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| Mice of this hybrid cross develop an autoimmune disease resembling human systemic lupus erythematosus. Autoimmunity is characterized by high levels of antinuclear antibodies, hemolytic anemia, proteinuria, and progressive immune complex glomerulonephritis. NZBWF1/J mice have been used as a model for autoimmune disease since the early 1960s elucidating not only the complex immunobiological responses and mechanisms but also the genetic basis for the complex multifactorial disease. | |||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
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Description
Strain Information
Former Names NZBWF1/J (Changed: 24-JAN-06 ) Type *F1 Hybrid; Additional information on Hybrid Strains. Visit our online Nomenclature tutorial. Breeding Considerations This strain is a good breeder. Species laboratory mouse Parentals NZB/BlNJ (000684) Female x NZW/LacJ (001058) Male H2 Haplotype d/z
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agouti
Related Genotype: A/a Tyrp1b/+ p Tyrc/+ +Description
Systemic lupus erythematosus (SLE), is a chronic, inflammatory, autoimmune disease of unknown origin. There is strong evidence supporting the role of genetics in determining susceptibility and resistance to the disease. NZBWF1/J develop an autoimmune disease resembling human systemic lupus erythematosus. Autoimmunity is characterized by high levels of antinuclear antibodies, hemolytic anemia, proteinuria, and progressive immune complex glomerulonephritis. The incidence and severity of symptoms is more pronounced in females. The average lifespan for NZBWF1 is 245 days for females and 406 days for males. NZBWF1/J mice have been used as a model for autoimmune disease since the early 1960s elucidating not only the complex immunobiological responses and mechanisms but also the genetic basis for the complex multifactorial disease.Development
These mice are a hybrid cross between NZB/BlNJ (000684) Female x NZW/LacJ (001058) Male .
Related Strains
F1 Hybrid
100492 B6129PF1/J 100409 B6129PF1/J-Aw-J/Aw 101043 B6129SF1/J 100002 B6AF1/J 100010 B6C3F1/J 001022 B6C3FeF1/J a/a 001201 B6CBACaF1/J-Aw-J/A 100011 B6CBAF1/J 100006 B6D2F1/J 001875 B6EiC3SnF1/J 019019 B6FVBF1/J 100012 B6SJLF1/J 100004 C3D2F1/J 001203 C3FeB6F1/J A/Aw-J 100003 CAF1/J 100007 CB6F1/J 100009 CByB6F1/J View F1 Hybrid (17 strains)
Additional Web Information
JAX® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Immunology, Inflammation and Autoimmunity Research
Autoimmunity
lupus erythematosus
Genes & Alleles
Gene & Allele Information provided by MGI
Currently there are no related genes or alleles for this strain.Genotyping
Genotyping Information
Hybrid mice are produced from breeding two different inbred strains together (F1) or the breeding of hybrids together (F2); no genotyping required.
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Dubois EL; Horowitz RE; Demopoulos HB; Teplitz R. 1966. NZB/NZW mice as a model of Systemic Lupus Erythematosus J Am Med Assoc 195(4):145-9. [MGI Ref ID J:27856]
Additional References
Rigby RJ; Rozzo SJ; Boyle JJ; Lewis M; Kotzin BL; Vyse TJ. 2004. New loci from New Zealand Black and New Zealand White mice on chromosomes 4 and 12 contribute to lupus-like disease in the context of BALB/c. J Immunol 172(7):4609-17. [PubMed: 15034079] [MGI Ref ID J:88464]
Talal N. 1972. Immunological hyperactivity in New Zealand mice. In: Tolerance, Autoimmunity and Aging. Thomas, Springfield, Ill. [MGI Ref ID J:25417]
Theofilopoulos AN; Dixon FJ. 1985. Murine models of systemic lupus erythematosus. Adv Immunol 37:269-390. [PubMed: 3890479] [MGI Ref ID J:109952]
Theofilopoulos AN; McConahey PJ; Izui S; Eisenberg RA; Pereira AB; Creighton WD. 1980. A comparative immunologic analysis of several murine strains with autoimmune manifestations. Clin Immunol Immunopathol 15(3):258-78. [PubMed: 6445246] [MGI Ref ID J:26453]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number MP16
Colony Maintenance
Breeding Considerations This strain is a good breeder. Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Weeks of Age Price per mouse (US dollars $) Gender 3 weeks $50.00 Female or Male 4 weeks $50.00 Female or Male 5 weeks $50.00 Female or Male 6 weeks $52.40 Female or Male 7 weeks $54.80 Female or Male 8 weeks $57.20 Female or Male 9 weeks $59.60 Female or Male 10 weeks $62.00 Female or Male 11 weeks $64.40 Female or Male 12 weeks $66.80 Female or Male 13 weeks $69.20 Female or Male 14 weeks $71.60 Female or Male 15 weeks $74.00 Female or Male 16 weeks $76.40 Female 17 weeks $78.80 Female 18 weeks $81.20 Female 19 weeks $83.60 Female 20 weeks $86.00 Female Standard Supply
Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.
Supply Notes
- Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
| Pricing for International shipping destinations |
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Live Mice
Weeks of Age Price per mouse (US dollars $) Gender 3 weeks $65.00 Female or Male 4 weeks $65.00 Female or Male 5 weeks $65.00 Female or Male 6 weeks $68.20 Female or Male 7 weeks $71.30 Female or Male 8 weeks $74.40 Female or Male 9 weeks $77.50 Female or Male 10 weeks $80.60 Female or Male 11 weeks $83.80 Female or Male 12 weeks $86.90 Female or Male 13 weeks $90.00 Female or Male 14 weeks $93.10 Female or Male 15 weeks $96.20 Female or Male 16 weeks $99.40 Female 17 weeks $102.50 Female 18 weeks $105.60 Female 19 weeks $108.70 Female 20 weeks $111.80 Female Standard Supply
Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.
Supply Notes
- Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
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Standard Supply
Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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