Strain Name:

NOD.B6-(D11Mit167)/DvsJ

Stock Number:

025224

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Availability:

Under Development - Now Accepting Orders

Estimated Available for Distribution Date: 10-NOV-14
This congenic line was generated by SNP and MIT marker assisted transfer to NOD of a B6 derived chromosome 11 segment delineated by the marker D11Mit167. The following set of stocks are useful in further characterizing the previously published Idd32 locus (Diabetes 60:1354, 2011) defined by an AI4 T cell transfer protocol where the NOD variant paradoxically contributes to diabetes resistance: Stock No. 024949; Stock No. 025223; Stock No. 025224.

Description

Strain Information

Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   05-JUN-14
Specieslaboratory mouse
GenerationN6F7+F1 (18-JUL-14)
Generation Definitions
 
Donating Investigator Dave Serreze,   JAX
Donating Investigator John Driver,   University of Florida

Description
These congenic mice exhibit spontaneous diabetes similar to the phenotype observed in NOD wildtype mice. When treated with AI4 T-cells these mice exhibit accelerated diabetes when compared to NOD controls. This congenic line was generated by SNP and MIT marker assisted transfer to NOD of a B6 derived chromosome 11 segment delineated by the marker D11Mit167.

The following set of stocks are useful in further characterizing the previously published Idd32 locus (Diabetes 60:1354, 2011) defined by an AI4 T cell transfer protocol where the NOD variant paradoxically contributes to diabetes resistance: Stock No. 024949; Stock No. 025223; Stock No. 025224.

Development
(B6.NOD-H2g7xNOD) F2 mice were backcrossed to NOD/ShiLtDvs mice for 5 generations prior to inbreeding to fix the B6 congenic interval defined by the D11Mit167 markerto homozygosity. Current generation is N6F7 (May 2014).

Control Information

  Control
   000664 C57BL/6J (approximate)
   001976 NOD/ShiLtJ (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of D11Mit167
024949   B6.NOD-(D11Mit167) H2g7/DvsJ
025223   B6.NOD-(D11Mit167-D11Mit48) H2g7/DvsJ
View Strains carrying other alleles of D11Mit167     (2 strains)

Strains carrying other alleles of Idd32
024949   B6.NOD-(D11Mit167) H2g7/DvsJ
025223   B6.NOD-(D11Mit167-D11Mit48) H2g7/DvsJ
View Strains carrying other alleles of Idd32     (2 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains
      NOD Transgenics

Genes & Alleles

Gene & Allele Information provided by MGI

 
Gene Symbol and Name D11Mit167, DNA segment, Chr 11, Massachusetts Institute of Technology 167
Chromosome 11
 
Gene Symbol and Name Idd32, insulin dependent diabetes susceptibility 32
Chromosome 11

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Driver JP; Chen YG; Zhang W; Asrat S; Serreze DV. 2011. Unmasking genes in a type 1 diabetes-resistant mouse strain that enhances pathogenic CD8 T-cell responses. Diabetes 60(4):1354-9. [PubMed: 21307079]  [MGI Ref ID J:171763]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX18

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice can be bred as homozygotes for the congenic segment.
Mating SystemHomozygote x Homozygote         (Female x Male)   05-JUN-14

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


 

This strain is currently Under Development - Now Accepting Orders.
Estimated Available for Distribution Date: 10-NOV-14

Please note: You may now place orders for this strain although it is not yet ready for distribution. Estimated available for distribution dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for distribution depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain.

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $232.00Female or MaleHomozygous for (D11Mit167)  
Price per Pair (US dollars $)Pair Genotype
$464.00Homozygous for (D11Mit167) x Homozygous for (D11Mit167)  

Standard Supply

Under Development - Now Accepting Orders The strain development process (i.e. importation, rederivation, and colony expansion) usually takes six to nine months.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $301.60Female or MaleHomozygous for (D11Mit167)  
Price per Pair (US dollars $)Pair Genotype
$603.20Homozygous for (D11Mit167) x Homozygous for (D11Mit167)  

Standard Supply

Under Development - Now Accepting Orders The strain development process (i.e. importation, rederivation, and colony expansion) usually takes six to nine months.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Under Development - Now Accepting Orders The strain development process (i.e. importation, rederivation, and colony expansion) usually takes six to nine months.

General Supply Notes

Control Information

  Control
   000664 C57BL/6J (approximate)
   001976 NOD/ShiLtJ (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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