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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names WBB6F1/J-KitW/KitW-v (Changed: 23-FEB-06 ) Type Mutant Stock; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Type *F1 Hybrid; Additional information on Hybrid Strains. Visit our online Nomenclature tutorial. Species laboratory mouse
View larger imageAppearance
white coat, black eyes, affected
Related Genotype: a/a KitW/KitW-v
black with white belly spot, occasionally has white head blaze, tail has white tip, affected
Related Genotype: a/a KitW/+
grey with light belly and white spot, light tail, affected
Related Genotype: a/a KitW-v/+
black, unaffected
Related Genotype: a/a +/+Important Note
This strain is heterozygous for the retinal degeneration allele Pde6brd1.Description
Kit mutant mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. KitW-v homozygotes resemble KitW homozygotes in color, anemia, and germ cells, but many of them survive to maturity. The lack of germ cells in mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone. KitW/KitW-v double heterozygotes are viable but sterile because of germ cell deficiency. They are also mast cell deficient. KitW/KitW-v double heterozygotes lack intermediate cells, derived from melanoblasts, in the stria vascularis resulting in endocochlear degeneration, loss of endocochlear potential, and hearing impairment.
Control Information
| Control | ||
|---|---|---|
| +/+ from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying KitW-v allele
000599 B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J 000194 B6.Cg-Lx KitW-v/J 000350 B6By.Cg-KitW-v MitfMi-wh T/J 000049 C57BL/6J-KitW-v/J View Strains carrying KitW-v (4 strains)
000164 B6.Cg-KitW/J 000092 FL/1Re-KitW/J 000692 WB/ReJ KitW/J
006564 B6(C)-KitW-41J Gusbmps/BrkJ 000495 B6.C-H38c/By-KitW-56J/J 000560 B6.C-H7b/By KitW-50J/J 000122 B6.C3-KitW-44J/J 000991 B6.C58-KitW-57J/J 002283 B6.Cg-KitW-19H/EiJ 000133 B6.Cg-KitW-24J/J 000139 B6.Cg-KitW-25J/J 005051 B6.Cg-KitW-sh/HNihrJaeBsmJ 000171 B6.D2-KitW-45J/J 001563 B6.D2-KitW-73J/J 001177 B6.LP-KitW-49J/J 000627 C3H/HeJ-KitW-x/J 000847 C3Sn.B6-KitW-39J/J 000166 C57BL/6J-KitW-17J/J 000167 C57BL/6J-KitW-18J/J 000169 C57BL/6J-KitW-20J/J 000117 C57BL/6J-KitW-34J/J 000128 C57BL/6J-KitW-35J/J 000134 C57BL/6J-KitW-37J/J 000062 C57BL/6J-KitW-39J/J 000121 C57BL/6J-KitW-40J/J 000119 C57BL/6J-KitW-41J/J 000127 C57BL/6J-KitW-42J/J 000129 C57BL/6J-KitW-43J/J 000990 C57BL/6J-KitW-55J/J 001179 C57BL/6J-KitW-62J/J 000965 CBACa.C3-KitW-x/J 000993 NZB/BlNJ-KitW-59J/J
004297 B6.CXB1-Pde6brd10/J 003647 B6EiC3Sn.BLiAF1 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004766 C57BL/6J-Pde6brd1-2J/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
Additional Web Information
Genetic Quality Control Annual Report
JAX® NOTES, Winter 1991; 444. Coat Colors of Anemic Mice.
Phenotype
Phenotype Information
assigned by genotype
KitW/KitW-v
involves: C57BL/6 * WB
- digestive/alimentary phenotype
- peptic ulcer (MGI Ref ID J:6393)
- 40% developed prepyloric ulcer, however no duodenal ulcers were found
- tumorigenesis
- papilloma (MGI Ref ID J:6393)
- 40% developed forestomach papillomas
- esophageal papilloma (MGI Ref ID J:6393)
- observed papillomas in the lower end of the esophagus but not in the upper two-thirds of the esophagus
- immune system phenotype
- abnormal response to transplant (MGI Ref ID J:6084)
- after receiving splenocytes from Kitl
/Kitl donors, 15 weeks later, mice exhibit significant increase in mast cell numbers in skin, stomach and mesentery - after receiving skin grafts from Kitl
/Kitl donors, no increase in mast cell number in skin is seen, compared to increase observed in reciprocal transplant KitW/KitW-v
(WB/ReJ KitW x C57BL/6J-KitW-v/J)F1-KitW/KitW-v/J
- life span-post-weaning/aging
- increased sensitivity to induced morbidity/mortality (MGI Ref ID J:113500)
- significantly higher mortality is exhibited by mutants (88%) by day 21 after induction of anti-glomerular basement membrane glomerulonephritis than wild-type (25%)
- cardiovascular system phenotype
- altered response to myocardial infarction (MGI Ref ID J:106065)
- exhibit worse heart function and greater cardiac dilatation at 35 days after myocardial infarction than wild-type, showing decreased left ventricle end-systolic pressure and left ventricle thickness, increased left ventricle end-systolic volume, heart-to-body weight ratio, septal wall thickness, percentage of left ventricle infracted and collagen content, and significantly different stoke volume, and positive and negative dp/dt
- wild-type bone marrow transplanted into mutant mice rescues the adverse cardiac remodeling and impaired cardiac function after myocardial infarction and shows increased mobilization of angiogenic and natural killer cells
- increased infarction size (MGI Ref ID J:106065)
- 35 days after myocardial infarction show increased percentage of left ventricle infracted
- decreased vascular permeability (MGI Ref ID J:84660)
- do not display increased vascular permeability in the dura mater in response to acute restrain stress as is seen in wild-type controls
- homeostasis/metabolism phenotype
- abnormal interferon level (MGI Ref ID J:131785)
- treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased levels of IFN-gamma
- abnormal interleukin level (MGI Ref ID J:131785)
- treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased levels of IL-4 (51%), IL-5 (35%), IL-6 (39%), and IL-17 (39%) in cultured peribronchiolar lymph nodes
- altered response to myocardial infarction (MGI Ref ID J:106065)
- exhibit worse heart function and greater cardiac dilatation at 35 days after myocardial infarction than wild-type, showing decreased left ventricle end-systolic pressure and left ventricle thickness, increased left ventricle end-systolic volume, heart-to-body weight ratio, septal wall thickness, percentage of left ventricle infracted and collagen content, and significantly different stoke volume, and positive and negative dp/dt
- wild-type bone marrow transplanted into mutant mice rescues the adverse cardiac remodeling and impaired cardiac function after myocardial infarction and shows increased mobilization of angiogenic and natural killer cells
- increased infarction size (MGI Ref ID J:106065)
- 35 days after myocardial infarction show increased percentage of left ventricle infracted
- increased porphyrin level (MGI Ref ID J:5985)
- moderate but significant increase in protoporphrin levels in red blood cells compared to controls
- proteinuria (MGI Ref ID J:113500)
- mice develop increased proteinuria compared to wild-type, 7 and 14 days after induction of anti-glomerular basement membrane (GBM) glomerulonephritis (GN)
- immune system phenotype
- *normal* immune system phenotype (MGI Ref ID J:125656)
- sensitized mice have a normal early phase reaction (initial phase of bronchoconstriction) after ovalbumin challenge
- abnormal interferon level (MGI Ref ID J:131785)
- treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased levels of IFN-gamma
- abnormal interleukin level (MGI Ref ID J:131785)
- treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased levels of IL-4 (51%), IL-5 (35%), IL-6 (39%), and IL-17 (39%) in cultured peribronchiolar lymph nodes
- decreased inflammatory response (MGI Ref ID J:131785)
- treatment with Hrh4 antagonist (JNJ 10191584) during ovalbumin challenge results in decreased total bronchoalveolar lavage cell numbers (54%) and eosinophils (75%)
- kidney inflammation (MGI Ref ID J:113500)
- more T cells and macrophages infiltrate kidneys compared to control mice; increased numbers of CD4+ T cells and macrophages are found in glomeruli compared to controls on day 14 after anti-GBM GN
- renal/urinary system phenotype
- abnormal renal glomerulus morphology (MGI Ref ID J:113500)
- in mice there is accumulation of PAS stain-positive material as well as crescent formation in glomeruli, compared to wild-type
- kidney inflammation (MGI Ref ID J:113500)
- more T cells and macrophages infiltrate kidneys compared to control mice; increased numbers of CD4+ T cells and macrophages are found in glomeruli compared to controls on day 14 after anti-GBM GN
- proteinuria (MGI Ref ID J:113500)
- mice develop increased proteinuria compared to wild-type, 7 and 14 days after induction of anti-glomerular basement membrane (GBM) glomerulonephritis (GN)
- hematopoietic system phenotype
- abnormal red blood cell (MGI Ref ID J:5985)
- moderate but significant increase in protoporphrin levels in red blood cells compared to controls
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
KitW/KitW-v
involves: C57BL/6J
- liver/biliary system phenotype
- hepatic steatosis (MGI Ref ID J:125831)
- seen in P7.5 mutants and adults
KitW/KitW-v
involves: C57BL * C57BL/6 * WB
- life span-post-weaning/aging
- increased sensitivity to induced morbidity/mortality (MGI Ref ID J:125964)
- unlike in wild type mice, all mice treated with ET-1 die by 60 minutes
- increased sensitivity to xenobiotic induced morbidity/mortality (MGI Ref ID J:125964)
- all mice die following treatment with S6b unlike wild type mice
- homeostasis/metabolism phenotype
- abnormal response/metabolism to endogenous compounds (MGI Ref ID J:125964)
- unlike in wild type mice, all mice treated with ET-1 die by 60 minutes
- increased sensitivity to xenobiotic induced morbidity/mortality (MGI Ref ID J:125964)
- all mice die following treatment with S6b unlike wild type mice
This mouse can be used to support research in many areas including:
KitW-v relatedHematological Research
Anemia, Iron Deficiency and Transport Defects
Mast Cell Deficiency
Internal/Organ Research
Gastrointestinal Defects
KitW relatedCancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence
Gonadal Tumors: ovarian
Oncogenes
Dermatology Research
Color and White Spotting Defects
Developmental Biology Research
Neural Crest Defects
Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Skin Defects
Immunology and Inflammation Research
Immunodeficiency
Mast Cell Deficiency
Mouse/Human Gene Homologs
piebaldism
synpolydactyly
Neurobiology Research
Receptor Defects
Vestibular and Hearing Defects
Reproductive Biology Research
Developmental Defects Affecting Gonads
germ cell deficient
Fertility Defects
Gonadal Tumors
ovarian
Research Tools
Immunology and Inflammation Research
Mast Cell Deficiency
Sensorineural Research
Vestibular and Hearing Defects
Pde6brd1 relatedCancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence
Gonadal Tumors: ovarian
Oncogenes
Dermatology Research
Color and White Spotting Defects
Developmental Biology Research
Neural Crest Defects
Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Skin Defects
Immunology and Inflammation Research
Immunodeficiency
Mast Cell Deficiency
Mouse/Human Gene Homologs
piebaldism
synpolydactyly
Neurobiology Research
Receptor Defects
Vestibular and Hearing Defects
Reproductive Biology Research
Developmental Defects Affecting Gonads
germ cell deficient
Fertility Defects
Gonadal Tumors
ovarian
Research Tools
Immunology and Inflammation Research
Mast Cell Deficiency
Sensorineural Research
Retinal Degeneration
Vestibular and Hearing Defects
Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
Genes & Alleles
Gene & Allele Information
| Allele Symbol | KitW-v | ||
|---|---|---|---|
| Allele Name | viable dominant spotting | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | KitWv; Wv; Wv; | ||
| Strain of Origin | C57BL | ||
| Gene Symbol and Name | Kit, kit oncogene | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male; | ||
| Molecular Note | A C to T point mutation at nucleotide 2007 results in a threonine to methionine substitution at amino acid 660. [MGI Ref ID J:24351] | ||
| Allele Symbol | KitW | ||
| Allele Name | dominant spotting | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | W; | ||
| Strain of Origin | old mutant of the mouse fancy | ||
| Gene Symbol and Name | Kit, kit oncogene | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male; | ||
| General Note | This is an old mutant of the mouse fancy. KitW mutants are a potential model for human inherited pure red cell anemia, called Diamond-Blackfan anemia (OMIM 205900), but mouse mutants do not respond to corticosteroid treatment as do human patients. Thus, the mechanism of anemia causation in the two conditions must be different (J:14286). | ||
| Molecular Note | A guanosine to adenosine substitution at the first nucleotide at the 5' boundary of the intron following the transmembrane exon results in two different aberrantly spliced transcripts putatively expressed in a tissue specific manner. A deletion of 107 bp was found in transcripts from mast cells of mutant mice. A deletion of 234 was found in transcripts from brain or bone marrow cells. The GT to AT point mutation probably disrupted a splice donor site, thereby causing exon skipping. The 107 bp deletion could have resulted from skipping of a transmembrane region exon and the 234 bp deletion from skipping 3 exons. The 107 bp deletion would generate a stop codon 12 bp downstream because of a frame shift, whereas the larger deletion would still be in frame. Northern blot analysis indicated that mast cells from mutants have only 31-37% of the transcripts as mast cells derived from normal bone marrow, suggesting that the mutation may reduce efficiency and authenticity of transcription and splicing. [MGI Ref ID J:91867] | ||
| Allele Symbol | Pde6brd1 | ||
| Allele Name | retinal degeneration 1 | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Pdebrd1; rd; rd-1; rd1; rodless retina; | ||
Genotyping
Genotyping Information
The Jackson Laboratory uses phenotype to determine genotypes for the WBB6F1/J-KitW/KitW-v/J mouse strain. See appearances for this strain under the Description tab.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv). Cancer Res 52(8):2304-9. [PubMed: 1559233] [MGI Ref ID J:468]
Murphy ED. 1972. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. J Natl Cancer Inst 48(5):1283-95. [PubMed: 4337905] [MGI Ref ID J:5274]
Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. [PubMed: 1693331] [MGI Ref ID J:10528]
Reis MM; Tsai MC; Schlegel PN; Feliciano M; Raffaelli R; Rosenwaks Z; Palermo GD. 2000. Xenogeneic transplantation of human spermatogonia. Zygote 8(2):97-105. [PubMed: 10857580] [MGI Ref ID J:109890]
Shyu H; Hsu S; Hsieh-Li H; Li H. 2001. A novel member of the RBCC family, Trif, expressed specifically in the spermatids of mouse testis. Mech Dev 108(1-2):213-6. [PubMed: 11578878] [MGI Ref ID J:71914]
Additional References
Cara DC; Ebbert KV; McCafferty DM. 2004. Mast cell-independent mechanisms of immediate hypersensitivity: a role for platelets. J Immunol 172(8):4964-71. [PubMed: 15067077] [MGI Ref ID J:89115]
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768] [MGI Ref ID J:75095]
Del Rio L; Bennouna S; Salinas J; Denkers EY. 2001. CXCR2 Deficiency Confers Impaired Neutrophil Recruitment and Increased Susceptibility During Toxoplasma gondii Infection. J Immunol 167(11):6503-9. [PubMed: 11714818] [MGI Ref ID J:72824]
Feldweg AM; Friend DS; Zhou JS; Kanaoka Y; Daheshia M; Li L; Austen KF; Katz HR. 2003. gp49B1 suppresses stem cell factor-induced mast cell activation-secretion and attendant inflammation in vivo. Eur J Immunol 33(8):2262-8. [PubMed: 12884301] [MGI Ref ID J:84936]
Godau J; Heller T; Hawlisch H; Trappe M; Howells E; Best J; Zwirner J; Verbeek JS; Hogarth PM; Gerard C; Van Rooijen N; Klos A; Gessner JE; Kohl J. 2004. C5a initiates the inflammatory cascade in immune complex peritonitis. J Immunol 173(5):3437-45. [PubMed: 15322209] [MGI Ref ID J:92709]
Kitamura Y; Kasugai T; Ebi Y; Nomura S. 1991. Fibroblast-dependent differentiation/proliferation of mast cells. Skin Pharmacol 4 Suppl 1:2-7. [PubMed: 1764248] [MGI Ref ID J:619]
Kitazawa T; Streilein JW. 2000. Hapten-specific tolerance promoted by calcitonin gene-related peptide. J Invest Dermatol 115(6):942-8. [PubMed: 11121123] [MGI Ref ID J:66566]
Lawrence CE; Paterson YY; Wright SH; Knight PA; Miller HR. 2004. Mouse mast cell protease-1 is required for the enteropathy induced by gastrointestinal helminth infection in the mouse. Gastroenterology 127(1):155-65. [PubMed: 15236182] [MGI Ref ID J:93616]
Migliaccio AR; Rana RA; Sanchez M; Lorenzini R; Centurione L; Bianchi L; Vannucchi AM; Migliaccio G; Orkin SH. 2003. GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant. J Exp Med 197(3):281-96. [PubMed: 12566412] [MGI Ref ID J:81780]
Perera EM; Martin H; Seeherunvong T; Kos L; Hughes IA; Hawkins JR; Berkovitz GD. 2001. Tescalcin, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, Col9a3, and renin are expressed in the mouse testis during the early stages of gonadal differentiation. Endocrinology 142(1):455-63. [PubMed: 11145610] [MGI Ref ID J:67267]
Perez-Losada J; Sanchez-Martin M; Perez-Caro M; Perez-Mancera PA; Sanchez-Garcia I. 2003. The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug. Oncogene 22(27):4205-11. [PubMed: 12833143] [MGI Ref ID J:84568]
Sanchez-Martin M; Rodriguez-Garcia A; Perez-Losada J; Sagrera A; Read AP; Sanchez-Garcia I. 2002. SLUG (SNAI2) deletions in patients with Waardenburg disease. Hum Mol Genet 11(25):3231-6. [PubMed: 12444107] [MGI Ref ID J:80529]
Sivarao DV; Mashimo HL; Thatte HS; Goyal RK. 2001. Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice. Gastroenterology 121(1):34-42. [PubMed: 11438492] [MGI Ref ID J:70182]
Valentin M; Balvers M; Pusch W; Weinbauer GF; Knudsen J; Ivell R. 2000. Structure and expression of the mouse gene encoding the endozepine-like peptide from haploid male germ cells Eur J Biochem 267(17):5438-49. [PubMed: 10951202] [MGI Ref ID J:64182]
Welch JS; Escoubet-Lozach L; Sykes DB; Liddiard K; Greaves DR; Glass CK. 2002. TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism. J Biol Chem 277(45):42821-9. [PubMed: 12215441] [MGI Ref ID J:80048]
Wipke BT; Wang Z; Nagengast W; Reichert DE; Allen PM. 2004. Staging the initiation of autoantibody-induced arthritis: a critical role for immune complexes. J Immunol 172(12):7694-702. [PubMed: 15187152] [MGI Ref ID J:90825]
KitW-v relatedKitW relatedAllix S; Reyes-Gomez E; Aubin-Houzelstein G; Noel D; Tiret L; Panthier JJ; Bernex F. 2008. Uterine contractions depend on KIT-positive interstitial cells in the mouse: genetic and pharmacological evidence. Biol Reprod 79(3):510-7. [PubMed: 18480468] [MGI Ref ID J:140900]
Anderson AL; Sporici R; Lambris J; Larosa D; Levinson AI. 2006. Pathogenesis of B-cell superantigen-induced immune complex-mediated inflammation. Infect Immun 74(2):1196-203. [PubMed: 16428769] [MGI Ref ID J:104987]
Antonchuk J; Hyland CD; Hilton DJ; Alexander WS. 2004. Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors. Blood 104(5):1306-13. [PubMed: 15138166] [MGI Ref ID J:92703]
Aoki H; Yamada Y; Hara A; Kunisada T. 2009. Two distinct types of mouse melanocyte: differential signaling requirement for the maintenance of non-cutaneous and dermal versus epidermal melanocytes. Development 136(15):2511-21. [PubMed: 19553284] [MGI Ref ID J:152856]
April CS; Barsh GS. 2007. Distinct Pigmentary and Melanocortin 1 Receptor-Dependent Components of Cutaneous Defense against Ultraviolet Radiation. PLoS Genet 3(1):e9. [PubMed: 17222061] [MGI Ref ID J:118235]
Arinobu Y; Iwasaki H; Gurish MF; Mizuno S; Shigematsu H; Ozawa H; Tenen DG; Austen KF; Akashi K. 2005. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc Natl Acad Sci U S A 102(50):18105-10. [PubMed: 16330751] [MGI Ref ID J:104357]
Ayach BB; Yoshimitsu M; Dawood F; Sun M; Arab S; Chen M; Higuchi K; Siatskas C; Lee P; Lim H; Zhang J; Cukerman E; Stanford WL; Medin JA; Liu PP. 2006. Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Proc Natl Acad Sci U S A 103(7):2304-9. [PubMed: 16467148] [MGI Ref ID J:106065]
Azuma T; Dojyo M; Ito S; Yamazaki Y; Miyaji H; Ito Y; Suto H; Kuriyama M; Kato T; Kohli Y. 1999. Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice. Dig Dis Sci 44(6):1177-83. [PubMed: 10389693] [MGI Ref ID J:57206]
Balvers M; Spiess AN; Domagalski R; Hunt N; Kilic E; Mukhopadhyay AK; Hanks E; Charlton HM; Ivell R. 1998. Relaxin-like factor expression as a marker of differentiation in the mouse testis and ovary. Endocrinology 139(6):2960-70. [PubMed: 9607807] [MGI Ref ID J:114270]
Baumann U; Chouchakova N; Gewecke B; Kohl J; Carroll MC; Schmidt RE; Gessner JE. 2001. Distinct tissue site-specific requirements of mast cells and complement components C3/C5a receptor in IgG immune complex-induced injury of skin and lung. J Immunol 167(2):1022-7. [PubMed: 11441111] [MGI Ref ID J:120524]
Beamer WG; Tennent BJ. 1986. Gonadotropin uptake in genetic and irradiation models of ovarian tumorigenesis. Biol Reprod 34(4):761-70. [PubMed: 3085740] [MGI Ref ID J:48594]
Beckett EA; McGeough CA; Sanders KM; Ward SM. 2003. Pacing of interstitial cells of Cajal in the murine gastric antrum: neurally mediated and direct stimulation. J Physiol 553(Pt 2):545-59. [PubMed: 14500772] [MGI Ref ID J:105541]
Beckett EA; Ro S; Bayguinov Y; Sanders KM; Ward SM. 2007. Kit signaling is essential for development and maintenance of interstitial cells of Cajal and electrical rhythmicity in the embryonic gastrointestinal tract. Dev Dyn 236(1):60-72. [PubMed: 16937373] [MGI Ref ID J:116633]
Bennett JL; Blanchet MR; Zhao L; Zbytnuik L; Antignano F; Gold M; Kubes P; McNagny KM. 2009. Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis. J Immunol 182(9):5507-14. [PubMed: 19380799] [MGI Ref ID J:147712]
Bernstein SE. 1969. Hereditary disorders of the rodent erythron. In: Genetics in Laboratory Animal Medicine. Natl Acad Sci Publ, Washington, DC. [MGI Ref ID J:30699]
Biedermann T; Kneilling M; Mailhammer R; Maier K; Sander CA; Kollias G; Kunkel SL; Hultner L; Rocken M. 2000. Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2 J Exp Med 192(10):1441-52. [PubMed: 11085746] [MGI Ref ID J:65843]
Binstadt BA; Patel PR; Alencar H; Nigrovic PA; Lee DM; Mahmood U; Weissleder R; Mathis D; Benoist C. 2006. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7(3):284-92. [PubMed: 16444258] [MGI Ref ID J:112604]
Boddy G; Daniel EE. 2005. Role of l-Ca(2+) channels in intestinal pacing in wild-type and W/W(V) mice. Am J Physiol Gastrointest Liver Physiol 288(3):G439-46. [PubMed: 15486346] [MGI Ref ID J:97237]
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Waskow C; Terszowski G; Costa C; Gassmann M; Rodewald HR. 2004. Rescue of lethal c-KitW/W mice by erythropoietin. Blood 104(6):1688-95. [PubMed: 15178584] [MGI Ref ID J:92961]
Wehrle-Haller B; Weston JA. 1995. Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway. Development 121(3):731-42. [PubMed: 7536655] [MGI Ref ID J:40215]
Weller K; Foitzik K; Paus R; Syska W; Maurer M. 2006. Mast cells are required for normal healing of skin wounds in mice. FASEB J 20(13):2366-8. [PubMed: 16966487] [MGI Ref ID J:129739]
Wershil BK; Castagliuolo I; Pothoulakis C. 1998. Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in mice. Gastroenterology 114(5):956-64. [PubMed: 9558284] [MGI Ref ID J:107762]
Wershil BK; Theodos CM; Galli SJ; Titus RG. 1994. Mast cells augment lesion size and persistence during experimental Leishmania major infection in the mouse. J Immunol 152(9):4563-71. [PubMed: 8157970] [MGI Ref ID J:17706]
Williams CM; Galli SJ. 2000. Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J Exp Med 192(3):455-62. [PubMed: 10934234] [MGI Ref ID J:63872]
Won KJ; Sanders KM; Ward SM. 2005. Interstitial cells of Cajal mediate mechanosensitive responses in the stomach. Proc Natl Acad Sci U S A 102(41):14913-8. [PubMed: 16204383] [MGI Ref ID J:102473]
Yang-Feng TL; Ullrich A; Francke U. 1987. The oncogene c-kit (KIT) is located on human Chromosome 4 and mouse Chromosome 5. Cytogenet Cell Genet 46:723. [MGI Ref ID J:12308]
Yokozeki H; Wu MH; Sumi K; Igawa K; Miyazaki Y; Katayama I; Takeda K; Akira S; Nishioka K. 2003. Th2 cytokines, IgE and mast cells play a crucial role in the induction of para-phenylenediamine-induced contact hypersensitivity in mice. Clin Exp Immunol 132(3):385-92. [PubMed: 12780683] [MGI Ref ID J:83737]
Zhou JS; Xing W; Friend DS; Austen KF; Katz HR. 2007. Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis. J Exp Med 204(12):2797-802. [PubMed: 17998392] [MGI Ref ID J:128512]
oRdog T; Baldo M; Danko R; Sanders KM. 2002. Plasticity of electrical pacemaking by interstitial cells of Cajal and gastric dysrhythmias in W/W mutant mice. Gastroenterology 123(6):2028-40. [PubMed: 12454859] [MGI Ref ID J:80620]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX5
Colony Maintenance
Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided 3-5 weeks $92.35 Female or Male Compound Heterozygote for KitW/KitW-v 6 weeks $95.00 Female or Male Compound Heterozygote for KitW/KitW-v 7 weeks $97.65 Female or Male Compound Heterozygote for KitW/KitW-v 8 weeks $100.30 Female or Male Compound Heterozygote for KitW/KitW-v 3-5 weeks $92.35 Female or Male Heterozygous for KitW-v 6 weeks $95.00 Female or Male Heterozygous for KitW-v 7 weeks $97.65 Female or Male Heterozygous for KitW-v 8 weeks $100.30 Female or Male Heterozygous for KitW-v 3-5 weeks $92.35 Female or Male Heterozygous for KitW 6 weeks $95.00 Female or Male Heterozygous for KitW 7 weeks $97.65 Female or Male Heterozygous for KitW 8 weeks $100.30 Female or Male Heterozygous for KitW
Pairs /Price (US dollars $) Pair Genotype $216.90 WB/ReJ KitW/J (000692) x C57BL/6J-KitW-v/J (000049)
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided 3-5 weeks $120.10 Female or Male Compound Heterozygote for KitW/KitW-v 6 weeks $123.60 Female or Male Compound Heterozygote for KitW/KitW-v 7 weeks $127.10 Female or Male Compound Heterozygote for KitW/KitW-v 8 weeks $130.60 Female or Male Compound Heterozygote for KitW/KitW-v 3-5 weeks $120.10 Female or Male Heterozygous for KitW-v 6 weeks $123.60 Female or Male Heterozygous for KitW-v 7 weeks $127.10 Female or Male Heterozygous for KitW-v 8 weeks $130.60 Female or Male Heterozygous for KitW-v 3-5 weeks $120.10 Female or Male Heterozygous for KitW 6 weeks $123.60 Female or Male Heterozygous for KitW 7 weeks $127.10 Female or Male Heterozygous for KitW 8 weeks $130.60 Female or Male Heterozygous for KitW
Pairs /Price (US dollars $) Pair Genotype $282.00 WB/ReJ KitW/J (000692) x C57BL/6J-KitW-v/J (000049)
Additional Supply Details
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Supply Details
| Standard Supply | Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months. |
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| Supply Notes |
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| Important Note | |
| This strain is heterozygous for the retinal degeneration allele Pde6brd1. | |
Control Information
| Control | ||
|---|---|---|
| +/+ from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.