Conplastic strains
Definition
A conplastic strain has the nuclear genome of one strain and the mitochondrial genome of another. It is developed by backcrossing the nuclear genome from one inbred strain into the cytoplasm of another (the mitochondrial or donor parent is always the female parent during the backcrossing program). As with congenic strains, a minimum of 10 backcross generations is required, counting the N1 generation as the first generation. A conplastic strain is maintained by backcrossing the female mitochondrial donor strain to the male recipient strain (in the nomenclature example below, the female PWD/Ph mouse is backcrossed to the male C57BL/6J mouse).
Also the donor strain name is superscripted (see Stock No. 005761)
Conplastic Strain Nomenclature
The strain name of a conplastic strain consists, in order, of the name of the strain with the nuclear genome, a hyphen (-), the abbreviation for mitochondria (mt), and the name of the strain with the mitochondrial genome (the donor strain). For example, C57BL/6J-mtPWD/Ph/ForeJ (005761) is a strain with the nuclear genome of C57BL/6J and the mitochondrial genome of PWD/Ph.
