelerated autoimmune disease in BXSB mice: transfer by bone marrow and spleen cells. J Immunol 125(3):1032-6. [PubMed: 7410826]  [MGI Ref ID J:6372]

Fairhurst AM; Hwang SH; Wang A; Tian XH; Boudreaux C; Zhou XJ; Casco J; Li QZ; Connolly JE; Wakeland EK. 2008. Yaa autoimmune phenotypes are conferred by overexpression of TLR7. Eur J Immunol 38(7):1971-8. [PubMed: 18521959]  [MGI Ref ID J:137309]

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Hang LM; Izui S; Dixon FJ. 1981. (NZW x BXSB)F1 hybrid. A model of acute lupus and coronary vascular disease with myocardial infarction. J Exp Med 154(1):216-21. [PubMed: 7252427]  [MGI Ref ID J:38157]

Hudgins CC; Steinberg RT; Klinman DM; Reeves MJ; Steinberg AD. 1985. Studies of consomic mice bearing the Y chromosome of the BXSB mouse. J Immunol 134(6):3849-54. [PubMed: 3989299]  [MGI Ref ID J:7823]

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Hyde LA; Stavnezer AJ; Bimonte HA; Sherman GF; Denenberg VH. 2002. Spatial and nonspatial Morris maze learning: impaired behavioral flexibility in mice with ectopias located in the prefrontal cortex. Behav Brain Res 133(2):247-59. [PubMed: 12110458]  [MGI Ref ID J:108472]

Izui S; Masuda K; Yoshida H. 1984. Acute SLE in F1 hybrids between SB/Le and NZW mice; prominently enhanced formation of gp70 immune complexes by a Y chromosome-associated factor from SB/Le mice. J Immunol 132(2):701-4. [PubMed: 6690614]  [MGI Ref ID J:7276]

Izui S; Merino R; Fossati L; Iwamoto M. 1994. The role of the Yaa gene in lupus syndrome. Int Rev Immunol 11(3):211-30. [PubMed: 7930846]  [MGI Ref ID J:21990]

Jansson L; Holmdahl R. 1994. The Y chromosome-linked autoimmune accelerating yaa gene suppresses collagen-induced arthritis. Eur J Immunol 24(5):1213-7. [PubMed: 8181531]  [MGI Ref ID J:18810]

Kamada H; Takaoka Y; Kitagaki K; Nagai H. 1995. Effect of cyclophosphamide on lymphokine production in MRL/lpr.Yaa mice. Inflamm Res 44(11):491-8. [PubMed: 8597884]  [MGI Ref ID J:30518]

Kawano H; Abe M; Zhang D; Saikawa T; Fujimori M; Hirose S; Shirai T. 1992. Heterozygosity of the major histocompatibility complex controls the autoimmune disease in (NZW x BXSB) F1 mice. Clin Immunol Immunopathol 65(3):308-14. [PubMed: 1451334]  [MGI Ref ID J:3381]

Khaled AR; Butfiloski EJ; Villas B; Sobel ES; Schiffenbauer J. 1999. Aberrant expression of the NF-kappaB and IkappaB proteins in B cells from viable motheaten mice. Autoimmunity 30(2):115-28. [PubMed: 10435725]  [MGI Ref ID J:117314]

Kikuchi S; Amano H; Amano E; Fossati-Jimack L; Santiago-Raber ML; Moll T; Ida A; Kotzin BL; Izui S. 2005. Identification of 2 major loci linked to autoimmune hemolytic anemia in NZB mice. Blood 106(4):1323-9. [PubMed: 15860660]  [MGI Ref ID J:117292]

Kikuchi S; Fossati-Jimack L; Moll T; Amano H; Amano E; Ida A; Ibnou-Zekri N; Laporte C; Santiago-Raber ML; Rozzo SJ; Kotzin BL; Izui S. 2005. Differential role of three major New Zealand black-derived loci linked with Yaa-induced murine lupus nephritis. J Immunol 174(2):1111-7. [PubMed: 15634937]  [MGI Ref ID J:95829]

Kikuchi S; Santiago-Raber ML; Amano H; Amano E; Fossati-Jimack L; Moll T; Kotzin BL; Izui S. 2006. Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus. J Immunol 176(5):3240-7. [PubMed: 16493085]  [MGI Ref ID J:129409]

Kim HJ; Wang X; Radfar S; Sproule TJ; Roopenian DC; Cantor H. 2011. CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice. Proc Natl Acad Sci U S A 108(5):2010-5. [PubMed: 21233417]  [MGI Ref ID J:169125]

Kofler R; McConahey PJ; Duchosal MA; Balderas RS; Theofilopoulos AN; Dixon FJ. 1991. An autosomal recessive gene that delays expression of lupus in BXSB mice. J Immunol 146(4):1375-9. [PubMed: 1991974]  [MGI Ref ID J:10973]

Kono DH; Balomenos D; Park MS; Theofilopoulos AN. 2000. Development of lupus in BXSB mice is independent of IL-4. J Immunol 164(1):38-42. [PubMed: 10604990]  [MGI Ref ID J:112421]

Kuroki A; Moll T; Lopez-Hoyos M; Fossati-Jimack L; Ibnou-Zekri N; Kikuchi S; Merino J; Merino R; Izui S. 2004. Enforced Bcl-2 expression in B lymphocytes induces rheumatoid factor and anti-DNA production, but the Yaa mutation promotes only anti-DNA production. Eur J Immunol 34(4):1077-84. [PubMed: 15048718]  [MGI Ref ID J:88856]

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Lin Q; Xiu Y; Jiang Y; Tsurui H; Nakamura K; Kodera S; Ohtsuji M; Ohtsuji N; Shiroiwa W; Tsukamoto K; Amano H; Amano E; Kinoshita K; Sudo K; Nishimura H; Izui S; Shirai T; Hirose S. 2006. Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus. J Immunol 177(3):1646-54. [PubMed: 16849473]  [MGI Ref ID J:137977]

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Health & husbandry

Health & Colony Maintenance Information

Colony Maintenance

Breeding & HusbandryTo maintain the live colony, homozygous mice may be bred together. Both homozygous and heterozygous mice develop spontaneous lupus-like autoimmune syndrome similarly to BXSB/MpJ inbred mice (Stock No. 000740): mortality in males starts at ~13 weeks of age with 50% lethality by ~30 weeks and 76% lethality by ~40 weeks. Females develop a greatly attenuated form of autoimmune disease because they lack Yaa. The expected coat color is white-bellied agouti.

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