Strain Name:

BXSB.129S2(C)-Cd1tm1Gru/DcrJ

Stock Number:

021565

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Availability:

Cryopreserved - Ready for recovery

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Common Names: BXSB-Cd1-/-;     BXSB.Yaa CD1-/-;     BXSB.Yaa Cd1d1/Cd1d2-/-;     CD1-deficient BXSB.Yaa;    
BXSB.Yaa CD1-/- (BXSB.Yaa Cd1d1/Cd1d2-/-) mice are a BXSB-congenic strain carrying a null mutation of the CD1 antigen complex that abolished both CD1.1 (Cd1d1) and CD1.2 (Cd1d2) expression; resulting in natural killer T cell (NKT)-deficiency. These BXSB.Yaa CD1-/- mice may be useful in studying the role of natural killer T cells (NKTs) in spontaneous lupus-like autoimmune syndrome.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHeterozygote x Heterozygote         (Female x Male)   11-FEB-14
Specieslaboratory mouse
 
Donating InvestigatorDr. Derry Roopenian,   The Jackson Laboratory

Description
BXSB.Yaa CD1-/- (BXSB.Yaa Cd1d1/Cd1d2-/-) mice are a BXSB-congenic strain carrying a null mutation of the CD1 antigen complex; both CD1.1 (Cd1d1) and CD1.2 (Cd1d2) expression is abolished. Homozygous (CD1-/-) mice are natural killer T cell (NKT)-deficient.

Homozygous mice are viable and fertile. Both homozygous and heterozygous mice develop spontaneous lupus-like autoimmune syndrome similarly to BXSB/MpJ inbred mice (Stock No. 000740): mortality in males starts at ~13 weeks of age with 50% lethality by ~30 weeks and 76% lethality by ~40 weeks. Females develop a greatly attenuated form of autoimmune disease because they lack Yaa.

BALB/c-congenic mice harboring this null mutation of the CD1 antigen complex are described and available from The Jackson Laboratory Repository as Stock No. 003814.

Development
The murine CD1 locus is composed of two closely linked genes, CD1.1 (Cd1d1) and CD1.2 (Cd1d2), arranged in opposite transcriptional orientations and separated by an ~9 kbp intergenic region. Dr. Michael J. Grusby (Harvard Medical School) created the CD1 null allele (Cd1tm1Gru) with a single targeting event that (i) replaced most of the Cd1d1 locus with a neomycin selection cassette, (ii) deleted the Cd1d2 locus, and (iii) retained the intergenic region. BALB/c-congenic mice harboring this null mutation of the CD1 antigen complex are described and available from The Jackson Laboratory Repository as Stock No. 003814.
Dr. Derry C. Roopenian (The Jackson Laboratory) obtained some of these mutant mice and backcrossed them with BXSB/MpJ inbred mice (Stock No. 000740) for 12 generations, and then maintained the colony by breeding homozygous mice together. In 2002, Dr. Roopenian froze embryos from BXSB.Yaa CD1-/- mice at generation N12. In 2013, this frozen stock was transferred to The Jackson Laboratory Repository (Autoimmune Resource) to establish Stock No. 021565. Male mice have the BXSB/MpJ-derived Y chromosome that contains the Y-linked autoimmune accelerator locus (Yaa).

Control Information

  Control
   000740 BXSB/MpJ
 
  Considerations for Choosing Controls

Related Strains

View Autoimmune Resource     (12 strains)

View BXSB Strain     (13 strains)

View Y Chromosomal Aberrations     (17 strains)

Strains carrying   Cd1tm1Gru allele
003814   C.129S2-Cd1tm1Gru/J
002962   C;129S-Cd1tm1Gru/J
View Strains carrying   Cd1tm1Gru     (2 strains)

View Strains carrying   Yaa     (7 strains)

Strains carrying other alleles of Yaa
000742   BXSB.B6-Yaa+/J
001925   BXSB.B6-Yaa+/MobJ
021330   BXSB.B6-Yaa+/MobJDcrJ
View Strains carrying other alleles of Yaa     (3 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Cd1tm1Gru/Cd1tm1Gru

        involves: 129S2/SvPas * BALB/c
  • mortality/aging
  • decreased susceptibility to infection induced morbidity/mortality
    • cumulative mortality 7 days after infection with Coxsackie virus is 25% as compared to 67% for controls   (MGI Ref ID J:126220)
  • immune system phenotype
  • *normal* immune system phenotype
    • despite near absence of IL-4-secreting NK-like T cells in the thymus, homozygotes are able to mount a normal TH2 response producing IgE levels comparable to those detected in control littermates after immunization with anti-IgD   (MGI Ref ID J:47769)
    • abnormal eosinophil cell number
      • substantial reduction in airway eosinophilia in response to OVA challenge   (MGI Ref ID J:84720)
    • absent NK T cells
      • homozygotes show near absence of the NK-like thymocyte population that secretes large amounts of IL-4 immediately after T cell receptor ligation and is characterized as heat-stable antigen (HAS)-/low, Vbeta8int CD44high (the NK1.1 marker is not expressed in the 129 and BALB/c genetic background of homozygous mutant mice)   (MGI Ref ID J:47769)
    • decreased CD4-positive, alpha beta T cell number
      • decreased Interferon gamma positive CD4+ cells   (MGI Ref ID J:126220)
    • decreased interleukin-4 secretion
      • in vivo, homozygotes fail to promptly produce IL-4 after intravenous injection with anti-CD3   (MGI Ref ID J:47769)
      • in contrast, the induction of IFN-gamma mRNA after T cell receptor ligation remains unaffected   (MGI Ref ID J:47769)
    • decreased susceptibility to infection induced morbidity/mortality
      • cumulative mortality 7 days after infection with Coxsackie virus is 25% as compared to 67% for controls   (MGI Ref ID J:126220)
    • myocarditis
      • reduced incidence of myocarditis caused by Coxsackie virus infection   (MGI Ref ID J:126220)
  • hematopoietic system phenotype
  • abnormal eosinophil cell number
    • substantial reduction in airway eosinophilia in response to OVA challenge   (MGI Ref ID J:84720)
  • absent NK T cells
    • homozygotes show near absence of the NK-like thymocyte population that secretes large amounts of IL-4 immediately after T cell receptor ligation and is characterized as heat-stable antigen (HAS)-/low, Vbeta8int CD44high (the NK1.1 marker is not expressed in the 129 and BALB/c genetic background of homozygous mutant mice)   (MGI Ref ID J:47769)
  • decreased CD4-positive, alpha beta T cell number
    • decreased Interferon gamma positive CD4+ cells   (MGI Ref ID J:126220)
  • tumorigenesis
  • decreased metastatic potential
    • metastasis to the lung is reduced as measured by iv injection of colon carcinoma cell line CT26   (MGI Ref ID J:118828)
  • cardiovascular system phenotype
  • myocarditis
    • reduced incidence of myocarditis caused by Coxsackie virus infection   (MGI Ref ID J:126220)
  • respiratory system phenotype
  • abnormal airway responsiveness
    • hyper-reactivity does not develop in response to OVA challenge   (MGI Ref ID J:84720)

Cd1tm1Gru/Cd1tm1Gru

        B6.129S2-Cd1tm1Gru
  • cardiovascular system phenotype
  • decreased susceptibility to induced choroidal neovascularization
    • area of choroidal neovascularization induced by photocoagulation is significantly reduced   (MGI Ref ID J:138197)
  • vision/eye phenotype
  • decreased susceptibility to induced choroidal neovascularization
    • area of choroidal neovascularization induced by photocoagulation is significantly reduced   (MGI Ref ID J:138197)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      lupus erythematosus
      lupus erythematosus, control
CD Antigens, Antigen Receptors, and Histocompatibility Markers
      genes regulating susceptibility to infectious disease and endotoxin
Growth Factors/Receptors/Cytokines
Immunodeficiency
      T cell deficiency
      specific T cell deficiency

Internal/Organ Research
Lymphoid Tissue Defects
      T cell deficiency

Research Tools
Genetics Research
      Tissue/Cell Markers: T cell specific surface marker
Immunology, Inflammation and Autoimmunity Research
      T cell deficiency
      T cell deficiency, xenograft/transplant host
      T cell specific surface marker
      specific T cell deficiency

Cd1tm1Gru related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Yaa related
Autoimmunity
      lupus erythematosus

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Cd1tm1Gru
Allele Name targeted mutation 1, Michael Grusby
Allele Type Targeted (Null/Knockout)
Common Name(s) CD1-; CD1d KO; CD1tm1Gru; Cd1d1/Cd1d2tm1Gru; Cd1d-;
Mutation Made ByDr. Michael Grusby,   Harvard Medical School
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Cd1, CD1 antigen complex
Chromosome 3
Molecular Note Both the Cd1d1 gene and the adjacent Cd1d2 gene were mutated in this allele. The coding sequence of Cd1d1 was replaced with a neomycin selection cassette and the coding sequence of Cd1d2 was deleted; however, the intergenic sequence was retained. Flow cytometric analysis on thymocytes derived from homozygous mice confirmed that no stable encoded protein was expressed on the cell surface. [MGI Ref ID J:47769]
 
Allele Symbol Yaa
Allele Name accelerated autoimmunity and lymphoproliferation
Allele Type Spontaneous
Common Name(s) Is(XOfd1-Mid1;Y)1Mp; Tp(X;Y)1Ekw;
Strain of OriginSB/Le
Gene Symbol and Name Yaa, accelerated autoimmunity and lymphoproliferation transposition
Chromosome Y
Gene Common Name(s) Tp(X;Y)1Ekw;
General Note In congenic C57BL/6 Yaa mice expression of Tlr7 is increased 2-fold.
Molecular Note An approximately 4 MB region of the X chromosome that includes at least 13 known genes (spanning from Ofd1 to Mid1) was translocated to the Y chromosome adjacent to the pseudoautosomal region. Increased RNA expression of Msl3, Tlr7, Tmsb4x and Rab9 was detected in follicular B cells. [MGI Ref ID J:109758] [MGI Ref ID J:111064] [MGI Ref ID J:140028]

Genotyping

Genotyping Information

Genotyping Protocols

Cd1tm1Gru, Melt Curve Analysis


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

McPhee CG; Sproule TJ; Shin DM; Bubier JA; Schott WH; Steinbuck MP; Avenesyan L; Morse HC 3rd; Roopenian DC. 2011. MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis. J Immunol 187(9):4695-704. [PubMed: 21964024]  [MGI Ref ID J:179430]

Smiley ST; Kaplan MH; Grusby MJ. 1997. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science 275(5302):977-9. [PubMed: 9020080]  [MGI Ref ID J:47769]

Additional References

Cd1tm1Gru related

Akbari O; Stock P; Meyer E; Kronenberg M; Sidobre S; Nakayama T; Taniguchi M; Grusby MJ; DeKruyff RH; Umetsu DT. 2003. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med 9(5):582-8. [PubMed: 12669034]  [MGI Ref ID J:84720]

Amprey JL; Im JS; Turco SJ; Murray HW; Illarionov PA; Besra GS; Porcelli SA; Spath GF. 2004. A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan. J Exp Med 200(7):895-904. [PubMed: 15466622]  [MGI Ref ID J:93947]

Askenase PW; Itakura A; Leite-de-Moraes MC; Lisbonne M; Roongapinun S; Goldstein DR; Szczepanik M. 2005. TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo. J Immunol 175(10):6390-401. [PubMed: 16272291]  [MGI Ref ID J:119381]

Bilenki L; Wang S; Yang J; Fan Y; Joyee AG; Yang X. 2005. NK T cell activation promotes Chlamydia trachomatis infection in vivo. J Immunol 175(5):3197-206. [PubMed: 16116210]  [MGI Ref ID J:113211]

Bilenki L; Yang J; Fan Y; Wang S; Yang X. 2004. Natural killer T cells contribute to airway eosinophilic inflammation induced by ragweed through enhanced IL-4 and eotaxin production. Eur J Immunol 34(2):345-54. [PubMed: 14768039]  [MGI Ref ID J:87671]

Bochtler P; Kroger A; Schirmbeck R; Reimann J. 2008. Type I IFN-induced, NKT cell-mediated negative control of CD8 T cell priming by dendritic cells. J Immunol 181(3):1633-43. [PubMed: 18641299]  [MGI Ref ID J:137877]

Boyton R. 2008. The role of natural killer T cells in lung inflammation. J Pathol 214(2):276-82. [PubMed: 18161753]  [MGI Ref ID J:130987]

Brinster C; Shevach EM. 2008. Costimulatory effects of IL-1 on the expansion/differentiation of CD4+CD25+Foxp3+ and CD4+CD25+Foxp3- T cells. J Leukoc Biol 84(2):480-7. [PubMed: 18477692]  [MGI Ref ID J:138445]

Burdin N; Brossay L; Kronenberg M. 1999. Immunization with alpha-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis. Eur J Immunol 29(6):2014-25. [PubMed: 10382765]  [MGI Ref ID J:115308]

Campos RA; Szczepanik M; Itakura A; Akahira-Azuma M; Sidobre S; Kronenberg M; Askenase PW. 2003. Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity. J Exp Med 198(12):1785-96. [PubMed: 14676294]  [MGI Ref ID J:132827]

Chen YT; Kung JT. 2005. CD1d-independent developmental acquisition of prompt IL-4 gene inducibility in thymus CD161(NK1)-CD44lowCD4+CD8- T cells is associated with complementarity determining region 3-diverse and biased Vbeta2/Vbeta7/Vbeta8/Valpha3.2 T cell receptor usage. J Immunol 175(10):6537-50. [PubMed: 16272308]  [MGI Ref ID J:119395]

Cogen AL; Moore TA. 2009. Beta2-microglobulin-dependent bacterial clearance and survival during murine Klebsiella pneumoniae bacteremia. Infect Immun 77(1):360-6. [PubMed: 18981251]  [MGI Ref ID J:143765]

Crespo FA; Sun X; Cripps JG; Fernandez-Botran R. 2006. The immunoregulatory effects of gangliosides involve immune deviation favoring type-2 T cell responses. J Leukoc Biol 79(3):586-95. [PubMed: 16415169]  [MGI Ref ID J:106139]

Dao T; Guo D; Ploss A; Stolzer A; Saylor C; Boursalian TE; Im JS; Sant'Angelo DB. 2004. Development of CD1d-restricted NKT cells in the mouse thymus. Eur J Immunol 34(12):3542-52. [PubMed: 15549774]  [MGI Ref ID J:94598]

Dieli F; Sireci G; Russo D; Taniguchi M; Ivanyi J; Fernandez C; Troye-Blomberg M; De Leo G; Salerno A. 2000. Resistance of natural killer T cell-deficient mice to systemic shwartzman reaction J Exp Med 192(11):1645-52. [PubMed: 11104806]  [MGI Ref ID J:66081]

Duthie MS; Kahn M; White M; Kapur RP; Kahn SJ. 2005. Critical proinflammatory and anti-inflammatory functions of different subsets of CD1d-restricted natural killer T cells during Trypanosoma cruzi infection. Infect Immun 73(1):181-92. [PubMed: 15618153]  [MGI Ref ID J:94792]

Duthie MS; Kahn SJ. 2005. NK cell activation and protection occur independently of natural killer T cells during Trypanosoma cruzi infection. Int Immunol 17(5):607-13. [PubMed: 15802307]  [MGI Ref ID J:98423]

Duthie MS; Wleklinski-Lee M; Smith S; Nakayama T; Taniguchi M; Kahn SJ. 2002. During Trypanosoma cruzi infection CD1d-restricted NK T cells limit parasitemia and augment the antibody response to a glycophosphoinositol-modified surface protein. Infect Immun 70(1):36-48. [PubMed: 11748161]  [MGI Ref ID J:74567]

Eberl G; Brawand P; MacDonald HR. 2000. Selective bystander proliferation of memory CD4+ and CD8+ T cells upon NK T or T cell activation. J Immunol 165(8):4305-11. [PubMed: 11035065]  [MGI Ref ID J:119149]

Eberl G; Lees R; Smiley ST; Taniguchi M; Grusby MJ; MacDonald HR. 1999. Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells. J Immunol 162(11):6410-9. [PubMed: 10352254]  [MGI Ref ID J:111012]

Etogo AO; Nunez J; Lin CY; Toliver-Kinsky TE; Sherwood ER. 2008. NK but not CD1-restricted NKT cells facilitate systemic inflammation during polymicrobial intra-abdominal sepsis. J Immunol 180(9):6334-45. [PubMed: 18424757]  [MGI Ref ID J:134676]

Exley MA; Bigley NJ; Cheng O; Tahir SM; Smiley ST; Carter QL; Stills HF; Grusby MJ; Koezuka Y; Taniguchi M; Balk SP. 2001. CD1d-reactive T-cell activation leads to amelioration of disease caused by diabetogenic encephalomyocarditis virus. J Leukoc Biol 69(5):713-8. [PubMed: 11358978]  [MGI Ref ID J:69645]

Facciotti F; Ramanjaneyulu GS; Lepore M; Sansano S; Cavallari M; Kistowska M; Forss-Petter S; Ni G; Colone A; Singhal A; Berger J; Xia C; Mori L; De Libero G. 2012. Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus. Nat Immunol 13(5):474-80. [PubMed: 22426352]  [MGI Ref ID J:185375]

Fujita K; Kobayashi M; Brutkiewicz RR; Hanafusa T; Herndon DN; Suzuki F. 2006. Role for IL-4 nonproducing NKT cells in CC-chemokine ligand 2-induced Th2 cell generation. Immunol Cell Biol 84(1):44-50. [PubMed: 16277637]  [MGI Ref ID J:105853]

Gallina G; Dolcetti L; Serafini P; De Santo C; Marigo I; Colombo MP; Basso G; Brombacher F; Borrello I; Zanovello P; Bicciato S; Bronte V. 2006. Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest 116(10):2777-90. [PubMed: 17016559]  [MGI Ref ID J:114986]

Gapin L; Cheroutre H; Kronenberg M. 1999. Cutting edge: TCR alpha beta+ CD8 alpha alpha+ T cells are found in intestinal intraepithelial lymphocytes of mice that lack classical MHC class I molecules. J Immunol 163(8):4100-4. [PubMed: 10510343]  [MGI Ref ID J:111019]

Glass WG; Subbarao K; Murphy B; Murphy PM. 2004. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. J Immunol 173(6):4030-9. [PubMed: 15356152]  [MGI Ref ID J:92752]

Guidry TV; Hunter RL Jr; Actor JK. 2006. CD3+ cells transfer the hypersensitive granulomatous response to mycobacterial glycolipid trehalose 6,6'-dimycolate in mice. Microbiology 152(Pt 12):3765-75. [PubMed: 17159227]  [MGI Ref ID J:135938]

Hansen DS; Siomos MA; Buckingham L; Scalzo AA; Schofield L. 2003. Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex. Immunity 18(3):391-402. [PubMed: 12648456]  [MGI Ref ID J:82493]

Hansen DS; Siomos MA; De Koning-Ward T; Buckingham L; Crabb BS; Schofield L. 2003. CD1d-restricted NKT cells contribute to malarial splenomegaly and enhance parasite-specific antibody responses. Eur J Immunol 33(9):2588-98. [PubMed: 12938235]  [MGI Ref ID J:85449]

Hermans IF; Silk JD; Gileadi U; Salio M; Mathew B; Ritter G; Schmidt R; Harris AL; Old L; Cerundolo V. 2003. NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells. J Immunol 171(10):5140-7. [PubMed: 14607913]  [MGI Ref ID J:119212]

Hijioka K; Sonoda KH; Tsutsumi-Miyahara C; Fujimoto T; Oshima Y; Taniguchi M; Ishibashi T. 2008. Investigation of the role of CD1d-restricted invariant NKT cells in experimental choroidal neovascularization. Biochem Biophys Res Commun 374(1):38-43. [PubMed: 18606153]  [MGI Ref ID J:138197]

Hongo D; Tang X; Dutt S; Nador RG; Strober S. 2012. Interactions between NKT cells and Tregs are required for tolerance to combined bone marrow and organ transplants. Blood 119(6):1581-9. [PubMed: 22174155]  [MGI Ref ID J:181731]

Hu M; Bassett JH; Danks L; Howell PG; Xu K; Spanoudakis E; Kotsianidis I; Boyde A; Williams GR; Horwood N; Roberts IA; Karadimitris A. 2011. Activated invariant NKT cells regulate osteoclast development and function. J Immunol 186(5):2910-7. [PubMed: 21278350]  [MGI Ref ID J:169382]

Huber S; Sartini D; Exley M. 2003. Role of CD1d in coxsackievirus B3-induced myocarditis. J Immunol 170(6):3147-53. [PubMed: 12626572]  [MGI Ref ID J:126220]

Hwang SJ; Kim JH; Kim HY; Kim S; Chung DH. 2010. FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration. Lab Invest 90(1):9-19. [PubMed: 19823172]  [MGI Ref ID J:156416]

Jones DD; DeIulio GA; Winslow GM. 2012. Antigen-driven induction of polyreactive IgM during intracellular bacterial infection. J Immunol 189(3):1440-7. [PubMed: 22730531]  [MGI Ref ID J:189791]

Jones TG; Hallgren J; Humbles A; Burwell T; Finkelman FD; Alcaide P; Austen KF; Gurish MF. 2009. Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells. J Immunol 183(8):5251-60. [PubMed: 19783672]  [MGI Ref ID J:153832]

Kang TW; Yevsa T; Woller N; Hoenicke L; Wuestefeld T; Dauch D; Hohmeyer A; Gereke M; Rudalska R; Potapova A; Iken M; Vucur M; Weiss S; Heikenwalder M; Khan S; Gil J; Bruder D; Manns M; Schirmacher P; Tacke F; Ott M; Luedde T; Longerich T; Kubicka S; Zender L. 2011. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 479(7374):547-51. [PubMed: 22080947]  [MGI Ref ID J:179823]

Kim HJ; Kim HY; Kim BK; Kim S; Chung DH. 2006. Engagement of glucocorticoid-induced TNF receptor costimulates NKT cell activation in vitro and in vivo. J Immunol 176(6):3507-15. [PubMed: 16517719]  [MGI Ref ID J:129510]

Kim HY; Kim S; Chung DH. 2006. FcgammaRIII engagement provides activating signals to NKT cells in antibody-induced joint inflammation. J Clin Invest 116(9):2484-92. [PubMed: 16917543]  [MGI Ref ID J:114452]

Kobrynski LJ; Sousa AO; Nahmias AJ; Lee FK. 2005. Cutting edge: antibody production to pneumococcal polysaccharides requires CD1 molecules and CD8+ T cells. J Immunol 174(4):1787-90. [PubMed: 15699104]  [MGI Ref ID J:96541]

Koh YI; Shim JU; Lee JH; Chung IJ; Min JJ; Rhee JH; Lee HC; Chung DH; Wi JO. 2010. Natural killer T cells are dispensable in the development of allergen-induced airway hyperresponsiveness, inflammation and remodelling in a mouse model of chronic asthma. Clin Exp Immunol 161(1):159-70. [PubMed: 20456411]  [MGI Ref ID J:162137]

Konishi J; Iwabuchi K; Iwabuchi C; Ato M; Nagata JI; Onoe K; Nakagawa KI; Kasai M; Ogasawara K; Kawakami K; Onoe K. 2000. Thymic epithelial cells responsible for impaired generation of NK-T thymocytes in Alymphoplasia mutant mice. Cell Immunol 206(1):26-35. [PubMed: 11161435]  [MGI Ref ID J:67083]

Kupz A; Scott TA; Belz GT; Andrews DM; Greyer M; Lew AM; Brooks AG; Smyth MJ; Curtiss R 3rd; Bedoui S; Strugnell RA. 2013. Contribution of Thy1+ NK cells to protective IFN-gamma production during Salmonella Typhimurium infections. Proc Natl Acad Sci U S A 110(6):2252-7. [PubMed: 23345426]  [MGI Ref ID J:194337]

Lai D; Zhu J; Wang T; Hu-Li J; Terabe M; Berzofsky JA; Clayberger C; Krensky AM. 2011. KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells. J Exp Med 208(5):1093-103. [PubMed: 21482696]  [MGI Ref ID J:177312]

Lee HH; Meyer EH; Goya S; Pichavant M; Kim HY; Bu X; Umetsu SE; Jones JC; Savage PB; Iwakura Y; Casasnovas JM; Kaplan G; Freeman GJ; DeKruyff RH; Umetsu DT. 2010. Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity. J Immunol 185(9):5225-35. [PubMed: 20889552]  [MGI Ref ID J:165181]

Lee KA; Kang MH; Lee YS; Kim YJ; Kim DH; Ko HJ; Kang CY. 2008. A distinct subset of natural killer T cells produces IL-17, contributing to airway infiltration of neutrophils but not to airway hyperreactivity. Cell Immunol 251(1):50-5. [PubMed: 18423430]  [MGI Ref ID J:136265]

Lee YJ; Holzapfel KL; Zhu J; Jameson SC; Hogquist KA. 2013. Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells. Nat Immunol 14(11):1146-54. [PubMed: 24097110]  [MGI Ref ID J:208662]

Liu XS; Leerberg J; MacDonald K; Leggatt GR; Frazer IH. 2009. IFN-{gamma} promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host. J Immunol 183(1):51-8. [PubMed: 19535638]  [MGI Ref ID J:150112]

Liu Y; Teige A; Mondoc E; Ibrahim S; Holmdahl R; Issazadeh-Navikas S. 2011. Endogenous collagen peptide activation of CD1d-restricted NKT cells ameliorates tissue-specific inflammation in mice. J Clin Invest 121(1):249-64. [PubMed: 21157037]  [MGI Ref ID J:171844]

Loh C; Pau E; Lajoie G; Li TT; Baglaenko Y; Cheung YH; Chang NH; Wither JE. 2011. Epistatic suppression of fatal autoimmunity in New Zealand black bicongenic mice. J Immunol 186(10):5845-53. [PubMed: 21464090]  [MGI Ref ID J:173104]

Mannoor MK; Weerasinghe A; Halder RC; Reza S; Morshed M; Ariyasinghe A; Watanabe H; Sekikawa H; Abo T. 2001. Resistance to malarial infection is achieved by the cooperation of NK1.1(+) and NK1.1(-) subsets of intermediate TCR cells which are constituents of innate immunity. Cell Immunol 211(2):96-104. [PubMed: 11591113]  [MGI Ref ID J:115622]

Mantell BS; Stefanovic-Racic M; Yang X; Dedousis N; Sipula IJ; O'Doherty RM. 2011. Mice Lacking NKT Cells but with a Complete Complement of CD8 T-Cells Are Not Protected against the Metabolic Abnormalities of Diet-Induced Obesity. PLoS One 6(6):e19831. [PubMed: 21674035]  [MGI Ref ID J:174137]

McPherson M; Wei B; Turovskaya O; Fujiwara D; Brewer S; Braun J. 2008. Colitis immunoregulation by CD8+ T cell requires T cell cytotoxicity and B cell peptide antigen presentation. Am J Physiol Gastrointest Liver Physiol 295(3):G485-92. [PubMed: 18617557]  [MGI Ref ID J:141865]

Meissner NN; Lund FE; Han S; Harmsen A. 2005. CD8 T cell-mediated lung damage in response to the extracellular pathogen pneumocystis is dependent on MHC class I expression by radiation-resistant lung cells. J Immunol 175(12):8271-9. [PubMed: 16339567]  [MGI Ref ID J:122256]

Mizoguchi A; Mizoguchi E; Takedatsu H; Blumberg RS; Bhan AK. 2002. Chronic Intestinal Inflammatory Condition Generates IL-10-Producing Regulatory B Cell Subset Characterized by CD1d Upregulation. Immunity 16(2):219-30. [PubMed: 11869683]  [MGI Ref ID J:74718]

Moens L; Jeurissen A; Nierkens S; Boon L; Van Kaer L; Kasran A; Wuyts G; Ceuppens JL; Bossuyt X. 2009. Generation of antibody responses to pneumococcal capsular polysaccharides is independent of CD1 expression in mice. Infect Immun 77(5):1976-80. [PubMed: 19188354]  [MGI Ref ID J:148125]

Mulero MC; Ferres-Marco D; Islam A; Margalef P; Pecoraro M; Toll A; Drechsel N; Charneco C; Davis S; Bellora N; Gallardo F; Lopez-Arribillaga E; Asensio-Juan E; Rodilla V; Gonzalez J; Iglesias M; Shih V; Mar Alba M; Di Croce L; Hoffmann A; Miyamoto S; Villa-Freixa J; Lopez-Bigas N; Keyes WM; Dominguez M; Bigas A; Espinosa L. 2013. Chromatin-bound IkappaBalpha regulates a subset of polycomb target genes in differentiation and cancer. Cancer Cell 24(2):151-66. [PubMed: 23850221]  [MGI Ref ID J:201834]

Mycko MP; Ferrero I; Wilson A; Jiang W; Bianchi T; Trumpp A; MacDonald HR. 2009. Selective requirement for c-Myc at an early stage of V(alpha)14i NKT cell development. J Immunol 182(8):4641-8. [PubMed: 19342639]  [MGI Ref ID J:147743]

Napolitano A; Pittoni P; Beaudoin L; Lehuen A; Voehringer D; Macdonald HR; Dellabona P; Casorati G. 2013. Functional Education of Invariant NKT Cells by Dendritic Cell Tuning of SHP-1. J Immunol 190(7):3299-308. [PubMed: 23427253]  [MGI Ref ID J:194522]

Oh K; Kim S; Park SH; Gu H; Roopenian D; Chung DH; Kim YS; Lee DS. 2005. Direct regulatory role of NKT cells in allogeneic graft survival is dependent on the quantitative strength of antigenicity. J Immunol 174(4):2030-6. [PubMed: 15699132]  [MGI Ref ID J:96581]

Ohwatari R; Iwabuchi K; Iwabuchi C; Morohashi T; Sawa H; Hioki K; Kobayashi K; Fukuda S; Inuyama Y; Onoe K. 2001. Developmental and functional analyses of CD8(+) NK1.1(+) T cells in class-I-restricted TCR transgenic mice. Cell Immunol 213(1):24-33. [PubMed: 11747353]  [MGI Ref ID J:115422]

Rachitskaya AV; Hansen AM; Horai R; Li Z; Villasmil R; Luger D; Nussenblatt RB; Caspi RR. 2008. Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J Immunol 180(8):5167-71. [PubMed: 18390697]  [MGI Ref ID J:134247]

Ragin MJ; Sahu N; August A. 2006. Differential regulation of cytokine production by CD1d-restricted NKT cells in response to superantigen staphylococcal enterotoxin B exposure. Infect Immun 74(1):282-8. [PubMed: 16368982]  [MGI Ref ID J:104272]

Roelofs-Haarhuis K; Wu X; Gleichmann E. 2004. Oral tolerance to nickel requires CD4+ invariant NKT cells for the infectious spread of tolerance and the induction of specific regulatory T cells. J Immunol 173(2):1043-50. [PubMed: 15240692]  [MGI Ref ID J:91933]

Schipper HS; Rakhshandehroo M; van de Graaf SF; Venken K; Koppen A; Stienstra R; Prop S; Meerding J; Hamers N; Besra G; Boon L; Nieuwenhuis EE; Elewaut D; Prakken B; Kersten S; Boes M; Kalkhoven E. 2012. Natural killer T cells in adipose tissue prevent insulin resistance. J Clin Invest 122(9):3343-54. [PubMed: 22863618]  [MGI Ref ID J:191302]

Schumann J; Mycko MP; Dellabona P; Casorati G; MacDonald HR. 2006. Cutting edge: influence of the TCR Vbeta domain on the selection of semi-invariant NKT cells by endogenous ligands. J Immunol 176(4):2064-8. [PubMed: 16455960]  [MGI Ref ID J:129129]

Sfondrini L; Besusso D; Zoia MT; Rodolfo M; Invernizzi AM; Taniguchi M; Nakayama T; Colombo MP; Menard S; Balsari A. 2002. Absence of the CD1 molecule up-regulates antitumor activity induced by CpG oligodeoxynucleotides in mice. J Immunol 169(1):151-8. [PubMed: 12077240]  [MGI Ref ID J:132386]

Shi FD; Flodstrom M; Balasa B; Kim SH; Van Gunst K; Strominger JL; Wilson SB; Sarvetnick N. 2001. Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse. Proc Natl Acad Sci U S A 98(12):6777-82. [PubMed: 11390999]  [MGI Ref ID J:69908]

Shimamura M; Huang YY. 2002. Presence of a novel subset of NKT cells bearing an invariant V(alpha)19.1-J(alpha)26 TCR alpha chain. FEBS Lett 516(1-3):97-100. [PubMed: 11959111]  [MGI Ref ID J:109181]

Shimamura M; Huang YY; Hidaka H. 2011. Modulation of Immunoglobulin Production by Invariant Valpha19-Jalpha33 TCR-Bearing Cells. PLoS One 6(6):e20915. [PubMed: 21698203]  [MGI Ref ID J:174283]

Shimamura M; Huang YY; Kobayashi M; Goji H. 2009. Altered production of immunoregulatory cytokines by invariant Valpha19 TCR-bearing cells dependent on the duration and intensity of TCR engagement. Int Immunol 21(2):179-85. [PubMed: 19106232]  [MGI Ref ID J:144520]

Sille FC; Boxem M; Sprengers D; Veerapen N; Besra G; Boes M. 2009. Distinct requirements for CD1d intracellular transport for development of V(alpha)14 iNKT cells. J Immunol 183(3):1780-8. [PubMed: 19587020]  [MGI Ref ID J:151699]

Sille FC; Martin C; Jayaraman P; Rothchild A; Fortune S; Besra GS; Behar SM; Boes M. 2011. Requirement for invariant chain in macrophages for Mycobacterium tuberculosis replication and CD1d antigen presentation. Infect Immun 79(8):3053-63. [PubMed: 21576321]  [MGI Ref ID J:175273]

Singer DS; Zinger H; Kohn LD; Mozes E. 1999. Differing MHC class I requirements for induction and propagation of experimental systemic lupus erythematosus. Eur J Immunol 29(7):2259-68. [PubMed: 10427989]  [MGI Ref ID J:115300]

Smiley ST; Lanthier PA; Couper KN; Szaba FM; Boyson JE; Chen W; Johnson LL. 2005. Exacerbated susceptibility to infection-stimulated immunopathology in CD1d-deficient mice. J Immunol 174(12):7904-11. [PubMed: 15944296]  [MGI Ref ID J:100871]

Sprengers D; Sille FC; Derkow K; Besra GS; Janssen HL; Schott E; Boes M. 2008. Critical role for CD1d-restricted invariant NKT cells in stimulating intrahepatic CD8 T-cell responses to liver antigen. Gastroenterology 134(7):2132-43. [PubMed: 18549881]  [MGI Ref ID J:137194]

Sriram V; Du W; Gervay-Hague J; Brutkiewicz RR. 2005. Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells. Eur J Immunol 35(6):1692-1701. [PubMed: 15915536]  [MGI Ref ID J:99187]

Stevenson HL; Crossley EC; Thirumalapura N; Walker DH; Ismail N. 2008. Regulatory roles of CD1d-restricted NKT cells in the induction of toxic shock-like syndrome in an animal model of fatal ehrlichiosis. Infect Immun 76(4):1434-44. [PubMed: 18212072]  [MGI Ref ID J:133436]

Stock P; Lombardi V; Kohlrautz V; Akbari O. 2009. Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. J Immunol 182(8):5116-22. [PubMed: 19342692]  [MGI Ref ID J:147488]

Swann JB; Uldrich AP; van Dommelen S; Sharkey J; Murray WK; Godfrey DI; Smyth MJ. 2009. Type I natural killer T cells suppress tumors caused by p53 loss in mice. Blood 113(25):6382-5. [PubMed: 19234138]  [MGI Ref ID J:150094]

Teige A; Bockermann R; Hasan M; Olofsson KE; Liu Y; Issazadeh-Navikas S. 2010. CD1d-dependent NKT cells play a protective role in acute and chronic arthritis models by ameliorating antigen-specific Th1 responses. J Immunol 185(1):345-56. [PubMed: 20525883]  [MGI Ref ID J:161617]

Terabe M; Swann J; Ambrosino E; Sinha P; Takaku S; Hayakawa Y; Godfrey DI; Ostrand-Rosenberg S; Smyth MJ; Berzofsky JA. 2005. A nonclassical non-Valpha14Jalpha18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance. J Exp Med 202(12):1627-33. [PubMed: 16365146]  [MGI Ref ID J:118828]

Tonti E; Fedeli M; Napolitano A; Iannacone M; von Andrian UH; Guidotti LG; Abrignani S; Casorati G; Dellabona P. 2012. Follicular helper NKT cells induce limited B cell responses and germinal center formation in the absence of CD4(+) T cell help. J Immunol 188(7):3217-22. [PubMed: 22379027]  [MGI Ref ID J:183101]

Tonti E; Galli G; Malzone C; Abrignani S; Casorati G; Dellabona P. 2009. NKT-cell help to B lymphocytes can occur independently of cognate interaction. Blood 113(2):370-6. [PubMed: 18832653]  [MGI Ref ID J:144427]

Tucker SN; Jessup HK; Fujii H; Wilson CB. 2002. Enforced expression of the Ikaros isoform IK5 decreases the numbers of extrathymic intraepithelial lymphocytes and natural killer 1.1+ T cells. Blood 99(2):513-9. [PubMed: 11781232]  [MGI Ref ID J:130654]

Van Maele L; Carnoy C; Cayet D; Songhet P; Dumoutier L; Ferrero I; Janot L; Erard F; Bertout J; Leger H; Sebbane F; Benecke A; Renauld JC; Hardt WD; Ryffel B; Sirard JC. 2010. TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa. J Immunol 185(2):1177-85. [PubMed: 20566828]  [MGI Ref ID J:162022]

Weidanz WP; Lafleur G; Brown A; Burns JM Jr; Gramaglia I; van der Heyde HC. 2010. {gamma}{delta} T Cells but Not NK Cells Are Essential for Cell-Mediated Immunity against Plasmodium chabaudi Malaria. Infect Immun 78(10):4331-40. [PubMed: 20660608]  [MGI Ref ID J:164250]

Wingender G; Kronenberg M. 2008. Role of NKT cells in the digestive system. IV. The role of canonical natural killer T cells in mucosal immunity and inflammation. Am J Physiol Gastrointest Liver Physiol 294(1):G1-8. [PubMed: 17947447]  [MGI Ref ID J:130517]

Yang SH; Jin JZ; Lee SH; Park H; Kim CH; Lee DS; Kim S; Chung NH; Kim YS. 2007. Role of NKT cells in allogeneic islet graft survival. Clin Immunol 124(3):258-66. [PubMed: 17662658]  [MGI Ref ID J:123919]

Yuan J; Nguyen CK; Liu X; Kanellopoulou C; Muljo SA. 2012. Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis. Science 335(6073):1195-200. [PubMed: 22345399]  [MGI Ref ID J:181640]

Zullo AJ; Benlagha K; Bendelac A; Taparowsky EJ. 2007. Sensitivity of NK1.1-negative NKT cells to transgenic BATF defines a role for activator protein-1 in the expansion and maturation of immature NKT cells in the thymus. J Immunol 178(1):58-66. [PubMed: 17182540]  [MGI Ref ID J:141947]

Yaa related

Anders HJ; Krug A; Pawar RD. 2008. Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus. Eur J Immunol 38(7):1795-9. [PubMed: 18581336]  [MGI Ref ID J:137453]

Arabo A; Costa O; Tron F; Caston J. 2005. Spatial and motor abilities during the course of autoimmune disease in (NZW x BXSB)F1 lupus-prone mice. Behav Brain Res 165(1):126-37. [PubMed: 16168499]  [MGI Ref ID J:115747]

Baccala R; Gonzalez-Quintial R; Schreiber RD; Lawson BR; Kono DH; Theofilopoulos AN. 2012. Anti-IFN-alpha/beta Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice. J Immunol 189(12):5976-84. [PubMed: 23175700]  [MGI Ref ID J:190844]

Boehm GW; Sherman GF; Hoplight BJ 2nd; Hyde LA; Bradway DM; Galaburda AM; Ahmed SA; Denenberg VH. 1998. Learning in year-old female autoimmune BXSB mice. Physiol Behav 64(1):75-82. [PubMed: 9661985]  [MGI Ref ID J:49007]

Boross P; Arandhara VL; Martin-Ramirez J; Santiago-Raber ML; Carlucci F; Flierman R; van der Kaa J; Breukel C; Claassens JW; Camps M; Lubberts E; Salvatori D; Rastaldi MP; Ossendorp F; Daha MR; Cook HT; Izui S; Botto M; Verbeek JS. 2011. The inhibiting Fc receptor for IgG, FcgammaRIIB, is a modifier of autoimmune susceptibility. J Immunol 187(3):1304-13. [PubMed: 21724994]  [MGI Ref ID J:179175]

Bubier JA; Sproule TJ; Foreman O; Spolski R; Shaffer DJ; Morse HC 3rd; Leonard WJ; Roopenian DC. 2009. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci U S A 106(5):1518-23. [PubMed: 19164519]  [MGI Ref ID J:144484]

Deane JA; Pisitkun P; Barrett RS; Feigenbaum L; Town T; Ward JM; Flavell RA; Bolland S. 2007. Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation. Immunity 27(5):801-10. [PubMed: 17997333]  [MGI Ref ID J:127600]

Denenberg VH; Hoplight B; Sherman GF; Mobraaten LE. 2001. Effects of the uterine environment and neocortical ectopias upon behavior of BXSB-Yaa+mice. Dev Psychobiol 38(3):154-63. [PubMed: 11279592]  [MGI Ref ID J:72331]

Denenberg VH; Sherman G; Schrott LM; Waters NS; Boehm GW; Galaburda AM; Mobraaten LE. 1996. Effects of embryo transfer and cortical ectopias upon the behavior of BXSB-Yaa and BXSB-Yaa + mice. Brain Res Dev Brain Res 93(1-2):100-8. [PubMed: 8804696]  [MGI Ref ID J:33655]

Eisenberg RA; Izui S; McConahey PJ; Hang L; Peters CJ; Theofilopoulos AN; Dixon FJ. 1980. Male determined accelerated autoimmune disease in BXSB mice: transfer by bone marrow and spleen cells. J Immunol 125(3):1032-6. [PubMed: 7410826]  [MGI Ref ID J:6372]

Fairhurst AM; Hwang SH; Wang A; Tian XH; Boudreaux C; Zhou XJ; Casco J; Li QZ; Connolly JE; Wakeland EK. 2008. Yaa autoimmune phenotypes are conferred by overexpression of TLR7. Eur J Immunol 38(7):1971-8. [PubMed: 18521959]  [MGI Ref ID J:137309]

Fossati L; Iwamoto M; Merino R; Izui S. 1995. Selective enhancing effect of the Yaa gene on immune responses against self and foreign antigens. Eur J Immunol 25(1):166-73. [PubMed: 7843228]  [MGI Ref ID J:22499]

Fossati L; Sobel ES; Iwamoto M; Cohen PL; Eisenberg RA; Izui S. 1995. The Yaa gene-mediated acceleration of murine lupus: Yaa- T cells from non-autoimmune mice collaborate with Yaa+ B cells to produce lupus autoantibodies in vivo. Eur J Immunol 25(12):3412-7. [PubMed: 8566031]  [MGI Ref ID J:31227]

Hang LM; Izui S; Dixon FJ. 1981. (NZW x BXSB)F1 hybrid. A model of acute lupus and coronary vascular disease with myocardial infarction. J Exp Med 154(1):216-21. [PubMed: 7252427]  [MGI Ref ID J:38157]

Hudgins CC; Steinberg RT; Klinman DM; Reeves MJ; Steinberg AD. 1985. Studies of consomic mice bearing the Y chromosome of the BXSB mouse. J Immunol 134(6):3849-54. [PubMed: 3989299]  [MGI Ref ID J:7823]

Hugin AW; Fossati-Jimack L; Izui S. 2000. The autoimmune accelerating yaa mutation does not accelerate murine AIDS. Cell Immunol 200(2):76-80. [PubMed: 10753498]  [MGI Ref ID J:114277]

Hyde LA; Stavnezer AJ; Bimonte HA; Sherman GF; Denenberg VH. 2002. Spatial and nonspatial Morris maze learning: impaired behavioral flexibility in mice with ectopias located in the prefrontal cortex. Behav Brain Res 133(2):247-59. [PubMed: 12110458]  [MGI Ref ID J:108472]

Izui S; Masuda K; Yoshida H. 1984. Acute SLE in F1 hybrids between SB/Le and NZW mice; prominently enhanced formation of gp70 immune complexes by a Y chromosome-associated factor from SB/Le mice. J Immunol 132(2):701-4. [PubMed: 6690614]  [MGI Ref ID J:7276]

Izui S; Merino R; Fossati L; Iwamoto M. 1994. The role of the Yaa gene in lupus syndrome. Int Rev Immunol 11(3):211-30. [PubMed: 7930846]  [MGI Ref ID J:21990]

Jansson L; Holmdahl R. 1994. The Y chromosome-linked autoimmune accelerating yaa gene suppresses collagen-induced arthritis. Eur J Immunol 24(5):1213-7. [PubMed: 8181531]  [MGI Ref ID J:18810]

Kamada H; Takaoka Y; Kitagaki K; Nagai H. 1995. Effect of cyclophosphamide on lymphokine production in MRL/lpr.Yaa mice. Inflamm Res 44(11):491-8. [PubMed: 8597884]  [MGI Ref ID J:30518]

Kawano H; Abe M; Zhang D; Saikawa T; Fujimori M; Hirose S; Shirai T. 1992. Heterozygosity of the major histocompatibility complex controls the autoimmune disease in (NZW x BXSB) F1 mice. Clin Immunol Immunopathol 65(3):308-14. [PubMed: 1451334]  [MGI Ref ID J:3381]

Khaled AR; Butfiloski EJ; Villas B; Sobel ES; Schiffenbauer J. 1999. Aberrant expression of the NF-kappaB and IkappaB proteins in B cells from viable motheaten mice. Autoimmunity 30(2):115-28. [PubMed: 10435725]  [MGI Ref ID J:117314]

Kikuchi S; Amano H; Amano E; Fossati-Jimack L; Santiago-Raber ML; Moll T; Ida A; Kotzin BL; Izui S. 2005. Identification of 2 major loci linked to autoimmune hemolytic anemia in NZB mice. Blood 106(4):1323-9. [PubMed: 15860660]  [MGI Ref ID J:117292]

Kikuchi S; Fossati-Jimack L; Moll T; Amano H; Amano E; Ida A; Ibnou-Zekri N; Laporte C; Santiago-Raber ML; Rozzo SJ; Kotzin BL; Izui S. 2005. Differential role of three major New Zealand black-derived loci linked with Yaa-induced murine lupus nephritis. J Immunol 174(2):1111-7. [PubMed: 15634937]  [MGI Ref ID J:95829]

Kikuchi S; Santiago-Raber ML; Amano H; Amano E; Fossati-Jimack L; Moll T; Kotzin BL; Izui S. 2006. Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus. J Immunol 176(5):3240-7. [PubMed: 16493085]  [MGI Ref ID J:129409]

Kim HJ; Wang X; Radfar S; Sproule TJ; Roopenian DC; Cantor H. 2011. CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice. Proc Natl Acad Sci U S A 108(5):2010-5. [PubMed: 21233417]  [MGI Ref ID J:169125]

Kofler R; McConahey PJ; Duchosal MA; Balderas RS; Theofilopoulos AN; Dixon FJ. 1991. An autosomal recessive gene that delays expression of lupus in BXSB mice. J Immunol 146(4):1375-9. [PubMed: 1991974]  [MGI Ref ID J:10973]

Kono DH; Balomenos D; Park MS; Theofilopoulos AN. 2000. Development of lupus in BXSB mice is independent of IL-4. J Immunol 164(1):38-42. [PubMed: 10604990]  [MGI Ref ID J:112421]

Kuroki A; Moll T; Lopez-Hoyos M; Fossati-Jimack L; Ibnou-Zekri N; Kikuchi S; Merino J; Merino R; Izui S. 2004. Enforced Bcl-2 expression in B lymphocytes induces rheumatoid factor and anti-DNA production, but the Yaa mutation promotes only anti-DNA production. Eur J Immunol 34(4):1077-84. [PubMed: 15048718]  [MGI Ref ID J:88856]

Leiter EH; Prochazka M; Shultz LD. 1987. Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice. J Immunol 138(10):3224-9. [PubMed: 3553324]  [MGI Ref ID J:32752]

Lin Q; Xiu Y; Jiang Y; Tsurui H; Nakamura K; Kodera S; Ohtsuji M; Ohtsuji N; Shiroiwa W; Tsukamoto K; Amano H; Amano E; Kinoshita K; Sudo K; Nishimura H; Izui S; Shirai T; Hirose S. 2006. Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus. J Immunol 177(3):1646-54. [PubMed: 16849473]  [MGI Ref ID J:137977]

Maeda K; Malykhin A; Teague-Weber BN; Sun XH; Farris AD; Coggeshall KM. 2009. Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosus-prone B6.Sle1.Yaa animals. Blood 113(19):4534-40. [PubMed: 19224760]  [MGI Ref ID J:148718]

McPhee CG; Bubier JA; Sproule TJ; Park G; Steinbuck MP; Schott WH; Christianson GJ; Morse HC 3rd; Roopenian DC. 2013. IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice. J Immunol 191(9):4581-8. [PubMed: 24078696]  [MGI Ref ID J:206236]

Merino R; Fossati L; Lacour M; Lemoine R; Higaki M; Izui S. 1992. H-2-linked control of the Yaa gene-induced acceleration of lupus-like autoimmune disease in BXSB mice. Eur J Immunol 22(2):295-9. [PubMed: 1537372]  [MGI Ref ID J:2011]

Merino R; Iwamoto M; Gershwin ME; Izui S. 1994. The Yaa gene abrogates the major histocompatibility complex association of murine lupus in (NZB x BXSB)F1 hybrid mice. J Clin Invest 94(2):521-5. [PubMed: 8040305]  [MGI Ref ID J:19547]

Merino R; Shibata T; De Kossodo S; Izui S. 1989. Differential effect of the autoimmune Yaa and lpr genes on the acceleration of lupus-like syndrome in MRL/MpJ mice. Eur J Immunol 19(11):2131-7. [PubMed: 2599002]  [MGI Ref ID J:108759]

Moll T; Martinez-Soria E; Santiago-Raber ML; Amano H; Pihlgren-Bosch M; Marinkovic D; Izui S. 2005. Differential activation of anti-erythrocyte and anti-DNA autoreactive B lymphocytes by the Yaa mutation. J Immunol 174(2):702-9. [PubMed: 15634889]  [MGI Ref ID J:132847]

Morel L; Croker BP; Blenman KR; Mohan C; Huang G; Gilkeson G; Wakeland EK. 2000. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci U S A 97(12):6670-5. [PubMed: 10841565]  [MGI Ref ID J:62719]

Murphy ED; Roths JB. 1979. A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum 22(11):1188-94. [PubMed: 315777]  [MGI Ref ID J:6235]

Ozaki K; Spolski R; Ettinger R; Kim HP; Wang G; Qi CF; Hwu P; Shaffer DJ; Akilesh S; Roopenian DC; Morse HC 3rd; Lipsky PE; Leonard WJ. 2004. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol 173(9):5361-71. [PubMed: 15494482]  [MGI Ref ID J:93740]

Pisetsky DS; Klatt C; Dawson D; Roths JB. 1985. The influence of Yaa on anti-DNA responses of B6-lpr mice. Clin Immunol Immunopathol 37(3):369-76. [PubMed: 3931946]  [MGI Ref ID J:109825]

Pisitkun P; Deane JA; Difilippantonio MJ; Tarasenko T; Satterthwaite AB; Bolland S. 2006. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 312(5780):1669-72. [PubMed: 16709748]  [MGI Ref ID J:109758]

Rankin J; Boyle JJ; Rose SJ; Gabriel L; Lewis M; Thiruudaian V; Rogers NJ; Izui S; Morley BJ. 2007. The Bxs6 locus of BXSB mice is sufficient for high-level expression of gp70 and the production of gp70 immune complexes. J Immunol 178(7):4395-401. [PubMed: 17371996]  [MGI Ref ID J:145049]

Rosenblatt N; Hartmann KU; Loor F. 1994. The Yaa gene-dependent B-cell deficiency worsens the generalized lymphadenopathy and autoimmunity of C57BL/6-gld male mice. Immunology 83(3):476-83. [PubMed: 7835973]  [MGI Ref ID J:21189]

Rosenblatt N; Hartmann KU; Loor F. 1994. The Yaa mutation induces the development of autoimmunity in mice heterozygous for the gld (generalized lymphadenopathy disease) mutation. Cell Immunol 156(2):519-28. [PubMed: 8025960]  [MGI Ref ID J:19169]

Santiago ML; Fossati L; Jacquet C; Muller W; Izui S; Reininger L. 1997. Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome. J Exp Med 185(1):65-70. [PubMed: 8996242]  [MGI Ref ID J:37574]

Santiago ML; Mary C; Parzy D; Jacquet C; Montagutelli X; Parkhouse RM; Lemoine R; Izui S; Reininger L. 1998. Linkage of a major quantitative trait locus to Yaa gene-induced lupus-like nephritis in (NZW x C57BL/6)F1 mice. Eur J Immunol 28(12):4257-67. [PubMed: 9862363]  [MGI Ref ID J:52110]

Santiago-Raber ML; Kikuchi S; Borel P; Uematsu S; Akira S; Kotzin BL; Izui S. 2008. Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus. J Immunol 181(2):1556-62. [PubMed: 18606711]  [MGI Ref ID J:137656]

Schrott LM; Waters NS; Boehm GW; Sherman GF; Morrison L; Rosen GD; Behan PO; Galaburda AM; Denenberg VH. 1993. Behavior, cortical ectopias, and autoimmunity in BXSB-Yaa and BXSB-Yaa+ mice. Brain Behav Immun 7(3):205-23. [PubMed: 8147964]  [MGI Ref ID J:14455]

Shimizu M; Sekine K; Matsuzawa A; Iwaguchi T. 1992. Cell electrophoretic characterization of abnormally expanded lymphocytes in autoimmune lprcg, lpr, gld and Yaa mice, and of thymocyte subsets. Electrophoresis 13(3):136-42. [PubMed: 1592043]  [MGI Ref ID J:2361]

Smith HR; Chused TM; Steinberg AD. 1983. The effect of the X-linked immune deficiency gene (xid) upon the Y chromosome-related disease of BXSB mice. J Immunol 131(3):1257-62. [PubMed: 6886419]  [MGI Ref ID J:7172]

Subramanian S; Tus K; Li QZ; Wang A; Tian XH; Zhou J; Liang C; Bartov G; McDaniel LD; Zhou XJ; Schultz RA; Wakeland EK. 2006. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci U S A 103(26):9970-5. [PubMed: 16777955]  [MGI Ref ID J:111064]

Suzuki H; Yasukawa K; Saito T; Narazaki M; Hasegawa A; Taga T; Kishimoto T. 1993. Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal. Eur J Immunol 23(5):1078-82. [PubMed: 8477802]  [MGI Ref ID J:4970]

Taguchi N; Hashimoto Y; Naiki M; Farr AG; Boyd RL; Ansari AA; Shultz LD; Kotzin BL; Dorshkind K; Ikehara S; Gershwin ME. 1999. Abnormal thymic expression of epithelial cell adhesion molecule (EP-CAM) in New Zealand Black (NZB) mice. J Autoimmun 13(4):393-404. [PubMed: 10585755]  [MGI Ref ID J:59174]

Takahashi S; Fossati L; Iwamoto M; Merino R; Motta R; Kobayakawa T; Izui S. 1996. Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J Clin Invest 97(7):1597-604. [PubMed: 8601623]  [MGI Ref ID J:32235]

Takeoka Y; Taguchi N; Shultz L; Boyd RL; Naiki M; Ansari AA; Gershwin ME. 1999. Apoptosis and the thymic microenvironment in murine lupus. J Autoimmun 13(3):325-34. [PubMed: 10550220]  [MGI Ref ID J:58407]

Teuscher C; Noubade R; Spach K; McElvany B; Bunn JY; Fillmore PD; Zachary JF; Blankenhorn EP. 2006. Evidence that the Y chromosome influences autoimmune disease in male and female mice. Proc Natl Acad Sci U S A 103(21):8024-9. [PubMed: 16702550]  [MGI Ref ID J:110221]

The Australian Phenomics Facility at The Australian National University. 2006. Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University MGI Direct Data Submission :.  [MGI Ref ID J:104190]

Theofilopoulos AN; Eisenberg RA; Bourdon M; Crowell JS Jr; Dixon FJ. 1979. Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes. J Exp Med 149(2):516-34. [PubMed: 762500]  [MGI Ref ID J:108760]

Waisberg M; Tarasenko T; Vickers BK; Scott BL; Willcocks LC; Molina-Cruz A; Pierce MA; Huang CY; Torres-Velez FJ; Smith KG; Barillas-Mury C; Miller LH; Pierce SK; Bolland S. 2011. Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice. Proc Natl Acad Sci U S A 108(3):1122-7. [PubMed: 21187399]  [MGI Ref ID J:169698]

Wilber A; O'Connor TP; Lu ML; Karimi A; Schneider MC. 2003. Dnase1l3 deficiency in lupus-prone MRL and NZB/W F1 mice. Clin Exp Immunol 134(1):46-52. [PubMed: 12974753]  [MGI Ref ID J:109815]

Wofsy D; Kerger CE; Seaman WE. 1984. Monocytosis in the BXSB model for systemic lupus erythematosus. J Exp Med 159(2):629-34. [PubMed: 6363600]  [MGI Ref ID J:7308]

Yoh K; Shibuya K; Morito N; Nakano T; Ishizaki K; Shimohata H; Nose M; Izui S; Shibuya A; Koyama A; Engel JD; Yamamoto M; Takahashi S. 2003. Transgenic overexpression of GATA-3 in T lymphocytes improves autoimmune glomerulonephritis in mice with a BXSB/MpJ-Yaa genetic background. J Am Soc Nephrol 14(10):2494-502. [PubMed: 14514727]  [MGI Ref ID J:131473]

Zhang MC; Furukawa H; Tokunaka K; Saiga K; Date F; Owada Y; Nose M; Ono M. 2008. Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice. Immunogenetics 60(10):599-607. [PubMed: 18677469]  [MGI Ref ID J:140028]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryTo maintain the live colony, homozygous mice may be bred together. Both homozygous and heterozygous mice develop spontaneous lupus-like autoimmune syndrome similarly to BXSB/MpJ inbred mice (Stock No. 000740): mortality in males starts at ~13 weeks of age with 50% lethality by ~30 weeks and 76% lethality by ~40 weeks. Females develop a greatly attenuated form of autoimmune disease because they lack Yaa. The expected coat color is white-bellied agouti.
Mating SystemHeterozygote x Heterozygote         (Female x Male)   11-FEB-14

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   000740 BXSB/MpJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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General inquiries regarding Terms of Use

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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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