Minimize noise. Keep in the quietest area possible, away from doors, sinks, and heavy traffic.
Minimize handling, especially with females close to delivering or with new litters. Stressed mothers are more likely to cannibalize or abandon their young.
Keep males and females together whenever possible to maximize breeding and reduce stress. If a male needs to be removed, do not remove him when the female is about to give birth, and do not return to the cage until pups are weaned.
Handle mice gently with forceps. Disinfect forceps between cages and change gloves frequently, to avoid spreading scents.
Maximize darkness. Move to the darkest location available, away from exit signs and other night light sources. Ensure that the dark cycle is maintained once the lights are turned off.
Provide nesting materials. Nestlets, kimwipes or other soft, fibrous material provide security and enrichment that may enhance productivity. See ‘Enrichment’ suggestions in the Mouse room conditions section.
Consider changing diets. Diets with a higher (or lower) fat or protein content, compared to your standard diet, may improve productivity of a challenging strain.