Strain Name:

WBB6F1/J-KitW/KitW-v/J

Stock Number:

100410

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Availability:

Level 4

KitW/KitW-v double heterozygotes are are mast cell deficient, and lack intermediate cells derived from melanoblasts in the stria vascularis resulting in endocochlear degeneration, loss of endocochlear potential, and hearing impairment.

Description

Strain Information

Former Names WBB6F1/J-KitW/KitW-v    (Changed: 23-FEB-06 )
Type Mutant Stock; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Type *F1 Hybrid;
Additional information on Hybrid Strains.
Visit our online Nomenclature tutorial.
Breeding Considerations This strain is an exceptional breeder.
Specieslaboratory mouse

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Appearance
white coat, black eyes, affected
Related Genotype: a/a KitW/KitW-v

black with white belly spot, occasionally has white head blaze, tail has white tip, affected
Related Genotype: a/a KitW/+

grey with light belly and white spot, light tail, affected
Related Genotype: a/a KitW-v/+

black, unaffected
Related Genotype: a/a +/+

Important Note
This strain is heterozygous for the retinal degeneration allele Pde6brd1.

Description
Kit mutant mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. KitW-v homozygotes resemble KitW homozygotes in color, anemia, and germ cells, but many of them survive to maturity. The lack of germ cells in mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone. KitW/KitW-v double heterozygotes are viable but sterile because of germ cell deficiency. They are also mast cell deficient. KitW/KitW-v double heterozygotes lack intermediate cells, derived from melanoblasts, in the stria vascularis resulting in endocochlear degeneration, loss of endocochlear potential, and hearing impairment.

Control Information

  Control
   +/+ from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   KitW-v allele
016588   A.B6-KitW-v/BeiMmjax
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
000194   B6.Cg-Lx KitW-v/J
000350   B6By.Cg-KitW-v MitfMi-wh T/J
000049   C57BL/6J-KitW-v/J
View Strains carrying   KitW-v     (5 strains)

Strains carrying   KitW allele
000164   B6.Cg-KitW/J
000092   FL/1Re-KitW/J
000692   WB/ReJ KitW/J
View Strains carrying   KitW     (3 strains)

Strains carrying   Pde6brd1 allele
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002   B6.C3-Pde6brd1 Hps4le/J
001022   B6C3FeF1/J a/a
000652   BDP/J
000653   BUB/BnJ
002439   C3.129P2(B6)-B2mtm1Unc/J
005494   C3.129S1(B6)-Grm1rcw/J
000509   C3.Cg-Lystbg-2J/J
000480   C3.MRL-Faslpr/J
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
004326   C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
006435   C3Fe.SW-Soaa/MonJ
001904   C3H-Atcayji-hes/J
000659   C3H/HeJ
000511   C3H/HeJ-Ap3d1mh-2J/J
000784   C3H/HeJ-Faslgld/J
002433   C3H/HeJ-Sptbn4qv-lnd2J/J
005972   C3H/HeJBirLtJ
001824   C3H/HeJSxJ
000635   C3H/HeOuJ
000474   C3H/HeSn
001431   C3H/HeSn-ocd/J
000661   C3H/HeSnJ
002333   C3H/HeSnJ-gri/J
001576   C3He-Atp7btx-J/J
000658   C3HeB/FeJ
002588   C3HeB/FeJ-Eya1bor/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001908   C3HfB/BiJ
001502   C3Sn.B6-Epha4rb/EiGrsrJ
002235   C3Sn.C3-Ctnna2cdf/J
001547   C3Sn.Cg-Cm/J
001906   C3fBAnl.Cg-Catb/AnlJ
000656   CBA/J
000813   CBA/J-Atp7aMo-pew/J
000660   DA/HuSnJ
000023   FL/1ReJ
000025   FL/4ReJ
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
002539   FVB.129P2-Abcb4tm1Bor/J
002935   FVB.129S2(B6)-Ccnd1tm1Wbg/J
002953   FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170   FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003078   FVB.Cg-Tg(WapIgf1)39Dlr/J
003487   FVB.Cg-Tg(XGFAP-lacZ)3Mes/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
002384   FVB/N-Tg(UcpDta)1Kz/J
001800   FVB/NJ
001491   FVB/NMob
000804   HPG/BmJ
000734   MOLD/RkJ
000550   MOLF/EiJ
002423   NON/ShiLtJ
000679   P/J
000680   PL/J
000268   RSV/LeJ
000269   SB/LeJ
010968   SB;C3Sn-Lrp4mdig-2J/GrsrJ
005651   SJL.AK-Thy1a/TseJ
000686   SJL/J
000688   ST/bJ
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648   STOCK a/a Cln6nclf/J
000279   STOCK gr +/+ Ap3d1mh/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
004770   SW.B6-Soab/J
002023   SWR.M-Emv21 Emv22/J
000689   SWR/J
000939   SWR/J-Clcn1adr-mto/J
000692   WB/ReJ KitW/J
000693   WC/ReJ KitlSl/J
View Strains carrying   Pde6brd1     (73 strains)

View Strains carrying other alleles of Kit     (32 strains)

View Strains carrying other alleles of Pde6b     (13 strains)

Additional Web Information

JAX® NOTES, Winter 1991; 444. Coat Colors of Anemic Mice.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Gastrointestinal Stromal Tumor; GIST   (KIT)
Mast Cell Disease   (KIT)
Piebald Trait; PBT   (KIT)
Testicular Germ Cell Tumor; TGCT   (KIT)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

KitW/KitW-v

        involves: C57BL/6 * WB
  • digestive/alimentary phenotype
  • peptic ulcer
    • 40% developed prepyloric ulcer, however no duodenal ulcers were found   (MGI Ref ID J:6393)
  • tumorigenesis
  • increased papilloma incidence
    • 40% developed forestomach papillomas   (MGI Ref ID J:6393)
    • increased esophageal papilloma incidence
      • observed papillomas in the lower end of the esophagus but not in the upper two-thirds of the esophagus   (MGI Ref ID J:6393)
  • immune system phenotype
  • abnormal response to transplant
    • after receiving splenocytes from Kitl/Kitl donors, 15 weeks later, mice exhibit significant increase in mast cell numbers in skin, stomach and mesentery   (MGI Ref ID J:6084)
    • after receiving skin grafts from Kitl/Kitl donors, no increase in mast cell number in skin is seen, compared to increase observed in reciprocal transplant   (MGI Ref ID J:6084)

KitW/KitW-v

        (WB/ReJ KitW x C57BL/6J-KitW-v/J)F1-KitW/KitW-v/J
  • mortality/aging
  • increased sensitivity to induced morbidity/mortality
    • significantly higher mortality is exhibited by mutants (88%) by day 21 after induction of anti-glomerular basement membrane glomerulonephritis than wild-type (25%)   (MGI Ref ID J:113500)
  • cardiovascular system phenotype
  • altered response to myocardial infarction
    • exhibit worse heart function and greater cardiac dilatation at 35 days after myocardial infarction than wild-type, showing decreased left ventricle end-systolic pressure and left ventricle thickness, increased left ventricle end-systolic volume, heart-to-body weight ratio, septal wall thickness, percentage of left ventricle infracted and collagen content, and significantly different stoke volume, and positive and negative dp/dt   (MGI Ref ID J:106065)
    • wild-type bone marrow transplanted into mutant mice rescues the adverse cardiac remodeling and impaired cardiac function after myocardial infarction and shows increased mobilization of angiogenic and natural killer cells   (MGI Ref ID J:106065)
    • increased myocardial infarction size
      • 35 days after myocardial infarction show increased percentage of left ventricle infracted   (MGI Ref ID J:106065)
  • decreased vascular permeability
    • do not display increased vascular permeability in the dura mater in response to acute restrain stress as is seen in wild-type controls   (MGI Ref ID J:84660)
  • homeostasis/metabolism phenotype
  • abnormal interferon level
    • treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased levels of IFN-gamma   (MGI Ref ID J:131785)
  • abnormal interleukin level
    • treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased levels of IL-4 (51%), IL-5 (35%), IL-6 (39%), and IL-17 (39%) in cultured peribronchiolar lymph nodes   (MGI Ref ID J:131785)
  • abnormal response/metabolism to endogenous compounds
    • mice exhibit reduced adenosine-induced airway responsiveness compared with wild-type mice   (MGI Ref ID J:123463)
  • altered response to myocardial infarction
    • exhibit worse heart function and greater cardiac dilatation at 35 days after myocardial infarction than wild-type, showing decreased left ventricle end-systolic pressure and left ventricle thickness, increased left ventricle end-systolic volume, heart-to-body weight ratio, septal wall thickness, percentage of left ventricle infracted and collagen content, and significantly different stoke volume, and positive and negative dp/dt   (MGI Ref ID J:106065)
    • wild-type bone marrow transplanted into mutant mice rescues the adverse cardiac remodeling and impaired cardiac function after myocardial infarction and shows increased mobilization of angiogenic and natural killer cells   (MGI Ref ID J:106065)
    • increased myocardial infarction size
      • 35 days after myocardial infarction show increased percentage of left ventricle infracted   (MGI Ref ID J:106065)
  • increased erythrocyte protoporphyrin level
    • moderate but significant increase in protoporphrin levels in red blood cells compared to controls   (MGI Ref ID J:5985)
  • increased urine protein level
    • mice develop increased proteinuria compared to wild-type, 7 and 14 days after induction of anti-glomerular basement membrane (GBM) glomerulonephritis (GN)   (MGI Ref ID J:113500)
  • immune system phenotype
  • *normal* immune system phenotype
    • sensitized mice have a normal early phase reaction (initial phase of bronchoconstriction) after ovalbumin challenge   (MGI Ref ID J:125656)
    • abnormal interferon level
      • treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased levels of IFN-gamma   (MGI Ref ID J:131785)
    • abnormal interleukin level
      • treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased levels of IL-4 (51%), IL-5 (35%), IL-6 (39%), and IL-17 (39%) in cultured peribronchiolar lymph nodes   (MGI Ref ID J:131785)
    • decreased inflammatory response
      • treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased total bronchoalveolar lavage cell numbers (54%) and eosinophils (75%)   (MGI Ref ID J:131785)
    • impaired neutrophil recruitment
      • mice fail to exhibit adenosine-induced neutrophil recruitment unlike wild-type mice   (MGI Ref ID J:123463)
    • kidney inflammation
      • more T cells and macrophages infiltrate kidneys compared to control mice; increased numbers of CD4+ T cells and macrophages are found in glomeruli compared to controls on day 14 after anti-GBM GN   (MGI Ref ID J:113500)
  • renal/urinary system phenotype
  • abnormal renal glomerulus morphology
    • in mice there is accumulation of PAS stain-positive material as well as crescent formation in glomeruli, compared to wild-type   (MGI Ref ID J:113500)
    • glomerular crescent
      • crescent formation in glomeruli   (MGI Ref ID J:113500)
  • increased urine protein level
    • mice develop increased proteinuria compared to wild-type, 7 and 14 days after induction of anti-glomerular basement membrane (GBM) glomerulonephritis (GN)   (MGI Ref ID J:113500)
  • kidney inflammation
    • more T cells and macrophages infiltrate kidneys compared to control mice; increased numbers of CD4+ T cells and macrophages are found in glomeruli compared to controls on day 14 after anti-GBM GN   (MGI Ref ID J:113500)
  • hematopoietic system phenotype
  • impaired neutrophil recruitment
    • mice fail to exhibit adenosine-induced neutrophil recruitment unlike wild-type mice   (MGI Ref ID J:123463)
  • increased erythrocyte protoporphyrin level
    • moderate but significant increase in protoporphrin levels in red blood cells compared to controls   (MGI Ref ID J:5985)
  • respiratory system phenotype
  • decreased airway responsiveness
    • mice exhibit reduced adenosine-induced airway responsiveness and neutrophil recruitment compared with wild-type mice   (MGI Ref ID J:123463)

KitW/KitW-v

        (WB KitW x B6.Cg-KitW-v)F1
  • immune system phenotype
  • decreased susceptibility to induced arthritis
    • after receiving i.p. injections of K/BxN mouse serum in an antibody-induced (autoimmune) arthritis model, mice are protected from arthritis, except for mild and transient symptoms   (MGI Ref ID J:178942)
  • decreased susceptibility to type I hypersensitivity reaction
    • following passive systemic anaphylaxis induced by IgE antigen challenge, mice fail to exhibit increased plasma histamine levels or temporary decrease in rectal temperature unlike wild-type mice   (MGI Ref ID J:197334)
  • skeleton phenotype
  • decreased susceptibility to induced arthritis
    • after receiving i.p. injections of K/BxN mouse serum in an antibody-induced (autoimmune) arthritis model, mice are protected from arthritis, except for mild and transient symptoms   (MGI Ref ID J:178942)
  • homeostasis/metabolism phenotype
  • abnormal body temperature
    • following passive systemic anaphylaxis induced by IgE antigen challenge, mice fail to exhibit temporary decrease in rectal temperature unlike wild-type mice   (MGI Ref ID J:197334)
  • abnormal histamine physiology
    • following passive systemic anaphylaxis induced by IgE antigen challenge, mice fail to exhibit increased plasma histamine levels unlike wild-type mice   (MGI Ref ID J:197334)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

KitW-v/Kit+

        involves: C57BL * DBA
  • pigmentation phenotype
  • belly spot
    • a spot is always present on the belly   (MGI Ref ID J:125080)
  • diluted coat color   (MGI Ref ID J:125080)
  • head spot
    • a head spot frequently but not always occurs   (MGI Ref ID J:125080)
  • hematopoietic system phenotype
  • macrocytic anemia
    • mild macrocytic anemia   (MGI Ref ID J:125080)
  • integument phenotype
  • belly spot
    • a spot is always present on the belly   (MGI Ref ID J:125080)
  • diluted coat color   (MGI Ref ID J:125080)
  • head spot
    • a head spot frequently but not always occurs   (MGI Ref ID J:125080)

KitW-v/Kit+

        involves: C57BL
  • integument phenotype
  • abnormal coat/hair pigmentation
    • variable amount of white spotting   (MGI Ref ID J:2447)
    • slightly diluted coat color   (MGI Ref ID J:2447)
  • pigmentation phenotype
  • abnormal coat/hair pigmentation
    • variable amount of white spotting   (MGI Ref ID J:2447)
    • slightly diluted coat color   (MGI Ref ID J:2447)
  • reproductive system phenotype
  • *normal* reproductive system phenotype
    • fertile   (MGI Ref ID J:2447)

KitW/KitW-v

        Background Not Specified
  • endocrine/exocrine gland phenotype
  • abnormal Sertoli cell morphology
    • serum albumin is detected in adluminal compartment of seminiferous tubules; an indication of sertoli cell tight junction barrier dysfunction   (MGI Ref ID J:210656)
  • reproductive system phenotype
  • abnormal Sertoli cell morphology
    • serum albumin is detected in adluminal compartment of seminiferous tubules; an indication of sertoli cell tight junction barrier dysfunction   (MGI Ref ID J:210656)

KitW/KitW-v

        involves: C57BL
  • digestive/alimentary phenotype
  • abnormal digestive system physiology
    • the mean resting lower esophageal sphincter pressure is significantly lower   (MGI Ref ID J:70182)
  • abnormal interstitial cell of Cajal morphology
    • absence of intramuscular interstitial cells of Cajal from the lower esophageal sphincter   (MGI Ref ID J:70182)
  • muscle phenotype
  • abnormal muscle physiology
    • the mean resting lower esophageal sphincter pressure is significantly lower   (MGI Ref ID J:70182)

KitW/KitW-v

        involves: C57BL/6J
  • liver/biliary system phenotype
  • hepatic steatosis
    • seen in P7.5 mutants and adults   (MGI Ref ID J:125831)

KitW/KitW-v

        involves: C57BL * C57BL/6 * WB
  • mortality/aging
  • increased sensitivity to induced morbidity/mortality
    • unlike in wild type mice, all mice treated with ET-1 die by 60 minutes   (MGI Ref ID J:125964)
    • increased sensitivity to xenobiotic induced morbidity/mortality
      • all mice die following treatment with S6b unlike wild type mice   (MGI Ref ID J:125964)
  • homeostasis/metabolism phenotype
  • abnormal response/metabolism to endogenous compounds
    • unlike in wild type mice, all mice treated with ET-1 die by 60 minutes   (MGI Ref ID J:125964)
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • all mice die following treatment with S6b unlike wild type mice   (MGI Ref ID J:125964)

KitW/KitW-v

        involves: C57BL/6
  • immune system phenotype
  • *normal* immune system phenotype
    • after 6 weeks of exposure to phorbol myristate acetate (PMA), a 10 to 100 fold increase in mast cells in the normally deficient skin is observed; wild-type mice exhibit a 3-4-fold increase following chronic inflammation   (MGI Ref ID J:178942)
    • decreased basophil cell number
      • mice show reduced numbers of splenic basophils   (MGI Ref ID J:178942)
    • decreased mast cell number
      • mice have no peritoneal or connective tissue mast cells   (MGI Ref ID J:178942)
  • hematopoietic system phenotype
  • decreased basophil cell number
    • mice show reduced numbers of splenic basophils   (MGI Ref ID J:178942)
  • decreased mast cell number
    • mice have no peritoneal or connective tissue mast cells   (MGI Ref ID J:178942)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Hematological Research
Anemia, Iron Deficiency and Transport Defects
Mast Cell Deficiency

Internal/Organ Research
Gastrointestinal Defects

KitW-v related

Cancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence
      Gonadal Tumors
      Gonadal Tumors: ovarian
Oncogenes

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neural Crest Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Skin Defects

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      Mast Cell Deficiency

Neurobiology Research
Hearing Defects
Receptor Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads
      germ cell deficient
Fertility Defects
Gonadal Tumors
      ovarian

Research Tools
Immunology, Inflammation and Autoimmunity Research
      Mast Cell Deficiency

Sensorineural Research
Hearing Defects

KitW related

Cancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence
      Gonadal Tumors
      Gonadal Tumors: ovarian
Oncogenes

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neural Crest Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Skin Defects

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      Mast Cell Deficiency

Neurobiology Research
Hearing Defects
Receptor Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads
      germ cell deficient
Fertility Defects
Gonadal Tumors
      ovarian

Research Tools
Immunology, Inflammation and Autoimmunity Research
      Mast Cell Deficiency

Sensorineural Research
Hearing Defects
Retinal Degeneration

Pde6brd1 related

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol KitW-v
Allele Name viable dominant spotting
Allele Type Spontaneous
Common Name(s) KitWv; W'; W2; Wv; Wv;
Strain of Originsilvered black strain
Gene Symbol and Name Kit, kit oncogene
Chromosome 5
Gene Common Name(s) Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male;
Molecular Note A C to T point mutation at nucleotide 2007 results in a threonine to methionine substitution at amino acid 660. [MGI Ref ID J:24351]
 
Allele Symbol KitW
Allele Name dominant spotting
Allele Type Spontaneous
Common Name(s) W;
Strain of Originold mutant of the mouse fancy
Gene Symbol and Name Kit, kit oncogene
Chromosome 5
Gene Common Name(s) Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male;
General Note This is an old mutant of the mouse fancy. KitW mutants are a potential model for human inherited pure red cell anemia, called Diamond-Blackfan anemia (OMIM 205900), but mouse mutants do not respond to corticosteroid treatment as do human patients. Thus, the mechanism of anemia causation in the two conditions must be different (J:14286).
Molecular Note A guanosine to adenosine substitution at the first nucleotide at the 5' boundary of the intron following the transmembrane exon results in two different aberrantly spliced transcripts putatively expressed in a tissue specific manner. A deletion of 107 bp was found in transcripts from mast cells of mutant mice. A deletion of 234 was found in transcripts from brain or bone marrow cells. The GT to AT point mutation probably disrupted a splice donor site, thereby causing exon skipping. The 107 bp deletion could have resulted from skipping of a transmembrane region exon and the 234 bp deletion from skipping 3 exons. The 107 bp deletion would generate a stop codon 12 bp downstream because of a frame shift, whereas the larger deletion would still be in frame. Northern blot analysis indicated that mast cells from mutants have only 31-37% of the transcripts as mast cells derived from normal bone marrow, suggesting that the mutation may reduce efficiency and authenticity of transcription and splicing. [MGI Ref ID J:91867]
 
Allele Symbol Pde6brd1
Allele Name retinal degeneration 1
Allele Type Spontaneous
Common Name(s) Pdebrd1; rd; rd-1; rd1; rodless retina;
Strain of Originvarious
Gene Symbol and Name Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Chromosome 5
Gene Common Name(s) CSNB3; CSNBAD2; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10;
General Note The following inbred strains are known to be homozygous for Pde6b: C3H sublines, CBA/J, FVB/NJ, PL/J, SB, SJL/J, and SWR/J.
Molecular Note Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested. [MGI Ref ID J:11513] [MGI Ref ID J:4366] [MGI Ref ID J:51361]

Genotyping

Genotyping Information

The Jackson Laboratory uses phenotype to determine genotypes for the WBB6F1/J-KitW/KitW-v/J mouse strain. See appearances for this strain under the Description tab.

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv). Cancer Res 52(8):2304-9. [PubMed: 1559233]  [MGI Ref ID J:468]

Murphy ED. 1972. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. J Natl Cancer Inst 48(5):1283-95. [PubMed: 4337905]  [MGI Ref ID J:5274]

Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. [PubMed: 1693331]  [MGI Ref ID J:10528]

Reis MM; Tsai MC; Schlegel PN; Feliciano M; Raffaelli R; Rosenwaks Z; Palermo GD. 2000. Xenogeneic transplantation of human spermatogonia. Zygote 8(2):97-105. [PubMed: 10857580]  [MGI Ref ID J:109890]

Shyu H; Hsu S; Hsieh-Li H; Li H. 2001. A novel member of the RBCC family, Trif, expressed specifically in the spermatids of mouse testis. Mech Dev 108(1-2):213-6. [PubMed: 11578878]  [MGI Ref ID J:71914]

Additional References

Cara DC; Ebbert KV; McCafferty DM. 2004. Mast cell-independent mechanisms of immediate hypersensitivity: a role for platelets. J Immunol 172(8):4964-71. [PubMed: 15067077]  [MGI Ref ID J:89115]

Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768]  [MGI Ref ID J:75095]

Del Rio L; Bennouna S; Salinas J; Denkers EY. 2001. CXCR2 Deficiency Confers Impaired Neutrophil Recruitment and Increased Susceptibility During Toxoplasma gondii Infection. J Immunol 167(11):6503-9. [PubMed: 11714818]  [MGI Ref ID J:72824]

Feldweg AM; Friend DS; Zhou JS; Kanaoka Y; Daheshia M; Li L; Austen KF; Katz HR. 2003. gp49B1 suppresses stem cell factor-induced mast cell activation-secretion and attendant inflammation in vivo. Eur J Immunol 33(8):2262-8. [PubMed: 12884301]  [MGI Ref ID J:84936]

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Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $170.50Female or MaleCompound Heterozygote for KitW/KitW-v  
4 weeks $170.50Female or MaleCompound Heterozygote for KitW/KitW-v  
5 weeks $170.50Female or MaleCompound Heterozygote for KitW/KitW-v  
6 weeks $173.95Female or MaleCompound Heterozygote for KitW/KitW-v  
7 weeks $177.40Female or MaleCompound Heterozygote for KitW/KitW-v  
8 weeks $180.85Female or MaleCompound Heterozygote for KitW/KitW-v  
3 weeks $159.30Female or MaleHeterozygous for KitW-v  
4 weeks $159.30Female or MaleHeterozygous for KitW-v  
5 weeks $159.30Female or MaleHeterozygous for KitW-v  
6 weeks $162.75Female or MaleHeterozygous for KitW-v  
7 weeks $166.20Female or MaleHeterozygous for KitW-v  
8 weeks $169.65Female or MaleHeterozygous for KitW-v  
3 weeks $159.30Female or MaleHeterozygous for KitW  
4 weeks $159.30Female or MaleHeterozygous for KitW  
5 weeks $159.30Female or MaleHeterozygous for KitW  
6 weeks $162.75Female or MaleHeterozygous for KitW  
7 weeks $166.20Female or MaleHeterozygous for KitW  
8 weeks $169.65Female or MaleHeterozygous for KitW  
Price per Pair (US dollars $)Pair Genotype
$498.00WB/ReJ KitW/J (000692) x C57BL/6J-KitW-v/J (000049)  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $221.70Female or MaleCompound Heterozygote for KitW/KitW-v  
4 weeks $221.70Female or MaleCompound Heterozygote for KitW/KitW-v  
5 weeks $221.70Female or MaleCompound Heterozygote for KitW/KitW-v  
6 weeks $226.20Female or MaleCompound Heterozygote for KitW/KitW-v  
7 weeks $230.70Female or MaleCompound Heterozygote for KitW/KitW-v  
8 weeks $235.20Female or MaleCompound Heterozygote for KitW/KitW-v  
3 weeks $207.10Female or MaleHeterozygous for KitW-v  
4 weeks $207.10Female or MaleHeterozygous for KitW-v  
5 weeks $207.10Female or MaleHeterozygous for KitW-v  
6 weeks $211.60Female or MaleHeterozygous for KitW-v  
7 weeks $216.10Female or MaleHeterozygous for KitW-v  
8 weeks $220.60Female or MaleHeterozygous for KitW-v  
3 weeks $207.10Female or MaleHeterozygous for KitW  
4 weeks $207.10Female or MaleHeterozygous for KitW  
5 weeks $207.10Female or MaleHeterozygous for KitW  
6 weeks $211.60Female or MaleHeterozygous for KitW  
7 weeks $216.10Female or MaleHeterozygous for KitW  
8 weeks $220.60Female or MaleHeterozygous for KitW  
Price per Pair (US dollars $)Pair Genotype
$647.40WB/ReJ KitW/J (000692) x C57BL/6J-KitW-v/J (000049)  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Control Information

  Control
   +/+ from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

This strain is heterozygous for the retinal degeneration allele Pde6brd1.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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