Strain Name:

BXSB.129(Cg)-Il21rtm1Wjl/DcrJ

Stock Number:

021568

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Availability:

Repository- Live

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Common Names: BXSB.Yaa IL-21R-/-;     BXSB.Yaa Il21r-/-;    
IL-21R-deficient BXSB.Yaa mice (BXSB.Yaa/Il21r-/- or BXSB.Yaa Il21r-/-) are a BXSB/MpJ-congenic strain carrying a null mutation of the interleukin 21 receptor. The IL-21 signaling deficiency of BXSB-Yaa/Il21r-/- mice prevents the humoral, leukocytic, and kidney manifestations of the spontaneous lupus-like autoimmune syndrome observed for BXSB/MpJ inbred mice. These BXSB-Yaa/Il21r-/- mice may be useful in studying the role of IL-21 signaling in autoimmune disease.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   27-JAN-14
Specieslaboratory mouse
GenerationN11F18pN1
Generation Definitions
 
Donating InvestigatorDr. Derry Roopenian,   The Jackson Laboratory

Description
IL-21R-deficient BXSB.Yaa mice (BXSB.Yaa/Il21r-/- or BXSB.Yaa Il21r-/-) are a BXSB/MpJ-congenic strain carrying a null mutation of the interleukin 21 receptor.

BXSB/MpJ inbred males (Stock No. 000740) develop a spontaneous lupus-like autoimmune syndrome: mortality starts at ~13 weeks of age with 50% lethality by ~30 weeks and 76% lethality by ~40 weeks. BXSB/MpJ inbred females develop a greatly attenuated form of autoimmune disease because they lack Yaa.

Homozygous (IL-21R-/-) mice are viable and fertile with normal lifespan. Homozygotes lack IL-21 signaling and have decreased immunoglobulin levels, decreased Th17 T cell differentation, and decreased production of IL-17. Compared to BXSB/MpJ, the IL-21 signaling-deficiency of BXSB.Yaa/Il21r-/- mice prevents the humoral, leukocytic, and kidney manifestations of the spontaneous autoimmune syndrome in both males and females.

Heterozygous males (BXSB.Yaa/IL-21R+/-) develop the BXSB/MpJ autoimmune phenotype. Heterozygous females develop a greatly attenuated form of autoimmune disease because they lack Yaa.

Development
The IL-21R null allele (Il21rtm1Wjl) was designed by Dr. Warren J. Leonard (National Institutes of Health) with a neomycin resistance cassette replacing several coding exons of the Il21r gene (interleukin 21 receptor) on chromosome 7. Specifically, the sequences encoding the signal peptide through the transmembrane domain were deleted (only 5 amino acids of the signal peptide were retained); this results in a frameshift mutation of the cytoplasmic domain encoding sequence. The targeting vector was electroporated into 129-derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts and chimeric mice were bred to wildtype animals to obtain germline transmitting founder mice. In 2004, IL-21R mutant mice backcrossed six generations onto BALB/c were sent to Dr. Derry C. Roopenian (The Jackson Laboratory). There, they were bred with C57BL/6 for at least one generation. Next, the mutant mice were backcrossed with BXSB/MpJ inbred mice (Stock No. 000740) for 11 generations, and then maintained by breeding homozygous mice together. In 2013, Dr. Roopenian sent some BXSB.Yaa/Il21r-/- mice at generation N11F18 to The Jackson Laboratory Repository (Autoimmune Resource) to establish Stock No. 021568. Male mice have the BXSB/MpJ-derived Y chromosome that contains the Y-linked autoimmune accelerator locus (Yaa).

Control Information

  Control
   000740 BXSB/MpJ
 
  Considerations for Choosing Controls

Related Strains

View Autoimmune Resource     (11 strains)

View BXSB Strain     (12 strains)

View Y Chromosomal Aberrations     (16 strains)

Strains carrying   Yaa allele
021569   B6.Cg-Sle1NZM2410/Aeg Yaa/DcrJ
000483   B6.SB-Yaa/J
000740   BXSB/MpJ
View Strains carrying   Yaa     (3 strains)

Strains carrying other alleles of Il21r
019115   B6N.129-Il21rtm1Kopf/J
View Strains carrying other alleles of Il21r     (1 strain)

Strains carrying other alleles of Yaa
000742   BXSB.B6-Yaa+/J
001925   BXSB.B6-Yaa+/MobJ
021330   BXSB.B6-Yaa+/MobJDcrJ
View Strains carrying other alleles of Yaa     (3 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
IgE Responsiveness, Atopic; IGER   (IL21R)
Il21r Immunodeficiency   (IL21R)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Il21rtm1Wjl/Il21rtm1Wjl X/Yaa

        BXSB.Cg-Il21rtm1Wjl Yaa/Dcr
  • mortality/aging
  • *normal* mortality/aging
    • the hypergammaglobulinemia, autoantibody production, reduced frequencies of marginal zone B cells and monocytosis, renal disease, and premature morbidity that are found in Yaa bearing mice with at least one wildtype copy of the interleukin 21 receptor are ameliorated or prevented by the disruption of the interleukin 21 receptor   (MGI Ref ID J:144484)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cell Biology Research
Signal Transduction

Developmental Biology Research
Internal/Organ Defects
      Lymphoid Tissue Defects
      hematopoietic defects
Lymphoid Tissue Defects
      hematopoietic defects

Hematological Research
Hematopoietic Defects

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      B and T cell deficiency
      B cell deficiency
      lupus erythematosus
      lupus erythematosus, control
Growth Factors/Receptors/Cytokines
Immunodeficiency
      B and T cell deficiency
      B cell defects
      B cell deficiency
      B, T, and NK cell deficiency
      NK Cell Deficiency
      NK Cell and Cd8 T Cell defects
      T cell deficiency
      defects in humoral immune responses
      specific T cell deficiency
Inflammation
      B and T cell deficiency
Intracellular Signaling Molecules
Lymphoid Tissue Defects
      B and T cell deficiency
      hematopoietic development

Internal/Organ Research
Lymphoid Tissue Defects
      B and T cell deficiency
      T cell deficiency
Thymus Defects
      B and T cell deficient

Research Tools
Cancer Research
      B, T, and NK cell deficiency, xenograft/transplant host
Genetics Research
      Tissue/Cell Markers: B cell specific marker
      Tissue/Cell Markers: T cell specific surface marker
Immunology, Inflammation and Autoimmunity Research
      B and T cell deficiency
      B cell deficiency
      B cell specific marker
      B cell specific surface marker
      B, T, and NK cell deficiency
      NK Cell Deficiency
      T cell deficiency
      T cell deficiency, xenograft/transplant host
      T cell specific surface marker
      production of B cells and antibodies
      specific T cell deficiency
Toxicology Research
      B and T cell deficiency, xenograft transplant host

Virology Research
B and T Cell Deficiency

Yaa related

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      lupus erythematosus

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Il21rtm1Wjl
Allele Name targeted mutation 1, Warren J Leonard
Allele Type Targeted (knock-out)
Common Name(s) IL-21R-;
Strain of Origin129
Gene Symbol and Name Il21r, interleukin 21 receptor
Chromosome 7
Gene Common Name(s) CD360; NILR;
Molecular Note The endogenous locus was disrupted by the insertion of a neomycin selection cassette. Sequence encoding the majority of the signal peptide through the transmembrane domain was replaced by neo, resulting in a frameshift mutation affecting sequence encoding the cytoplasmic domain. Transcript was undetected by RT-PCR analysis of thymocytes obtained from homozygous mutant mice. [MGI Ref ID J:80474] [MGI Ref ID J:95221]
 
Allele Symbol Yaa
Allele Name accelerated autoimmunity and lymphoproliferation
Allele Type Spontaneous
Common Name(s) Is(XOfd1-Mid1;Y)1Mp; Tp(X;Y)1Ekw;
Strain of OriginSB/Le
Gene Symbol and Name Yaa, accelerated autoimmunity and lymphoproliferation transposition
Chromosome Y
Gene Common Name(s) Tp(X;Y)1Ekw;
General Note In congenic C57BL/6 Yaa mice expression of Tlr7 is increased 2-fold.
Molecular Note An approximately 4 MB region of the X chromosome that includes at least 13 known genes (spanning from Ofd1 to Mid1) was translocated to the Y chromosome adjacent to the pseudoautosomal region. Increased RNA expression of Msl3, Tlr7, Tmsb4x and Rab9 was detected in follicular B cells. [MGI Ref ID J:109758] [MGI Ref ID J:111064] [MGI Ref ID J:140028]

Genotyping

Genotyping Information

Genotyping Protocols

Generic Neo Melt Curve Analysis, Melt Curve Analysis
Il21rtm1Wjl-Alt 1, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Bubier JA; Sproule TJ; Foreman O; Spolski R; Shaffer DJ; Morse HC 3rd; Leonard WJ; Roopenian DC. 2009. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci U S A 106(5):1518-23. [PubMed: 19164519]  [MGI Ref ID J:144484]

Ozaki K; Spolski R; Feng CG; Qi CF; Cheng J; Sher A; Morse HC 3rd; Liu C; Schwartzberg PL; Leonard WJ. 2002. A critical role for IL-21 in regulating immunoglobulin production. Science 298(5598):1630-4. [PubMed: 12446913]  [MGI Ref ID J:80474]

Additional References

Il21rtm1Wjl related

Cedeno-Laurent F; Opperman M; Barthel SR; Kuchroo VK; Dimitroff CJ. 2012. Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol 188(7):3127-37. [PubMed: 22345665]  [MGI Ref ID J:183114]

Coquet JM; Chakravarti S; Smyth MJ; Godfrey DI. 2008. Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. J Immunol 180(11):7097-101. [PubMed: 18490706]  [MGI Ref ID J:136354]

Datta S; Sarvetnick NE. 2008. IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms. PLoS ONE 3(9):e3118. [PubMed: 18773086]  [MGI Ref ID J:143945]

Elsaesser H; Sauer K; Brooks DG. 2009. IL-21 is required to control chronic viral infection. Science 324(5934):1569-72. [PubMed: 19423777]  [MGI Ref ID J:150018]

Hanash AM; Kappel LW; Yim NL; Nejat RA; Goldberg GL; Smith OM; Rao UK; Dykstra L; Na IK; Holland AM; Dudakov JA; Liu C; Murphy GF; Leonard WJ; Heller G; van den Brink MR. 2011. Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL. Blood 118(2):446-55. [PubMed: 21596854]  [MGI Ref ID J:174877]

Hinrichs CS; Spolski R; Paulos CM; Gattinoni L; Kerstann KW; Palmer DC; Klebanoff CA; Rosenberg SA; Leonard WJ; Restifo NP. 2008. IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood 111(11):5326-33. [PubMed: 18276844]  [MGI Ref ID J:135563]

Horikawa M; Weimer ET; DiLillo DJ; Venturi GM; Spolski R; Leonard WJ; Heise MT; Tedder TF. 2013. Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice. J Immunol 190(3):1158-68. [PubMed: 23275601]  [MGI Ref ID J:193035]

Ishigame H; Zenewicz LA; Sanjabi S; Licona-Limon P; Nakayama M; Leonard WJ; Flavell RA. 2013. Excessive Th1 responses due to the absence of TGF-beta signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis. Proc Natl Acad Sci U S A 110(17):6961-6. [PubMed: 23569233]  [MGI Ref ID J:196160]

Jang E; Cho SH; Park H; Paik DJ; Kim JM; Youn J. 2009. A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice. J Immunol 182(8):4649-56. [PubMed: 19342640]  [MGI Ref ID J:147742]

Karnowski A; Chevrier S; Belz GT; Mount A; Emslie D; D'Costa K; Tarlinton DM; Kallies A; Corcoran LM. 2012. B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1. J Exp Med 209(11):2049-64. [PubMed: 23045607]  [MGI Ref ID J:190912]

Kim SV; Xiang WV; Kwak C; Yang Y; Lin XW; Ota M; Sarpel U; Rifkin DB; Xu R; Littman DR. 2013. GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science 340(6139):1456-9. [PubMed: 23661644]  [MGI Ref ID J:199126]

King IL; Fortier A; Tighe M; Dibble J; Watts GF; Veerapen N; Haberman AM; Besra GS; Mohrs M; Brenner MB; Leadbetter EA. 2011. Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner. Nat Immunol 13(1):44-50. [PubMed: 22120118]  [MGI Ref ID J:178990]

King IL; Mohrs K; Mohrs M. 2010. A Nonredundant Role for IL-21 Receptor Signaling in Plasma Cell Differentiation and Protective Type 2 Immunity against Gastrointestinal Helminth Infection. J Immunol 185(10):6138-45. [PubMed: 20926797]  [MGI Ref ID J:165648]

Lee CK; Raz R; Gimeno R; Gertner R; Wistinghausen B; Takeshita K; DePinho RA; Levy DE. 2002. STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity 17(1):63-72. [PubMed: 12150892]  [MGI Ref ID J:78088]

McGuire HM; Vogelzang A; Ma CS; Hughes WE; Silveira PA; Tangye SG; Christ D; Fulcher D; Falcone M; King C. 2011. A Subset of Interleukin-21(+) Chemokine Receptor CCR9(+) T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity. Immunity 34(4):602-15. [PubMed: 21511186]  [MGI Ref ID J:171596]

McGuire HM; Walters S; Vogelzang A; Lee CM; Webster KE; Sprent J; Christ D; Grey S; King C. 2011. Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models. Diabetes 60(3):867-75. [PubMed: 21357471]  [MGI Ref ID J:169677]

McPhee CG; Bubier JA; Sproule TJ; Park G; Steinbuck MP; Schott WH; Christianson GJ; Morse HC 3rd; Roopenian DC. 2013. IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice. J Immunol 191(9):4581-8. [PubMed: 24078696]  [MGI Ref ID J:206236]

McPhee CG; Sproule TJ; Shin DM; Bubier JA; Schott WH; Steinbuck MP; Avenesyan L; Morse HC 3rd; Roopenian DC. 2011. MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis. J Immunol 187(9):4695-704. [PubMed: 21964024]  [MGI Ref ID J:179430]

Novy P; Huang X; Leonard WJ; Yang Y. 2011. Intrinsic IL-21 Signaling Is Critical for CD8 T Cell Survival and Memory Formation in Response to Vaccinia Viral Infection. J Immunol 186(5):2729-38. [PubMed: 21257966]  [MGI Ref ID J:169411]

Oh I; Ozaki K; Meguro A; Hatanaka K; Kadowaki M; Matsu H; Tatara R; Sato K; Iwakura Y; Nakae S; Sudo K; Teshima T; Leonard WJ; Ozawa K. 2010. Altered effector CD4+ T cell function in IL-21R-/- CD4+ T cell-mediated graft-versus-host disease. J Immunol 185(3):1920-6. [PubMed: 20574002]  [MGI Ref ID J:162476]

Pot C; Jin H; Awasthi A; Liu SM; Lai CY; Madan R; Sharpe AH; Karp CL; Miaw SC; Ho IC; Kuchroo VK. 2009. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J Immunol 183(2):797-801. [PubMed: 19570826]  [MGI Ref ID J:151633]

Rasheed MA; Latner DR; Aubert RD; Gourley T; Spolski R; Davis CW; Langley WA; Ha SJ; Ye L; Sarkar S; Kalia V; Konieczny BT; Leonard WJ; Ahmed R. 2013. Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells. J Virol 87(13):7737-46. [PubMed: 23637417]  [MGI Ref ID J:198436]

Seo GY; Youn J; Kim PH. 2009. IL-21 ensures TGF-beta 1-induced IgA isotype expression in mouse Peyer's patches. J Leukoc Biol 85(5):744-50. [PubMed: 19168593]  [MGI Ref ID J:149704]

Simard N; Konforte D; Tran AH; Esufali J; Leonard WJ; Paige CJ. 2011. Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow. J Immunol 186(9):5244-53. [PubMed: 21430229]  [MGI Ref ID J:172860]

Singh NJ; Chen C; Schwartz RH. 2006. The impact of T cell intrinsic antigen adaptation on peripheral immune tolerance. PLoS Biol 4(11):e340. [PubMed: 17048986]  [MGI Ref ID J:116094]

Sondergaard H; Coquet JM; Uldrich AP; McLaughlin N; Godfrey DI; Sivakumar PV; Skak K; Smyth MJ. 2009. Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity. J Immunol 183(11):7326-36. [PubMed: 19915059]  [MGI Ref ID J:157388]

Spolski R; Kashyap M; Robinson C; Yu Z; Leonard WJ. 2008. IL-21 signaling is critical for the development of type I diabetes in the NOD mouse. Proc Natl Acad Sci U S A 105(37):14028-33. [PubMed: 18779574]  [MGI Ref ID J:139075]

Spolski R; Kim HP; Zhu W; Levy DE; Leonard WJ. 2009. IL-21 mediates suppressive effects via its induction of IL-10. J Immunol 182(5):2859-67. [PubMed: 19234181]  [MGI Ref ID J:146251]

Spolski R; Wang L; Wan CK; Bonville CA; Domachowske JB; Kim HP; Yu Z; Leonard WJ. 2012. IL-21 promotes the pathologic immune response to pneumovirus infection. J Immunol 188(4):1924-32. [PubMed: 22238461]  [MGI Ref ID J:181192]

Sun J; Dodd H; Moser EK; Sharma R; Braciale TJ. 2011. CD4(+) T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nat Immunol 12(4):327-34. [PubMed: 21297642]  [MGI Ref ID J:170347]

Sweet RA; Ols ML; Cullen JL; Milam AV; Yagita H; Shlomchik MJ. 2011. Facultative role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo. Proc Natl Acad Sci U S A 108(19):7932-7. [PubMed: 21518858]  [MGI Ref ID J:172199]

Vogelzang A; McGuire HM; Yu D; Sprent J; Mackay CR; King C. 2008. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29(1):127-37. [PubMed: 18602282]  [MGI Ref ID J:137867]

Wan CK; Oh J; Li P; West EE; Wong EA; Andraski AB; Spolski R; Yu ZX; He J; Kelsall BL; Leonard WJ. 2013. The Cytokines IL-21 and GM-CSF Have Opposing Regulatory Roles in the Apoptosis of Conventional Dendritic Cells. Immunity 38(3):514-27. [PubMed: 23453633]  [MGI Ref ID J:194831]

Wang L; Yu CR; Kim HP; Liao W; Telford WG; Egwuagu CE; Leonard WJ. 2011. Key role for IL-21 in experimental autoimmune uveitis. Proc Natl Acad Sci U S A 108(23):9542-7. [PubMed: 21593413]  [MGI Ref ID J:173351]

Yates JL; Racine R; McBride KM; Winslow GM. 2013. T cell-dependent IgM memory B cells generated during bacterial infection are required for IgG responses to antigen challenge. J Immunol 191(3):1240-9. [PubMed: 23804710]  [MGI Ref ID J:205726]

Yoshida N; Kitayama D; Arima M; Sakamoto A; Inamine A; Watanabe-Takano H; Hatano M; Koike T; Tokuhisa T. 2011. CXCR4 Expression on Activated B Cells Is Downregulated by CD63 and IL-21. J Immunol 186(5):2800-8. [PubMed: 21270405]  [MGI Ref ID J:169389]

Yoshizaki A; Miyagaki T; DiLillo DJ; Matsushita T; Horikawa M; Kountikov EI; Spolski R; Poe JC; Leonard WJ; Tedder TF. 2012. Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature 491(7423):264-8. [PubMed: 23064231]  [MGI Ref ID J:189218]

Zeng R; Spolski R; Finkelstein SE; Oh S; Kovanen PE; Hinrichs CS; Pise-Masison CA; Radonovich MF; Brady JN; Restifo NP; Berzofsky JA; Leonard WJ. 2005. Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. J Exp Med 201(1):139-48. [PubMed: 15630141]  [MGI Ref ID J:95221]

Zhou L; Ivanov II; Spolski R; Min R; Shenderov K; Egawa T; Levy DE; Leonard WJ; Littman DR. 2007. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 8(9):967-74. [PubMed: 17581537]  [MGI Ref ID J:124293]

Zotos D; Coquet JM; Zhang Y; Light A; D'Costa K; Kallies A; Corcoran LM; Godfrey DI; Toellner KM; Smyth MJ; Nutt SL; Tarlinton DM. 2010. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med 207(2):365-78. [PubMed: 20142430]  [MGI Ref ID J:158826]

Yaa related

Anders HJ; Krug A; Pawar RD. 2008. Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus. Eur J Immunol 38(7):1795-9. [PubMed: 18581336]  [MGI Ref ID J:137453]

Arabo A; Costa O; Tron F; Caston J. 2005. Spatial and motor abilities during the course of autoimmune disease in (NZW x BXSB)F1 lupus-prone mice. Behav Brain Res 165(1):126-37. [PubMed: 16168499]  [MGI Ref ID J:115747]

Baccala R; Gonzalez-Quintial R; Schreiber RD; Lawson BR; Kono DH; Theofilopoulos AN. 2012. Anti-IFN-alpha/beta Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice. J Immunol 189(12):5976-84. [PubMed: 23175700]  [MGI Ref ID J:190844]

Boehm GW; Sherman GF; Hoplight BJ 2nd; Hyde LA; Bradway DM; Galaburda AM; Ahmed SA; Denenberg VH. 1998. Learning in year-old female autoimmune BXSB mice. Physiol Behav 64(1):75-82. [PubMed: 9661985]  [MGI Ref ID J:49007]

Boross P; Arandhara VL; Martin-Ramirez J; Santiago-Raber ML; Carlucci F; Flierman R; van der Kaa J; Breukel C; Claassens JW; Camps M; Lubberts E; Salvatori D; Rastaldi MP; Ossendorp F; Daha MR; Cook HT; Izui S; Botto M; Verbeek JS. 2011. The inhibiting Fc receptor for IgG, FcgammaRIIB, is a modifier of autoimmune susceptibility. J Immunol 187(3):1304-13. [PubMed: 21724994]  [MGI Ref ID J:179175]

Deane JA; Pisitkun P; Barrett RS; Feigenbaum L; Town T; Ward JM; Flavell RA; Bolland S. 2007. Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation. Immunity 27(5):801-10. [PubMed: 17997333]  [MGI Ref ID J:127600]

Denenberg VH; Hoplight B; Sherman GF; Mobraaten LE. 2001. Effects of the uterine environment and neocortical ectopias upon behavior of BXSB-Yaa+mice. Dev Psychobiol 38(3):154-63. [PubMed: 11279592]  [MGI Ref ID J:72331]

Denenberg VH; Sherman G; Schrott LM; Waters NS; Boehm GW; Galaburda AM; Mobraaten LE. 1996. Effects of embryo transfer and cortical ectopias upon the behavior of BXSB-Yaa and BXSB-Yaa + mice. Brain Res Dev Brain Res 93(1-2):100-8. [PubMed: 8804696]  [MGI Ref ID J:33655]

Eisenberg RA; Izui S; McConahey PJ; Hang L; Peters CJ; Theofilopoulos AN; Dixon FJ. 1980. Male determined accelerated autoimmune disease in BXSB mice: transfer by bone marrow and spleen cells. J Immunol 125(3):1032-6. [PubMed: 7410826]  [MGI Ref ID J:6372]

Fairhurst AM; Hwang SH; Wang A; Tian XH; Boudreaux C; Zhou XJ; Casco J; Li QZ; Connolly JE; Wakeland EK. 2008. Yaa autoimmune phenotypes are conferred by overexpression of TLR7. Eur J Immunol 38(7):1971-8. [PubMed: 18521959]  [MGI Ref ID J:137309]

Fossati L; Iwamoto M; Merino R; Izui S. 1995. Selective enhancing effect of the Yaa gene on immune responses against self and foreign antigens. Eur J Immunol 25(1):166-73. [PubMed: 7843228]  [MGI Ref ID J:22499]

Fossati L; Sobel ES; Iwamoto M; Cohen PL; Eisenberg RA; Izui S. 1995. The Yaa gene-mediated acceleration of murine lupus: Yaa- T cells from non-autoimmune mice collaborate with Yaa+ B cells to produce lupus autoantibodies in vivo. Eur J Immunol 25(12):3412-7. [PubMed: 8566031]  [MGI Ref ID J:31227]

Hang LM; Izui S; Dixon FJ. 1981. (NZW x BXSB)F1 hybrid. A model of acute lupus and coronary vascular disease with myocardial infarction. J Exp Med 154(1):216-21. [PubMed: 7252427]  [MGI Ref ID J:38157]

Hudgins CC; Steinberg RT; Klinman DM; Reeves MJ; Steinberg AD. 1985. Studies of consomic mice bearing the Y chromosome of the BXSB mouse. J Immunol 134(6):3849-54. [PubMed: 3989299]  [MGI Ref ID J:7823]

Hugin AW; Fossati-Jimack L; Izui S. 2000. The autoimmune accelerating yaa mutation does not accelerate murine AIDS. Cell Immunol 200(2):76-80. [PubMed: 10753498]  [MGI Ref ID J:114277]

Hyde LA; Stavnezer AJ; Bimonte HA; Sherman GF; Denenberg VH. 2002. Spatial and nonspatial Morris maze learning: impaired behavioral flexibility in mice with ectopias located in the prefrontal cortex. Behav Brain Res 133(2):247-59. [PubMed: 12110458]  [MGI Ref ID J:108472]

Izui S; Masuda K; Yoshida H. 1984. Acute SLE in F1 hybrids between SB/Le and NZW mice; prominently enhanced formation of gp70 immune complexes by a Y chromosome-associated factor from SB/Le mice. J Immunol 132(2):701-4. [PubMed: 6690614]  [MGI Ref ID J:7276]

Izui S; Merino R; Fossati L; Iwamoto M. 1994. The role of the Yaa gene in lupus syndrome. Int Rev Immunol 11(3):211-30. [PubMed: 7930846]  [MGI Ref ID J:21990]

Jansson L; Holmdahl R. 1994. The Y chromosome-linked autoimmune accelerating yaa gene suppresses collagen-induced arthritis. Eur J Immunol 24(5):1213-7. [PubMed: 8181531]  [MGI Ref ID J:18810]

Kamada H; Takaoka Y; Kitagaki K; Nagai H. 1995. Effect of cyclophosphamide on lymphokine production in MRL/lpr.Yaa mice. Inflamm Res 44(11):491-8. [PubMed: 8597884]  [MGI Ref ID J:30518]

Kawano H; Abe M; Zhang D; Saikawa T; Fujimori M; Hirose S; Shirai T. 1992. Heterozygosity of the major histocompatibility complex controls the autoimmune disease in (NZW x BXSB) F1 mice. Clin Immunol Immunopathol 65(3):308-14. [PubMed: 1451334]  [MGI Ref ID J:3381]

Khaled AR; Butfiloski EJ; Villas B; Sobel ES; Schiffenbauer J. 1999. Aberrant expression of the NF-kappaB and IkappaB proteins in B cells from viable motheaten mice. Autoimmunity 30(2):115-28. [PubMed: 10435725]  [MGI Ref ID J:117314]

Kikuchi S; Amano H; Amano E; Fossati-Jimack L; Santiago-Raber ML; Moll T; Ida A; Kotzin BL; Izui S. 2005. Identification of 2 major loci linked to autoimmune hemolytic anemia in NZB mice. Blood 106(4):1323-9. [PubMed: 15860660]  [MGI Ref ID J:117292]

Kikuchi S; Fossati-Jimack L; Moll T; Amano H; Amano E; Ida A; Ibnou-Zekri N; Laporte C; Santiago-Raber ML; Rozzo SJ; Kotzin BL; Izui S. 2005. Differential role of three major New Zealand black-derived loci linked with Yaa-induced murine lupus nephritis. J Immunol 174(2):1111-7. [PubMed: 15634937]  [MGI Ref ID J:95829]

Kikuchi S; Santiago-Raber ML; Amano H; Amano E; Fossati-Jimack L; Moll T; Kotzin BL; Izui S. 2006. Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus. J Immunol 176(5):3240-7. [PubMed: 16493085]  [MGI Ref ID J:129409]

Kim HJ; Wang X; Radfar S; Sproule TJ; Roopenian DC; Cantor H. 2011. CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice. Proc Natl Acad Sci U S A 108(5):2010-5. [PubMed: 21233417]  [MGI Ref ID J:169125]

Kofler R; McConahey PJ; Duchosal MA; Balderas RS; Theofilopoulos AN; Dixon FJ. 1991. An autosomal recessive gene that delays expression of lupus in BXSB mice. J Immunol 146(4):1375-9. [PubMed: 1991974]  [MGI Ref ID J:10973]

Kono DH; Balomenos D; Park MS; Theofilopoulos AN. 2000. Development of lupus in BXSB mice is independent of IL-4. J Immunol 164(1):38-42. [PubMed: 10604990]  [MGI Ref ID J:112421]

Kuroki A; Moll T; Lopez-Hoyos M; Fossati-Jimack L; Ibnou-Zekri N; Kikuchi S; Merino J; Merino R; Izui S. 2004. Enforced Bcl-2 expression in B lymphocytes induces rheumatoid factor and anti-DNA production, but the Yaa mutation promotes only anti-DNA production. Eur J Immunol 34(4):1077-84. [PubMed: 15048718]  [MGI Ref ID J:88856]

Leiter EH; Prochazka M; Shultz LD. 1987. Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice. J Immunol 138(10):3224-9. [PubMed: 3553324]  [MGI Ref ID J:32752]

Lin Q; Xiu Y; Jiang Y; Tsurui H; Nakamura K; Kodera S; Ohtsuji M; Ohtsuji N; Shiroiwa W; Tsukamoto K; Amano H; Amano E; Kinoshita K; Sudo K; Nishimura H; Izui S; Shirai T; Hirose S. 2006. Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus. J Immunol 177(3):1646-54. [PubMed: 16849473]  [MGI Ref ID J:137977]

Maeda K; Malykhin A; Teague-Weber BN; Sun XH; Farris AD; Coggeshall KM. 2009. Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosus-prone B6.Sle1.Yaa animals. Blood 113(19):4534-40. [PubMed: 19224760]  [MGI Ref ID J:148718]

McPhee CG; Bubier JA; Sproule TJ; Park G; Steinbuck MP; Schott WH; Christianson GJ; Morse HC 3rd; Roopenian DC. 2013. IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice. J Immunol 191(9):4581-8. [PubMed: 24078696]  [MGI Ref ID J:206236]

McPhee CG; Sproule TJ; Shin DM; Bubier JA; Schott WH; Steinbuck MP; Avenesyan L; Morse HC 3rd; Roopenian DC. 2011. MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis. J Immunol 187(9):4695-704. [PubMed: 21964024]  [MGI Ref ID J:179430]

Merino R; Fossati L; Lacour M; Lemoine R; Higaki M; Izui S. 1992. H-2-linked control of the Yaa gene-induced acceleration of lupus-like autoimmune disease in BXSB mice. Eur J Immunol 22(2):295-9. [PubMed: 1537372]  [MGI Ref ID J:2011]

Merino R; Iwamoto M; Gershwin ME; Izui S. 1994. The Yaa gene abrogates the major histocompatibility complex association of murine lupus in (NZB x BXSB)F1 hybrid mice. J Clin Invest 94(2):521-5. [PubMed: 8040305]  [MGI Ref ID J:19547]

Merino R; Shibata T; De Kossodo S; Izui S. 1989. Differential effect of the autoimmune Yaa and lpr genes on the acceleration of lupus-like syndrome in MRL/MpJ mice. Eur J Immunol 19(11):2131-7. [PubMed: 2599002]  [MGI Ref ID J:108759]

Moll T; Martinez-Soria E; Santiago-Raber ML; Amano H; Pihlgren-Bosch M; Marinkovic D; Izui S. 2005. Differential activation of anti-erythrocyte and anti-DNA autoreactive B lymphocytes by the Yaa mutation. J Immunol 174(2):702-9. [PubMed: 15634889]  [MGI Ref ID J:132847]

Morel L; Croker BP; Blenman KR; Mohan C; Huang G; Gilkeson G; Wakeland EK. 2000. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci U S A 97(12):6670-5. [PubMed: 10841565]  [MGI Ref ID J:62719]

Murphy ED; Roths JB. 1979. A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum 22(11):1188-94. [PubMed: 315777]  [MGI Ref ID J:6235]

Ozaki K; Spolski R; Ettinger R; Kim HP; Wang G; Qi CF; Hwu P; Shaffer DJ; Akilesh S; Roopenian DC; Morse HC 3rd; Lipsky PE; Leonard WJ. 2004. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol 173(9):5361-71. [PubMed: 15494482]  [MGI Ref ID J:93740]

Pisetsky DS; Klatt C; Dawson D; Roths JB. 1985. The influence of Yaa on anti-DNA responses of B6-lpr mice. Clin Immunol Immunopathol 37(3):369-76. [PubMed: 3931946]  [MGI Ref ID J:109825]

Pisitkun P; Deane JA; Difilippantonio MJ; Tarasenko T; Satterthwaite AB; Bolland S. 2006. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 312(5780):1669-72. [PubMed: 16709748]  [MGI Ref ID J:109758]

Rankin J; Boyle JJ; Rose SJ; Gabriel L; Lewis M; Thiruudaian V; Rogers NJ; Izui S; Morley BJ. 2007. The Bxs6 locus of BXSB mice is sufficient for high-level expression of gp70 and the production of gp70 immune complexes. J Immunol 178(7):4395-401. [PubMed: 17371996]  [MGI Ref ID J:145049]

Rosenblatt N; Hartmann KU; Loor F. 1994. The Yaa gene-dependent B-cell deficiency worsens the generalized lymphadenopathy and autoimmunity of C57BL/6-gld male mice. Immunology 83(3):476-83. [PubMed: 7835973]  [MGI Ref ID J:21189]

Rosenblatt N; Hartmann KU; Loor F. 1994. The Yaa mutation induces the development of autoimmunity in mice heterozygous for the gld (generalized lymphadenopathy disease) mutation. Cell Immunol 156(2):519-28. [PubMed: 8025960]  [MGI Ref ID J:19169]

Santiago ML; Fossati L; Jacquet C; Muller W; Izui S; Reininger L. 1997. Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome. J Exp Med 185(1):65-70. [PubMed: 8996242]  [MGI Ref ID J:37574]

Santiago ML; Mary C; Parzy D; Jacquet C; Montagutelli X; Parkhouse RM; Lemoine R; Izui S; Reininger L. 1998. Linkage of a major quantitative trait locus to Yaa gene-induced lupus-like nephritis in (NZW x C57BL/6)F1 mice. Eur J Immunol 28(12):4257-67. [PubMed: 9862363]  [MGI Ref ID J:52110]

Santiago-Raber ML; Kikuchi S; Borel P; Uematsu S; Akira S; Kotzin BL; Izui S. 2008. Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus. J Immunol 181(2):1556-62. [PubMed: 18606711]  [MGI Ref ID J:137656]

Schrott LM; Waters NS; Boehm GW; Sherman GF; Morrison L; Rosen GD; Behan PO; Galaburda AM; Denenberg VH. 1993. Behavior, cortical ectopias, and autoimmunity in BXSB-Yaa and BXSB-Yaa+ mice. Brain Behav Immun 7(3):205-23. [PubMed: 8147964]  [MGI Ref ID J:14455]

Shimizu M; Sekine K; Matsuzawa A; Iwaguchi T. 1992. Cell electrophoretic characterization of abnormally expanded lymphocytes in autoimmune lprcg, lpr, gld and Yaa mice, and of thymocyte subsets. Electrophoresis 13(3):136-42. [PubMed: 1592043]  [MGI Ref ID J:2361]

Smith HR; Chused TM; Steinberg AD. 1983. The effect of the X-linked immune deficiency gene (xid) upon the Y chromosome-related disease of BXSB mice. J Immunol 131(3):1257-62. [PubMed: 6886419]  [MGI Ref ID J:7172]

Subramanian S; Tus K; Li QZ; Wang A; Tian XH; Zhou J; Liang C; Bartov G; McDaniel LD; Zhou XJ; Schultz RA; Wakeland EK. 2006. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci U S A 103(26):9970-5. [PubMed: 16777955]  [MGI Ref ID J:111064]

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Takahashi S; Fossati L; Iwamoto M; Merino R; Motta R; Kobayakawa T; Izui S. 1996. Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J Clin Invest 97(7):1597-604. [PubMed: 8601623]  [MGI Ref ID J:32235]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX18

Colony Maintenance

Breeding & HusbandryTo maintain the live colony, homozygous mice may be bred together. Homozygous animals of both sexes do not develop the spontaneous autoimmune phenotype observed for BXSB/MpJ inbred mice (Stock No. 000740). Heterozygotes will develop the sex-specific autoimmune phenotype of BXSB/MpJ. The expected coat color is white-bellied agouti.
Mating SystemHomozygote x Homozygote         (Female x Male)   27-JAN-14

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $232.00Female or MaleHomozygous for Il21rtm1Wjl  
Price per Pair (US dollars $)Pair Genotype
$464.00Homozygous for Il21rtm1Wjl x Homozygous for Il21rtm1Wjl  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $301.60Female or MaleHomozygous for Il21rtm1Wjl  
Price per Pair (US dollars $)Pair Genotype
$603.20Homozygous for Il21rtm1Wjl x Homozygous for Il21rtm1Wjl  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Control Information

  Control
   000740 BXSB/MpJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

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