Strain Name:

129S-Abca4tm1Ght/J

Stock Number:

023725

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Availability:

Repository- Live

Abcr- mice may be useful for studying ABCR-mediated photoreceptor degeneration.

Description

Strain Information

Type Coisogenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemWild-type x Heterozygote         (Female x Male)   26-NOV-13
Mating SystemHeterozygote x Wild-type         (Female x Male)   26-NOV-13
Specieslaboratory mouse
Generation?+pN1 (03-MAR-14)
Generation Definitions
 
Donating Investigator Gabriel H. Travis,   UCLA School of Medicine

Description
Abcr- mice have a neo cassette replacing the promoter and exon 1 of the ATP-binding cassette, sub-family A (ABC1), member 4 (Abca4) gene, abolishing gene expression. ABCR (ABCA4) is a retina-specific protein localized in outer segment disk edges of rod photoreceptors. Mutations in ABCR have been linked to the onset of macular degenerations such as Stargardt macular dystrophy (STGD), recessive retinitis pigmentosa, recessive cone-rod dystrophy, and age-related macular degeneration (AMD). ABCR acts as a transmembrane flippase transporter for phosphatidylethanolamine (N-Ret-PE) which moves N-Ret-PE from inside of the photoreceptor disks out to the cytoplasmic surface. The retinal pigment epithelium (RPE) of the Abcr- mice accumulates of bis-retinoid-lipofuscin material, which is further amplified after supplementation with Vitamin A. The major bis-retinoid-lipofuscin pigment in the RPE of Abcr-/- mice and STGD1 patients is A2E. The knockout mice exhibit slow-photoreceptor degeneration and delayed dark adaptation following a photobleach. Abcr homozygotes null mice are viable and fertile.

Development
A targeting vector was designed to replace the promoter and exon 1 of the ATP-binding cassette, sub-family A (ABC1), member 4 (Abca4) gene with a neomycin resistance (neo) cassette in reverse orientation to the gene. The construct was electroporated into 129S4/SvJae-derived J1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts and the resulting chimeric males were bred to 129SvEv females. These mice were maintained on a 129SvEv background. Upon arrival at The Jackson Laboratory, mice were bred to 129S1/SvImJ (Stock No. 002448) for at least one generation to establish the colony.

Control Information

  Control
   002448 129S1/SvImJ (approximate)
 
  Considerations for Choosing Controls

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Cone-Rod Dystrophy 3; CORD3
Retinitis Pigmentosa 19; RP19
Stargardt Disease 1; STGD1
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Macular Degeneration, Age-Related, 2; ARMD2   (ABCA4)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Abca4tm1Ght/Abca4tm1Ght

        involves: 129S4/SvJae
  • vision/eye phenotype
  • abnormal eye physiology
    • A2E fluorescent product (from condensation of all-trans-retinal) is detected at much higher levels than in wild-type or Rdh12-deficient mice   (MGI Ref ID J:117483)
  • abnormal retinal pigment epithelium morphology
    • levels of lipofuscin and its associated metabolites are 20-fold higher than in controls in the retinal pigment epithelium of mice supplemented with vitamin A   (MGI Ref ID J:141801)
  • homeostasis/metabolism phenotype
  • abnormal vitamin A level
    • mice supplemented with vitamin A accumulate more higher levels of all-trans retinoic acid in both the liver and eyes   (MGI Ref ID J:141801)
  • pigmentation phenotype
  • abnormal retinal pigment epithelium morphology
    • levels of lipofuscin and its associated metabolites are 20-fold higher than in controls in the retinal pigment epithelium of mice supplemented with vitamin A   (MGI Ref ID J:141801)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Abca4tm1Ght/Abca4tm1Ght

        involves: 129S4/SvJae * C57BL/6
  • vision/eye phenotype
  • abnormal Bruch membrane morphology
    • Bruch's membrane between the retinal pigment epithelium and choroid is thickened   (MGI Ref ID J:56317)
  • abnormal eye physiology
    • mutants exhibit a transient accumulation of all-trans- retinaldehyde and transient depletion of all-trans-retinol and all-trans-retinyl esters following photobleach   (MGI Ref ID J:56317)
    • delayed dark adaptation   (MGI Ref ID J:56317)
  • abnormal photoreceptor outer segment morphology
    • mutants exhibit a 1.6-fold increase in phosphatidyletanolamine in the outer segments of retinal pigment epithelium   (MGI Ref ID J:56317)
    • mutants exhibit the presence of protonated and absence of nonprotonated N-retinylidene-phosphatidylethanolamine in outer segments   (MGI Ref ID J:56317)
  • abnormal retinal pigment epithelium morphology
    • 16 and 20 week old mutants exhibit lipofuscin accumulation in the retinal pigment epithelium   (MGI Ref ID J:56317)
    • 44 week old eyes show accumulation of dense bodies within retinal pigment epithelium cells, including large oval structures of high electron density   (MGI Ref ID J:56317)
  • retinal photoreceptor degeneration
    • mutants show a 35% mean reduction in a-wave amplitude up to 1 year of age, suggesting a slow photoreceptor degeneration   (MGI Ref ID J:56317)
  • nervous system phenotype
  • abnormal photoreceptor outer segment morphology
    • mutants exhibit a 1.6-fold increase in phosphatidyletanolamine in the outer segments of retinal pigment epithelium   (MGI Ref ID J:56317)
    • mutants exhibit the presence of protonated and absence of nonprotonated N-retinylidene-phosphatidylethanolamine in outer segments   (MGI Ref ID J:56317)
  • retinal photoreceptor degeneration
    • mutants show a 35% mean reduction in a-wave amplitude up to 1 year of age, suggesting a slow photoreceptor degeneration   (MGI Ref ID J:56317)
  • pigmentation phenotype
  • abnormal retinal pigment epithelium morphology
    • 16 and 20 week old mutants exhibit lipofuscin accumulation in the retinal pigment epithelium   (MGI Ref ID J:56317)
    • 44 week old eyes show accumulation of dense bodies within retinal pigment epithelium cells, including large oval structures of high electron density   (MGI Ref ID J:56317)

Abca4tm1Ght/Abca4tm1Ght

        involves: 129S4/SvJae * BALB/c
  • vision/eye phenotype
  • abnormal retinal pigment epithelium morphology
    • levels of lipofuscin and its associated metabolites are higher than in controls in the retinal pigment epithelium of mice, especially when diet is supplemented with vitamin A   (MGI Ref ID J:141801)
    • the fractional area of lipofuscin granules in the RPE is 0.11 and reaches 0.14 when supplemented with vitamin A as compared to 0.053 in albino controls fed a control diet   (MGI Ref ID J:141801)
  • photoreceptor outer segment degeneration
    • the outer segment is approximately 40% degenerated with OS shortening by 11 months of age   (MGI Ref ID J:141801)
  • thin retinal outer nuclear layer
    • the outer nuclear layer of 11-month old albinos contains 6 to 7 rows compared to 10 to 11 rows for controls   (MGI Ref ID J:141801)
  • pigmentation phenotype
  • abnormal retinal pigment epithelium morphology
    • levels of lipofuscin and its associated metabolites are higher than in controls in the retinal pigment epithelium of mice, especially when diet is supplemented with vitamin A   (MGI Ref ID J:141801)
    • the fractional area of lipofuscin granules in the RPE is 0.11 and reaches 0.14 when supplemented with vitamin A as compared to 0.053 in albino controls fed a control diet   (MGI Ref ID J:141801)
  • nervous system phenotype
  • photoreceptor outer segment degeneration
    • the outer segment is approximately 40% degenerated with OS shortening by 11 months of age   (MGI Ref ID J:141801)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Eye Defects

Research Tools
Sensorineural Research
      retinal degeneration

Sensorineural Research
Eye Defects
Retinal Degeneration
      retinitis pigmentosa

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Abca4tm1Ght
Allele Name targeted mutation 1, Gabriel H Travis
Allele Type Targeted (Null/Knockout)
Common Name(s) abcr-;
Strain of Origin129S4/SvJae
Gene Symbol and Name Abca4, ATP-binding cassette, sub-family A (ABC1), member 4
Chromosome 3
Gene Common Name(s) ABC10; ABCR; ARMD2; ATP-binding cassette 10; AW050280; Abc10; CORD3; D430003I15Rik; FFM; RIKEN cDNA D430003I15 gene; RMP; RP19; Rim protein; STGD; STGD1; expressed sequence AW050280;
Molecular Note Replacement of a 4 kb genomic fragment containing the promoter and first exon with a neomycin cassette. Immunoblot analysis of retinal homogenates failed to detect any protein in samples derived from homozygous mice. [MGI Ref ID J:56317]

Genotyping

Genotyping Information

Genotyping Protocols

Abca4tm1Ght, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Weng J; Mata NL; Azarian SM; Tzekov RT; Birch DG; Travis GH. 1999. Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice. Cell 98(1):13-23. [PubMed: 10412977]  [MGI Ref ID J:56317]

Additional References

Abca4tm1Ght related

Anderson OA; Finkelstein A; Shima DT. 2013. A2E induces IL-1ss production in retinal pigment epithelial cells via the NLRP3 inflammasome. PLoS One 8(6):e67263. [PubMed: 23840644]  [MGI Ref ID J:203718]

Bui TV; Han Y; Radu RA; Travis GH; Mata NL. 2006. Characterization of native retinal fluorophores involved in biosynthesis of A2E and lipofuscin-associated retinopathies. J Biol Chem 281(26):18112-9. [PubMed: 16638746]  [MGI Ref ID J:114357]

Charbel Issa P; Singh MS; Lipinski DM; Chong NV; Delori FC; Barnard AR; MacLaren RE. 2012. Optimization of in vivo confocal autofluorescence imaging of the ocular fundus in mice and its application to models of human retinal degeneration. Invest Ophthalmol Vis Sci 53(2):1066-75. [PubMed: 22169101]  [MGI Ref ID J:191520]

Chen Y; Okano K; Maeda T; Chauhan V; Golczak M; Maeda A; Palczewski K. 2012. Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration. J Biol Chem 287(7):5059-69. [PubMed: 22184108]  [MGI Ref ID J:182451]

Chen Y; Palczewska G; Mustafi D; Golczak M; Dong Z; Sawada O; Maeda T; Maeda A; Palczewski K. 2013. Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration. J Clin Invest 123(12):5119-34. [PubMed: 24231350]  [MGI Ref ID J:207755]

Chen Y; Sawada O; Kohno H; Le YZ; Subauste C; Maeda T; Maeda A. 2013. Autophagy protects the retina from light-induced degeneration. J Biol Chem 288(11):7506-18. [PubMed: 23341467]  [MGI Ref ID J:196891]

Conley SM; Cai X; Makkia R; Wu Y; Sparrow JR; Naash MI. 2012. Increased cone sensitivity to ABCA4 deficiency provides insight into macular vision loss in Stargardt's dystrophy. Biochim Biophys Acta 1822(7):1169-79. [PubMed: 22033104]  [MGI Ref ID J:185019]

Fishkin NE; Sparrow JR; Allikmets R; Nakanishi K. 2005. Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate. Proc Natl Acad Sci U S A 102(20):7091-6. [PubMed: 15870200]  [MGI Ref ID J:99240]

Grey AC; Crouch RK; Koutalos Y; Schey KL; Ablonczy Z. 2011. Spatial localization of A2E in the retinal pigment epithelium. Invest Ophthalmol Vis Sci 52(7):3926-33. [PubMed: 21357388]  [MGI Ref ID J:181440]

Guha S; Baltazar GC; Coffey EE; Tu LA; Lim JC; Beckel JM; Patel S; Eysteinsson T; Lu W; O'Brien-Jenkins A; Laties AM; Mitchell CH. 2013. Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor. FASEB J 27(11):4500-9. [PubMed: 23964074]  [MGI Ref ID J:203956]

Guha S; Baltazar GC; Tu LA; Liu J; Lim JC; Lu W; Argall A; Boesze-Battaglia K; Laties AM; Mitchell CH. 2012. Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem 122(4):823-33. [PubMed: 22639870]  [MGI Ref ID J:187447]

Han Z; Conley SM; Makkia RS; Cooper MJ; Naash MI. 2012. DNA nanoparticle-mediated ABCA4 delivery rescues Stargardt dystrophy in mice. J Clin Invest 122(9):3221-6. [PubMed: 22886305]  [MGI Ref ID J:191429]

Kim SR; Fishkin N; Kong J; Nakanishi K; Allikmets R; Sparrow JR. 2004. Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E. Proc Natl Acad Sci U S A 101(32):11668-72. [PubMed: 15277666]  [MGI Ref ID J:99461]

Kim SR; Jang YP; Jockusch S; Fishkin NE; Turro NJ; Sparrow JR. 2007. The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model. Proc Natl Acad Sci U S A 104(49):19273-8. [PubMed: 18048333]  [MGI Ref ID J:128487]

Kohno H; Maeda T; Perusek L; Pearlman E; Maeda A. 2014. CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration. J Immunol 192(8):3816-27. [PubMed: 24639355]  [MGI Ref ID J:210001]

Liu J; Lu W; Guha S; Baltazar GC; Coffey EE; Laties AM; Rubenstein RC; Reenstra WW; Mitchell CH. 2012. Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells. Am J Physiol Cell Physiol 303(2):C160-9. [PubMed: 22572847]  [MGI Ref ID J:191152]

Liu J; Lu W; Reigada D; Nguyen J; Laties AM; Mitchell CH. 2008. Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery. Invest Ophthalmol Vis Sci 49(2):772-80. [PubMed: 18235027]  [MGI Ref ID J:132587]

Ma L; Kaufman Y; Zhang J; Washington I. 2011. C20-D3-vitamin A Slows Lipofuscin Accumulation and Electrophysiological Retinal Degeneration in a Mouse Model of Stargardt Disease. J Biol Chem 286(10):7966-74. [PubMed: 21156790]  [MGI Ref ID J:170397]

Maeda A; Golczak M; Maeda T; Palczewski K. 2009. Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. Invest Ophthalmol Vis Sci 50(11):5435-43. [PubMed: 19553623]  [MGI Ref ID J:154653]

Maeda A; Maeda T; Golczak M; Chou S; Desai A; Hoppel CL; Matsuyama S; Palczewski K. 2009. Involvement of all-trans-retinal in acute light-induced retinopathy of mice. J Biol Chem 284(22):15173-83. [PubMed: 19304658]  [MGI Ref ID J:150515]

Maeda A; Maeda T; Golczak M; Palczewski K. 2008. Retinopathy in mice induced by disrupted all-trans-retinal clearance. J Biol Chem 283(39):26684-93. [PubMed: 18658157]  [MGI Ref ID J:142322]

Maeda A; Maeda T; Imanishi Y; Sun W; Jastrzebska B; Hatala DA; Winkens HJ; Hofmann KP; Janssen JJ; Baehr W; Driessen CA; Palczewski K. 2006. Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. J Biol Chem 281(49):37697-704. [PubMed: 17032653]  [MGI Ref ID J:117483]

Maeda A; Palczewska G; Golczak M; Kohno H; Dong Z; Maeda T; Palczewski K. 2014. Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice. Proc Natl Acad Sci U S A 111(14):E1428-37. [PubMed: 24706832]  [MGI Ref ID J:208625]

Maeda T; Maeda A; Matosky M; Okano K; Roos S; Tang J; Palczewski K. 2009. Evaluation of potential therapies for a mouse model of human age-related macular degeneration caused by delayed all-trans-retinal clearance. Invest Ophthalmol Vis Sci 50(10):4917-25. [PubMed: 19494204]  [MGI Ref ID J:154536]

Maiti P; Kong J; Kim SR; Sparrow JR; Allikmets R; Rando RR. 2006. Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation. Biochemistry 45(3):852-60. [PubMed: 16411761]  [MGI Ref ID J:106138]

Mata NL; Tzekov RT; Liu X; Weng J; Birch DG; Travis GH. 2001. Delayed dark-adaptation and lipofuscin accumulation in abcr+/- mice: implications for involvement of ABCR in age-related macular degeneration. Invest Ophthalmol Vis Sci 42(8):1685-90. [PubMed: 11431429]  [MGI Ref ID J:70248]

Mata NL; Weng J; Travis GH. 2000. Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration. Proc Natl Acad Sci U S A 97(13):7154-9. [PubMed: 10852960]  [MGI Ref ID J:62911]

Nociari MM; Lehmann GL; Perez Bay AE; Radu RA; Jiang Z; Goicochea S; Schreiner R; Warren JD; Shan J; Adam de Beaumais S; Menand M; Sollogoub M; Maxfield FR; Rodriguez-Boulan E. 2014. Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium. Proc Natl Acad Sci U S A 111(14):E1402-8. [PubMed: 24706818]  [MGI Ref ID J:208628]

Okano K; Maeda A; Chen Y; Chauhan V; Tang J; Palczewska G; Sakai T; Tsuneoka H; Palczewski K; Maeda T. 2012. Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light-induced damage. J Neurochem 121(1):146-56. [PubMed: 22220722]  [MGI Ref ID J:184334]

Pawar AS; Qtaishat NM; Little DM; Pepperberg DR. 2008. Recovery of rod photoresponses in ABCR-deficient mice. Invest Ophthalmol Vis Sci 49(6):2743-55. [PubMed: 18263807]  [MGI Ref ID J:136885]

Qtaishat NM; Pepperberg DR. 2007. Preservation of retinoid influx into eye tissues of ABCR-deficient mice. Curr Eye Res 32(12):1073-82. [PubMed: 18085472]  [MGI Ref ID J:130834]

Radu RA; Hu J; Yuan Q; Welch DL; Makshanoff J; Lloyd M; McMullen S; Travis GH; Bok D. 2011. Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration. J Biol Chem 286(21):18593-601. [PubMed: 21464132]  [MGI Ref ID J:173786]

Radu RA; Mata NL; Bagla A; Travis GH. 2004. Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration. Proc Natl Acad Sci U S A 101(16):5928-33. [PubMed: 15067110]  [MGI Ref ID J:89615]

Radu RA; Yuan Q; Hu J; Peng JH; Lloyd M; Nusinowitz S; Bok D; Travis GH. 2008. Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation. Invest Ophthalmol Vis Sci 49(9):3821-9. [PubMed: 18515570]  [MGI Ref ID J:141801]

Shiose S; Chen Y; Okano K; Roy S; Kohno H; Tang J; Pearlman E; Maeda T; Palczewski K; Maeda A. 2011. Toll-like Receptor 3 Is Required for Development of Retinopathy Caused by Impaired All-trans-retinal Clearance in Mice. J Biol Chem 286(17):15543-55. [PubMed: 21383019]  [MGI Ref ID J:172084]

Wu Y; Fishkin NE; Pande A; Pande J; Sparrow JR. 2009. Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease. J Biol Chem 284(30):20155-66. [PubMed: 19478335]  [MGI Ref ID J:152624]

Yamamoto K; Yoon KD; Ueda K; Hashimoto M; Sparrow JR. 2011. A novel bisretinoid of retina is an adduct on glycerophosphoethanolamine. Invest Ophthalmol Vis Sci 52(12):9084-90. [PubMed: 22039245]  [MGI Ref ID J:191397]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX18

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, homozygous mice may be bred together.
Mating SystemWild-type x Heterozygote         (Female x Male)   26-NOV-13
Heterozygote x Wild-type         (Female x Male)   26-NOV-13

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $232.00Female or MaleHeterozygous for Abca4tm1Ght  
$232.00Female or MaleHomozygous for Abca4tm1Ght  
Price per Pair (US dollars $)Pair Genotype
$464.00Heterozygous for Abca4tm1Ght x Heterozygous for Abca4tm1Ght  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $301.60Female or MaleHeterozygous for Abca4tm1Ght  
$301.60Female or MaleHomozygous for Abca4tm1Ght  
Price per Pair (US dollars $)Pair Genotype
$603.20Heterozygous for Abca4tm1Ght x Heterozygous for Abca4tm1Ght  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   002448 129S1/SvImJ (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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