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Strain Name:

WCB6F1/J KitlSl KitlSl-d

Stock Number:

100401

Availability:

Repository- Live

Price and Supply Information

General Terms and Conditions

Former Name      WCB6F1/J-KitlSl/KitlSl-d    (Changed: 23-FEB-06 )
Genes & Alleles   Kitl;   KitlSl-d;   KitlSl;   Pde6b;   Pde6brd1;

Product Information

Strain Details

Type *F1 Hybrid
Additional information on Hybrid Strains.
Type JAX® GEMM® Strain - Mutant Stock
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Spontaneous Mutation
Specieslaboratory mouse

Appearance
black eyed, white coat, affected
Related Genotype: a/a KitlSl/KitlSl-d

grey with light belly, infrequent belly spot, affected (reversed phenotype on F1 hybrid background)
Related Genotype: a/a KitlSl/+

dark grey with white head blaze, affected (reversed phenotype on F1 hybrid background)
Related Genotype: a/a KitlSl-d/+

black, unaffected
Related Genotype: a/a +/+

Important Note
This strain is heterozygous for the retinal degeneration allele Pde6brd1.

Strain Description
The multiple steel mutations (KitlSl) behave in a semidominant fashion and cause deficiencies in pigment cells, germ cells, and blood cells paralleling those caused by the Kit locus mutations (dominant spotting alleles). Many steel alleles cause severe anemia resulting in death in utero of homozygous mutant mice. However, mice homozygous for some steel mutations and compound heterozygotes for two steel alleles (e.g., KitlSl/KitlSl-d) are viable and have black eyes and a white coat; they have severe macrocytic anemia, and both sexes are usually sterile due to failure of germ cells to migrate correctly during development. Mice heterozygous for a single steel mutation have diluted coat color with a small amount of white spotting, are viable and fertile, and may have a slight macrocytic anemia. Primordial germ cells are absent in the nonviable steel homozygotes and severely reduced in steel heterozygotes. Mast cells are virtually absent in skin and other tissues of steel mutant mice. Tumors tend to develop in germ-cell-deficient ovaries with advancing age.

Mammalian Phenotype Terms assigned by genotype

KitlSl/KitlSl-d

        involves: C57BL/6 * WC
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:5758)
    • 69% of mice live until 4 weeks of age, and 59% survive to 5 months; life span of mice reaching 5 months is reduced 51% vs wild type
    • 88% of mice die from leukemia or ulcerative dermatitis
  • growth/size phenotype
  • weight loss (MGI Ref ID J:5758)
    • dermatitis is accompanied by weight loss
  • hematopoietic system phenotype
  • abnormal reticulocyte morphology (MGI Ref ID J:27511)
    • reticulocyte percentages are higher (8-12%) than in KitlW/KitlW-v mice
  • anemia (MGI Ref ID J:2777)
    • packed cell volumes (PCVs) are 28.8 compared to ~45 for controls
    • surviving mice show macrocytic anemia
  • decreased hematocrit (MGI Ref ID J:27511)
    • hematocrit is lower than normal (~29%) and have lower than normal numbers of macrocytic erythrocytes
  • thymus atrophy (MGI Ref ID J:5758)
    • at autopsy, thymic atrophy was observed in mice that developed ulcerative dermatitis
  • reproductive system phenotype
  • *normal* reproductive system phenotype (MGI Ref ID J:5547)
    • although mutants show a severe deficiency of primordial germ cells (PGCs), migration remaining PGCs from gut endoderm to gonadal ridges appears normal
    • decreased primordial germ cell number (MGI Ref ID J:5547)
      • mean of total PGC counts in embryos on E9 do not differ from mutant counts on E10 and E11; however, means of counts from normal embryos on E10 and E11 are 3 and 8-fold higher than day 9 mean PGC count, indicating a paucity of PGCs in mutants
    • infertility (MGI Ref ID J:5547)
      • mice carrying two mutant alleles at the Kitl locus are sterile
  • tumorigenesis
  • abnormal tumor incidence (MGI Ref ID J:5758)
    • no mice develop reticulum cell neoplasms compared to 30% of controls at 889 days of age
    • leukemia (MGI Ref ID J:5758)
      • lymphocytic leukemia develops in mice (37%) at average age of 370 days vs 5% incidence in wild type and heterozygous mice at 965 days of age
    • papilloma (MGI Ref ID J:2777)
      • mice develop gastric papillomas, with greater frequency than controls
  • immune system phenotype
  • dermatitis (MGI Ref ID J:5758)
    • progressive ulcerative dermatitis develops at average age of 441 days (56% incidence), predominantly on the head and neck and in the axilla vs 20% of controls at 772 days of age; only 5 mice displayed lymphocytic leukemia as well
  • stomach inflammation (MGI Ref ID J:2777)
    • mixed inflammatory infiltrates are seen in lamina propria and submucosa of stomach
  • thymus atrophy (MGI Ref ID J:5758)
    • at autopsy, thymic atrophy was observed in mice that developed ulcerative dermatitis
  • digestive/alimentary phenotype
  • abnormal stomach morphology (MGI Ref ID J:2777)
    • lamina propria of forestomach is mildly edematous with mixed inflammatory infiltrate
    • all layers of forestomach are increased in thickness, but stratum spinosum and stratum corneum are most affected
    • abnormal stomach epithelium morphology (MGI Ref ID J:2777)
      • forestomach is significantly thicker (187 um) than controls (40 um)
      • abnormal stomach squamous epithelium morphology (MGI Ref ID J:2777)
        • nonglandular portion of forestomach is consists of stratified squammous epithelium that is significantly thicker than controls and appears as short folds extending into lamina propria in endophytic pattern
  • peptic ulcer (MGI Ref ID J:2777)
    • one mutant had an ulcer in glandular portion of stomach
  • stomach inflammation (MGI Ref ID J:2777)
    • mixed inflammatory infiltrates are seen in lamina propria and submucosa of stomach
  • skin/coat/nails phenotype
  • dermatitis (MGI Ref ID J:5758)
    • progressive ulcerative dermatitis develops at average age of 441 days (56% incidence), predominantly on the head and neck and in the axilla vs 20% of controls at 772 days of age; only 5 mice displayed lymphocytic leukemia as well

KitlSl/KitlSl-d

        (WC/ReJ KitlSl x B6.D2-KitlSl-d/J)F1-KitlSl/KitlSl-d/J
  • growth/size phenotype
  • decreased body weight (MGI Ref ID J:111273)
    • male mutants weigh 29, 27, and 13% less than than wild-type littermates at 5, 7, and 12 weeks of age
  • postnatal growth retardation (MGI Ref ID J:111273)
    • at 5 weeks, tibial length in males is less than controls, but by 12 weeks there has been catch-up growth and no significant difference is detected
  • skeleton phenotype
  • abnormal bone mineralization (MGI Ref ID J:111273)
    • whole body bone mineral content (BMC) is reduced in males compared to controls at all age groups
    • in females, wild type BMC is higher than in female mutants at 5 weeks
    • decreased bone density (MGI Ref ID J:111273)
      • bone mineral density (BMD) in males is significantly reduced at all age groups compared to controls; whole body as well as long bone and lumbar vertebral BMD are reduced
      • in females, BMD at 5 weeks is reduced compared to controls with exception of the femur
      • magnitude of change for each bone is larger in male mutants (9-41%) than female mutants (5-25%)
  • abnormal cancellous bone morphology (MGI Ref ID J:111273)
    • cancellous bone volume/tissue volume is significantly reduced compared to wild-type
  • abnormal osteoblast physiology (MGI Ref ID J:111273)
    • in culture, primary osteoblasts display decreased mineralization compared to wild-type when both are treated with BMP-2
  • abnormal osteoclast morphology (MGI Ref ID J:111273)
    • osteoclast surface per bone surface is increased from 59% at 5 weeks to 441% at 12 weeks compared to wild-type males
  • abnormal skeleton development (MGI Ref ID J:111273)
    • bone formation rate is decreased in 5 week old mice and to a lesser extent at 7 weeks, but no difference is seen at 12 weeks
  • decreased cortical bone thickness (MGI Ref ID J:111273)
    • cortical and marrow area of tibias is reduced in males vs controls
  • hematopoietic system phenotype
  • abnormal osteoclast morphology (MGI Ref ID J:111273)
    • osteoclast surface per bone surface is increased from 59% at 5 weeks to 441% at 12 weeks compared to wild-type males
  • abnormal red blood cell (MGI Ref ID J:5985)
    • moderate but significant increase in protoporphrin levels in red blood cells compared to controls
  • immune system phenotype
  • abnormal osteoclast morphology (MGI Ref ID J:111273)
    • osteoclast surface per bone surface is increased from 59% at 5 weeks to 441% at 12 weeks compared to wild-type males
  • homeostasis/metabolism phenotype
  • increased porphyrin level (MGI Ref ID J:5985)
    • moderate but significant increase in protoporphrin levels in red blood cells compared to controls

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

KitlSl-d/Kitl+

        either: DBA/2J or (C57BL/6 x DBA/2)F1
  • pigmentation phenotype
  • diluted coat color (MGI Ref ID J:13392)
    • heterozygotes have a slightly diluted coat color
  • skin/coat/nails phenotype
  • diluted coat color (MGI Ref ID J:13392)
    • heterozygotes have a slightly diluted coat color

KitlSl-d/Kitl+

        either: (involves: C57BL/6 * DBA/2J) or (involves: C3H * C57BL/6 * DBA/2J * WC)
  • hematopoietic system phenotype
  • anemia (MGI Ref ID J:6084)
    • mice are slightly anemic
  • decreased mast cell number (MGI Ref ID J:6084)
    • heterozygotes have decreased mast cell numbers in dorsal skin compared to wild type
  • immune system phenotype
  • decreased mast cell number (MGI Ref ID J:6084)
    • heterozygotes have decreased mast cell numbers in dorsal skin compared to wild type

KitlSl-d/Kitl+

        C3.D2-KitlSl-d
  • hematopoietic system phenotype
  • increased mean corpuscular hemoglobin (MGI Ref ID J:79293)
    • significantly increased compared to wild-type at P24-25
  • increased mean corpuscular volume (MGI Ref ID J:79293)
    • significantly increased compared to wild-type at P24-25
  • low mean erythrocyte cell number (MGI Ref ID J:79293)
    • at P1, mean red blood cell (RBC) counts are not different from KitlSl-d / KitlSl-gb compound heterozygotes (2.9 x 109 cells/ml; 4.1 x 109 cells/ml in wild-type mice)
  • macrocytic anemia (MGI Ref ID J:79293)
    • mild at birth
  • pigmentation phenotype
  • abnormal ventral coat pigmentation (MGI Ref ID J:79293)
    • diluted ventrum
  • head spot (MGI Ref ID J:79293)
  • skin/coat/nails phenotype
  • abnormal ventral coat pigmentation (MGI Ref ID J:79293)
    • diluted ventrum
  • head spot (MGI Ref ID J:79293)

KitlSl-d/KitlSl-d

        C3.D2-KitlSl-d
  • life span-post-weaning/aging
  • *normal* life span-post-weaning/aging (MGI Ref ID J:79293)
    • homozygotes are viable with expected number of homozygotes observed at P1; 83% of mice survive to P18, similar to wild-type
  • hematopoietic system phenotype
  • decreased hematocrit (MGI Ref ID J:79293)
    • significantly lower than wild-type at P24-25
  • increased mean corpuscular hemoglobin concentration (MGI Ref ID J:79293)
    • significantly increased compared to wild-type at P24-25
  • increased mean corpuscular volume (MGI Ref ID J:79293)
    • significantly increased compared to wild-type at P24-25
  • low mean erythrocyte cell number (MGI Ref ID J:79293)
    • significantly lower than wild-type at birth (32% of wild-type value)
  • macrocytic anemia (MGI Ref ID J:79293)
    • severe at birth
  • reproductive system phenotype
  • abnormal primordial germ cell morphology (MGI Ref ID J:115437)
    • between E9.5 and 10.5, most PGCs are found with in the hindgut and these have abnormal morphology, while in wild-type embryos most PGCs are found in dorsal portions of mesentery
    • decreased primordial germ cell number (MGI Ref ID J:115437)
      • moderate numbers of primordial germ cells (PGCs) are seen in genital ridges relative to wild-type and KitlSl-gb homozygotes at E11.5
      • at E9.5, PGCs are located primarily in the ventral axis of the hindgut while in wild-type PGCs are found primarily associated with the hindgut epithelium or in the dorsal axis of the hindgut; total PGC number in mutant embryos is 22% of wild-type
  • cellular phenotype
  • abnormal cell migration (MGI Ref ID J:115437)
    • at E10.5, only 45% of total PGCs have migrated from hindgut, compared to 93% in wild-type
  • abnormal cell proliferation (MGI Ref ID J:115437)
    • proliferation indices of migratory (in mesentery and genital ridges) and postmigratory PGCs (in genital ridges) at 10.5 and 11.5 are significantly reduced compared to wild-type values (54-66% of wild-type values)
  • increased apoptosis (MGI Ref ID J:115437)
    • at E10.5, many PGCs in hindgut appear to be disintegrating; abnormal PGCs in hindgut tend to be nonmotile and apoptotic

KitlSl/KitlSl-d

        involves: C3H * C57BL/6 * DBA/2J * WC
  • hematopoietic system phenotype
  • decreased mast cell number (MGI Ref ID J:6084)
    • in early postnatal mice, mast cell number in skin is ~4% of wild type number
    • adult mice have <1% of numbers in wild type mice
    • no mast cells are detected in stomachs and mesenteries of adult mutants; none are found in cecum, bone marrow, spleen, thymus, heart, lung, kidney, liver or brain in mutants of various ages
  • immune system phenotype
  • abnormal response to transplant (MGI Ref ID J:6084)
    • after receiving skin grafts from Kit/Kit donors, a significant increase in mast cell number in skin is seen, compared no increase observed in reciprocal transplant
  • decreased mast cell number (MGI Ref ID J:6084)
    • in early postnatal mice, mast cell number in skin is ~4% of wild type number
    • adult mice have <1% of numbers in wild type mice
    • no mast cells are detected in stomachs and mesenteries of adult mutants; none are found in cecum, bone marrow, spleen, thymus, heart, lung, kidney, liver or brain in mutants of various ages

Gene & Allele Details

Allele Symbol KitlSl-d
Allele Name steel Dickie
Common Name(s) KL; MGF; MgfSl-d; Sld; Sld;
Strain of OriginDBA/2J
Gene Symbol and Name Kitl, kit ligand
Chromosome 10
Gene Common Name(s) Clo; Con; DKFZp686F2250; Gb; KL-1; Kl1; Kl2; MGF; Mgf; SCF; SF; SHEP7; SLF; Sl; Steel; Steel factor; cloud gray; contrasted; grizzle-belly; mast cell growth factor; steel; stem cell factor;
General Note

Genbank ID for this allele: M64262

Molecular Note A 4kb deletion in genomic DNA results in the absence of 241bp of wild type cDNA and the addition of 67bp of novel sequence, a 174bp net loss. The region that is deleted begins 5 amino acids N-terminal to the transmembrane domain and results in termination of the open reading frame after an additional 3 amino acids. The resulting protein is a soluble truncated one, lacking both transmembrane and cytoplasmic domains. Northern analysis indicates that mRNA is transcribed at nearly wild-type levels in adult tiss [MGI Ref ID J:10750] [MGI Ref ID J:20286] [MGI Ref ID J:40339]
 
Allele Symbol KitlSl
Allele Name steel
Common Name(s) MgfSl; Sl;
Strain of OriginC3H
Gene Symbol and Name Kitl, kit ligand
Chromosome 10
Gene Common Name(s) Clo; Con; DKFZp686F2250; Gb; KL-1; Kl1; Kl2; MGF; Mgf; SCF; SF; SHEP7; SLF; Sl; Steel; Steel factor; cloud gray; contrasted; grizzle-belly; mast cell growth factor; steel; stem cell factor;
General Note Numerous experiments have demonstrated that precursors of pigment cells and blood cells of homozygotes behave normally when transplanted to an environment of wild-type cells, and that the locus exerts its effect through action of cells in the microenvironment of the apparently affected cells. This steel allele is semidominant. The original steel mutation arose spontaneously in the C3H inbred strain the Oak Ridge National Laboratory. Primordial germ cells are absent in KitlSl/KitlSl and deficient in KitlSl/+. There is no pigment-forming ability in the skin of KitlSl/KitlSl embryos (J:28098). KitlSl derived-fibroblasts are incapable of binding the KIT receptor, as normal fibroblasts can (J:10749). KitlSl is a deletion of the locus (J:10748)(J:6031).
Molecular Note By Southern blotting, it was concluded that this allele contains a deletion encompassing most, if not all, of the coding region of the gene. A probe corresponding to nucleotides 6 to 685 of the cDNA failed to hybridize to DNA obtained from embryos homozygous for this allele. PCR analysis with primers for sequences at various distances from the Kit gene narrowed the 5' and 3' deletion endpoints to a 350 and a 380 base-pair region, respectively. Sequencing of the product of PCR using primers designed to span the deletion revealed that it extends through 973,366 base pairs on Chromosome 10 between nucleotide positions 99,177,807 and 100,151,173 (NCBI Map Viewer, Build 36.1), with a 4-base pair insertion joining the deletion endpoints, and contains 6 predicted and 3 known genes. [MGI Ref ID J:10750] [MGI Ref ID J:115283]
 
Allele Symbol Pde6brd1
Allele Name retinal degeneration 1
Common Name(s) rd; rd-1; rd1; rodless retina;

Control Information

  Allele   Control
 KitlSl  Wild-type from the colony
   Wild-type from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for JAX® GEMM® Strains

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Related Strains

Strains carrying   KitlSl-d allele
000160   B6.D2-KitlSl-d/J
000161   WB.D2-KitlSl-d/J
View Strains carrying   KitlSl-d     (2 strains)

Strains carrying   KitlSl allele
000124   B6.Cg-KitlSl Krt71Ca/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
000693   WC/ReJ KitlSl/J
View Strains carrying   KitlSl     (3 strains)

Strains carrying   Pde6brd1 allele
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002   B6.C3-Pde6brd1 Hps4le/J
001022   B6C3FeF1/J a/a
000652   BDP/J
000653   BUB/BnJ
002439   C3.129P2(B6)-B2mtm1Unc/J
005494   C3.129S1(B6)-Grm1rcw/J
000480   C3.MRL-Faslpr/J
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
005973   C3Bir.129P2(B6)-Il10C3Bir/LtJ
004326   C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
001906   C3Ga.Cg-Catb/J
001904   C3H-Atcayji-hes/J
000659   C3H/HeJ
000784   C3H/HeJ-Faslgld/J
000509   C3H/HeJ-Lystbg-2J/J
002433   C3H/HeJ-Spnb4qv-lnd2J/J
005972   C3H/HeJBirLtJ
001824   C3H/HeJSxJ
000635   C3H/HeOuJ
000474   C3H/HeSn
001431   C3H/HeSn-ocd/J
000661   C3H/HeSnJ
002235   C3H/HeSnJ-Ctnna2cdf/J
002333   C3H/HeSnJ-gri/J
006435   C3HeB.SW-Soaa/MonJ
000658   C3HeB/FeJ
001576   C3HeB/FeJ-Atp7btx-J/J
002588   C3HeB/FeJ-Eya1bor/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001886   C3HeB/FeJLe a/a-gnd/J
001908   C3HfB/BiJ
001502   C3Sn.B6-Epha4rb/J
001547   C3Sn.Cg-Cm/J
000656   CBA/J
000813   CBA/J-Atp7aMo-pew/J
000660   DA/HuSnJ
000023   FL/1ReJ
000025   FL/4ReJ
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
002539   FVB.129P2-Abcb4tm1Bor/J
002935   FVB.129S2(B6)-Ccnd1tm1Wbg/J
002953   FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170   FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003078   FVB.Cg-Tg(WapIgf1)39Dlr/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
002374   FVB/N-Tg(MMTV-PyVT)634Mul/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
002384   FVB/N-Tg(UcpDta)1Kz/J
001800   FVB/NJ
003487   FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
001491   FVB/NMob
000734   MOLD/RkJ
000550   MOLF/EiJ
002423   NON/ShiLtJ
000679   P/J
000680   PL/J
100299   PLSJLF1/J
000269   SB/LeJ
005651   SJL.AK-Thy1a/TseJ
000686   SJL/J
000688   ST/bJ
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648   STOCK a/a Cln6nclf/J
000279   STOCK gr +/+ Ap3d1mh/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
004770   SW.B6-Soab/J
002023   SWR.M-Emv21 Emv22/J
000689   SWR/J
000939   SWR/J-Clcn1adr-mto/J
000692   WB/ReJ KitW/J
100410   WBB6F1/J-KitW/KitW-v/J
000693   WC/ReJ KitlSl/J
View Strains carrying   Pde6brd1     (74 strains)

Strains carrying other alleles of Kitl
000090   129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
002993   B6.Cg-KitlSl-18H/EiJ
001380   C3Sn.Cg-KitlSl-con/J
003252   C57BL/6J-KitlSl-20J/J
006839   C57BL/6J-KitlSl-22J/J
000979   STOCK KitlSl-16J/J
View Strains carrying other alleles of Kitl     (6 strains)

View Strains carrying other alleles of Pde6b     (8 strains)

Additional Web Information

JAX® NOTES, February 2001; 481. Mgf Gene Name Changes to Kitl.
JAX® NOTES, Winter 1991; 444. Coat Colors of Anemic Mice.

Animal Health Reports

Room Number           FGB27

Research Applications

This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence (Gonadal Tumors: testicular teratomas)

Hematological Research
Anemia, Iron Deficiency and Transport Defects
Mast Cell Deficiency

Mouse/Human Gene Homologs
synpolydactyly

KitlSl-d related

Cancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence (Gonadal Tumors: ovarian and testicular)

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neural Tube Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Hypothalamus/Pituitary Defects
Skin Defects

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines
Immunodeficiency (Mast Cell Deficiency)

Neurobiology Research
Vestibular and Hearing Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads (germ cell deficient)
Fertility Defects
Gonadal Tumors (ovarian and testicular)

Research Tools
Immunology and Inflammation Research (Mast Cell Deficiency)

Sensorineural Research
Vestibular and Hearing Defects

KitlSl related

Cancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence (Gonadal Tumors: ovarian and testicular)

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neural Crest Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Hypothalamus/Pituitary Defects
Skin Defects

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines
Immunodeficiency (Mast Cell Deficiency)

Neurobiology Research
Vestibular and Hearing Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads (germ cell deficient)
Fertility Defects
Gonadal Tumors (ovarian and testicular)

Research Tools
Immunology and Inflammation Research (Mast Cell Deficiency)

Sensorineural Research
Vestibular and Hearing Defects

Pde6brd1 related

Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive

Sensorineural Research
Retinal Degeneration

References

Selected Reference(s)

Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv). Cancer Res 52(8):2304-9. [PubMed: 1559233]  [MGI Ref ID J:468]

Hayashi C; Sonoda T; Nakano T; Nakayama H; Kitamura Y. 1985. Mast-cell precursors in the skin of mouse embryos and their deficiency in embryos of Sl/Sld genotype. Dev Biol 109(1):234-41. [PubMed: 3987963]  [MGI Ref ID J:7810]

Huang E; Nocka K; Beier DR; Chu TY; Buck J; Lahm HW; Wellner D; Leder P; Besmer P. 1990. The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell 63(1):225-33. [PubMed: 1698557]  [MGI Ref ID J:10751]

Murphy ED. 1977. Effects of mutant steel alleles on leukemogenesis and life-span in the mouse. J Natl Cancer Inst 58(1):107-10. [PubMed: 319242]  [MGI Ref ID J:5758]

Shinohara T; Avarbock MR; Brinster RL. 2000. Functional analysis of spermatogonial stem cells in Steel and cryptorchid infertile mouse models. Dev Biol 220(2):401-11. [PubMed: 10753526]  [MGI Ref ID J:61712]

Zsebo KM; Williams DA; Geissler EN; Broudy VC; Martin FH; Atkins HL; Hsu RY; Birkett NC; Okino KH; Murdock DC; Jacobsen FW; Langley KE; Smith KA; Takeishi T; Cattanach BM; Galli SJ; Suggs SV. 1990. Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 63(1):213-24. [PubMed: 1698556]  [MGI Ref ID J:10750]

Additional References

Price and Supply Information

Strain Name: WCB6F1/J KitlSl KitlSl-d
Stock Number: 100401

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:

*Pricing for Shipping Destination selected:

        International

Price(s) in US dollars ($)Genotype(s) Provided
Individual Mouse Price $219.10Compound Heterozygote for allele KitlSl and allele KitlSl-d
Pair $298.90WC/ReJ KitlSl/J (000693) x B6.D2-KitlSl-d/J (000160)

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes Histology and Tissue Collection Services are available for all JAX® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-207-288-5845.
Usually shipped between four and eight weeks of age.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.
View Control Pricing Information for JAX® Strains.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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