Strain Name:

NOD.Cg-Stat4tm1Gru Thy1a Ifngr1tm1Agt Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/LmbrJ

Stock Number:

024476

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Availability:

Under Development - Now Accepting Orders

Estimated Available for Distribution Date: 10-NOV-14
Use Restrictions Apply, see Terms of Use
These mutant mice carry Stat4 and Ifngr1 knock out alleles, the Tg(TcraBDC2.5,TcrbBDC2.5)1Doi and Thy1a, and are defective in generation of Th1 cells. This strain has applications in studies of Type 1 diabetes and for adoptive transfer studies.

Description

Strain Information

Type Variant Allele;
Type Congenic; Mutant Strain; Targeted Mutation; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygotes for the Stat4tm1Gru, Thy1a, and Ifngr1tm1Agt alleles and hemizygous for the Tg(TcraBDC2.5,TcrbBDC2.5)1Doi transgene x these mice can be bred as homozygotes for the Stat4tm1Gru, Thy1a, and Ifngr1tm1Agt alleles and wildtype for the Tg(TcraBDC2.5,TcrbBDC2.5)1Doi transgene and reciprocal
Specieslaboratory mouse
 
Donating Investigator Linda M Bradley,   Sanford Burnham Medical Research Institute

Description
These mice are homozygous for the Stat4tm1Gru, Thy1a Ifngr1tm1Agt targeted mutation alleles, homozygous for the Thy1a spontaneous mutation allele and hemizygous for the Tg(TcraBDC2.5,TcrbBDC2.5)1Doi transgene. Unable to respond to IL12 and IFNgamma, the mutant mice are defective in generation of Th1 cells.

Development
Homozygote NOD.129S2-Stat4tm1Gru/JbsJ (Stock No. 004671) mice, homozygote NOD.NON-Thy1/1LtJ (Stock No. 004483) mice, mice on the NOD background homozygous for the Ifngr1tm1Agt allele and mice on the NOD background hemizygous for the Tg(TcraBDC2.5,TcrbBDC2.5)1Doi transgene were bred together to generate this mutant strain.

Control Information

  Control
   001976 NOD/ShiLtJ (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Ifngr1tm1Agt allele
002702   129-Ifngr1tm1Agt/J
003288   B6.129S7-Ifngr1tm1Agt/J
007077   CByJ.129S7(B6)-Ifngr1tm1Agt/J
View Strains carrying   Ifngr1tm1Agt     (3 strains)

Strains carrying   Stat4tm1Gru allele
003750   C.129S2-Stat4tm1Gru Stat6tm1Gru/J
002826   C.129S2-Stat4tm1Gru/J
004671   NOD.129S2-Stat4tm1Gru/JbsJ
View Strains carrying   Stat4tm1Gru     (3 strains)

View Strains carrying   Thy1a     (18 strains)

Strains carrying   Tg(TcraBDC2.5,TcrbBDC2.5)1Doi allele
004460   NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/DoiJ
View Strains carrying   Tg(TcraBDC2.5,TcrbBDC2.5)1Doi     (1 strain)

Strains carrying other alleles of Ifngr1
025394   C57BL/6N-Ifngr1tm1.1Rds/J
025545   C57BL/6N-Ifngr1tm1.2Rds/J
View Strains carrying other alleles of Ifngr1     (2 strains)

Strains carrying other alleles of Tcra
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
003199   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J
002116   B6.129S2-Tcratm1Mom/J
022073   B6.Cg-Rag1tm1Mom Thy1a Tg(Tcra2C,Tcrb2C)1Dlo/J
008684   B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J
014550   B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
005655   B6.Cg-Tg(Tcra,Tcrb)3Ayr/J
008428   B6.Cg-Tg(Tcra,Tcrb)HRCAll/J
008429   B6.Cg-Tg(Tcra,Tcrb)HRVAll/J
008006   B6.Cg-Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/J
004194   B6.Cg-Tg(TcraTcrb)425Cbn/J
005236   B6.Cg-Tg(TcraY1,TcrbY1)416Tev/J
004554   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRaAI4)1Dvs/DvsJ
002115   B6;129S2-Tcratm1Mom/J
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
002408   B6;SJL-Tg(TcrAND)53Hed/J
007848   BXSB.129P2(Cg)-Tcratm1Mjo/TheoJ
021880   BXSB.B6-Tg(TcraTcrb)1100Mjb/DcrJ
004364   C.Cg-Tcratm1Mom Tcrbtm1Mom/J
003303   C.Cg-Tg(DO11.10)10Dlo/J
002045   C.SJL-Tcrac/SlkJ
002047   C.SJL-Tcrba Tcrac/SlkJ
014639   C57BL/6-Tg(Cd4-TcraDN32D3)1Aben/J
011005   C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/J
006912   C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J
003831   C57BL/6-Tg(TcraTcrb)1100Mjb/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
005694   D1Lac.Cg-Tg(Tcra,Tcrb)24Efro/J
017314   NOD-Tg(TcraTcrb)2H6Lwn/J
004444   NOD.129P2(C)-Tcratm1Mjo/DoiJ
006436   NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcraAI4)1Dvs/DvsJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/DvsJ
004347   NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs/DvsJ
009377   NOD.Cg-Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse/J
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004696   NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
010526   NOD.Cg-Tg(TcraTcrbNY4.1)1Pesa/DvsJ
005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006303   NOD.FVB-Tg(TcraBDC12-4.1)10Jos/GseJ
004334   NOD/ShiLt-Tg(TcraAI4)1Dvs
018030   SJL.Cg-Tg(TcraTcrbVP2)1Bkim/J
002597   STOCK Tg(TcrHEL3A9)1Mmd/J
View Strains carrying other alleles of Tcra     (47 strains)

Strains carrying other alleles of Tcrb
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
003200   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRB)C14Jg/J
002122   B6.129P2-Tcrbtm1Mom Tcrdtm1Mom/J
002118   B6.129P2-Tcrbtm1Mom/J
022073   B6.Cg-Rag1tm1Mom Thy1a Tg(Tcra2C,Tcrb2C)1Dlo/J
008684   B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J
014550   B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
005655   B6.Cg-Tg(Tcra,Tcrb)3Ayr/J
008428   B6.Cg-Tg(Tcra,Tcrb)HRCAll/J
008429   B6.Cg-Tg(Tcra,Tcrb)HRVAll/J
008006   B6.Cg-Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/J
004194   B6.Cg-Tg(TcraTcrb)425Cbn/J
005236   B6.Cg-Tg(TcraY1,TcrbY1)416Tev/J
008430   B6.Cg-Tg(Tcrb)HRBAll/J
004555   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRbAI4)1Dvs/DvsJ
002121   B6;129P-Tcrbtm1Mom Tcrdtm1Mom/J
002117   B6;129P2-Tcrbtm1Mom/J
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
002408   B6;SJL-Tg(TcrAND)53Hed/J
021880   BXSB.B6-Tg(TcraTcrb)1100Mjb/DcrJ
004364   C.Cg-Tcratm1Mom Tcrbtm1Mom/J
003303   C.Cg-Tg(DO11.10)10Dlo/J
002047   C.SJL-Tcrba Tcrac/SlkJ
002046   C.SJL-Tcrba/SlkJ
011005   C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/J
006912   C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J
003831   C57BL/6-Tg(TcraTcrb)1100Mjb/J
003540   C57L/J-Tg(Tcrb)93Vbo/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
007081   CByJ.129P2(B6)-Tcrbtm1Mom/J
005694   D1Lac.Cg-Tg(Tcra,Tcrb)24Efro/J
017314   NOD-Tg(TcraTcrb)2H6Lwn/J
023082   NOD.129P2(Cg)-Tcrbtm1Mom/MnkaJ
006437   NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcrbAI4)1Dvs/DvsJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/DvsJ
009377   NOD.Cg-Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse/J
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004696   NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
010526   NOD.Cg-Tg(TcraTcrbNY4.1)1Pesa/DvsJ
005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006304   NOD.FVB-Tg(TcrbBDC12-4.1)82Gse/GseJ
004335   NOD/ShiLt-Tg(TcrbAI4)1Dvs
018030   SJL.Cg-Tg(TcraTcrbVP2)1Bkim/J
002597   STOCK Tg(TcrHEL3A9)1Mmd/J
View Strains carrying other alleles of Tcrb     (49 strains)

Strains carrying other alleles of Thy1
017798   B6.Cg-Mapttm1Hnd Tg(Thy1-MAPT*)3610Gds/Mmjax
009126   B6.Cg-Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
008730   B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
007901   B6.Cg-Tg(Thy1-Brainbow1.0)HLich/J
007911   B6.Cg-Tg(Thy1-Brainbow1.1)MLich/J
007921   B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J
003710   B6.Cg-Tg(Thy1-CFP)23Jrs/J
014131   B6.Cg-Tg(Thy1-CFP)IJrs/GfngJ
007940   B6.Cg-Tg(Thy1-CFP/COX8A)C1Lich/J
007967   B6.Cg-Tg(Thy1-CFP/COX8A)S2Lich/J
012597   B6.Cg-Tg(Thy1-COL25A1)861Yfu/J
007612   B6.Cg-Tg(Thy1-COP4/EYFP)18Gfng/J
007615   B6.Cg-Tg(Thy1-COP4/EYFP)9Gfng/J
013161   B6.Cg-Tg(Thy1-Clomeleon)1Gjau/J
007919   B6.Cg-Tg(Thy1-EGFP)OJrs/GfngJ
005630   B6.Cg-Tg(Thy1-EYFP)15Jrs/J
009611   B6.Cg-Tg(Thy1-Nlgn1)6Hnes/J
009612   B6.Cg-Tg(Thy1-Nlgn2)6Hnes/J
021069   B6.Cg-Tg(Thy1-PA-GFP)5Rmpl/J
021070   B6.Cg-Tg(Thy1-PA-GFP)6Rmpl/J
003709   B6.Cg-Tg(Thy1-YFP)16Jrs/J
003782   B6.Cg-Tg(Thy1-YFP)HJrs/J
005627   B6.Cg-Tg(Thy1-YFP/Syp)10Jrs/J
007606   B6.Cg-Tg(Thy1-cre/ERT2,-EYFP)AGfng/J
004807   B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax
007910   B6;CBA-Tg(Thy1-Brainbow1.0)LLich/J
011070   B6;CBA-Tg(Thy1-EGFP)SJrs/NdivJ
017892   B6;CBA-Tg(Thy1-GCaMP2.2c)8Gfng/J
017893   B6;CBA-Tg(Thy1-GCaMP3)6Gfng/J
014130   B6;CBA-Tg(Thy1-YFP)GJrs/GfngJ
014651   B6;CBA-Tg(Thy1-spH)21Vnmu/J
015814   B6;CBA-Tg(Thy1-spH)64Vnmu/FrkJ
012341   B6;SJL-Tg(Thy1-COP3/EYFP)1Gfng/J
012344   B6;SJL-Tg(Thy1-COP3/EYFP)4Gfng/J
012348   B6;SJL-Tg(Thy1-COP3/EYFP)8Gfng/J
012350   B6;SJL-Tg(Thy1-COP4*H134R/EYFP)20Gfng/J
008004   B6;SJL-Tg(Thy1-ECFP/VAMP2)1Sud/J
012836   B6;SJL-Tg(Thy1-TARDBP)4Singh/J
007610   B6;SJL-Tg(Thy1-cre/ERT2,-EYFP)VGfng/J
012332   B6;SJL-Tg(Thy1-hop/EYFP)2Gfng/J
012334   B6;SJL-Tg(Thy1-hop/EYFP)4Gfng/J
006554   B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
017590   B6SJL-Tg(Thy1-DCTN1*G59S)M2Pcw/J
007880   B6SJL-Tg(Thy1-Stx1a/EYFP)1Sud/J
007856   B6SJL-Tg(Thy1-Syt1/ECFP)1Sud/J
017589   B6SJL-Tg(Thy1-TARDBP*G298S)S97Pcw/J
024703   C3A.Cg-Pde6b+Tg(Thy1-CFP)23Jrs/SjJ
007027   C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
010800   C57BL/6-Tg(Thy1-PTGS2)300Kand/J
010703   C57BL/6-Tg(Thy1-PTGS2)303Kand/J
012769   C57BL/6-Tg(Thy1-Sncg)HvP36Putt/J
024339   C57BL/6J-Tg(Thy1-GCaMP6f)GP5.11Dkim/J
025393   C57BL/6J-Tg(Thy1-GCaMP6f)GP5.17Dkim/J
024276   C57BL/6J-Tg(Thy1-GCaMP6f)GP5.5Dkim/J
024275   C57BL/6J-Tg(Thy1-GCaMP6s)GP4.3Dkim/J
025533   C57BL/6N-Sncatm1Mjff Tg(Thy1-SNCA)15Mjff/J
016936   C57BL/6N-Tg(Thy1-SNCA)12Mjff/J
017682   C57BL/6N-Tg(Thy1-SNCA)15Mjff/J
024704   D2.Cg-Gpnmb+Tg(Thy1-CFP)23Jrs/SjJ
025018   D2.Cg-Gpnmb+Tg(Thy1-YFP)HJrs/SjJ
018671   D2.Cg-Tg(Thy1-CFP)23Jrs/SjJ
024705   D2.Cg-Tg(Thy1-YFP)HJrs/SjJ
025019   D2.Cg-Tg(Thy1-YFP/Syp)10Jrs/SjJ
008230   FVB(Cg)-Tg(Thy1-SOD1*G93A)T3Hgrd/J
006143   FVB/N-Tg(Thy1-cre)1Vln/J
021226   STOCK Tg(Thy1-Brainbow3.1)18Jrs/J
021225   STOCK Tg(Thy1-Brainbow3.1)3Jrs/J
021227   STOCK Tg(Thy1-Brainbow3.2)7Jrs/J
013162   STOCK Tg(Thy1-Clomeleon)12Gjau/J
013163   STOCK Tg(Thy1-Clomeleon)13Gjau/J
007788   STOCK Tg(Thy1-EGFP)MJrs/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
View Strains carrying other alleles of Thy1     (72 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Atypical Mycobacteriosis, Familial   (IFNGR1)
Helicobacter Pylori Infection, Susceptibility to   (IFNGR1)
Hepatitis B Virus, Susceptibility to   (IFNGR1)
Mycobacterium Tuberculosis, Susceptibility to   (IFNGR1)
Systemic Lupus Erythematosus, Susceptibility to, 11; SLEB11   (STAT4)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Type 1 Diabetes (IDDM)

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      Type 1 Diabetes

Ifngr1tm1Agt related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Stat4tm1Gru related
Immunodeficiency
Intracellular Signaling Molecules
Thy1a related
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Research Tools
Genetics Research
      Tissue/Cell Markers
      Tissue/Cell Markers: T cell specific surface marker
Immunology, Inflammation and Autoimmunity Research
      T cell specific surface marker

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ifngr1tm1Agt
Allele Name targeted mutation 1, Michel Aguet
Allele Type Targeted (Null/Knockout)
Common Name(s) G129; IFN-gamma R-; IFN-gamma R0; IFN-gamma-R KO; IFN-gammaR KO; IFN-gammaR-; IFN-gammaR1-; IFN-gammaR0; IFN-gammaRalpha_; IFNgR KO; IFNgammaR KO; IFn type II receptor; Ifngr-; Ifngr1-;
Mutation Made ByDr. Michel Aguet,   Swiss Inst. for Experimental Cancer Res.
Strain of Origin129S7/SvEvBrd-Hprt<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt<+>
Gene Symbol and Name Ifngr1, interferon gamma receptor 1
Chromosome 10
Gene Common Name(s) CD119; IFN-gamma R; IFN-gammaR; IFNGR; Ifgr; Nktar;
Molecular Note Insertion of a neomycin cassette into exon V, which encodes an extracellular membrane-proximal portion of the receptor. [MGI Ref ID J:61321] [MGI Ref ID J:63815] [MGI Ref ID J:96036]
 
Allele Symbol Stat4tm1Gru
Allele Name targeted mutation 1, Michael J Grusby
Allele Type Targeted (Null/Knockout)
Common Name(s) Stat4-;
Mutation Made ByDr. Michael Grusby,   Harvard Medical School
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Stat4, signal transducer and activator of transcription 4
Chromosome 1
Gene Common Name(s) SLEB11;
Molecular Note The exon encoding amino acids 263 through 314 was disrupted by the insertion of a neomycin selection cassette. The encoded protein was undetectable in the thymi and lymph nodes of homozygous mutant mice by immunoblot analysis. [MGI Ref ID J:34059]
 
Allele Symbol Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
Allele Name transgene insertion 1, Christophe Benoist
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) BDC-2.5/N TCR Tg; BDC2.5; Tg(TcraBDC2.5)2Doi; Tg(TcrbBDC2.5)2Doi;
Strain of Origin(C57BL/6 x SJL)F2
Expressed Gene Tcra, T cell receptor alpha chain, mouse, laboratory
Expressed Gene Tcrb, T cell receptor beta chain, mouse, laboratory
Promoter Tcra, T cell receptor alpha chain, mouse, laboratory
Promoter Tcrb, T cell receptor beta chain, mouse, laboratory
Molecular Note This transgene results from the coinjection of two constructs derived from diabetogenic T-cell clone BDC2.5. The Tcra construct contains a rearranged Tcra sequence (V alpha J alpha) that begins 20 bp 5' of the ATG site and ends 30 bp 3' of the splice donor sequence of J alpha 17. The 6.5 Tcrb construct contains rearranged Tcrb sequence (V beta D beta J beta) flanked by 2 kb of 5' regulatory sequences and 3.5 kb of 3' DNA containing the unrearranged J beta 1.3 to J beta 1.6 sequences, and precedes a 12 kb sequence containing the C beta 2 region. [MGI Ref ID J:77007]
 
 
 
Allele Symbol Thy1a
Allele Name a variant
Allele Type Not Applicable
Common Name(s) Thy-1.1; Thy1.1; Thy1a; theta-AKR; thetaAKR;
Site of ExpressionThe Thy1 locus determines a surface antigen present on cells of the thymus, a number of mouse leukemias, brain, and in lesser amounts on lymph node and spleen cells.
Gene Symbol and Name Thy1, thymus cell antigen 1, theta
Chromosome 9
Gene Common Name(s) CD7; CD90; T25; Thy 1.2; Thy-1; Thy-1.2; Thy1.1; Thy1.2; theta;
General Note

The Thy1 locus determines a surface antigen present on cells of the thymus, a number of mouse leukemias, brain, and in lesser amounts on lymph node and spleen cells. The allele Thy1a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains; the allele Thy1b determines an antigenic specificity, Thy-1.2, found in the C3HeB/Fe and many other strains (J:5243, J:5012, J:4469). The Thy1 antigen is probably present on all T lymphocytes and absent from all B lymphocytes, and it thus serves as a valuable T-cell marker (J:5243). It is very widely used in experiments designed to determine the distribution and function of T-cells. Thy1 specifies a T-cell surface glycoprotein, T25, with a molecular weight of 25 kDa (J:5707). The protein appears to be anchored in the cell membrane by a lipid that is either phosphotidylinositol or closely related to it (J:12016). Thy1 may function in the cell membrane as a signal transduction molecule (J:8333). The Thy1 locus, or possibly a gene closely linked to it, controls quantitative expression of a protein that isthe same size as Thy1 and is expressed on thymus and brain but not on lymph node and spleen cells (J:7900).

Molecular Note The allele Thy1a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains.

Genotyping

Genotyping Information

Genotyping Protocols

Ifngr1tm1Agt, High Resolution Melting
Stat4tm1Gru, Melt Curve Analysis
Tg(TcraBDC2.5)1Doi, Tg(TcrbBDC2.5)2Doi, Melt Curve Analysis
Thy1aEnd Point, End Point Analysis


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Christianson SW; Shultz LD; Leiter EH. 1993. Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors. Diabetes 42(1):44-55. [PubMed: 8093606]  [MGI Ref ID J:34990]

Huang S; Hendriks W; Althage A; Hemmi S; Bluethmann H; Kamijo R; Vilcek J; Zinkernagel RM; Aguet M. 1993. Immune response in mice that lack the interferon-gamma receptor [see comments] Science 259(5102):1742-5. [PubMed: 8456301]  [MGI Ref ID J:63815]

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Thy1a related

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Mori Y; Kodaka T; Kato T; Kanagawa EM; Kanagawa O. 2009. Critical role of IFN-gamma in CFA-mediated protection of NOD mice from diabetes development. Int Immunol 21(11):1291-9. [PubMed: 19778991]  [MGI Ref ID J:154177]

Pang S; Zhang L; Wang H; Yi Z; Li L; Gao L; Zhao J; Tisch R; Katz JD; Wang B. 2009. CD8(+) T cells specific for beta cells encounter their cognate antigens in the islets of NOD mice. Eur J Immunol 39(10):2716-24. [PubMed: 19658094]  [MGI Ref ID J:153282]

Parsa R; Andresen P; Gillett A; Mia S; Zhang XM; Mayans S; Holmberg D; Harris RA. 2012. Adoptive transfer of immunomodulatory M2 macrophages prevents type 1 diabetes in NOD mice. Diabetes 61(11):2881-92. [PubMed: 22745325]  [MGI Ref ID J:208522]

Pauken KE; Jenkins MK; Azuma M; Fife BT. 2013. PD-1, but not PD-L1, expressed by islet-reactive CD4+ T cells suppresses infiltration of the pancreas during type 1 diabetes. Diabetes 62(8):2859-69. [PubMed: 23545706]  [MGI Ref ID J:208973]

Perone MJ; Bertera S; Tawadrous ZS; Shufesky WJ; Piganelli JD; Baum LG; Trucco M; Morelli AE. 2006. Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice. J Immunol 177(8):5278-89. [PubMed: 17015713]  [MGI Ref ID J:139444]

Phillips JM; Parish NM; Drage M; Cooke A. 2001. Cutting edge: interactions through the IL-10 receptor regulate autoimmune diabetes. J Immunol 167(11):6087-91. [PubMed: 11714766]  [MGI Ref ID J:119045]

Raine T; Zaccone P; Mastroeni P; Cooke A. 2006. Salmonella typhimurium infection in nonobese diabetic mice generates immunomodulatory dendritic cells able to prevent type 1 diabetes. J Immunol 177(4):2224-33. [PubMed: 16887982]  [MGI Ref ID J:138394]

Rivas EI; Driver JP; Garabatos N; Presa M; Mora C; Rodriguez F; Serreze DV; Stratmann T. 2011. Targeting of a T cell agonist Peptide to lysosomes by DNA vaccination induces tolerance in the nonobese diabetic mouse. J Immunol 186(7):4078-87. [PubMed: 21346228]  [MGI Ref ID J:170837]

Rosmalen JG; Martin T; Dobbs C; Voerman JS; Drexhage HA; Haskins K; Leenen PJ. 2000. Subsets of macrophages and dendritic cells in nonobese diabetic mouse pancreatic inflammatory infiltrates: correlation with the development of diabetes. Lab Invest 80(1):23-30. [PubMed: 10652999]  [MGI Ref ID J:59988]

Ruan Q; Kameswaran V; Zhang Y; Zheng S; Sun J; Wang J; DeVirgiliis J; Liou HC; Beg AA; Chen YH. 2011. The Th17 immune response is controlled by the Rel-RORgamma-RORgamma T transcriptional axis. J Exp Med 208(11):2321-33. [PubMed: 22006976]  [MGI Ref ID J:178764]

Saxena V; Ondr JK; Magnusen AF; Munn DH; Katz JD. 2007. The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse. J Immunol 179(8):5041-53. [PubMed: 17911589]  [MGI Ref ID J:137009]

Sgouroudis E; Albanese A; Piccirillo CA. 2008. Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice. J Immunol 181(9):6283-92. [PubMed: 18941219]  [MGI Ref ID J:140729]

Shi FD; Flodstrom M; Balasa B; Kim SH; Van Gunst K; Strominger JL; Wilson SB; Sarvetnick N. 2001. Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse. Proc Natl Acad Sci U S A 98(12):6777-82. [PubMed: 11390999]  [MGI Ref ID J:69908]

Simoni Y; Gautron AS; Beaudoin L; Bui LC; Michel ML; Coumoul X; Eberl G; Leite-de-Moraes M; Lehuen A. 2011. NOD mice contain an elevated frequency of iNKT17 cells that exacerbate diabetes. Eur J Immunol 41(12):3574-85. [PubMed: 22002883]  [MGI Ref ID J:179619]

Stadinski BD; Delong T; Reisdorph N; Reisdorph R; Powell RL; Armstrong M; Piganelli JD; Barbour G; Bradley B; Crawford F; Marrack P; Mahata SK; Kappler JW; Haskins K. 2010. Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol 11(3):225-31. [PubMed: 20139986]  [MGI Ref ID J:158628]

Suwanai H; Wilcox MA; Mathis D; Benoist C. 2010. A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice. Proc Natl Acad Sci U S A 107(20):9305-10. [PubMed: 20439722]  [MGI Ref ID J:160284]

Tarbell KV; Petit L; Zuo X; Toy P; Luo X; Mqadmi A; Yang H; Suthanthiran M; Mojsov S; Steinman RM. 2007. Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J Exp Med 204(1):191-201. [PubMed: 17210729]  [MGI Ref ID J:125329]

Thomas HE; Irawaty W; Darwiche R; Brodnicki TC; Santamaria P; Allison J; Kay TW. 2004. IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse. Diabetes 53(1):113-121. [PubMed: 14693705]  [MGI Ref ID J:87251]

Tonkin DR; Haskins K. 2009. Regulatory T cells enter the pancreas during suppression of type 1 diabetes and inhibit effector T cells and macrophages in a TGF-beta-dependent manner. Eur J Immunol 39(5):1313-22. [PubMed: 19404982]  [MGI Ref ID J:148088]

Tritt M; Sgouroudis E; d'Hennezel E; Albanese A; Piccirillo CA. 2008. Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes. Diabetes 57(1):113-23. [PubMed: 17928397]  [MGI Ref ID J:132415]

Tsai S; Serra P; Clemente-Casares X; Slattery RM; Santamaria P. 2013. Dendritic cell-dependent in vivo generation of autoregulatory T cells by antidiabetogenic MHC class II. J Immunol 191(1):70-82. [PubMed: 23740949]  [MGI Ref ID J:205347]

Tsui H; Chan Y; Tang L; Winer S; Cheung RK; Paltser G; Selvanantham T; Elford AR; Ellis JR; Becker DJ; Ohashi PS; Dosch HM. 2008. Targeting of pancreatic glia in type 1 diabetes. Diabetes 57(4):918-28. [PubMed: 18198358]  [MGI Ref ID J:135214]

Turley SJ; Lee JW; Dutton-Swain N; Mathis D; Benoist C. 2005. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci U S A 102(49):17729-33. [PubMed: 16317068]  [MGI Ref ID J:104385]

Ueno A; Cho S; Cheng L; Wang J; Hou S; Nakano H; Santamaria P; Yang Y. 2007. Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes. Diabetes 56(6):1686-93. [PubMed: 17360980]  [MGI Ref ID J:126514]

Vaitaitis GM; Carter JR; Waid DM; Olmstead MH; Wagner DH Jr. 2013. An alternative role for Foxp3 as an effector T cell regulator controlled through CD40. J Immunol 191(2):717-25. [PubMed: 23776180]  [MGI Ref ID J:205447]

Vence L; Benoist C; Mathis D. 2004. Fas deficiency prevents type 1 diabetes by inducing hyporesponsiveness in islet beta-cell-reactive T-cells. Diabetes 53(11):2797-803. [PubMed: 15504959]  [MGI Ref ID J:108733]

Wagner DH Jr; Vaitaitis G; Sanderson R; Poulin M; Dobbs C; Haskins K. 2002. Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes. Proc Natl Acad Sci U S A 99(6):3782-7. [PubMed: 11891296]  [MGI Ref ID J:126524]

Waldner H; Sobel RA; Price N; Kuchroo VK. 2006. The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells. J Immunol 176(9):5455-62. [PubMed: 16622013]  [MGI Ref ID J:131655]

Wallet MA; Flores RR; Wang Y; Yi Z; Kroger CJ; Mathews CE; Earp HS; Matsushima G; Wang B; Tisch R. 2009. MerTK regulates thymic selection of autoreactive T cells. Proc Natl Acad Sci U S A 106(12):4810-5. [PubMed: 19251650]  [MGI Ref ID J:147153]

Wallet MA; Sen P; Flores RR; Wang Y; Yi Z; Huang Y; Mathews CE; Earp HS; Matsushima G; Wang B; Tisch R. 2008. MerTK is required for apoptotic cell-induced T cell tolerance. J Exp Med 205(1):219-32. [PubMed: 18195070]  [MGI Ref ID J:131291]

Wan X; Guloglu FB; VanMorlan AM; Rowland LM; Jain R; Haymaker CL; Cascio JA; Dhakal M; Hoeman CM; Tartar DM; Zaghouani H. 2012. Mechanisms underlying antigen-specific tolerance of stable and convertible Th17 cells during suppression of autoimmune diabetes. Diabetes 61(8):2054-65. [PubMed: 22751698]  [MGI Ref ID J:208518]

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Wang J; Cho S; Ueno A; Cheng L; Xu BY; Desrosiers MD; Shi Y; Yang Y. 2008. Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation. J Immunol 181(4):2438-45. [PubMed: 18684934]  [MGI Ref ID J:140188]

Wei J; Loke P; Zang X; Allison JP. 2011. Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity. J Exp Med 208(8):1683-94. [PubMed: 21727190]  [MGI Ref ID J:177612]

Wen L; Wong FS; Sherwin R; Mora C. 2002. Human DQ8 can substitute for murine I-A(g7) in the selection of diabetogenic T cells restricted to I-A(g71). J Immunol 168(7):3635-40. [PubMed: 11907129]  [MGI Ref ID J:75571]

Wills-Karp M; Rani R; Dienger K; Lewkowich I; Fox JG; Perkins C; Lewis L; Finkelman FD; Smith DE; Bryce PJ; Kurt-Jones EA; Wang TC; Sivaprasad U; Hershey GK; Herbert DR. 2012. Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection. J Exp Med 209(3):607-22. [PubMed: 22329990]  [MGI Ref ID J:182513]

Xiang Y; Peng J; Tai N; Hu C; Zhou Z; Wong FS; Wen L. 2012. The dual effects of B cell depletion on antigen-specific T cells in BDC2.5NOD mice. J Immunol 188(10):4747-58. [PubMed: 22490442]  [MGI Ref ID J:188690]

Yadav D; Judkowski V; Flodstrom-Tullberg M; Sterling L; Redmond WL; Sherman L; Sarvetnick N. 2004. B7-2 (CD86) controls the priming of autoreactive CD4 T cell response against pancreatic islets. J Immunol 173(6):3631-9. [PubMed: 15356107]  [MGI Ref ID J:92756]

Yi W; Seth NP; Martillotti T; Wucherpfennig KW; Sant'Angelo DB; Denzin LK. 2010. Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence. J Clin Invest 120(4):1324-36. [PubMed: 20200448]  [MGI Ref ID J:159696]

Yi Z; Diz R; Martin AJ; Morillon YM; Kline DE; Li L; Wang B; Tisch R. 2012. Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies. Diabetes 61(11):2871-80. [PubMed: 22751694]  [MGI Ref ID J:208520]

Yi Z; Li L; Garland A; He Q; Wang H; Katz JD; Tisch R; Wang B. 2012. IFN-gamma receptor deficiency prevents diabetes induction by diabetogenic CD4+, but not CD8+, T cells. Eur J Immunol 42(8):2010-8. [PubMed: 22865049]  [MGI Ref ID J:187880]

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Zou L; Mendez F; Martin-Orozco N; Peterson EJ. 2008. Defective positive selection results in T cell lymphopenia and increased autoimmune diabetes in ADAP-deficient BDC2.5-C57BL/6 mice. Eur J Immunol 38(4):986-94. [PubMed: 18383041]  [MGI Ref ID J:133782]

Health & husbandry

Health & Colony Maintenance Information

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice can be bred as homozygotes for the Stat4tm1Gru, Thy1a, and Ifngr1tm1Agt alleles and hemizygous for the Tg(TcraBDC2.5,TcrbBDC2.5)1Doi transgene.
Mating SystemHomozygotes for the Stat4tm1Gru, Thy1a, and Ifngr1tm1Agt alleles and hemizygous for the Tg(TcraBDC2.5,TcrbBDC2.5)1Doi transgene x these mice can be bred as homozygotes for the Stat4tm1Gru, Thy1a, and Ifngr1tm1Agt alleles and wildtype for the Tg(TcraBDC2.5,TcrbBDC2.5)1Doi transgene and reciprocal

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


 

This strain is currently Under Development - Now Accepting Orders.
Estimated Available for Distribution Date: 10-NOV-14

Please note: You may now place orders for this strain although it is not yet ready for distribution. Estimated available for distribution dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for distribution depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain.

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $232.00Female or MaleHomozygous for Stat4tm1Gru, Homozygous for Thy1a, Homozygous for Ifngr1tm1Agt, Hemizygous for Tg(TcraBDC2.5,TcrbBDC2.5)1Doi  
$232.00Female or MaleHomozygous for Stat4tm1Gru, Homozygous for Thy1a, Homozygous for Ifngr1tm1Agt, Noncarrier  
Price per Pair (US dollars $)Pair Genotype
$464.00Homozygous for Stat4tm1Gru Homozygous for Thy1a Homozygous for Ifngr1tm1Agt Noncarrier x Homozygous for Stat4tm1Gru Homozygous for Thy1a Homozygous for Ifngr1tm1Agt Hemizygous for Tg(TcraBDC2.5,TcrbBDC2.5)1Doi  

Standard Supply

Under Development - Now Accepting Orders The strain development process (i.e. importation, rederivation, and colony expansion) usually takes six to nine months.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $301.60Female or MaleHomozygous for Stat4tm1Gru, Homozygous for Thy1a, Homozygous for Ifngr1tm1Agt, Hemizygous for Tg(TcraBDC2.5,TcrbBDC2.5)1Doi  
$301.60Female or MaleHomozygous for Stat4tm1Gru, Homozygous for Thy1a, Homozygous for Ifngr1tm1Agt, Noncarrier  
Price per Pair (US dollars $)Pair Genotype
$603.20Homozygous for Stat4tm1Gru Homozygous for Thy1a Homozygous for Ifngr1tm1Agt Noncarrier x Homozygous for Stat4tm1Gru Homozygous for Thy1a Homozygous for Ifngr1tm1Agt Hemizygous for Tg(TcraBDC2.5,TcrbBDC2.5)1Doi  

Standard Supply

Under Development - Now Accepting Orders The strain development process (i.e. importation, rederivation, and colony expansion) usually takes six to nine months.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Under Development - Now Accepting Orders The strain development process (i.e. importation, rederivation, and colony expansion) usually takes six to nine months.

General Supply Notes

Control Information

  Control
   001976 NOD/ShiLtJ (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use


General Terms and Conditions


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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

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