Strain Name: |
NZBWF1/J |
|---|---|
Stock Number: |
100008 |
Availability: | Level 2 |
Price and Supply Information | |
General Terms and Conditions |
| Former Name |
NZBWF1/J (Changed: 24-JAN-06
) |
Product Information
Strain Details
Type *F1 Hybrid Additional information on Hybrid Strains. Species laboratory mouse Parentals NZB/BlNJ (000684) Female x NZW/LacJ (001058) Male H2 Haplotype d/z Appearance
agouti
Related Genotype: A/a Tyrp1b/+ p Tyrc/+ +Strain Description
Systemic lupus erythematosus (SLE), is a chronic, inflammatory, autoimmune disease of unknown origin. There is strong evidence supporting the role of genetics in determining susceptibility and resistance to the disease. NZBWF1/J develop an autoimmune disease resembling human systemic lupus erythematosus. Autoimmunity is characterized by high levels of antinuclear antibodies, hemolytic anemia, proteinuria, and progressive immune complex glomerulonephritis. The incidence and severity of with symptoms more pronounced in females. The average lifespan for NZBWF1 is 245 days for females and 406 days for males. NZBWF1/J mice have been used as a model for autoimmune disease since the early 1960s elucidating not only the complex immunobiological responses and mechanisms but also the genetic basis for the complex multifactorial disease.
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
F1 Hybrid
100492 B6129PF1/J 100409 B6129PF1/J-Aw-J/Aw 101043 B6129SF1/J 100002 B6AF1/J 100010 B6C3F1/J 001022 B6C3FeF1/J a/a 001201 B6CBACaF1/J-Aw-J/A 100011 B6CBAF1/J 100006 B6D2F1/J 001875 B6EiC3SnF1/J 100012 B6SJLF1/J 100004 C3D2F1/J 100016 C3FeB6F1/J 001203 C3FeB6F1/J A/Aw-J 100003 CAF1/J 100007 CB6F1/J 100009 CByB6F1/J 100015 CByD2F1/J 100019 CSJLF1/J 100299 PLSJLF1/J View F1 Hybrid (20 strains)
Additional Web Information
Genetic Quality Control Annual Report
JAX® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
Animal Health Reports
Room Number MP16
Research Applications
This mouse can be used to support research in many areas including:
Immunology and Inflammation Research
Autoimmunity (lupus erythematosus)
Price and Supply Information
| Strain Name: | NZBWF1/J |
| Stock Number: | 100008 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:
- USA, Canada and Mexico
- International
*Pricing for Shipping Destination selected:
International
| Price(s) in US dollars ($) | Genotype(s) Provided | ||||
|---|---|---|---|---|---|
| 3 weeks | $34.20 | Female | |||
| 4 weeks | $34.20 | Female | |||
| 5 weeks | $34.80 | Female | |||
| 6 weeks | $37.40 | Female | |||
| 7 weeks | $40.00 | Female | |||
| 8 weeks | $42.60 | Female | |||
| 9 weeks | $42.60 | Female | |||
| 10 weeks | $49.40 | Female | |||
| 11 weeks | $49.40 | Female | |||
| 12 weeks | $51.90 | Female | |||
| 13 weeks | $54.30 | Female | |||
| 14 weeks | $56.80 | Female | |||
| 15 weeks | $59.30 | Female | |||
| 3 weeks | $34.20 | Male | |||
| 4 weeks | $34.20 | Male | |||
| 5 weeks | $34.80 | Male | |||
| 6 weeks | $37.40 | Male | |||
| 7 weeks | $40.00 | Male | |||
| 8 weeks | $42.60 | Male | |||
| 9 weeks | $42.60 | Male | |||
| 10 weeks | $49.40 | Male | |||
| 11 weeks | $49.40 | Male | |||
| 12 weeks | $51.90 | Male | |||
| 13 weeks | $54.30 | Male | |||
| 14 weeks | $56.80 | Male | |||
| 15 weeks | $59.30 | Male | |||
Supply Details
| Standard Supply | Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request. |
|---|---|
| Supply Notes |
Histology and Tissue Collection Services are available for all JAX® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-207-288-5845. Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form