Strain Name:

FVB.129S6(Cg)-Foxo1tm1Rdp/J

Stock Number:

024756

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Availability:

Repository- Live

Foxo1L/L floxed mice may be useful for studying the regulatory role of the FOXO1 transcription factor on insulin signaling, glucose production and tumor suppression.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHeterozygote x Heterozygote         (Female x Male)   21-APR-14
Specieslaboratory mouse
GenerationN3+pN1 (30-JUN-14)
Generation Definitions
 
Donating InvestigatorDr. Ronald DePinho,   MD Anderson Cancer Center

Description
These Foxo1L/L mutant mice possess loxP sites flanking exon 2 of the forkhead box O1 (Foxo1) gene. FOXO1 is a transcription factor which mediates the transcription of glucose-6-phosphatase, leading to gluconeogenesis and adipogenesis. FOXO1 is involved in the regulation of insulin signaling and metabolic homeostasis, and has been shown to be a tumor suppressor. Mice that are homozygous for this allele are viable and fertile. When these mutant mice are bred to mice that express Cre recombinase, the resulting offspring will have exon 2 deleted in the cre-expressing tissue, resulting in inactivation of Foxo1 gene expression.

Development
A targeting vector was designed to insert a loxP site upstream of exon 2, and a frt-flanked neomycin resistance (neo) cassette followed by a second loxP site downstream of exon 2 of the forkhead box O1 (Foxo1) gene. The construct was electroporated into 129S6/SvEvTac-derived TC1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into blastocysts and resulting chimeric mice were bred to Tg(ACTFLPe)9205Dym transgenic mice to delete the neo cassette. Progeny were crossed to remove the Flp-expressing transgene. Mice were bred to FVB mice for at least 3 generations before being bred with mice carrying Foxo4tm1Rdp and Foxo3tm1Rdp. Upon arrival, mice were bred to FVB/NJ inbred mice (Stock No. 001800) for at least one generation to establish the colony. The three alleles in this strain were separated and maintained as separate strains (for Foxo4tm1Rdp see Stock No. 024757 and for Foxo3tm1Rdp see Stock No. 024668). Single mutants were bred to FVB/NJ for at least one more generation.

Control Information

  Control
   001800 FVB/NJ
 
  Considerations for Choosing Controls

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Rhabdomyosarcoma 2; RMS2   (FOXO1)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.

Foxo1tm1Rdp/Foxo1tm1Rdp Tg(Alb-cre)21Mgn/0

        involves: 129S1/Sv * C57BL/6 * DBA * FVB   (conditional)
  • homeostasis/metabolism phenotype
  • improved glucose tolerance   (MGI Ref ID J:137845)

Foxo1tm1Rdp/Foxo1tm1Rdp Tg(Mx1-cre)1Cgn/0

        involves: 129S1/Sv * C57BL/6 * CBA * FVB/N   (conditional)
  • mortality/aging
  • premature death
    • development of hemangiomas leads to premature death becoming significant at ~55 weeks of age with induced cre expression   (MGI Ref ID J:118179)
  • tumorigenesis
  • increased hemangioma incidence
    • when mice are treated with poly(I:C) to induce cre expression, 100% of females display mild hemangiomas in the uterus and perirenal fat by 60 weeks of age   (MGI Ref ID J:118179)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cell Biology Research
Transcriptional Regulation

Research Tools
Cre-lox System
      loxP-flanked Sequences
Diabetes and Obesity Research
      loxP
Metabolism Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Foxo1tm1Rdp
Allele Name targeted mutation 1, Ronald DePinho
Allele Type Targeted (Conditional ready (e.g. floxed), No functional change)
Common Name(s) Fox1loxP; FoxO1L; FoxO1flox; Foxo1F; Foxo1fl;
Strain of Origin129S6/SvEvTac
Gene Symbol and Name Foxo1, forkhead box O1
Chromosome 3
Gene Common Name(s) AI876417; Afxh; FKH1; FKHR; FOXO1A; Fkhr1; expressed sequence AI876417;
Molecular Note Exon 2 was flanked with loxP sites. This exon is the first coding exon and contains the C-terminal half of the full-length protein. [MGI Ref ID J:118179]

Genotyping

Genotyping Information

Genotyping Protocols

Foxo1tm1Rdp, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Paik JH; Kollipara R; Chu G; Ji H; Xiao Y; Ding Z; Miao L; Tothova Z; Horner JW; Carrasco DR; Jiang S; Gilliland DG; Chin L; Wong WH; Castrillon DH; DePinho RA. 2007. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128(2):309-23. [PubMed: 17254969]  [MGI Ref ID J:118179]

Additional References

Foxo1tm1Rdp related

Ai D; Chen C; Han S; Ganda A; Murphy AJ; Haeusler R; Thorp E; Accili D; Horton JD; Tall AR. 2012. Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice. J Clin Invest 122(4):1262-70. [PubMed: 22426206]  [MGI Ref ID J:184553]

Alkhatib A; Werner M; Hug E; Herzog S; Eschbach C; Faraidun H; Kohler F; Wossning T; Jumaa H. 2012. FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination. J Exp Med 209(2):395-406. [PubMed: 22291095]  [MGI Ref ID J:181696]

Ambrogini E; Almeida M; Martin-Millan M; Paik JH; Depinho RA; Han L; Goellner J; Weinstein RS; Jilka RL; O'Brien CA; Manolagas SC. 2010. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab 11(2):136-46. [PubMed: 20142101]  [MGI Ref ID J:158622]

Bartell SM; Kim HN; Ambrogini E; Han L; Iyer S; Serra Ucer S; Rabinovitch P; Jilka RL; Weinstein RS; Zhao H; O'Brien CA; Manolagas SC; Almeida M. 2014. FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun 5:3773. [PubMed: 24781012]  [MGI Ref ID J:208828]

Cheng Z; Guo S; Copps K; Dong X; Kollipara R; Rodgers JT; Depinho RA; Puigserver P; White MF. 2009. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med 15(11):1307-11. [PubMed: 19838201]  [MGI Ref ID J:154295]

Deng X; Zhang W; O-Sullivan I; Williams JB; Dong Q; Park EA; Raghow R; Unterman TG; Elam MB. 2012. FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c. J Biol Chem 287(24):20132-43. [PubMed: 22511764]  [MGI Ref ID J:186518]

Dengler HS; Baracho GV; Omori SA; Bruckner S; Arden KC; Castrillon DH; DePinho RA; Rickert RC. 2008. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol 9(12):1388-98. [PubMed: 18978794]  [MGI Ref ID J:143228]

Dong XC; Copps KD; Guo S; Li Y; Kollipara R; DePinho RA; White MF. 2008. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab 8(1):65-76. [PubMed: 18590693]  [MGI Ref ID J:137845]

Feng X; Wang H; Takata H; Day TJ; Willen J; Hu H. 2011. Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells. Nat Immunol 12(6):544-50. [PubMed: 21532575]  [MGI Ref ID J:172604]

Ferron M; Wei J; Yoshizawa T; Del Fattore A; DePinho RA; Teti A; Ducy P; Karsenty G. 2010. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 142(2):296-308. [PubMed: 20655470]  [MGI Ref ID J:164596]

Gan B; Lim C; Chu G; Hua S; Ding Z; Collins M; Hu J; Jiang S; Fletcher-Sananikone E; Zhuang L; Chang M; Zheng H; Wang YA; Kwiatkowski DJ; Kaelin WG Jr; Signoretti S; DePinho RA. 2010. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell 18(5):472-84. [PubMed: 21075312]  [MGI Ref ID J:166830]

Goertz MJ; Wu Z; Gallardo TD; Hamra FK; Castrillon DH. 2011. Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis. J Clin Invest 121(9):3456-66. [PubMed: 21865646]  [MGI Ref ID J:178240]

Haeusler RA; Kaestner KH; Accili D. 2010. FoxOs function synergistically to promote glucose production. J Biol Chem 285(46):35245-8. [PubMed: 20880840]  [MGI Ref ID J:167017]

Haeusler RA; Pratt-Hyatt M; Welch CL; Klaassen CD; Accili D. 2012. Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metab 15(1):65-74. [PubMed: 22197325]  [MGI Ref ID J:182348]

Iyer S; Ambrogini E; Bartell SM; Han L; Roberson PK; de Cabo R; Jilka RL; Weinstein RS; O'Brien CA; Manolagas SC; Almeida M. 2013. FOXOs attenuate bone formation by suppressing Wnt signaling. J Clin Invest 123(8):3409-19. [PubMed: 23867625]  [MGI Ref ID J:201398]

Kajimura D; Lee HW; Riley KJ; Arteaga-Solis E; Ferron M; Zhou B; Clarke CJ; Hannun YA; DePinho RA; Guo EX; Mann JJ; Karsenty G. 2013. Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab 17(6):901-15. [PubMed: 23684624]  [MGI Ref ID J:199264]

Kerdiles YM; Beisner DR; Tinoco R; Dejean AS; Castrillon DH; DePinho RA; Hedrick SM. 2009. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol 10(2):176-84. [PubMed: 19136962]  [MGI Ref ID J:144503]

Kerdiles YM; Stone EL; Beisner DL; McGargill MA; Ch'en IL; Stockmann C; Katayama CD; Hedrick SM. 2010. Foxo transcription factors control regulatory T cell development and function. Immunity 33(6):890-904. [PubMed: 21167754]  [MGI Ref ID J:167720]

Kim KW; Donato J Jr; Berglund ED; Choi YH; Kohno D; Elias CF; Depinho RA; Elmquist JK. 2012. FOXO1 in the ventromedial hypothalamus regulates energy balance. J Clin Invest 122(7):2578-89. [PubMed: 22653058]  [MGI Ref ID J:190474]

Kitamura T; Kitamura YI; Funahashi Y; Shawber CJ; Castrillon DH; Kollipara R; DePinho RA; Kitajewski J; Accili D. 2007. A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. J Clin Invest 117(9):2477-85. [PubMed: 17717603]  [MGI Ref ID J:127419]

Kitamura T; Kitamura YI; Kobayashi M; Kikuchi O; Sasaki T; Depinho RA; Accili D. 2009. Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1. Mol Cell Biol 29(16):4417-30. [PubMed: 19506018]  [MGI Ref ID J:151416]

Kobayashi M; Kikuchi O; Sasaki T; Kim HJ; Yokota-Hashimoto H; Lee YS; Amano K; Kitazumi T; Susanti VY; Kitamura YI; Kitamura T. 2012. FoxO1 as a double-edged sword in the pancreas: analysis of pancreas- and beta-cell-specific FoxO1 knockout mice. Am J Physiol Endocrinol Metab 302(5):E603-13. [PubMed: 22215655]  [MGI Ref ID J:184645]

Kode A; Mosialou I; Silva BC; Joshi S; Ferron M; Rached MT; Kousteni S. 2012. FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis. J Biol Chem 287(12):8757-68. [PubMed: 22298775]  [MGI Ref ID J:183276]

Kode A; Mosialou I; Silva BC; Rached MT; Zhou B; Wang J; Townes TM; Hen R; DePinho RA; Guo XE; Kousteni S. 2012. FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin. J Clin Invest 122(10):3490-503. [PubMed: 22945629]  [MGI Ref ID J:191669]

Lin A; Yao J; Zhuang L; Wang D; Han J; Lam EW; Gan B. 2014. The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress. Oncogene 33(24):3183-94. [PubMed: 23851496]  [MGI Ref ID J:212581]

Lin HV; Plum L; Ono H; Gutierrez-Juarez R; Shanabrough M; Borok E; Horvath TL; Rossetti L; Accili D. 2010. Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes 59(2):337-46. [PubMed: 19933998]  [MGI Ref ID J:164160]

Lu M; Wan M; Leavens KF; Chu Q; Monks BR; Fernandez S; Ahima RS; Ueki K; Kahn CR; Birnbaum MJ. 2012. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat Med 18(3):388-95. [PubMed: 22344295]  [MGI Ref ID J:181642]

Matsumoto M; Pocai A; Rossetti L; Depinho RA; Accili D. 2007. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor foxo1 in liver. Cell Metab 6(3):208-16. [PubMed: 17767907]  [MGI Ref ID J:129965]

Michelini RH; Doedens AL; Goldrath AW; Hedrick SM. 2013. Differentiation of CD8 memory T cells depends on Foxo1. J Exp Med 210(6):1189-200. [PubMed: 23712431]  [MGI Ref ID J:201197]

Paik JH; Ding Z; Narurkar R; Ramkissoon S; Muller F; Kamoun WS; Chae SS; Zheng H; Ying H; Mahoney J; Hiller D; Jiang S; Protopopov A; Wong WH; Chin L; Ligon KL; DePinho RA. 2009. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5(5):540-53. [PubMed: 19896444]  [MGI Ref ID J:154024]

Pajvani UB; Qiang L; Kangsamaksin T; Kitajewski J; Ginsberg HN; Accili D. 2013. Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability. Nat Med 19(8):1054-60. [PubMed: 23832089]  [MGI Ref ID J:199992]

Pajvani UB; Shawber CJ; Samuel VT; Birkenfeld AL; Shulman GI; Kitajewski J; Accili D. 2011. Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner. Nat Med 17(8):961-7. [PubMed: 21804540]  [MGI Ref ID J:174593]

Plum L; Lin HV; Aizawa KS; Liu Y; Accili D. 2012. InsR/FoxO1 signaling curtails hypothalamic POMC neuron number. PLoS One 7(2):e31487. [PubMed: 22319636]  [MGI Ref ID J:185235]

Plum L; Lin HV; Dutia R; Tanaka J; Aizawa KS; Matsumoto M; Kim AJ; Cawley NX; Paik JH; Loh YP; DePinho RA; Wardlaw SL; Accili D. 2009. The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat Med 15(10):1195-201. [PubMed: 19767734]  [MGI Ref ID J:154300]

Poche RA; Sharma R; Garcia MD; Wada AM; Nolte MJ; Udan RS; Paik JH; DePinho RA; Bartlett JD; Dickinson ME. 2012. Transcription factor FoxO1 is essential for enamel biomineralization. PLoS One 7(1):e30357. [PubMed: 22291941]  [MGI Ref ID J:184228]

Ponugoti B; Xu F; Zhang C; Tian C; Pacios S; Graves DT. 2013. FOXO1 promotes wound healing through the up-regulation of TGF-beta1 and prevention of oxidative stress. J Cell Biol 203(2):327-43. [PubMed: 24145170]  [MGI Ref ID J:208099]

Rached MT; Kode A; Silva BC; Jung DY; Gray S; Ong H; Paik JH; DePinho RA; Kim JK; Karsenty G; Kousteni S. 2010. FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest 120(1):357-68. [PubMed: 20038793]  [MGI Ref ID J:156762]

Rached MT; Kode A; Xu L; Yoshikawa Y; Paik JH; Depinho RA; Kousteni S. 2010. FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell Metab 11(2):147-60. [PubMed: 20142102]  [MGI Ref ID J:158621]

Ren H; Orozco IJ; Su Y; Suyama S; Gutierrez-Juarez R; Horvath TL; Wardlaw SL; Plum L; Arancio O; Accili D. 2012. FoxO1 target Gpr17 activates AgRP neurons to regulate food intake. Cell 149(6):1314-26. [PubMed: 22682251]  [MGI Ref ID J:186157]

Ren H; Plum-Morschel L; Gutierrez-Juarez R; Lu TY; Kim-Muller JY; Heinrich G; Wardlaw SL; Silver R; Accili D. 2013. Blunted refeeding response and increased locomotor activity in mice lacking FoxO1 in synapsin-Cre-expressing neurons. Diabetes 62(10):3373-83. [PubMed: 23835335]  [MGI Ref ID J:208948]

Rosborough BR; Raich-Regue D; Matta BM; Lee K; Gan B; DePinho RA; Hackstein H; Boothby M; Turnquist HR; Thomson AW. 2013. Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction. Blood 121(18):3619-30. [PubMed: 23444404]  [MGI Ref ID J:197572]

Sengupta A; Chakraborty S; Paik J; Yutzey KE; Evans-Anderson HJ. 2012. FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development. Dev Dyn 241(4):803-13. [PubMed: 22411556]  [MGI Ref ID J:181602]

Sengupta A; Molkentin JD; Paik JH; DePinho RA; Yutzey KE. 2011. FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. J Biol Chem 286(9):7468-78. [PubMed: 21159781]  [MGI Ref ID J:170395]

Shin DJ; Joshi P; Hong SH; Mosure K; Shin DG; Osborne TF. 2012. Genome-wide analysis of FoxO1 binding in hepatic chromatin: potential involvement of FoxO1 in linking retinoid signaling to hepatic gluconeogenesis. Nucleic Acids Res 40(22):11499-509. [PubMed: 23066095]  [MGI Ref ID J:200256]

Shin DJ; Osborne TF. 2009. FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action. J Biol Chem 284(17):11110-20. [PubMed: 19237543]  [MGI Ref ID J:149773]

Srinivasan L; Sasaki Y; Calado DP; Zhang B; Paik JH; DePinho RA; Kutok JL; Kearney JF; Otipoby KL; Rajewsky K. 2009. PI3 kinase signals BCR-dependent mature B cell survival. Cell 139(3):573-86. [PubMed: 19879843]  [MGI Ref ID J:157297]

Sykes SM; Lane SW; Bullinger L; Kalaitzidis D; Yusuf R; Saez B; Ferraro F; Mercier F; Singh H; Brumme KM; Acharya SS; Scholl C; Tothova Z; Attar EC; Frohling S; Depinho RA; Armstrong SA; Gilliland DG; Scadden DT. 2011. AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias. Cell 146(5):697-708. [PubMed: 21884932]  [MGI Ref ID J:176214]

Talchai C; Xuan S; Kitamura T; DePinho RA; Accili D. 2012. Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet 44(4):406-12, S1. [PubMed: 22406641]  [MGI Ref ID J:183890]

Talchai C; Xuan S; Lin HV; Sussel L; Accili D. 2012. Pancreatic beta Cell Dedifferentiation as a Mechanism of Diabetic beta Cell Failure. Cell 150(6):1223-34. [PubMed: 22980982]  [MGI Ref ID J:187963]

Tao R; Wei D; Gao H; Liu Y; Depinho RA; Dong XC. 2011. Hepatic FoxOs Regulate Lipid Metabolism via Modulation of Expression of the Nicotinamide Phosphoribosyltransferase Gene. J Biol Chem 286(16):14681-90. [PubMed: 21388966]  [MGI Ref ID J:171118]

Tao R; Xiong X; DePinho RA; Deng CX; Dong XC. 2013. FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression. J Biol Chem 288(41):29252-9. [PubMed: 23974119]  [MGI Ref ID J:203942]

Tao R; Xiong X; DePinho RA; Deng CX; Dong XC. 2013. Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. J Lipid Res 54(10):2745-53. [PubMed: 23881913]  [MGI Ref ID J:202625]

Tejera MM; Kim EH; Sullivan JA; Plisch EH; Suresh M. 2013. FoxO1 controls effector-to-memory transition and maintenance of functional CD8 T cell memory. J Immunol 191(1):187-99. [PubMed: 23733882]  [MGI Ref ID J:205349]

Tinkum KL; White LS; Marpegan L; Herzog E; Piwnica-Worms D; Piwnica-Worms H. 2013. Forkhead Box O1 (FOXO1), but not p53, Contributes to Robust Induction of p21 Expression in Fasted Mice. J Biol Chem :. [PubMed: 23918930]  [MGI Ref ID J:199432]

Tothova Z; Kollipara R; Huntly BJ; Lee BH; Castrillon DH; Cullen DE; McDowell EP; Lazo-Kallanian S; Williams IR; Sears C; Armstrong SA; Passegue E; DePinho RA; Gilliland DG. 2007. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128(2):325-39. [PubMed: 17254970]  [MGI Ref ID J:117892]

Tsuchiya K; Accili D. 2013. Liver sinusoidal endothelial cells link hyperinsulinemia to hepatic insulin resistance. Diabetes 62(5):1478-89. [PubMed: 23349480]  [MGI Ref ID J:208573]

Tsuchiya K; Tanaka J; Shuiqing Y; Welch CL; DePinho RA; Tabas I; Tall AR; Goldberg IJ; Accili D. 2012. FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metab 15(3):372-81. [PubMed: 22405072]  [MGI Ref ID J:182672]

Tsuchiya K; Westerterp M; Murphy AJ; Subramanian V; Ferrante AW Jr; Tall AR; Accili D. 2013. Expanded granulocyte/monocyte compartment in myeloid-specific triple FoxO knockout increases oxidative stress and accelerates atherosclerosis in mice. Circ Res 112(7):992-1003. [PubMed: 23420833]  [MGI Ref ID J:213325]

Wan M; Leavens KF; Saleh D; Easton RM; Guertin DA; Peterson TR; Kaestner KH; Sabatini DM; Birnbaum MJ. 2011. Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. Cell Metab 14(4):516-27. [PubMed: 21982711]  [MGI Ref ID J:177644]

Xiong X; Tao R; DePinho RA; Dong XC. 2012. The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. J Biol Chem 287(46):39107-14. [PubMed: 22992773]  [MGI Ref ID J:192959]

Yamazaki Y; Kamei Y; Sugita S; Akaike F; Kanai S; Miura S; Hirata Y; Troen BR; Kitamura T; Nishino I; Suganami T; Ezaki O; Ogawa Y. 2010. The cathepsin L gene is a direct target of FOXO1 in skeletal muscle. Biochem J 427(1):171-8. [PubMed: 20088826]  [MGI Ref ID J:161014]

Zhang K; Li L; Qi Y; Zhu X; Gan B; DePinho RA; Averitt T; Guo S. 2012. Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology 153(2):631-46. [PubMed: 22147007]  [MGI Ref ID J:181743]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX18

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, homozygous mice may be bred together.
Mating SystemHeterozygote x Heterozygote         (Female x Male)   21-APR-14

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $232.00Female or MaleHeterozygous for Foxo1tm1Rdp  
$232.00Female or MaleHomozygous for Foxo1tm1Rdp  
Price per Pair (US dollars $)Pair Genotype
$464.00Heterozygous for Foxo1tm1Rdp x Heterozygous for Foxo1tm1Rdp  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $301.60Female or MaleHeterozygous for Foxo1tm1Rdp  
$301.60Female or MaleHomozygous for Foxo1tm1Rdp  
Price per Pair (US dollars $)Pair Genotype
$603.20Heterozygous for Foxo1tm1Rdp x Heterozygous for Foxo1tm1Rdp  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   001800 FVB/NJ
 
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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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